Synthesis, structure-activity relationships, and in vitro antibacterial and antifungal activity evaluations of novel pyrazole carboxylic and dicarboxylic acid derivatives

European Journal of Medicinal Chemistry

Volumn 78, Issue , 2014, Pages 86-96

  Mert, Samet ^a   Kasimoǧullari, Rahmi ^a   Iça, Tuba ^a   Çolak, Ferdaǧ ^a   Altun, Ahmet ^b   Ok, Salim ^c  

^a DUMLUPINAR UNIVERSITY   (Turkey)

^b FATIH UNIVERSITY   (Turkey)

^c OHIO STATE UNIVERSITY   (United States)

Author keywords

Antibacterial; Antifungal activity; Pyrazole 3,4 dicarboxylic acid; Pyrazole 3 carboxylic acid; Structure activity relationship (SAR)

Indexed keywords

1 (3 NITROPHENYL) 5 PHENYL 1H PYRAZOLE 3,4 DICARBONYL DICHLORIDE; 1 (3 NITROPHENYL) 5 PHENYL 1H PYRAZOLE 3,4 DICARBOXYLIC ACID; 1 (3 NITROPHENYL) 5 PHENYL 1H PYRAZOLE 4 CARBOXYLIC ACID; 1 (3 NITROPHENYL) 5 PHENYL N3,N4 BIS[2 (TRIFLUOROMETHYL)PHENYL] 1H PYRAZOLE 3,4 DICARBOXAMIDE; 1 (3 NITROPHENYL) 5 PHENYL N3,N4 BIS[3 (TRIFLUOROMETHYL)PHENYL] 1H PYRAZOLE 3,4 DICARBOXAMIDE; 1 (3 NITROPHENYL) 5 PHENYL N3,N4 BIS[4 (TRIFLUOROMETHYL)PHENYL] 1H PYRAZOLE 3,4 DICARBOXAMIDE; 1 (3 NITROPHENYL) 5 PHENYL N3,N4 DI 3 TOLYL 1H PYRAZOLE 3,4 DICARBOXAMIDE; 1 (3 NITROPHENYL) 5 PHENYL N3,N4 DI 4 TOLYL 1H PYRAZOLE 3,4 DICARBOXAMIDE; 1 (3 NITROPHENYL)N3,N4 BIS(4 NITROPHENYL) 5 PHENYL 1H PYRAZOLE 3,4 DICARBOXAMIDE; 2 (3 NITROPHENYL) 3 PHENYL 5,6 DIHYDRO 2H PYRAZOLO[3,4 D]PYRIDAZINE 4,7 DIONE; ANTIFUNGAL AGENT; DICARBOXYLIC ACID; DICARBOXYLIC ACID DERIVATIVE; ETHYL 1 (3 NITROPHENYL) 5 PHENYL 3 [[2 (TRIFLUOROMETHYL)PHENYL]CARBAMOYL] 1H PYRAZOLE 4 CARBOXYLATE; ETHYL 1 (3 NITROPHENYL) 5 PHENYL 3 [[3 (TRIFLUOROMETHYL)PHENYL]CARBAMOYL] 1H PYRAZOLE 4 CARBOXYLATE; ETHYL 1 (3 NITROPHENYL) 5 PHENYL 3 [[4 (TRIFLUOROMETHYL)PHENYL]CARBAMOYL] 1H PYRAZOLE 4 CARBOXYLATE; ETHYL 3 [(2 FLUOROPHENYL)CARBAMOYL] 1 (3 NITROPHENYL) 5 PHENYL 1H PYRAZOLE 4 CARBOXYLATE; ETHYL 3 [(3 FLUOROPHENYL)CARBAMOYL] 1 (3 NITROPHENYL) 5 PHENYL 1H PYRAZOLE 4 CARBOXYLATE; ETHYL 3 [(4 FLUOROPHENYL)CARBAMOYL] 1 (3 NITROPHENYL) 5 PHENYL 1H PYRAZOLE 4 CARBOXYLATE; N3,N4 BIS(2 FLUOROPHENYL) 1 (3 NITROPHENYL) 5 PHENYL 1H PYRAZOLE 3,4 DICARBOXAMIDE; N3,N4 BIS(3 FLUOROPHENYL) 1 (3 NITROPHENYL) 5 PHENYL 1H PYRAZOLE 3,4 DICARBOXAMIDE; N3,N4 BIS(4 FLUOROPHENYL) 1 (3 NITROPHENYL) 5 PHENYL 1H PYRAZOLE 3,4 DICARBOXAMIDE; N3,N4 BIS(ETHYLCARBAMOTHIOYL) 1 (3 NITROPHENYL) 5 PHENYL 1H PYRAZOLE 3,4 DICARBOXAMIDE; N3,N4 BIS(ETHYLCARBAMOYL) 1 (3NITROPHENYL) 5 PHENYL 1H PYRAZOLE 3,4 DICARBOXAMIDE; N3,N4 BIS(METHYLCARBAMOYL) 1 (3 NITROPHENYL) 5 PHENYL 1H PYRAZOLE 3,4 DICARBOXAMIDE; N3,N4,1 TRIS(3 NITROPHENYL) 5 PHENYL 1H PYRAZOLE 3,4 DICARBOXAMIDE; PYRAZOLE; PYRAZOLE DERIVATIVE; UNCLASSIFIED DRUG; ANTIINFECTIVE AGENT;

AGAR DIFFUSION; ANTIBACTERIAL ACTIVITY; ANTIFUNGAL ACTIVITY; ARTICLE; CANDIDA ALBICANS; CANDIDA GLABRATA; CANDIDA PARAPSILOSIS; CANDIDA TROPICALIS; CARBON NUCLEAR MAGNETIC RESONANCE; CONTROLLED STUDY; DRUG SYNTHESIS; ENTEROCOCCUS FAECALIS; ESCHERICHIA COLI; INFRARED SPECTROSCOPY; MOLECULAR WEIGHT; NONHUMAN; PROTON NUCLEAR MAGNETIC RESONANCE; PSEUDOMONAS AERUGINOSA; STAPHYLOCOCCUS AUREUS; STRUCTURE ACTIVITY RELATION; CANDIDA; CHEMICAL STRUCTURE; CHEMISTRY; DOSE RESPONSE; DRUG EFFECTS; ENTEROCOCCUS FAECIUM; METHICILLIN RESISTANT STAPHYLOCOCCUS AUREUS; MICROBIAL SENSITIVITY TEST; SYNTHESIS;

ANTI-BACTERIAL AGENTS; ANTIFUNGAL AGENTS; CANDIDA; DICARBOXYLIC ACIDS; DOSE-RESPONSE RELATIONSHIP, DRUG; ENTEROCOCCUS FAECIUM; METHICILLIN-RESISTANT STAPHYLOCOCCUS AUREUS; MICROBIAL SENSITIVITY TESTS; MOLECULAR STRUCTURE; PYRAZOLES; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84906969303     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2014.03.033     Document Type: Article

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