Protein polymer nanoparticles engineered as chaperones protect against apoptosis in human retinal pigment epithelial cells

Journal of Controlled Release

Volumn 191, Issue , 2014, Pages 4-14

  Wang, Wan ^a   Sreekumar, Parameswaran G ^b   Valluripalli, Vinod ^a   Shi, Pu ^a   Wang, Jiawei ^a   Lin, Yi An ^e   Cui, Honggang ^e   Jannan, Ram ^b   Hinton, David R ^c   MacKay, J Andrew ^a,d  

^a UNIVERSITY OF SOUTHERN CALIFORNIA   (United States)

^b DOHENY EYE INSTITUTE   (United States)

^c UNIVERSITY OF SOUTHERN CALIFORNIA   (United States)

^d NONE   (United States)

^e Johns Hopkins University   (United States)

Author keywords

Anti apoptosis; Assembly; Cell uptake; Chaperone; Elastin like polypeptide (ELPs)

Indexed keywords

ALDEHYDES; ASSEMBLY; CELL DEATH; CELLS; CYTOLOGY; ELASTIN; FLUID DYNAMICS; FUNCTIONAL POLYMERS; GLYCOPROTEINS; HYDRODYNAMICS; NANOPARTICLES; OPHTHALMOLOGY; PEPTIDES; POLYMERS; POLYPEPTIDES;

AGE-RELATED MACULAR DEGENERATION; ANTI-APOPTOSIS; ANTI-INFLAMMATORY ACTIVITY; CELL UPTAKE; CHAPERONE; CONTROLLED RELEASE SYSTEMS; ELASTIN-LIKE POLYPEPTIDES; HUMAN RETINAL PIGMENT EPITHELIAL CELLS;

PROTEINS;

ALCOHOL DEHYDROGENASE; ALPHA CRYSTALLIN; CASPASE 3; ELASTIN; ELASTIN LIKE POLYPEPTIDE; HYDROGEN PEROXIDE; INSULIN; NANOPARTICLE; PROTEIN POLYMER NANOPARTICLE; TROPOELASTIN; UNCLASSIFIED DRUG; CASP3 PROTEIN, HUMAN; CHAPERONE; DELAYED RELEASE FORMULATION; DRUG CARRIER; HYBRID PROTEIN; PEPTIDE FRAGMENT;

ANTIPROLIFERATIVE ACTIVITY; APOPTOSIS; ARTICLE; BIOENGINEERING; CELL AGGREGATION; CELL INTERACTION; CELL PROTECTION; COMPARATIVE STUDY; DRUG POTENCY; FEASIBILITY STUDY; HUMAN; HYDRODYNAMICS; IN VITRO STUDY; MOLECULAR WEIGHT; NICK END LABELING; OPTICAL DENSITY; OXIDATIVE STRESS; PHASE TRANSITION; PIGMENT EPITHELIUM; PRIORITY JOURNAL; RETINA MACULA AGE RELATED DEGENERATION; ACTIVE TRANSPORT; CELL CULTURE; CHEMISTRY; DELAYED RELEASE FORMULATION; DRUG EFFECTS; ENZYME ACTIVATION; EPITHELIUM CELL; GENETICS; MEDICINAL CHEMISTRY; METABOLISM; NANOMEDICINE; PARTICLE SIZE; PATHOLOGY; PHARMACEUTICS; PROCEDURES; PROTEIN ENGINEERING; TIME;

ACTIVE TRANSPORT, CELL NUCLEUS; ALPHA-CRYSTALLIN B CHAIN; APOPTOSIS; CASPASE 3; CELLS, CULTURED; CHEMISTRY, PHARMACEUTICAL; CYTOPROTECTION; DELAYED-ACTION PREPARATIONS; DRUG CARRIERS; ENZYME ACTIVATION; EPITHELIAL CELLS; FEASIBILITY STUDIES; HUMANS; MOLECULAR CHAPERONES; NANOMEDICINE; NANOPARTICLES; OXIDATIVE STRESS; PARTICLE SIZE; PEPTIDE FRAGMENTS; PROTEIN ENGINEERING; RECOMBINANT FUSION PROTEINS; RETINAL PIGMENT EPITHELIUM; TECHNOLOGY, PHARMACEUTICAL; TIME FACTORS; TROPOELASTIN;

EID: 84906949227     PISSN: 01683659     EISSN: 18734995     Source Type: Journal    
DOI: 10.1016/j.jconrel.2014.04.028     Document Type: Article

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