메뉴 건너뛰기




Volumn 8, Issue 3, 2014, Pages 200-209

Design and evaluation of self-nanoemulsifying drug delivery systems for nebivolol hydrochloride

Author keywords

Dissolution; exvivo drug release; nebivolol hydrochloride; selfnanoemulsifying drug delivery systems; solubility studies

Indexed keywords

EXCIPIENT; NEBIVOLOL; POLYSORBATE 60;

EID: 84906995607     PISSN: 09738398     EISSN: 1998409X     Source Type: Journal    
DOI: 10.4103/0973-8398.139190     Document Type: Article
Times cited : (27)

References (69)
  • 1
    • 0002015409 scopus 로고    scopus 로고
    • Introduction: Semi-solid formulations for oral drug delivery
    • Robinson JR. Introduction: Semi-solid formulations for oral drug delivery. Bull Tech Gattefosse1996;89:11-3.
    • (1996) Bull Tech Gattefosse , vol.89 , pp. 11-13
    • Robinson, J.R.1
  • 2
    • 0029969048 scopus 로고    scopus 로고
    • Intrinsic solubility estimation and pH-solubility behavior of cosalane (NSC 658586), an extremely hydrophobic diprotic acid
    • Venkatesh S, Li J, Xu Y, Vishnuvajjala R, Anderson BD. Intrinsic solubility estimation and pH-solubility behavior of cosalane (NSC 658586), an extremely hydrophobic diprotic acid. Pharm. Res. 1996;13:1453-9.
    • (1996) Pharm. Res. , vol.13 , pp. 1453-1459
    • Venkatesh, S.1    Li, J.2    Xu, Y.3    Vishnuvajjala, R.4    Anderson, B.D.5
  • 3
    • 23144465464 scopus 로고    scopus 로고
    • Solubility enhancement of Cox-2 inhibitors using various solvent systems
    • Seedher N, Bhatia S. Solubility enhancement of Cox-2 inhibitors using various solvent systems. AAPS PharmSciTech 2003;4:E33.
    • (2003) AAPS PharmSciTech , vol.4 , pp. E33
    • Seedher, N.1    Bhatia, S.2
  • 4
    • 85008071016 scopus 로고
    • Studies on absorption of eutectic mixture. i A comparison of the behavior of eutectic mixture of sulfathiazole and that of ordinary sulfathiazole in man
    • Sekiguchi K, Obi N. Studies on absorption of eutectic mixture. I A comparison of the behavior of eutectic mixture of sulfathiazole and that of ordinary sulfathiazole in man. Chem Pharm Bull 1961;9:866-2.
    • (1961) Chem Pharm Bull , vol.9 , pp. 866-872
    • Sekiguchi, K.1    Obi, N.2
  • 5
    • 77953366143 scopus 로고    scopus 로고
    • Solid dispersions: An overview to modify bioavailability of poorly water soluble drugs
    • Tiwari R, Tiwari G, Srivastava B, Rai AK. Solid dispersions: An overview to modify bioavailability of poorly water soluble drugs. Int J Pharm Tech Res 2009;1:1338-49.
    • (2009) Int J Pharm Tech Res , vol.1 , pp. 1338-1349
    • Tiwari, R.1    Tiwari, G.2    Srivastava, B.3    Rai, A.K.4
  • 6
    • 0034601240 scopus 로고    scopus 로고
    • Improving drug solubility for oral delivery using solid dispersions
    • Leuner C, Dressman J. Improving drug solubility for oral delivery using solid dispersions. Eur J Pharm Biopharm 2000;50:47-60.
    • (2000) Eur J Pharm Biopharm , vol.50 , pp. 47-60
    • Leuner, C.1    Dressman, J.2
  • 7
    • 0020700268 scopus 로고
    • The solubility of benzodiazepines in sodium salicylate solution and a proposed mechanism for hydrotropic solubilization
    • Badwana AA, Khordaguib LK, Saleh AM, Khalil SA. The solubility of benzodiazepines in sodium salicylate solution and a proposed mechanism for hydrotropic solubilization. Int J Pharm 1982;13:67-74.
    • (1982) Int J Pharm , vol.13 , pp. 67-74
    • Badwana, A.A.1    Khordaguib, L.K.2    Saleh, A.M.3    Khalil, S.A.4
  • 8
    • 0035850224 scopus 로고    scopus 로고
    • Structure and design of polymeric surfactant-based drug delivery systems
    • Torchilin VP. Structure and design of polymeric surfactant-based drug delivery systems. J Control Release 2001;73:137-72.
    • (2001) J Control Release , vol.73 , pp. 137-172
    • Torchilin, V.P.1
  • 9
    • 0029819323 scopus 로고    scopus 로고
    • Pharmaceutical applications of cyclodextrins. I. Drug solubilization and stabilization
    • Loftsson T, Brewster ME. Pharmaceutical applications of cyclodextrins. I. Drug solubilization and stabilization. J Pharm Sci 1996;85:1017-25.
    • (1996) J Pharm Sci , vol.85 , pp. 1017-1025
    • Loftsson, T.1    Brewster, M.E.2
  • 10
    • 0030712909 scopus 로고    scopus 로고
    • Improved oral bioavailability of the hypocholesterolemic DMP 565 in dogs following oral dosing in oil and glycol solutions
    • Burcham DL, Maurin MB, Hausner EA, Huang SM. Improved oral bioavailability of the hypocholesterolemic DMP 565 in dogs following oral dosing in oil and glycol solutions. Biopharm Drug Dispos 1997;18:737-42.
    • (1997) Biopharm Drug Dispos , vol.18 , pp. 737-742
    • Burcham, D.L.1    Maurin, M.B.2    Hausner, E.A.3    Huang, S.M.4
  • 11
    • 33646547331 scopus 로고    scopus 로고
    • Microemulsions: A potential drug delivery system
    • Ghosh PK, Murthy RS. Microemulsions: A potential drug delivery system. Curr Drug Deliv 2006;3:167-80.
    • (2006) Curr Drug Deliv , vol.3 , pp. 167-180
    • Ghosh, P.K.1    Murthy, R.S.2
  • 12
    • 1842684453 scopus 로고    scopus 로고
    • Self-emulsifying drug delivery systems (SEDDS) for improved oral delivery of lipophilic drugs
    • Gursoy RN, Benita S. Self-emulsifying drug delivery systems (SEDDS) for improved oral delivery of lipophilic drugs. Biomed Pharmacother 2004;58:173-82.
    • (2004) Biomed Pharmacother , vol.58 , pp. 173-182
    • Gursoy, R.N.1    Benita, S.2
  • 13
    • 39149092022 scopus 로고    scopus 로고
    • Enhancing intestinal drug solubilisation using lipid-based delivery systems
    • Porter CJ, Pouton CW, Cuine JF, Charman WN. Enhancing intestinal drug solubilisation using lipid-based delivery systems. Adv Drug Deliv Rev 2008;60:673-91.
    • (2008) Adv Drug Deliv Rev , vol.60 , pp. 673-691
    • Porter, C.J.1    Pouton, C.W.2    Cuine, J.F.3    Charman, W.N.4
  • 14
    • 40149108427 scopus 로고    scopus 로고
    • Hydrogel-thickened nanoemulsion system for topical delivery of lipophilic drugs
    • Mou D, Chen H, Du D, Mao C, Wan J, Xu H, et al. Hydrogel-thickened nanoemulsion system for topical delivery of lipophilic drugs. Int J Pharm 2008;353:270-6.
    • (2008) Int J Pharm , vol.353 , pp. 270-276
    • Mou, D.1    Chen, H.2    Du, D.3    Mao, C.4    Wan, J.5    Xu, H.6
  • 15
    • 0028194817 scopus 로고
    • Self-emulsifying drug delivery systems (SEDDS) with polyglycolysed glycerides for improving in vitro dissolution and oral absorption of lipophilic drugs
    • Shah NH, Carvajal MT, Patel CI, Infeld MH, Malick AW. Self-emulsifying drug delivery systems (SEDDS) with polyglycolysed glycerides for improving in vitro dissolution and oral absorption of lipophilic drugs. Int J Pharm 1994;106:15-23.
    • (1994) Int J Pharm , vol.106 , pp. 15-23
    • Shah, N.H.1    Carvajal, M.T.2    Patel, C.I.3    Infeld, M.H.4    Malick, A.W.5
  • 16
    • 0029562489 scopus 로고
    • Lipid microemulsions for improving drug dissolution and oral absorption: Physical and biopharmaceutical aspects
    • Constantinides PP. Lipid microemulsions for improving drug dissolution and oral absorption: Physical and biopharmaceutical aspects. Pharm Res 1995;12:1561-72.
    • (1995) Pharm Res , vol.12 , pp. 1561-1572
    • Constantinides, P.P.1
  • 17
    • 33847394968 scopus 로고    scopus 로고
    • Lipids and lipid-based formulations: Optimizing the oral delivery of lipophilic drugs
    • Porter CJ, Trevaskis NL, Charman WN. Lipids and lipid-based formulations: Optimizing the oral delivery of lipophilic drugs. Nat Rev Drug Discov 2007;6:231-48.
    • (2007) Nat Rev Drug Discov , vol.6 , pp. 231-248
    • Porter, C.J.1    Trevaskis, N.L.2    Charman, W.N.3
  • 18
    • 76849109564 scopus 로고    scopus 로고
    • Self-emulsifying drug delivery systems (SEDDS): Formulation development, characterization, and applications
    • Singh B, Bandopadhyay S, Kapil R, Singh R, Katare O. Self-emulsifying drug delivery systems (SEDDS): Formulation development, characterization, and applications. Crit Rev Ther Drug Carrier Syst 2009;26:427-51.
    • (2009) Crit Rev Ther Drug Carrier Syst , vol.26 , pp. 427-451
    • Singh, B.1    Bandopadhyay, S.2    Kapil, R.3    Singh, R.4    Katare, O.5
  • 19
    • 0033812424 scopus 로고    scopus 로고
    • Lipids, lipophilic drugs, and oral drug delivery-some emerging concepts
    • Charman WN. Lipids, lipophilic drugs, and oral drug delivery-some emerging concepts. J Pharm Sci 2000;89:967-78.
    • (2000) J Pharm Sci , vol.89 , pp. 967-978
    • Charman, W.N.1
  • 20
    • 0026586447 scopus 로고
    • Self-emulsifying drug delivery systems: Formulation and biopharmaceutic evaluation of an investigational lipophilic compound
    • Charman SA, Charman WN, Rogge MC, Wilson TD, Dutko FJ, Pouton CW. Self-emulsifying drug delivery systems: Formulation and biopharmaceutic evaluation of an investigational lipophilic compound. Pharm Res 1992;9:87-93.
    • (1992) Pharm Res , vol.9 , pp. 87-93
    • Charman, S.A.1    Charman, W.N.2    Rogge, M.C.3    Wilson, T.D.4    Dutko, F.J.5    Pouton, C.W.6
  • 21
    • 0000009718 scopus 로고
    • Microemulsions
    • Swarbrick J, Boylan JC editors New York: Marcel Dekker
    • Eccleston J. Microemulsions. In: Swarbrick J, Boylan JC, editors. Encyclopedia of Pharmaceutical Technology. Vol. 9. New York: Marcel Dekker; 1994. p. 375-421.
    • (1994) Encyclopedia of Pharmaceutical Technology , vol.9 , pp. 375-421
    • Eccleston, J.1
  • 22
    • 0034614208 scopus 로고    scopus 로고
    • Microemulsion-based media as novel drug delivery systems
    • Lawrence MJ, Rees GD. Microemulsion-based media as novel drug delivery systems. Adv Drug Deliv Rev 2000;45:89-121.
    • (2000) Adv Drug Deliv Rev , vol.45 , pp. 89-121
    • Lawrence, M.J.1    Rees, G.D.2
  • 23
    • 39149091886 scopus 로고    scopus 로고
    • Evaluation of the impact of surfactant digestion on the bioavailability of danazol after oral administration of lipidic self-emulsifying formulations to dogs
    • Cuiné JF, McEvoy CL, Charman WN, Pouton CW, Edwards GA, Benameur H, et al. Evaluation of the impact of surfactant digestion on the bioavailability of danazol after oral administration of lipidic self-emulsifying formulations to dogs. J Pharm Sci 2008;97:995-1012.
    • (2008) J Pharm Sci , vol.97 , pp. 995-1012
    • Cuiné, J.F.1    McEvoy, C.L.2    Charman, W.N.3    Pouton, C.W.4    Edwards, G.A.5    Benameur, H.6
  • 24
    • 39149097505 scopus 로고    scopus 로고
    • What determines drug solubility in lipid vehicles: Is it predictable?
    • Rane SS, Anderson BD. What determines drug solubility in lipid vehicles: Is it predictable? Adv Drug Deliv Rev 2008;60:638-56.
    • (2008) Adv Drug Deliv Rev , vol.60 , pp. 638-656
    • Rane, S.S.1    Anderson, B.D.2
  • 25
    • 64149117052 scopus 로고    scopus 로고
    • Development and characterization of oral lipid-based amphotericin B formulations with enhanced drug solubility, stability and antifungal activity in rats infected with Aspergillus fumigatus or Candida albicans
    • Wasan EK, Bartlett K, Gershkovich P, Sivak O, Banno B, Wong Z, et al. Development and characterization of oral lipid-based amphotericin B formulations with enhanced drug solubility, stability and antifungal activity in rats infected with Aspergillus fumigatus or Candida albicans. Int J Pharm 2009;372:76-84.
    • (2009) Int J Pharm , vol.372 , pp. 76-84
    • Wasan, E.K.1    Bartlett, K.2    Gershkovich, P.3    Sivak, O.4    Banno, B.5    Wong, Z.6
  • 26
    • 33748290093 scopus 로고    scopus 로고
    • Preparation and evaluation of self-microemulsifying drug delivery systems (SMEDDS) containing atorvastatin
    • Shen H, Zhong M. Preparation and evaluation of self-microemulsifying drug delivery systems (SMEDDS) containing atorvastatin. J Pharm Pharmacol 2006;58:1183-91.
    • (2006) J Pharm Pharmacol , vol.58 , pp. 1183-1191
    • Shen, H.1    Zhong, M.2
  • 27
    • 0035895309 scopus 로고    scopus 로고
    • Self-emulsifying drug delivery systems (SEDDS) of coenzyme Q10: Formulation development and bioavailability assessment
    • Kommuru TR, Gurley B, Khan MA, Reddy IK. Self-emulsifying drug delivery systems (SEDDS) of coenzyme Q10: Formulation development and bioavailability assessment. Int J Pharm 2001;212:233-46.
    • (2001) Int J Pharm , vol.212 , pp. 233-246
    • Kommuru, T.R.1    Gurley, B.2    Khan, M.A.3    Reddy, I.K.4
  • 28
    • 45849115831 scopus 로고    scopus 로고
    • Development of solid self-emulsifying drug delivery systems: Preparation techniques and dosage forms
    • Tang B, Cheng G, Gu JC, Xu CH. Development of solid self-emulsifying drug delivery systems: Preparation techniques and dosage forms. Drug Discov Today 2008;13:606-12.
    • (2008) Drug Discov Today , vol.13 , pp. 606-612
    • Tang, B.1    Cheng, G.2    Gu, J.C.3    Xu, C.H.4
  • 29
    • 57449109685 scopus 로고    scopus 로고
    • Design and optimization of a new self-nanoemulsifying drug delivery system
    • Wang L, Dong J, Chen J, Eastoe J, Li X. Design and optimization of a new self-nanoemulsifying drug delivery system. J Colloid Interface Sci 2009;330:443-8.
    • (2009) J Colloid Interface Sci , vol.330 , pp. 443-448
    • Wang, L.1    Dong, J.2    Chen, J.3    Eastoe, J.4    Li, X.5
  • 30
    • 0029969387 scopus 로고    scopus 로고
    • An investigation into physical and chemical properties of semi-solid self-emulsifying systems for hard gelatin capsules
    • Halbaut L, Barbé C, Del Pozo A. An investigation into physical and chemical properties of semi-solid self-emulsifying systems for hard gelatin capsules. Int J Pharm 1996;2:203-12.
    • (1996) Int J Pharm , vol.2 , pp. 203-212
    • Halbaut, L.1    Barbé, C.2    Del Pozo, A.3
  • 31
    • 55949089032 scopus 로고    scopus 로고
    • A new self-emulsifying drug delivery system (SEDDS) for poorly soluble drugs: Characterization, dissolution, in vitro digestion and incorporation into solid pellets
    • Abdalla A, Klein S, Mäder K. A new self-emulsifying drug delivery system (SEDDS) for poorly soluble drugs: Characterization, dissolution, in vitro digestion and incorporation into solid pellets. Eur J Pharm Sci 2008;35:457-64.
    • (2008) Eur J Pharm Sci , vol.35 , pp. 457-464
    • Abdalla, A.1    Klein, S.2    Mäder, K.3
  • 33
    • 84906997006 scopus 로고    scopus 로고
    • Available from [Accessed on 2011 Sep 21]
    • Available from:http://www.fda.gov/bbs/topics/NEWS/2007/NEW01757.html. [Accessed on 2011 Sep 21].
  • 34
    • 84907006882 scopus 로고    scopus 로고
    • St. Louis MO: Forest Laboratories Inc hairsp;
    • St. Louis MO: Forest Laboratories, Inc.; 2007. Bystolic (nebivolol), package insert.
    • (2007) Bystolic (Nebivolol), Package Insert
  • 35
    • 38349110193 scopus 로고    scopus 로고
    • Nebivolol: Pharmacologic profile of an ultraselective, vasodilatory beta1-blocker
    • Prisant LM. Nebivolol: Pharmacologic profile of an ultraselective, vasodilatory beta1-blocker. J Clin Pharmacol 2008;48:225-39.
    • (2008) J Clin Pharmacol , vol.48 , pp. 225-239
    • Prisant, L.M.1
  • 36
    • 33747329054 scopus 로고    scopus 로고
    • Nebivolol: A review of its use in the management of hypertension and chronic heart failure
    • Moen MD, Wagstaff AJ. Nebivolol: A review of its use in the management of hypertension and chronic heart failure. Drugs 2006;66:1389-409.
    • (2006) Drugs , vol.66 , pp. 1389-1409
    • Moen, M.D.1    Wagstaff, A.J.2
  • 37
    • 33747796660 scopus 로고    scopus 로고
    • Nebivolol: A novel beta-blocker with nitric oxide-induced vasodilatation
    • Weiss R. Nebivolol: A novel beta-blocker with nitric oxide-induced vasodilatation. Vasc Health Risk Manag 2006;2:303-8.
    • (2006) Vasc Health Risk Manag , vol.2 , pp. 303-308
    • Weiss, R.1
  • 38
    • 79957665321 scopus 로고    scopus 로고
    • Study of cosurfactant effect on nanoemulsifying area and development of lercanidipine loaded (SNEDDS) self nanoemulsifying drug delivery system
    • Parmar N, Singla N, Amin S, Kohli K. Study of cosurfactant effect on nanoemulsifying area and development of lercanidipine loaded (SNEDDS) self nanoemulsifying drug delivery system. Colloids Surf B Biointerfaces 2011;86:327-38.
    • (2011) Colloids Surf B Biointerfaces , vol.86 , pp. 327-338
    • Parmar, N.1    Singla, N.2    Amin, S.3    Kohli, K.4
  • 39
    • 82855175094 scopus 로고    scopus 로고
    • Self-nanoemulsifying drug delivery system for adefovir dipivoxil: Design, characterization, in-vitro and ex-vivo evaluation
    • Gupta S, Chavhan S, Sawant K. Self-nanoemulsifying drug delivery system for adefovir dipivoxil: Design, characterization, in-vitro and ex-vivo evaluation. Colloids Surf A Physicochem Eng Asp 2011;392:145-55.
    • (2011) Colloids Surf A Physicochem Eng Asp , vol.392 , pp. 145-155
    • Gupta, S.1    Chavhan, S.2    Sawant, K.3
  • 40
    • 67549143093 scopus 로고    scopus 로고
    • Preparation and evaluation of self-nanoemulsifying tablets of carvedilol
    • Mahmoud EA, Bendas ER, Mohamed MI. Preparation and evaluation of self-nanoemulsifying tablets of carvedilol. AAPS Pharm Sci Tech 2009;10:183-92.
    • (2009) AAPS Pharm Sci Tech , vol.10 , pp. 183-192
    • Mahmoud, E.A.1    Bendas, E.R.2    Mohamed, M.I.3
  • 41
    • 69749105594 scopus 로고    scopus 로고
    • Self-nanoemulsifying drug delivery systems of tamoxifen citrate: Design and optimization
    • Elnaggar YS, El-Massik MA, Abdallah OY. Self-nanoemulsifying drug delivery systems of tamoxifen citrate: Design and optimization. Int J Pharm 2009;380:133-41.
    • (2009) Int J Pharm , vol.380 , pp. 133-141
    • Elnaggar, Y.S.1    El-Massik, M.A.2    Abdallah, O.Y.3
  • 43
    • 0343378079 scopus 로고
    • Oral anhydrous non-ionic nanoemulsions administered in soft gel capsules
    • Georgakopoulos E, Farah N, Vergnault G. Oral anhydrous non-ionic nanoemulsions administered in soft gel capsules. B.T. Gattefosse 1992;85:11-20.
    • (1992) B.T. Gattefosse , vol.85 , pp. 11-20
    • Georgakopoulos, E.1    Farah, N.2    Vergnault, G.3
  • 44
    • 33845576641 scopus 로고    scopus 로고
    • Design and evaluation of self-nanoemulsifying drug delivery systems (SNEDDS) for cefpodoxime proxetil
    • Date AA, Nagarsenker MS. Design and evaluation of self-nanoemulsifying drug delivery systems (SNEDDS) for cefpodoxime proxetil. Int J Pharm 2007;329:166-72.
    • (2007) Int J Pharm , vol.329 , pp. 166-172
    • Date, A.A.1    Nagarsenker, M.S.2
  • 46
    • 34447333390 scopus 로고    scopus 로고
    • Liquid spray formulations of xibornol by using self-microemulsifying drug delivery systems
    • Cirri M, Mura P, Mora PC. Liquid spray formulations of xibornol by using self-microemulsifying drug delivery systems. Int J Pharm 2007;340:84-91.
    • (2007) Int J Pharm , vol.340 , pp. 84-91
    • Cirri, M.1    Mura, P.2    Mora, P.C.3
  • 47
    • 41349096647 scopus 로고    scopus 로고
    • Preparation and evaluation of self-microemulsifying drug delivery system of oridonin
    • Zhang P, Liu Y, Feng N, Xu J. Preparation and evaluation of self-microemulsifying drug delivery system of oridonin. Int J Pharm 2008;355:269-76.
    • (2008) Int J Pharm , vol.355 , pp. 269-276
    • Zhang, P.1    Liu, Y.2    Feng, N.3    Xu, J.4
  • 48
    • 0037139412 scopus 로고    scopus 로고
    • Preparation and in vitro characterization of a eutectic based semisolid self-nanoemulsified drug delivery system (SNEDDS) of ubiquinone: Mechanism and progress of emulsion formation
    • Nazzal S, Smalyukh II, Lavrentovich OD, Khan MA. Preparation and in vitro characterization of a eutectic based semisolid self-nanoemulsified drug delivery system (SNEDDS) of ubiquinone: Mechanism and progress of emulsion formation. Int J Pharm 2002;235:247-65.
    • (2002) Int J Pharm , vol.235 , pp. 247-265
    • Nazzal, S.1    Smalyukh, I.I.2    Lavrentovich, O.D.3    Khan, M.A.4
  • 49
    • 0036741452 scopus 로고    scopus 로고
    • Effects of nonionic surfactants on membrane transporters in Caco-2 cell monolayers
    • Rege BD, Kao JP, Polli JE. Effects of nonionic surfactants on membrane transporters in Caco-2 cell monolayers. Eur J Pharm Sci 2002;16:237-46.
    • (2002) Eur J Pharm Sci , vol.16 , pp. 237-246
    • Rege, B.D.1    Kao, J.P.2    Polli, J.E.3
  • 50
    • 39149113817 scopus 로고    scopus 로고
    • Formulation of lipid-based delivery systems for oral administration: Materials, methods and strategies
    • Pouton CW, Porter CJ. Formulation of lipid-based delivery systems for oral administration: Materials, methods and strategies. Adv Drug Deliv Rev 2008;60:625-37.
    • (2008) Adv Drug Deliv Rev , vol.60 , pp. 625-637
    • Pouton, C.W.1    Porter, C.J.2
  • 51
    • 33846822906 scopus 로고    scopus 로고
    • Microemulsions as carriers for drugs and nutraceuticals
    • Spernath A, Aserin A. Microemulsions as carriers for drugs and nutraceuticals. Adv Colloid Interface Sci 2006;128-130:47-64.
    • (2006) Adv Colloid Interface Sci , vol.128-130 , pp. 47-64
    • Spernath, A.1    Aserin, A.2
  • 52
    • 0024565173 scopus 로고
    • Enhanced intestinal absorption of cyclosporine in rats through the reduction of emulsion droplet size
    • Tarr BD, Yalkowsky SH. Enhanced intestinal absorption of cyclosporine in rats through the reduction of emulsion droplet size. Pharm Res 1989;6:40-3.
    • (1989) Pharm Res , vol.6 , pp. 40-43
    • Tarr, B.D.1    Yalkowsky, S.H.2
  • 53
    • 0034671698 scopus 로고    scopus 로고
    • Charge-dependent interaction of self-emulsifying oil formulations with Caco-2 cells monolayers: Binding, effects on barrier function and cytotoxicity
    • Gershanik T, Haltner E, Lehr CM, Benita S. Charge-dependent interaction of self-emulsifying oil formulations with Caco-2 cells monolayers: Binding, effects on barrier function and cytotoxicity. Int J Pharm 2000;211:29-36.
    • (2000) Int J Pharm , vol.211 , pp. 29-36
    • Gershanik, T.1    Haltner, E.2    Lehr, C.M.3    Benita, S.4
  • 54
    • 1842609789 scopus 로고    scopus 로고
    • Development of self-microemulsifying drug delivery systems (SMEDDS) for oral bioavailability enhancement of simvastatin in beagle dogs
    • Kang BK, Lee JS, Chon SK, Jeong SY, Yuk SH, Khang G, et al. Development of self-microemulsifying drug delivery systems (SMEDDS) for oral bioavailability enhancement of simvastatin in beagle dogs. Int J Pharm 2004;274:65-73.
    • (2004) Int J Pharm , vol.274 , pp. 65-73
    • Kang, B.K.1    Lee, J.S.2    Chon, S.K.3    Jeong, S.Y.4    Yuk, S.H.5    Khang, G.6
  • 55
    • 0033805858 scopus 로고    scopus 로고
    • Lipid formulations for oral administration of drugs: Non-emulsifying, self-emulsifying and self-microemulsifying drug delivery systems
    • Pouton CW. Lipid formulations for oral administration of drugs: Non-emulsifying, self-emulsifying and self-microemulsifying drug delivery systems. Eur J Pharm Sci 2000;11 Suppl 2:S93-8.
    • (2000) Eur J Pharm Sci , vol.11 , Issue.SUPPL.. 2 , pp. S93-S98
    • Pouton, C.W.1
  • 56
    • 26444443601 scopus 로고    scopus 로고
    • Self emulsifying drug delivery systems (SEDDS): A review
    • Jose S, Kulkarni PK. Self emulsifying drug delivery systems (SEDDS): A review. Indian J Pharm Educ 2002;36:1-7.
    • (2002) Indian J Pharm Educ , vol.36 , pp. 1-7
    • Jose, S.1    Kulkarni, P.K.2
  • 57
    • 0035984949 scopus 로고    scopus 로고
    • Lipid-based formulations for intestinal lymphatic delivery
    • ODriscoll CM. Lipid-based formulations for intestinal lymphatic delivery. Eur J Pharm Sci 2002;15:405-15.
    • (2002) Eur J Pharm Sci , vol.15 , pp. 405-415
    • Odriscoll, C.M.1
  • 58
    • 0034601204 scopus 로고    scopus 로고
    • Self-dispersing lipid formulations for improving oral absorption of lipophilic drugs
    • Gershanik T, Benita S. Self-dispersing lipid formulations for improving oral absorption of lipophilic drugs. Eur J Pharm Biopharm 2000;50:179-88.
    • (2000) Eur J Pharm Biopharm , vol.50 , pp. 179-188
    • Gershanik, T.1    Benita, S.2
  • 59
    • 33846839082 scopus 로고    scopus 로고
    • Formulation and biopharmaceutical evaluation of silymarin using SMEDDS
    • Woo JS, Kim TS, Park JH, Chi SC. Formulation and biopharmaceutical evaluation of silymarin using SMEDDS. Arch Pharm Res 2007;30:82-9.
    • (2007) Arch Pharm Res , vol.30 , pp. 82-89
    • Woo, J.S.1    Kim, T.S.2    Park, J.H.3    Chi, S.C.4
  • 60
    • 21644461482 scopus 로고    scopus 로고
    • Formulation design of self-microemulsifying drug delivery systems for improved oral bioavailability of celecoxib
    • Subramanian N, Ray S, Ghosal SK, Bhadra R, Moulik SP. Formulation design of self-microemulsifying drug delivery systems for improved oral bioavailability of celecoxib. Biol Pharm Bull 2004;27:1993-9.
    • (2004) Biol Pharm Bull , vol.27 , pp. 1993-1999
    • Subramanian, N.1    Ray, S.2    Ghosal, S.K.3    Bhadra, R.4    Moulik, S.P.5
  • 61
    • 25144440877 scopus 로고    scopus 로고
    • Preparation and evaluation of SEDDS and SMEDDS containing carvedilol
    • Wei L, Sun P, Nie S, Pan W. Preparation and evaluation of SEDDS and SMEDDS containing carvedilol. Drug Dev Ind Pharm 2005;31:785-94.
    • (2005) Drug Dev Ind Pharm , vol.31 , pp. 785-794
    • Wei, L.1    Sun, P.2    Nie, S.3    Pan, W.4
  • 62
    • 10644257823 scopus 로고    scopus 로고
    • Effect of combined use of nonionic surfactant on formation of oil-in-water microemulsions
    • Li P, Ghosh A, Wagner RF, Krill S, Joshi YM, Serajuddin AT. Effect of combined use of nonionic surfactant on formation of oil-in-water microemulsions. Int J Pharm 2005;288:27-34.
    • (2005) Int J Pharm , vol.288 , pp. 27-34
    • Li, P.1    Ghosh, A.2    Wagner, R.F.3    Krill, S.4    Joshi, Y.M.5    Serajuddin, A.T.6
  • 63
    • 33847665647 scopus 로고    scopus 로고
    • Formulation of a self-emulsifying system for oral delivery of simvastatin: In vitro and in vivo evaluation
    • Patil P, Patil V, Paradkar A. Formulation of a self-emulsifying system for oral delivery of simvastatin: In vitro and in vivo evaluation. Acta Pharm 2007;57:111-22.
    • (2007) Acta Pharm , vol.57 , pp. 111-122
    • Patil, P.1    Patil, V.2    Paradkar, A.3
  • 64
    • 0030834788 scopus 로고    scopus 로고
    • Formulation and physical characterization of water-in-oil microemulsions containing long-versus medium-chain glycerides
    • Constantinides PP, Scalart JP. Formulation and physical characterization of water-in-oil microemulsions containing long-versus medium-chain glycerides. Int J Pharm 1997;158:57.
    • (1997) Int J Pharm , vol.158 , pp. 57
    • Constantinides, P.P.1    Scalart, J.P.2
  • 65
  • 66
    • 0033992180 scopus 로고    scopus 로고
    • Enhanced absorption of indomethacin after oral or rectal administration of a self-emulsifying system containing indomethacin to rats
    • Kim JY, Ku YS. Enhanced absorption of indomethacin after oral or rectal administration of a self-emulsifying system containing indomethacin to rats. Int J Pharm 2000;194:81-9.
    • (2000) Int J Pharm , vol.194 , pp. 81-89
    • Kim, J.Y.1    Ku, Y.S.2
  • 67
    • 0037093744 scopus 로고    scopus 로고
    • Improvement of physicochemical properties of N-4472 part i formulation design by using self-microemulsifying system
    • Itoh K, Tozuka Y, Oguchi T, Yamamoto K. Improvement of physicochemical properties of N-4472 part I formulation design by using self-microemulsifying system. Int J Pharm 2002;238:153-60.
    • (2002) Int J Pharm , vol.238 , pp. 153-160
    • Itoh, K.1    Tozuka, Y.2    Oguchi, T.3    Yamamoto, K.4
  • 69
    • 43249122851 scopus 로고    scopus 로고
    • Bioavailability of probucol from lipid and surfactant based formulations in minipigs: Influence of droplet size and dietary state
    • Nielsen FS, Petersen KB, Müllertz A. Bioavailability of probucol from lipid and surfactant based formulations in minipigs: Influence of droplet size and dietary state. Eur J Pharm Biopharm 2008;69:553-62.
    • (2008) Eur J Pharm Biopharm , vol.69 , pp. 553-562
    • Nielsen, F.S.1    Petersen, K.B.2    Müllertz, A.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.