Update: The search for the human cough receptor

Lung

Volumn 192, Issue 4, 2014, Pages 459-465

  McGarvey, Lorcan ^a  

^a QUEEN'S UNIVERSITY BELFAST   (United Kingdom)

Author keywords

Cough; Human; Receptor; Review

Indexed keywords

ACID SENSING ION CHANNEL; COUGH RECEPTOR; G PROTEIN COUPLED RECEPTOR; RECEPTOR; SLOW ADAPTING RECEPTOR; SODIUM CHANNEL; SULFUR DIOXIDE; TRANSIENT RECEPTOR POTENTIAL CHANNEL A1; TRANSIENT RECEPTOR POTENTIAL CHANNEL M8; UNCLASSIFIED DRUG; VANILLOID RECEPTOR 1; VANILLOID RECEPTOR 1 ANTAGONIST; ANTITUSSIVE AGENT; CELL SURFACE RECEPTOR; TRANSIENT RECEPTOR POTENTIAL CHANNEL;

ACTION POTENTIAL; ASTHMA; CARDIOTOXICITY; CLINICAL RESEARCH; COUGHING; DISEASE SEVERITY; HUMAN; HYPERSENSITIVITY; INTRACELLULAR SIGNALING; MECHANICAL STIMULATION; NOCICEPTION; PRIORITY JOURNAL; REFLEX; RESPIRATORY TRACT INFLAMMATION; REVIEW; SENSORY NERVE CELL; STIMULATION; THERMOREGULATION; TRANSLATIONAL RESEARCH; VAGOTOMY; ANIMAL; ANTAGONISTS AND INHIBITORS; COUGH; DRUG DESIGN; DRUG EFFECTS; METABOLISM; MOLECULARLY TARGETED THERAPY; PATHOPHYSIOLOGY; SIGNAL TRANSDUCTION;

ANIMALS; ANTITUSSIVE AGENTS; COUGH; DRUG DESIGN; HUMANS; MOLECULAR TARGETED THERAPY; RECEPTORS, CELL SURFACE; REFLEX; SIGNAL TRANSDUCTION; TRANSIENT RECEPTOR POTENTIAL CHANNELS;

EID: 84906936082     PISSN: 03412040     EISSN: 14321750     Source Type: Journal    
DOI: 10.1007/s00408-014-9581-x     Document Type: Review

References (74)

1. Mazzone SB (2005) An overview of the sensory receptors regulating cough. Cough 4(1):2
2. Canning BJ, Mazzone SB, Meeker SN, Mori N, Reynolds SM, Undem BJ (2004) Identification of the tracheal and laryngeal afferent neurones mediating cough in anaesthetized guinea-pigs. J Physiol 557(Pt 2):543-558 (Pubitemid 38807393)
3. McGarvey L, McKeagney P, Polley L, MacMahon J, Costello RW (2009) Are there clinical features of a sensitized cough reflex? Pulm Pharmacol Ther 22(2):59-64
4. Canning BJ (2008) The cough reflex in animals: relevance to human cough research. Lung 186(Suppl 1):S23-S28
5. McGarvey LP (2004) Cough. 6: Which investigations are most useful in the diagnosis of chronic cough? Thorax 59(4):342-346
6. Widdicombe JG (1952) Rapidly adapting mechanoreceptors in the trachea of the cat. J Physiol 118(2):46P-47P
7. Widdicombe JG (1954) Respiratory reflexes from the trachea and bronchi of the cat. J Physiol 123(1):55-70
8. Widdicombe JG (1954) Respiratory reflexes excited by inflation of the lungs. J Physiol 123(1):105-115
9. Hansson L, Wollmer P, Dahlbäck M, Karlsson JA (1992) Regional sensitivity of human airways to capsaicin-induced cough. Am Rev Respir Dis 145(5):1191-1195
10. May AJ, Widdicombe JG (1954) Depression of the cough reflex by pentobarbitone and some opium derivatives. Br J Pharmacol Chemother 9(3):335-340
11. Ivanco I, Korpas J (1954) Contribution to the laryngeal and tracheal cough. Bratisl Lek Listy 34(12):1391-1396
12. Sant'Ambrogio G, Widdicombe JG (1965) Respiratory reflexes acting on the diaphragm and inspiratory intercostal muscle of the rabbit. J Physiol 180(4):766-779
13. Tomori Z, Widdicombe JG (1969) Muscular, bronchomotor and cardiovascular reflexes elicited by mechanical stimulation of the respiratory tract. J Physiol 200(1):25-49
14. 2 inhalation on the cough reflex in rabbits. Ceskoslov Fysiol 30(3):243-245
15. Korpas J, Widdicombe JG (1983) Defensive respiratory reflexes in ferrets. Respiration 44(2):128-135 (Pubitemid 13189311)
16. Tatar M, Webber SE, Widdicombe JG (1988) Lung C-fibre receptor activation and defensive reflexes in anaesthetized cats. J Physiol 402:411-420
17. Gu Q, Lee LY (2006) Characterization of acid signaling in rat vagal pulmonary sensory neurons. Am J Physiol Lung Cell Mol Physiol 291(1):L58-L65
18. Mazzone SB, Reynolds SM, Mori N, Kollarik M, Farmer DG, Myers AC, Canning BJ (2009) Selective expression of a sodium pump isozyme by cough receptors and evidence for its essential role in regulating cough. J Neurosci 29(43):13662-13671
19. Mutoh T, Joad JP, Bonham AC (2000) Chronic passive cigarette smoke exposure augments bronchopulmonary C-fibre inputs to nucleus tractus solitarii neurones and reflex output in young guinea-pigs. J Physiol 523(Pt 1):223-233 (Pubitemid 30135834)
20. Bonham AC, Sekizawa S, Chen CY, Joad JP (2006) Plasticity of brainstem mechanisms of cough. Respir Physiol Neurobiol 152(3):312-319 (Pubitemid 44037509)
21. Bolser DC, Aziz SM, DeGennaro FC, Kreutner W, Egan RW, Siegel MI, Chapman RW (1993) Antitussive effects of GABAB agonists in the cat and guinea-pig. Br J Pharmacol 110(1):491-495 (Pubitemid 23257824)
22. Bolser DC, DeGennaro FC, O'Reilly S, Chapman RW, Kreutner W, Egan RW, Hey JA (1994) Peripheral and central sites of action of GABA-B agonists to inhibit the cough reflex in the cat and guinea pig. Br J Pharmacol 113(4):1344-1348 (Pubitemid 24364419)
23. Bolser DC, Hey JA, Chapman RW (1999) Influence of central antitussive drugs on the cough motor pattern. J Appl Physiol (1985) 86(3):1017-1024
24. Lavorini F, Fontana GA, Pantaleo T, Geri P, Piumelli R, Pistolesi M, Widdicombe J (2007) Fog-induced cough with impaired respiratory sensation in congenital central hypoventilation syndrome. Am J Respir Crit Care Med 176(8):825-832 (Pubitemid 47598485)
25. Mazzone SB, Cole LJ, Ando A, Egan GF, Farrell MJ (2011) Investigation of the neural control of cough and cough suppression in humans using functional brain imaging. J Neurosci 31(8):2948-2958
26. Mazzone SB, McGovern AE, Yang SK, Woo A, Phipps S, Ando A, Leech J, Farrell MJ (2013) Sensorimotor circuitry involved in the higher brain control of coughing. Cough 9(1):7. doi:10.1186/1745-9974-9-7
27. Widdicombe JG (1995) Neurophysiology of the cough reflex. Eur Respir J 8(7):1193-1202
28. Spina D, Page CP (2013) Regulating cough through modulation of sensory nerve function in the airways. Pulm Pharmacol Ther 26(5):486-490
29. Carr MJ (2013) Regulation of cough and action potentials by voltage-gated Na channels. Pulm Pharmacol Ther 26(5):508-509
30. Bickerman HA, Barach AL (1954) The experimental production of cough in human subjects induced by citric acid aerosols; preliminary studies on the evaluation of antitussive agents. Am J Med Sci 228(2):156-163
31. Simonsson BG, Jacobs FM, Nadel JA (1967) Role of autonomic nervous system and the cough reflex in the increased responsiveness of airways in patients with obstructive airway disease. J Clin Investig 46(11):1812-1818
32. Davenport PW (2008) Urge-to-cough: what can it teach us about cough? Lung 186(Suppl 1):S107-S111
33. Morice AH, McGarvey LP, Dicpinigaitis PV (2012) Cough hypersensitivity syndrome is an important clinical concept: a pro/con debate. Lung 190(1):3-9
34. Davenport PW (2009) Clinical cough I: the urge-to-cough: a respiratory sensation. Handb Exp Pharmacol 187:263-276
35. Bolser DC (2009) Central mechanisms II: pharmacology of brainstem pathways. Handb Exp Pharmacol 187:203-217
36. Smith JA, Hilton EC, Saulsberry L, Canning BJ (2012) Antitussive effects of memantine in guinea pigs. Chest 141(4):996-1002
37. Lowry RH, Wood AM, Higenbottam TW (1988) Effects of pH and osmolarity on aerosol-induced cough in normal volunteers. Clin Sci (Lond) 74(4):373-376 (Pubitemid 18090621)
38. Wong CH, Matai R, Morice AH (1999) Cough induced by low pH. Respir Med 93(1):58-61 (Pubitemid 29043945)
39. Kastelik JA, Thompson RH, Aziz I, Ojoo JC, Redington AE, Morice AH (2002) Sex-related differences in cough reflex sensitivity in patients with chronic cough. Am J Respir Crit Care Med 166(7):961-964 (Pubitemid 35193226)
40. Wong CH, Morice AH (1999) Cough threshold in patients with chronic obstructive pulmonary disease. Thorax 54(1):62-64
41. Fox AJ, Urban L, Barnes PJ, Dray A (1995) Effects of capsazepine against capsaicin- and proton-evoked excitation of single airway C-fibres and vagus nerve from the guinea-pig. Neuroscience 67(3):741-752
42. Caterina MJ, Schumacher MA, Tominaga M, Rosen TA, Levine JD, Julius D (1997) The capsaicin receptor: a heat-activated ion channel in the pain pathway. Nature 389(6653):816-824 (Pubitemid 27462969)
43. Kollarik M, Undem BJ (2004) Activation of bronchopulmonary vagal afferent nerves with bradykinin, acid and vanilloid receptor agonists in wild-type and TRPV1 -/- mice. J Physiol 555(Pt 1):115-123 (Pubitemid 38313065)
44. Khoo SG, Al-Alawi M, Walsh MT, Hannigan K, Glynn S, Thornton M, McQuaid S, Wang Y, Hamilton PW, Verriere V, Gleich GJ, Harvey BJ, Costello RW, McGarvey LP (2012) Eosinophil peroxidase induces the expression and function of acid-sensing ion channel-3 in allergic rhinitis: in vitro evidence in cultured epithelial cells. Clin Exp Allergy 42(7):1028-1039
45. Bessac BF, Jordt S-E (2008) Breathtaking TRP channels: TRPA1 and TRPV1 in airway chemosensation and reflex control. Physiology 23:360-370
46. Groneberg DA, Niimi A, Dinh QT, Cosio B, Hew M, Fischer A, Chung KF (2004) Increased expression of transient receptor potential vanilloid-1 in airway nerves of chronic cough. Am J Respir Crit Care Med 170:1276-1280 (Pubitemid 39657190)
47. Cantero-Recasens G, Gonzalez JR, Fandos C, Duran E, Smit LA, Kauffmann F, Antó JM, Valverde MA (2010) Loss-of-function of transient receptor potential vanilloid 1 (TRPV1) genetic variant is associated with lower risk of active childhood asthma. J Biol Chem 285:27532-27535
48. Zhu G, Gulsvik A, Bakke P, Ghatta S, Anderson W, Lomas DA, Silverman EK, Pillai SG (2009) Association of TRPV4 gene polymorphisms with chronic obstructive pulmonary disease. Hum Mol Genet 18:2053-2062
49. Smit LA, Kogevinas M, Anto JM, Bouzigon E, Gonzalez JR, Le Moual N et al (2012) Transient receptor potential genes, smoking, occupational exposures and cough in adults. Respir Res 13(1):26
50. Sabnis AS, Shadid M, Yost GS, Reilly CA (2008) Human lung epithelial cells express a functional cold-sensing TRPM8 variant. Am J Respir Cell Mol Biol 39:466-474
51. Birrell MA, Belvisi MG, Grace M, Sadofsky L, Faruqi S, Hele DJ, Maher SA, Freund-Michel V, Morice AH (2009) TRPA1 agonists evoke coughing in guinea-pig and human volunteers. Am J Respir Crit Care Med 180:1042-1047
52. McGarvey LP, Butler CA, Stokesberry S, Polley L, McQuaid S, Abdullah H, Ashraf S, McGahon MK, Curtis TM, Arron J, Choy D, Warke TJ, Bradding P, Ennis M, Zholos A, Costello RW, Heaney LG (2013) Increased expression of bronchial epithelial transient receptor potential vanilloid 1 channels in patients with severe asthma. J Allergy Clin Immunol. doi:10.1016/j.jaci.2013.09.016
53. Tang HB, Inoue A, Oshita K, Nakata Y (2004) Sensitization of vanilloid receptor 1 induced by bradykinin via the activation of second messenger signaling cascades in rat primary afferent neurons. Eur J Pharmacol 498(1-3):37-43 (Pubitemid 39208058)
54. Zhu W, Oxford GS (2007) Phosphoinositide-3-kinase and mitogen activated protein kinase signaling pathways mediate acute NGF sensitization of TRPV1. Mol Cell Neurosci 34(4):689-700 (Pubitemid 46486710)
55. Hsieh YL, Chiang H, Lue JH, Hsieh ST (2012) P2X3-mediated peripheral sensitization of neuropathic pain in resiniferatoxininduced neuropathy. Exp Neurol 235(1):316-325
56. Zhang N, Inan S, Cowan A, Sun R, Wang JM, Rogers TJ, Caterina M, Oppenheim JJ (2005) A proinflammatory chemokine, CCL3, sensitizes the heat- and capsaicin-gated ion channel TRPV1. Proc Natl Acad Sci USA 102(12):4536-4541 (Pubitemid 40397147)
57. Andrè E, Campi B, Materazzi S, Trevisani M, Amadesi S, Massi D, Creminon C, Vaksman N, Nassini R, Civelli M, Baraldi PG, Poole DP, Bunnett NW, Geppetti P, Patacchini R (2008) Cigarette smoke-induced neurogenic inflammation is mediated by alpha, beta-unsaturated aldehydes and the TRPA1 receptor in rodents. J Clin Investig 118(7):2574-2582 (Pubitemid 351949784)
58. Taylor-Clark TE, Ghatta S, Bettner W, Undem BJ (2009) Nitrooleic acid, an endogenous product of nitrative stress, activates nociceptive sensory nerves via the direct activation of TRPA1. Mol Pharmacol 75(4):820-829
59. Grace M, Birrell MA, Dubuis E, Maher SA, Belvisi MG (2012) Transient receptor potential channels mediate the tussive response to prostaglandin E2 and bradykinin. Thorax 67(10):891-900
60. Plevkova J, Kollarik M, Poliacek I, Brozmanova M, Surdenikova L, Tatar M, Mori N, Canning BJ (1985) The role of trigeminal nasal TRPM8-expressing afferent neurons in the antitussive effects of menthol. J Appl Physiol 115(2):268-274
61. Gavliakova S, Biringerova Z, Buday T, Brozmanova M, Calkovsky V, Poliacek I, Plevkova J (2013) Antitussive effects of nasal thymol challenges in healthy volunteers. Respir Physiol Neurobiol 187(1):104-107
62. Abdullah H, Heaney LG, Cosby SL, McGarvey LP (2014) Rhinovirus upregulates transient receptor potential channels in a human neuronal cell line: implications for respiratory virusinduced cough reflex sensitivity. Thorax 69(1):46-54
63. Bhattacharya A, Scott BP, Nasser N, Ao H, Maher MP, Dubin AE, Swanson DM, Shankley NP, Wickenden AD, Chaplan SR (2007) Pharmacology and antitussive efficacy of 4-(3-trifluoromethylpyridin-2-yl)-piperazine-1-carboxylic acid (5-trifluoromethylpyridin-2-yl)-amide (JNJ17203212), a transient receptor potential vanilloid 1 antagonist in guinea pigs. J Pharmacol Exp Ther 323(2):665-674 (Pubitemid 350005126)
64. Swanson DM, Dubin AE, Shah C, Nasser N, Chang L, Dax SL, Jetter M, Breitenbucher JG, Liu C, Mazur C, Lord B, Gonzales L, Hoey K, Rizzolio M, Bogenstaetter M, Codd EE, Lee DH, Zhang SP, Chaplan SR, Carruthers NI (2005) Identification and biological evaluation of 4-(3-trifluoromethylpyridin-2-yl) piperazine-1-carboxylic acid (5-trifluoromethylpyridin-2-yl)amide, a high affinity TRPV1 (VR1) vanilloid receptor antagonist. J Med Chem 48(6):1857-1872 (Pubitemid 40396317)
65. Smith JA, Murdoch RD, Newlands A, Smart K, Khalid S, Kelsall A, Holt K, Dockry R, Woodcock A (2012) The impact of a selective oral TRPV1 antagonist in patients with chronic cough. Thorax 67(Suppl 2):A128
66. Chen J, Joshi SK, DiDomenico S, Perner RJ, Mikusa JP, Gauvin DM, Segreti JA, Han P, Zhang XF, Niforatos W, Bianchi BR, Baker SJ, Zhong C, Simler GH, McDonald HA, Schmidt RG, McGaraughty SP, Chu KL, Faltynek CR, Kort ME, Reilly RM, Kym PR (2011) Selective blockade of TRPA1 channel attenuates pathological pain without altering noxious cold sensation or body temperature regulation. Pain 152(5):1165-1172
67. Preti D, Szallasi A, Patacchini R (2012) TRP channels as therapeutic targets in airway disorders: a patent review. Expert Opin Ther Pat 22(6):663-695
68. Howard P, Cayton RM, Brennan SR, Anderson PB (1977) Lignocaine aerosol and persistent cough. Br J Dis Chest 71(1):19-24 (Pubitemid 8018776)
69. Lim KG, Rank MA, Hahn PY, Keogh KA, Morgenthaler TI, Olson EJ (2013) Long-term safety of nebulized lidocaine for adults with difficult-to-control chronic cough: a case series. Chest 143(4):1060-1065
70. Kwong K, Carr MJ, Gibbard A, Savage TJ, Singh K, Jing J, Meeker S, Undem BJ (2008) Voltage-gated sodium channels in nociceptive versus non-nociceptive nodose vagal sensory neurons innervating guinea pig lungs. J Physiol 586(5):1321-1336 (Pubitemid 351321271)
71. Muroi Y, Ru F, Chou YL, Carr MJ, Undem BJ, Canning BJ (2013) Selective inhibition of vagal afferent nerve pathways regulating cough using NaV1.7 shRNA silencing in guinea pig nodose ganglia. Am J Physiol Regul Integr Comp Physiol 304(11):R1017-R1023
72. Chung KF, McGarvey L, Mazzone SB (2013) Chronic cough is a neuropathic condition. Lancet Respir Med 19(5):414-422
73. Round P, Priestley A, Robinson J (2011) An investigation of the safety and pharmacokinetics of the novel TRPV1 antagonist XEN-D0501 in healthy subjects. Br J Clin Pharmacol 72(6):921-931
74. Hughes JP, Chessell I, Malamut R, Perkins M, Bačkonja M, Baron R, Farrar JT, Field MJ, Gereau RW, Gilron I, McMahon SB, Porreca F, Rappaport BA, Rice F, Richman LK, Segerdahl M, Seminowicz DA, Watkins LR, Waxman SG, Wiech K, Woolf C (2012) Understanding chronic inflammatory and neuropathic pain. Ann NY Acad Sci 1255:30-44