Novel anticoagulant activity of polyamino acid offsets bacterial endotoxin-induced extrinsic hypercoagulation: Downregulation of monocytic tissue factor-dependent FVII activation

Journal of Cardiovascular Pharmacology

Volumn 42, Issue 4, 2003, Pages 477-483

  Chu, Arthur J ^a,d   Rauci, Mihai ^a   Nwobi, Obioma I ^a   Mathews, Suresh T ^b   Beydoun, Salwa ^c  

^a University School of Medicine   (United States)

^b WAYNE STATE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c DETROIT MEDICAL CENTER   (United States)

^d 416 Lande Medical Research Bldg ^*  (United States)

Author keywords

Endotoxin; Extrinsic coagulation; FVII activation; Polyamino acids; Sepsis; Tissue factor

Indexed keywords

BLOOD CLOTTING FACTOR; BLOOD CLOTTING FACTOR 10; BLOOD CLOTTING FACTOR 10A; BLOOD CLOTTING FACTOR 7; BLOOD CLOTTING FACTOR 7A; ENDOTOXIN; MONOCYTIC TISSUE FACTOR; POLYAMINOACID; POLYARGININE; POLYASPARTIC ACID; POLYLYSINE; POLYORNITHINE; UNCLASSIFIED DRUG;

ANTICOAGULATION; ARTICLE; BLOOD CLOTTING; CARDIOVASCULAR DISEASE; CATALYSIS; DISSEMINATED INTRAVASCULAR CLOTTING; DRUG EFFICACY; ENZYME ACTIVITY; HUMAN; HUMAN CELL; HYPERCOAGULABILITY; IC 50; INFLAMMATION; MONOCYTE; PRIORITY JOURNAL; PROTHROMBIN TIME; SEPSIS; WESTERN BLOTTING;

ANTICOAGULANTS; BLOOD COAGULATION; BLOOD COAGULATION TESTS; DOWN-REGULATION; ENZYME ACTIVATION; FACTOR VII; FACTOR XA; HUMANS; LIPOPOLYSACCHARIDES; MONOCYTES; PEPTIDES; POLYLYSINE; THROMBOPLASTIN; TUMOR CELLS, CULTURED;

EID: 0141530896     PISSN: 01602446     EISSN: None     Source Type: Journal    
DOI: 10.1097/00005344-200310000-00004     Document Type: Article

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