Sustained release of antibiotics from injectable and thermally responsive polypeptide depots

Journal of Biomedical Materials Research - Part B Applied Biomaterials

Volumn 90 B, Issue 1, 2009, Pages 67-74

  Adams Jr , Samuel B ^a   Shamji, Mohammed F ^b,c   Nettles, Dana L ^b   Hwang, Priscilla ^b   Setton, Lori A ^a,b  

^a DUKE UNIVERSITY MEDICAL CENTER   (United States)

^b Duke University   (United States)

^c UNIVERSITY OF OTTAWA   (Canada)

Author keywords

Antibiotic; Drug delivery; Elastin like polypeptide; Infection; Orthopedics; Polymer

Indexed keywords

BIODEGRADABLE POLYMERS; BIOPOLYMERS; DRUG DELIVERY; GLYCOPROTEINS; ORTHOPEDICS; PHASE TRANSITIONS; POLYPEPTIDES; SCAFFOLDS;

AQUEOUS SOLUTIONS; BIOACTIVE DRUGS; BIODEGRADABLE SCAFFOLD; BODY TEMPERATURE; DRUG CARRIER; DRUG LOADING; DRUG RELEASE; ELASTIN-LIKE POLYPEPTIDE; ELASTIN-LIKE POLYPEPTIDES; FIRST-ORDER; IMMUNE RESPONSE; IN-SITU; IN-SITU FORMING; IN-VITRO; INFECTION; ORTHOPAEDIC APPLICATIONS; ORTHOPEDIC APPLICATIONS; POLYMERIC SCAFFOLD; PROLONGED RELEASE; SUSTAINED RELEASE; THERMALLY RESPONSIVE; TIME CONSTANTS; VANCOMYCIN;

ANTIBIOTICS;

BIOPOLYMER; CEFAZOLIN; DRUG CARRIER; ELASTIN LIKE POLYPEPTIDE DERIVATIVE; POLYPEPTIDE; SCAFFOLD PROTEIN; UNCLASSIFIED DRUG; VANCOMYCIN;

AMINO ACID SEQUENCE; ARTICLE; BODY TEMPERATURE; DRUG ACTIVITY; DRUG DELIVERY SYSTEM; DRUG FORMULATION; DRUG MONITORING; DRUG RELEASE; DRUG RESPONSE; FLOW KINETICS; GENETIC ENGINEERING; IMMUNE RESPONSE; IN VITRO STUDY; NONHUMAN; PHASE TRANSITION; VISCOSITY;

AMINO ACID SEQUENCE; ANTI-BACTERIAL AGENTS; BACILLUS SUBTILIS; BIOCOMPATIBLE MATERIALS; CEFAZOLIN; DELAYED-ACTION PREPARATIONS; DRUG CARRIERS; MICROBIAL SENSITIVITY TESTS; RHEOLOGY; VANCOMYCIN;

EID: 67650806093     PISSN: 15524973     EISSN: 15524981     Source Type: Journal    
DOI: 10.1002/jbm.b.31254     Document Type: Article

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