Minimizing fucosylation in insect cell-derived glycoproteins reduces binding to IgE antibodies from the sera of patients with allergy

Biotechnology Journal

Volumn 9, Issue 9, 2014, Pages 1206-1214

  Palmberger, Dieter ^a   Ashjaei, Kazem ^b   Strell, Stephanie ^a   Hoffmann Sommergruber, Karin ^b   Grabherr, Reingard ^a  

^a UNIVERSITY OF NATURAL RESOURCES AND LIFE SCIENCES   (Austria)

^b MEDICAL UNIVERSITY OF VIENNA   (Austria)

Author keywords

Baculovirus; Fucose; Glycosylation; Insect cells; Vaccines

Indexed keywords

ANTIGENS; BIOACTIVITY; CELLS; CYTOLOGY; ESTERIFICATION; GLYCOPROTEINS; GLYCOSYLATION; VACCINES; VIRUSES; BACTERIA; GENES; POLYSACCHARIDES; RECOMBINANT PROTEINS;

BACULOVIRUS; BINDING ACTIVITIES; BIOLOGICAL IMPACTS; FUCOSE; HYPERSENSITIVITY REACTION; INSECT CELLS; PSEUDOMONAS AERUGINOSA; RECOMBINANT PROTEIN SECRETION; N-GLYCAN STRUCTURES; RECOMBINANT BACULOVIRUS;

ALLERGIES;

FUCOSE; GLYCAN; GUANOSINE DIPHOSPHATE; GUANOSINE DIPHOSPHATE 6 DEOXY DEXTRO LYXO 4 HEXULOSE REDUCTASE; GUANOSINE DIPHOSPHATE FUCOSE; IMMUNOGLOBULIN E; IMMUNOGLOBULIN E ANTIBODY; INFLUENZA VIRUS HEMAGGLUTININ; INSECT CELL DERIVED GLYCOPROTEIN; INSECT PROTEIN; RECOMBINANT PROTEIN; UNCLASSIFIED DRUG; ANTIBODY; ANTIGEN; ANTISERUM; BACTERIAL PROTEIN; GDP-6-DEOXY-D-LYXO-4-HEXULOSE REDUCTASE; GLYCOPROTEIN; HEMAGGLUTININ; INFLUENZA VACCINE; OXIDOREDUCTASE;

ALLERGY; ANIMAL CELL; ARTICLE; BACULOVIRIDAE; CONTROLLED STUDY; FUCOSYLATION; GLYCOSYLATION; INSECT CELL; MATRIX ASSISTED LASER DESORPTION IONIZATION TIME OF FLIGHT MASS SPECTROMETRY; NONHUMAN; PRIORITY JOURNAL; PROTEIN SYNTHESIS; PSEUDOMONAS AERUGINOSA; ANIMAL; GENETICS; HUMAN; HYPERSENSITIVITY; IMMUNOLOGY; INFLUENZA VIRUS A; INSECT; METABOLISM; SF9 CELL LINE;

ANIMALS; ANTIBODIES; ANTIGENS; BACTERIAL PROTEINS; BACULOVIRIDAE; FUCOSE; GLYCOPROTEINS; GLYCOSYLATION; HEMAGGLUTININS; HUMANS; HYPERSENSITIVITY; IMMUNE SERA; IMMUNOGLOBULIN E; INFLUENZA A VIRUS; INFLUENZA VACCINES; INSECTS; OXIDOREDUCTASES ACTING ON ALDEHYDE OR OXO GROUP DONORS; PSEUDOMONAS AERUGINOSA; RECOMBINANT PROTEINS; SF9 CELLS;

EID: 84906948184     PISSN: 18606768     EISSN: 18607314     Source Type: Journal    
DOI: 10.1002/biot.201400061     Document Type: Article

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