Optimization of conditions for clinical human hepatocyte infusion

Cell Transplantation

Volumn 13, Issue 6, 2004, Pages 677-689

  Fisher, Robert A ^a   Bu, Dawen ^a   Thompson, Melissa ^a   Wolfe, Luke ^a   Ritter, Joseph K ^b  

^a VIRGINIA COMMONWEALTH UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b VIRGINIA COMMONWEALTH UNIVERSITY MEDICAL CENTER   (United States)

Author keywords

Apoptosis; Culture media of hepatocytes; Cytotoxicity; Fatty liver donor; Hepatocyte transplantation; Hypothermia; Primary human hepatocytes; Transplantation

Indexed keywords

3 (4,5 DIMETHYL 2 THIAZOLYL) 2,5 DIPHENYLTETRAZOLIUM BROMIDE; ADENOSINE; ASPARTATE AMINOTRANSFERASE; CYTOCHROME P450 3A; DNA; GLUCURONOSYLTRANSFERASE 1A1; LACTATE DEHYDROGENASE; RINGER LACTATE SOLUTION; TRYPAN BLUE;

APOPTOSIS; ARTICLE; CELL DAMAGE; CELL PROLIFERATION; CELL VIABILITY; CLINICAL ARTICLE; CONTROLLED STUDY; CYTOTOXICITY; ENDOPLASMIC RETICULUM; FATTY LIVER; FEMALE; HEPATOCYTE TRANSPLANTATION; HUMAN; HUMAN CELL; HUMAN TISSUE; HYPOTHERMIA; INCUBATION TIME; LIVER CELL; MALE; MITOCHONDRION; PRIORITY JOURNAL; TEMPERATURE;

STAPHYLOCOCCUS PHAGE 3A;

EID: 12244277894     PISSN: 09636897     EISSN: None     Source Type: Journal    
DOI: 10.3727/000000004783983576     Document Type: Article

References (45)

1. Abrahamse, S. L.; Van Runnard, H., Hartman, R. J.; Chamuleau, R. A.; Van Guilk, T. M. Induction of necrosis and DNA fragmentation during hypothermic preservation of hepatocytes in UW, HTK, and Celsior. Cell Transplant. 12(1):59-68; 2003.
2. Alexandre, E.; Viollon-Abadie, C.; David, P.; Gandillet, A.; Coassolo, P.; Heyd, B.; Mantion, G.; Wolf, P.; Bachellier, P.; Richert, L. Cryopreserevation of adult human hepatocytes obtained from resected liver biopsies. Cryobiology 44:103-113; 2002.
3. Allen, K. J.; Soriano, H. E. Liver cell transplantation: The road to clinical application. J. Lab. Clin. Med. 138(5): 298-312; 2001.
4. Cakaloglu, Y.; Tredger, J. M.; Devlin, J.; Williams, R. Importance of cytochrome p-450 III A activity in determining dosage and blood levels of FK506 and cyclosporine in liver transplant recipients. Hepatology 20(2): 309-316; 1994.
5. Canizaro, P. C.; Prager, M. D.; Shires, G. T. The infusion of Ringers lactate solution during shock. Changes in lactate, excess lactate, and pH. Am. J. Surg. 122(4):494-501; 1971.
6. Chomczynski, P.; Sacchi, N. Single step method for RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction. Ann. Biochem. 162(1):156; 1987.
7. Cisneros, C.; Guillen, F.; Gomez, R.; Gutierrez, J.; Vorwald, P.; Montero, A.; Moreno, E. Analysis of warm ischemia time for prediction of primary nonfunction of the hepatic graft. Transpl. Proc. 23(3):1976; 1991.
8. Clavien, P. A.; Harvey, P. R.; Strasberg, S. M. Preservation and reperfusion injuries in Liver allografts. An overview and synthesis of current studies. Transplantation 53(5):957-978; 1992.
9. Den Butter, G.; Saunder, A.; Marsh, D. C.; Beizer, F. O.; Southhard, J. H. Comparison of solutions for preservation of the rabbit liver as tested by isolated perfusion. Transpl. Int. 8(6):466-471; 1995.
10. Fisher, R. A.; Posner, M. P.; Shiffman, M. L.; Mills, A. S.; Contos, M. J.; Beeston, J.; Bowman, T.; Wolfe, L. G.; Lee, H. M. Adenosine rise in human orthotopic liver transplantation: Results of a randomized, double-blind trial. Int. J. Surg. Invest. 1(1):55-66; 1999.
11. Fisher, R. A.; Strom, S. C. Human hepatocyte transplantation: Biology and therapy. In: Berry, M. N.; Edwards, A. M., eds. The hepatocyte review: Dordrecht: Kluwer Academic Publishers; 2000.
12. Fisher, R. A.; Strom, S. C.; Thompson, M. T.; Sanyal, A. J.; Freedman, A. O.; Rhodes, C. I.; Posner, M. P.; Lee, H. M. Human hepatocyte transplantation - a life bridge in terminal liver failure. Hepatology 18(Suppl.):66A; 1993.
13. Fox, I. J.; Chowdhury, J. R.; Kaufman, S. S.; Goertzen, T. C.; Chowdhury, N. R.; Warkentin, P. I.; Dorko, K.; Sauter, B. V.; Strom, S. C. Treatment of the Crigler-Najjar syndrome type I with hepatocyte transplantation. N. Engl. J. Med. 338(20):1422-1426; 1998.
14. Fu, T.; Guo, D.; Huang, X.; O'Gorman, M. R.; Huang, L.; Crawford, S. E.; Soriano, H. E. Apoptosis occurs in isolated and banked primary mouse hepatocytes. Cell Transplant. 10(1):59-66; 2001.
15. Furukawa, H.; Todo, S.; Imventarza, O.; Wu, Y. M.; Scotti, C.; Day, R.; Starzl, T. E. Cold ischemia time vs. outcome of human liver transplantation using UW solution. Transpl. Proc. 23:1550-1551; 1991.
16. Galle, P. R.; Hoffmann, W. J.; Walczak, H.; Schaller, H.; Otto, G.; Stremmel, W.; Krammer, P. H.; Runkel, L. Involvement of the CD95 (APO-1/Fas) receptor and ligand in liver damage. J. Exp. Med. 182:1223-1230; 1995.
17. Gantla, S.; Bakker, C. T.; Deocharan, B.; Thummala, N. R.; Zweiner, J.; Sinaasappel, M.; Roy Chowdhury, J.; Bosma, P. I.; Chowdhury, N. R. Splice-site mutations: A novel genetic mechanism of Crigler-Najjar syndrome type 1. Am. J. Hum. Genet. 62(3):585-592; 1998.
18. Gupta, S. Hepatocyte transplantation. J. Gastroenterol. Hepatol. 17(Suppl. 3):S287-S293; 2002.
19. Hussain, S. M.; Frazier, J. M. Involvement of apoptosis in hydrazine induced toxicity in rat primary hepatocytes. Toxicol. In Vitro 17(3):343-355; 2003.
20. Kim, J. S.; He, L.; Lemaster, J. J. Mitochondrial permeability transition: A common pathway to necrosis and apoptosis. Biochem. Biophys. Res. Commun. 304(3):463-470; 2003.
21. Kim, J. S.; Qian, T.; Lemasters, J. J. Mitochondrial permeability transition in the switch from necrotic to apoptotic cell death in ischemic rat hepatocytes. Gastroenterology 124(2):494-503; 2003.
22. Kostrubsky, V. E.; Ramachandran, V.; Venkataramanan, R.; Dorko, K.; Esplen, J. E.; Zhang, S.; Sinclair, J. F.; Wrighton, S. A.; Strom, S. C. The use of human hepatocyte cultures to study the induction of cytochrome P-450. Drug Metab. Dispos. 27(8):887-894; 1999.
23. Kostrubsky, V. E.; Sinclair, J. F.; Ramachandran, V.; Venkataramanan, R.; Wen, Y. H.; Kindt, E.; Galchev, V.; Rose, K.; Sinz, M.; Strom, S. C. The role of conjugation in hepatotoxicity of troglitazone in human and porcine hepatocyte cultures. Drug Metab. Dispos. 28(10): 1192-1197; 2000.
24. Marsh, D. C.; Lindell, S. L.; Fox, L. E.; Belzer, F. O.; Southad, J. H. Hypothermic preservation of hepatocytes: Role of cell swelling. Cryobiology 26(6):524-534; 1989.
25. Nagaki, M.; Moriwaki, H. How are hepatocytes sensitized to apoptosis? J. Gastroenterol. 37(12):1094-1096; 2002.
26. Nagata, S.; Golstein, P. The Fas death factor. Science 267: 1449; 1995.
27. Ning, X. H.; Chen, S. H.; Xu, C. S.; Li, L.; Qian, K.; Krueger, J. J.; Hyyti, O. M.; Portman, M. A. Hypothermic protection of the ischemic heart via alterations in apoptotic pathways as assessed by gene array analysis. J. Appl. Physiol. 92(5):2200-2207; 2002.
28. Ogasawara, J.; Watanabe-Fukunaga, R.; Adachi, M.; Matsuzawa, A.; Kasugai, T.; Kitamura, Y.; Itoh, N.; Suda, T.; Nagata, S. Lethal effect of the anti-Fas antibody in mice. Nature 364:806-809; 1993.
29. Ostrowska, A.; Bode, D. C.; Pruss, J.; Bilir, B.; Smith, G.; Zeisloft, S. Investigation of functional and morphological integrity of freshly isolated and cryopreserved human hepatocytes. Cell Tissue Bank 1(1):55-68; 2000.
30. Pahernik, S. A.; Thasler, W. E.; Mueller-Hoecker, J.; Schildberg, F. W.; Koebe, H. G. Hypothermic storage of pig hepatocytes: Influence of different storage solutions and cell density. Cryobiology 33(5):552-566; 1996.
31. 2 formation. FASEB J. 14:1953-1964; 2000.
32. Rauen, U.; Polzar, B.; Stephan, H.; Mannhert, H. G. De Groot, H. Cold-induced apoptosis in cultured hepatocytes and liver endothelial cells: Mediation by reactive oxygen species. FASEB J. 13:155-168; 1999.
33. Ritter, J. K.; Chen, F.; Sheen, Y. Y.; Tran, H. M.; Kimura, S.; Yeatman, M. T.; Owens, I. S. A novel complex locus UGT1 encodes human bilirubin, phenol, and other UDP-glucronosyltransferase isozymes with identical carboxyl termini. J. Biol. Chem. 267(5):3257-3261; 1992.
34. Ritter, J. K.; Kessler, F. K.; Thompson, M. T.; Grove, A. D.; Auyeung, D. J.; Fisher, R. A. Expression and inducibility of the human bilirubin UDP-glucronosyltransferase UGT1A1 in liver and cultured primary hepatocytes: Evidence for both genetic and environmental influences. Hepatology 30:476-484; 1999.
35. Runge, D.; Runge, D. M.; Jager, D.; Lubecki, K. A.; Stolz, D. B.; Karathanasis, S.; Kietzmann, T.; Strom, S. C.; Jungermann, K.; Fleig, W. E.; Michalopoulos, G. K. Serum-free, long-term cultures of human hepatocytes: Maintenance of cell morphology, transcription factors, and liver-specific functions. Biochem. Biophys. Res. Commun. 269(1):46-53; 2000.
36. Schuetz, E. G.; Schuetz, J. D.; Strom, S. C.; Fisher, R. A.; Thompson, M. T.; Molowa, D. T.; Li, D.; Guzelian, P. S. Regulation of human liver cytochrome P450 in the family 3A in primary and continuous culture of human hepatocytes. Hepatology 18(5):1254; 1993.
37. Southard, J. H.; Van Gulik, T. M.; Ametani, M. S.; Vreugdenhil, P. K.; Lindell, S. L.; Pienaar, B. L.; Belzer, F. O. Important components of the UW solution. Transplantation 49:251-257; 1990.
38. Sterling, R. K.; Fisher, R. A. Liver transplantation: Living donor, hepatocyte, and xenotransplantation. In: Gish, R. G., ed. Current and future treatment therapies for liver disease. Philadaelphia: W. B. Saunders; 2001:431-460.
39. Straatsburg, I. H.; Abrahamse, S. L.; Song, S. W.; Hartman, R. J.; Van Gulik, T. M. Evaluation of rat liver apoptotic and necrotic cell death after cold storage using UW, HTK, and Celsior. Transplantation 74(4):458-464; 2002.
40. Strom, S. C.; Dorko, K.; Thompson, M. T.; Pisarov, L. A.; Nussler, A. K. Large scale isolation and culture of human hepatocytes. In: Franco, D.; Boudjema, K.; Varet, B., eds. Ilots de Langerhans et hepatocytes. Vers une utilisation therapeutique. Paris: Les editions; 1998:195-205.
41. Strom, S. C.; Fisher, R. A.; Thompson, M. T.; Sanyal, A. J.; Cole, P. E.; Ham, J. M.; Posner, M. P. Hepatocyte transplantation as a bridge to orthotopic liver transplantation in terminal liver failure. Transplantation 63:559-569; 1997.
42. Strom, S. C.; Jirtle, R. L.; Jones, R. S.; Novicki, D. L.; Rosenberg, M. R.; Novotny, A.; Iron, G.; McLain, J. R.; Michalopoulos, G. Isolation, culture, and transplantation of human hepatocytes. J. Natl. Cancer Inst. 68(5):771-778; 1982.
43. Xu, L.; Yenari, M. A.; Steinberg, G. K.; Giffard, R. G. Mild hypothermia reduces apoptosis of mouse neurons in vitro early in the cascade. J. Cereb. Blood Flow Metab. 22(1):21-28; 2002.
44. Yenari, M. A.; Iwayama, S.; Cheng, D.; Sun, G. H.; Fujimura, M.; Morita-Fujimura, Y.; Chan, P. H.; Steinberg, G. K. Mild hypothermia attenuates cytochrome c release but does not alter Bcl-2 expression or caspase activation after experimental stroke. J. Cereb. Blood Flow Metab. 22(1):29-38; 2002.
45. Zvibel, I.; Smets, F.; Soriano, H. Anoikis: Roadblock to cell transplantation? Cell Transplant. 11(7):621-630; 2002.