Hypothermic storage of human hepatocytes for transplantation

Cell Transplantation

Volumn 23, Issue 9, 2014, Pages 1143-1151

  Gramignoli, Roberto ^a   Dorko, Kenneth ^b   Tahan, Veysel ^b   Skvorak, Kristen J ^b   Ellis, Ewa ^a   Jorns, Carl ^a   Ericzon, Bo Goran ^a   Fox, Ira J ^c   Strom, Stephen C ^a  

^a KAROLINSKA UNIVERSITY HOSPITAL   (Sweden)

^b UNIVERSITY OF PITTSBURGH SCHOOL OF MEDICINE   (United States)

^c CHILDREN S HOSPITAL OF PITTSBURGH   (United States)

Author keywords

Cold storage; Hepatic functions; Hepatocyte transplantation (HTx); Human hepatocyte preservation

Indexed keywords

AMMONIA; CASPASE 3; CASPASE 7; CYTOCHROME P450 1A1; CYTOCHROME P450 1A2; CYTOCHROME P450 2C9; CYTOCHROME P450 3A; CYTOCHROME P450 3A4; CYTOCHROME P450 3A7; RESORUFIN; TESTOSTERONE; UNIVERSITY OF WISCONSIN SOLUTION; ADENOSINE; ALLOPURINOL; CYTOCHROME P450; GLUTATHIONE; INSULIN; PRESERVATION SOLUTION; RAFFINOSE; UNIVERSITY OF WISCONSIN-LACTOBIONATE SOLUTION;

ADOLESCENT; ADULT; AGED; ARTICLE; CHILD; CONJUGATION; CONTROLLED STUDY; CRYOPRESERVATION; ENZYME ACTIVITY; FEMALE; HEPATOCYTE TRANSPLANTATION; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; HUMAN CELL; HUMAN TISSUE; INFANT; LIVER CELL; MALE; NEWBORN; CELL CULTURE; CELL SURVIVAL; CHEMISTRY; COLD; CYTOLOGY; DRUG EFFECTS; METABOLISM; MIDDLE AGED; PRESCHOOL CHILD; PROCEDURES; TRANSPLANTATION; YOUNG ADULT;

ADENOSINE; ADOLESCENT; ADULT; AGED; ALLOPURINOL; AMMONIA; CASPASE 3; CASPASE 7; CELL SURVIVAL; CELLS, CULTURED; CHILD; CHILD, PRESCHOOL; COLD TEMPERATURE; CRYOPRESERVATION; CYTOCHROME P-450 ENZYME SYSTEM; FEMALE; GLUTATHIONE; HEPATOCYTES; HUMANS; INFANT; INSULIN; MALE; MIDDLE AGED; ORGAN PRESERVATION SOLUTIONS; RAFFINOSE; YOUNG ADULT;

EID: 84906965325     PISSN: 09636897     EISSN: None     Source Type: Journal    
DOI: 10.3727/096368913X668627     Document Type: Article

References (30)

1. Abrahamse, S. L.; van Runnard Heimel, P.; Hartman, R. J.; Chamuleau, R. A.; van Gulik, T. M. Induction of necrosis and DNA fragmentation during hypothermic preservation of hepatocytes in UW, HTK, and Celsior solutions. Cell Transplant. 12(1):59–68; 2003.
2. Baccarani, U.; Adani, G. L.; Sanna, A.; Avellini, C.; Sainz Barriga, M.; Lorenzin, D.; Montanaro, D.; Gasparini, D.; Risaliti, A.; Donini, A. Portal vein thrombosis after intraportal hepatocytes transplantation in a liver transplant recipient. Transpl. Intl. 18(6):750–754; 2005.
3. Bartels-Stringer, M.; Verpalen, J. T.; Wetzels, J. F.; Russel, F. G.; Kramers, C. Iron chelation or anti-oxidants prevent renal cell damage in the rewarming phase after normoxic, but not hypoxic cold incubation. Cryobiology 54(3):258–264; 2007.
4. Belzer, F. O.; Southard, J. H. Principles of solid-organ preservation by cold storage. Transplantation 45(4):673–676; 1988.
5. Dhawan, A.; Mitry, R. R.; Hughes, R. D. Hepatocyte transplantation for liver-based metabolic disorders. J. Inherit. Metab. Dis. 29(2–3):431–435; 2006.
6. Dhawan, A.; Puppi, J.; Hughes, R. D.; Mitry, R. R. Human hepatocyte transplantation: Current experience and future challenges. Nat. Rev. Gastroenterol. Hepatol. 7(5):288– 298; 2010.
7. Fisher, R. A.; Bu, D.; Thompson, M.; Wolfe, L.; Ritter, J. K. Optimization of conditions for clinical human hepatocyte infusion. Cell Transplant. 13(6):677–689; 2004.
8. Fisher, R. A.; Strom, S. C. Human hepatocyte transplantation: Worldwide results. Transplantation 82(4):441–449; 2006.
9. Fox, I. J.; Chowdhury, J. R.; Kaufman, S. S.; Goertzen, T. C.; Chowdhury, N. R.; Warkentin, P. I.; Dorko, K.; Sauter, B. V.; Strom, S. C. Treatment of the Crigler-Najjar syndrome type I with hepatocyte transplantation. N. Engl. J. Med. 338(20):1422–1426; 1998.
10. Fox, I. J.; Soltys, K.; Mazariegos, G.; Sindhi, R.; Bond, G.; Vockley, G.; Arnold, G.; Strom, S.; Crowley, J.; Deutsch, M. Hepatocyte transplantation for liver based metabolic disorders. http://www.clinicalTrials.gov/NCT01345578; 2011.
11. Fu, T.; Blei, A. T.; Takamura, N.; Lin, T.; Guo, D.; Li, H.; O’Gorman, M. R.; Soriano, H. E. Hypothermia inhibits Fas-mediated apoptosis of primary mouse hepatocytes in culture. Cell Transplant. 13(6):667–676; 2004.
12. Gramignoli, R.; Green, M. L.; Tahan, V.; Dorko, K.; Skvorak, K. J.; Marongiu, F.; Zao, W.; Venkataramanan, R.; Ellis, E. C.; Geller, D.; Breite, A. G.; Dwulet, F. E.; McCarthy, R. C.; Strom, S. C. Development and application of purified tissue dissociation enzyme mixtures for human hepatocyte isolation. Cell Transplant. 21(6):1245–1260; 2012.
13. Gramignoli, R.; Tahan, V.; Dorko, K.; Skvorak, K. J.; Hansel, M. C.; Zao, W.; Venkataramanan, R.; Ellis, E. C.; Jorns, C.; Ericzon, B.-G.; Rosenborg, S.; Soltys, K.; Mazariegos, G. V.; Fox, I. J.; Wilson, M.; Grompe, M.; Strom, S. C. New potential cell source for hepatocyte transplantation: Discarded livers from metabolic disease liver transplants. Stem Cell Res. 11(1):563–573; 2013.
14. Kerkweg, U.; Jacob, M.; De Groot, H.; Mannherz, H. G.; Rauen, U. Cold-induced apoptosis of rat liver endothelial cells:Contribution of mitochondrial alterations.Transplantation 76(3):501–508; 2003.
15. Lee, K. W.; Lee, J. H.; Shin, S. W.; Kim, S. J.; Joh, J. W.; Lee, D. H.; Kim, J. W.; Park, H. Y.; Lee, S. Y.; Lee, H. H.; Park, J. W.; Kim, S. Y.; Yoon, H. H.; Jung, D. H.; Choe, Y. H.; Lee, S. K. Hepatocyte transplantation for glycogen storage disease type Ib. Cell Transplant. 16(6):629–637; 2007.
16. Lentsch, A. B.; Kato, A.; Yoshidome, H.; McMasters, K. M.; Edwards, M. J. Inflammatory mechanisms and therapeutic strategies for warm hepatic ischemia/reperfusion injury. Hepatology 32(2):169–173; 2000.
17. Ostrowska, A.; Bode, D. C.; Pruss, J.; Bilir, B.; Smith, G. D.; Zeisloft, S. Investigation of functional and morphological integrity of freshly isolated and cryopreserved human hepatocytes. Cell Tissue Bank. 1(1):55–68; 2000.
18. Pahernik, S. A.; Thasler, W. E.; Mueller-Hoecker, J.; Schildberg, F. W.; Koebe, H. G. Hypothernic storage of pig hepatocytes: Influence of different storage solutions and cell density. Cryobiology 33(5):552–566; 1996.
19. Pless, G.; Sauer, I. M.; Rauen, U. Improvement of the cold storage of isolated human hepatocytes. Cell Transplant. 21(1):23–37; 2012.
20. Poullain, M. G.; Fautrel, A.; Guyomard, C.; Chesne, C.; Grislain, L.; Guillouzo, A. Viability and primary culture of rat hepatocytes after hypothermic preservation: The superiority of the Leibovitz medium over the University of Wisconsin solution for cold storage. Hepatology 15(1):97– 106; 1992.
21. Puppi, J.; Strom, S. C.; Hughes, R. D.; Bansal, S.; Castell, J. V.; Dagher, I.; Ellis, E. C.; Nowak, G.; Ericzon, B. G.; Fox, I. J.; Gomez-Lechon, M. J.; Guha, C.; Gupta, S.; Mitry, R. R.; Ohashi, K.; Ott, M.; Reid, L.; Roy-Chowdhury, J.; Sokal, E.; Weber, A.; Dhawan, A. Improving the techniques for human hepatocyte transplantation: Report from a consensus meeting in London. Cell Transplant. 21(1):1–10;2012
22. Quintana, A. B.; Guibert, E. E.; Rodriguez, J. V. Effect of cold preservation/reperfusion on glycogen content of liver. Concise review. Ann. Hepatol. 4(1):25–31; 2005.
23. Rauen, U.; Kerkweg, U.; Weisheit, D.; Petrat, F.; Sustmann, R.; de Groot H.; Cold-induced apoptosis of hepatocytes: Mitochondrial permeability transition triggered by non-mitochondrial chelatable iron. Free Radical Biol. Med. 35(12):1664–1678; 2003.
24. Smets, F.; Najimi, M.; Sokal, E. M. Cell transplantation in the treatment of liver diseases. Pediatr. Transplant. 12(1):6–13; 2008.
25. Smets, F. N.; Chen, Y.; Wang, L. J.; Soriano, H. E. Loss of cell anchorage triggers apoptosis (anoikis) in primary mouse hepatocytes. Mol. Genet. Metab. 75(4):344–352; 2002.
26. Stefanovich, P.; Ezzell, R. M.; Sheehan, S. J.; Tompkins, R. G.; Yarmush, M. L.; Toner, M. Effects of hypothermia on the function, membrane integrity, and cytoskeletal structure of hepatocytes. Cryobiology 32(4):389–403; 1995.
27. Stephenne, X.; Debray, F. G.; Smets, F.; Jazouli, N.; Sana, G.; Tondreau, T.; Menten, R.; Goffette, P.; Boemer, F.; Schoos, R.; Gersting, S. W.; Najimi, M.; Muntau, A. C.; Goyens, P.; Sokal, E. M. Hepatocyte transplantation using the domino concept in a child with Tetrabiopterin non-responsive phenylketonuria. Cell Transplant. 21(12):2765– 2770; 2012.
28. Teoh, N. C.; Farrell, G. C. Hepatic ischemia reperfusion injury: Pathogenic mechanisms and basis for hepatoprotection. J. Gastroenterol. Hepatol. 18(8):891–902; 2003.
29. Terry, C.; Hughes, R. D.; Mitry, R. R.; Lehec, S. C.; Dhawan, A. Cryopreservation-induced nonattachment of human hepatocytes: Role of adhesion molecules. Cell Transplant. 16(6):639–647; 2007.
30. Wigg, A. J.; Phillips, J. W.; Berry, M. N. Maintenance of integrity and function of isolated hepatocytes during extended suspension culture at 25 degrees C. Liver Intl. 23(3):201–211; 2003.