The use of solid self-emulsifying systems in the delivery of diclofenac

International Journal of Pharmaceutics

Volumn 262, Issue 1-2, 2003, Pages 23-28

  Attama, A A ^a   Nzekwe, I T ^a   Nnamani, P O ^a   Adikwu, M U ^a   Onugu, C O ^b  

^a UNIVERSITY OF NIGERIA   (Nigeria)

^b Mobil Oil Producing Clinic   (Nigeria)

Author keywords

Diclofenac; Drug release; Goat fat; Self emulsifying system; Tween 65

Indexed keywords

DICLOFENAC; EMULSIFYING AGENT; FAT; PEPSIN A; POLYSORBATE 60; POLYSORBATE 65; UNCLASSIFIED DRUG;

ARTICLE; DRUG DELIVERY SYSTEM; DRUG SOLUBILITY; EMULSION; GOAT; LIQUEFACTION; MOULD; PRIORITY JOURNAL; SIMULATION; SOLID; STOMACH JUICE; TABLET;

EID: 0042634183     PISSN: 03785173     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0378-5173(03)00315-6     Document Type: Article

References (15)

1. Armstrong N.A., James K.C. Drug release from lipid-based dosage forms II. Int. J. Pharm. 6:1980;195-204.
2. Armstrong N.A., James K.C., Wong C.K. An in vitro model for assessing drug availability from lipophilic vehicles. J. Pharm. Pharmacol. 31:1979;657-662.
3. Attama A.A., Ezeabasili S.I., Adikwu M.U. In vitro evaluation of salicylic acid suppositories formulated with palm kernel oil/goat fat mixtures. J. Pharm. Res. Dev. 5:2000;17-22.
4. De Marco T.J., Levine R.R. Role of the lymphatics in the intestinal absorption and distribution of drugs. J. Pharmacol. Exp. Ther. 169:1969;142-151.
5. Kakemi K., Sezaki H., Muranishi S., Ogata H., Giga K. Mechanism of intestinal absorption from oily solution. Chem. Pharm. Bull. 20:1972;715-720.
6. Kim J.Y., Ku Y.S. Enhanced absorption of indomethacin after oral or rectal administration of a self-emulsifying system containing indomethacin in rats. Int. J. Pharm. 194:2000;81-89.
7. Lund, W., 1994. The Pharmaceutical Codex, Principles and Practice of Pharmaceutics. The Pharmaceutical Press, London, pp. 835-838.
8. Muranishi N., Kimugawa M., Nakajima Y., Muranishi S., Sezaki H. Mechanism for the inducement of intestinal absorption of poorly absorbed drugs by mixed micelles on the intestinal absorption of streptomycin in rats. Int. J. Pharm. 4:1980;271-276.
9. Palin K.J., Wilson C.G., Davis S.S., Philips A.J. The effect of oils on the lymphatic absorption of DDT. J. Pharm. Pharmacol. 34:1982;707-710.
10. Peppas N.A. Analysis of Fickian and non-Fickian drug release polymer. Pharm. Acta Helv. 60:1985;110-111.
11. Sekikawa H., Fukada N., Takada M.et al. Dissolution behaviour and gastrointestinal absorption of dicoumarol-polyvinyl-pyrrolidone and dicoumarol-β-cyclodextrin. Chem. Pharm. Bull. 31:1983;1350-1356.
12. Setnikar I., Fantelli S. Liquefaction time of rectal suppositories. J. Pharm. Sci. 51:1962;566-571.
13. Shah N.H., Carvajal M.T., Patel C.I., Infeld M.H., Malik A.W. Self-emulsifying drug delivery systems (SEDDS) with polyglycolysed glycerides for improving in vitro dissolution and oral absorption of lipophilic drugs. Int. J. Pharm. 106:1994;15-23.
14. Sugimoto M., Okagaki T., Narisawa S., Koida Y., Nakajima K. Improvement of dissolution characteristics and bioavailability of poorly water-soluble drugs by novel cogrinding method using water-soluble polymer. Int. J. Pharm. 160:1998;11-19.
15. York, P., 1988. The design of dosage forms. In: Aulton, M.E. (Ed.), Pharmaceutics, The Science of Dosage Form Design. Churchill Livingstone, Edinburgh, pp. 1-13.