N'-[(5-chloro-3-methyl-1-phenyl-1H-pyrazol-4-yl)methylene] 2/4-substituted hydrazides: Synthesis and anticonvulsant activity

European Journal of Medicinal Chemistry

Volumn 45, Issue 9, 2010, Pages 3943-3949

  Kaushik, Darpan ^a   Khan, Suroor Ahmad ^a   Chawla, Gita ^a   Kumar, Suresh ^a  

^a HAMDARD UNIVERSITY   (India)

Author keywords

5 Chloro 3 methyl 1 phenyl 1H pyrazole 4 carboxaldehyde; Acid hydrazide hydrazone; Anticonvulsant activity; Behavioural test; Vilsmeir Haack reaction

Indexed keywords

HYDRAZIDE DERIVATIVE; PENTETRAZOLE; PHENYTOIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTICONVULSANT ACTIVITY; ARTICLE; CENTRAL NERVOUS SYSTEM DEPRESSION; DOSE RESPONSE; DRUG INDUCED DISEASE; DRUG SCREENING; DRUG SYNTHESIS; ELECTRIC SHOCK; MOUSE; NEUROPROTECTION; NEUROTOXICITY; NONHUMAN; PHYSICAL CHEMISTRY; SEIZURE; SPECTROSCOPY; STRUCTURE ANALYSIS;

ANIMALS; ANTICONVULSANTS; BEHAVIOR, ANIMAL; DOSE-RESPONSE RELATIONSHIP, DRUG; ELECTROSHOCK; HYDRAZINES; MALE; MICE; NERVOUS SYSTEM; PENTYLENETETRAZOLE; SEIZURES; TIME FACTORS;

EID: 77955557118     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2010.05.049     Document Type: Article

References (19)

1. G.S. Bell, and J.W. Sander Seizure 11 Suppl. A 2002 306 314
2. J.M. Lopes Lima Curr. Pharmac. Design 6 2000 873 878
3. M. Berk, J. Segal, L. Janet, and M. Vorster Drugs 61 2001 1407 1414
4. J.S. Duncan Br. J. Clin. Pharmacol. 53 2002 123 131
5. M.J. Brodie Lancet 1990 350 354
6. P. Yogeshwari, D. Sriram, L.R.J. Suniljit, S.S. Kumar, and J.P. Stables Eur. J. Med. Chem. 37 2002 231 236
7. J.R. Dimmock, K.K. Sidhu, R.S. Thayer, P. Mack, M.J. Dutty, R.S. Read, and J.W. Quail J. Med. Chem. 36 1993 923 925
8. J.R. Dimmock, S.C. Vashitha, and J.P. Stables Eur. J. Med. Chem. 35 2000 241 248
9. S.N. Pandeya, P. Yogeshwari, and J.P. Stables Eur. J. Med. Chem. 35 2000 879 886
10. P. Yogeshwari, D. Sriram, V. Saraswat, J.V. Ragavendran, M.M. Kumar, R. Murugesan, R. Thirumurugan, and J.P. Stables Eur. J. Pharm. Sci. 20 2003 341 346
11. J.R. Dimmock, R.N. Puthucode, J.M. Smith, M. Hetherington, J.W. Quail, U. Pugazhenthi, T. Lechler, and J.P. Stables J. Med. Chem. 39 1996 3984 3997
12. R.N. Puthucode, U. Pugazhenthi, J.W. Quail, J.P. Stables, and J.R. Dimmock Eur. J. Med. Chem. 33 1998 595 607
13. P. Yogeeswari, D. Sriram, V. Veena, R. Kavya, K. Rakhra, J.V. Ragavendran, S. Mehta, R. Thirumurgan, and J.P. Stables Biomed. Pharmcother. 59 2005 51 55
14. M.G. Wong, J.A. Dejina, and P.R. Andrews J. Med. Chem. 29 1986 562 571
15. R.I. Krall, J.K. Penry, B.G. White, H.J. Kupferberg, and E.A. Swinyard Epilepsia 19 1978 409 417
16. R.J. Porter, J.J. Cereghino, G.D. Gladding, B.J. Hessei, H.J. Kupferberg, and B. Scoville Antiepileptic drug development program Cleve. Clin. Q. 51 1984 293 303
17. B.R. Brooks, R.E. Bruccoleri, B.D. Olafson, D.J. States, S. Swaminathan, and M. Karplus J. Comput. Chem. 4 1983 187 217
18. J.R. Boisser, and P. Simmon Arch. Int. Pharmacodyn. Ther. 158 1965 212 220
19. V.A. Farrar, M. Ciechanowicz-Rutkowska, J. Grochowski, P. Serda, T. Pilati, G. Filippini, C.N. Hinko, A. El-Assadi, J.A. Moore, I.O. Edafiogho, C.W. Andrews, M. Cory, J.M. Nicholson, and K.R. Scott J. Med. Chem. 36 1993 3517 3525