Influence of central antitussive drugs on the cough motor pattern

Journal of Applied Physiology

Volumn 86, Issue 3, 1999, Pages 1017-1024

  Bolser, Donald C ^a   Hey, John A ^b   Chapman, Richard W ^b  

^a University of Florida College of Veterinary Medicine   (United States)

^b MERCK RESEARCH LABORATORIES   (United States)

Author keywords

Abdominal; Brain stem; Control of breathing; Diaphragm; Rectus abdominis

Indexed keywords

3 (2 METHOXYBENZYLAMINO) 2 PHENYLPIPERIDINE; ANTITUSSIVE AGENT; BACLOFEN; CODEINE; DEXTROMETHORPHAN; MORPHINE; SAREDUTANT;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN STEM; BREATHING PATTERN; CAT; CONTROLLED STUDY; COUGHING; DIAPHRAGM MUSCLE; DOSE RESPONSE; DRUG EFFECT; ELECTROMYOGRAPHY; FEMALE; MALE; MOTOR PERFORMANCE; NONHUMAN; PRIORITY JOURNAL; RECTUS ABDOMINIS MUSCLE; RESPIRATION CONTROL; RESPIRATORY DRIVE; VERTEBRAL ARTERY;

EID: 0033056025     PISSN: 87507587     EISSN: None     Source Type: Journal    
DOI: 10.1152/jappl.1999.86.3.1017     Document Type: Article

References (34)

1. Adcock, J. J. Peripheral opioid receptors and the cough reflex. Respir. Med. 85, Suppl. A: 43-46, 1991.
2. Adcock, J. J., C. Schneider, and T. W. Smith. Effects of codeine, morphine, and a novel pentapeptide BW443C, on cough, nociception and ventilation in the unanesthetized guinea pig. Br. J. Pharmacol. 93: 93-100, 1988.
3. Bolser, D. C. Fictive cough in the cat. J. Appl. Physiol. 71: 2325-2331, 1991.
4. Bolser, D. C. Mechanisms of action of central and peripheral antitussive drugs. Pulm. Pharmacol. 9: 357-364, 1997.
5. Bolser, D. C., S. M. Aziz, F. C. DeGennaro, W. Kreutner, R. W. Egan, and R. W. Chapman. Antitussive effects of GABA-B agonists in the cat and guinea pig. Br. J. Pharmacol. 110: 491-495, 1993.
6. Bolser, D. C., and F. C. DeGennaro. Effect of codeine on the inspiratory and expiratory burst pattern during fictive cough in the cat. Brain Res. 662: 25-30, 1994.
7. Bolser, D. C., F. C. DeGennaro, R. W. Chapman, and J. A. Hey. Central and peripheral sites of action of antitussive drugs in the cat. In: Ventral Brainstem Mechanisms and Control of Respiration and Blood Pressure, edited by C. O. Trouth and R. M. Millis. New York: Dekker, 1995, p. 95-102.
8. Bolser, D. C., F. C. DeGennaro, S. O'Reilly, R. W. Chapman, W. Kreutner, R. W. Egan, and J. A. Hey. Peripheral and central sites of action of GABA-B agonists to inhibit the cough reflex in the cat and guinea pig. Br. J. Pharmacol. 113: 1344-1348, 1994.
9. Bolser, D. C., F. C. DeGennaro, S. O'Reilly, R. I. McLeod, and J. A. Hey. Central antitussive activity of the tachykinin receptor antagonists CP-99994 and SR-48968 in the guinea pig and cat. Br. J. Pharmacol. 121: 165-170, 1997.
10. Bolser, D. C., P. J. Reier, and P. W. Davenport. Differential responses of the anterolateral abdominal muscles during cough and expiratory loading in the cat (Abstract). Am. J. Respir. Crit. Care Med. 157: A781, 1998.
11. Chou, D. T., and S. C. Wang. Studies on the localization of the central cough mechanism: site of action of antitussive drugs. J. Pharmacol. Exp. Ther. 223: 249-253, 1975.
12. Choudry, N. B., and R. W. Fuller. Sensitivity of the cough reflex in patients with chronic cough. Eur. Respir. J. 5: 296-300, 1992.
13. De Troyer, A., and V. Ninane. Triangularis sterni: a primary muscle of breathing in the dog. J. Appl. Physiol. 60: 14-21, 1986.
14. DiMarco, A. F., M. S. DiMarco, K. P. Strohl, and M. D. Altose. Effects of expiratory threshold loading on thoracoabdominal motion in cats. Respir. Physiol. 57: 247-257, 1984.
15. Fregosi, R. F., S. L. Knuth, D. K. Ward, and D. Bartlett, Jr. Hypoxia inhibits abdominal expiratory nerve activity. J. Appl. Physiol. 63: 211-220, 1987.
16. Hanecek, J., A. Davies, and J. G. Widdicombe. Influence of lung stretch receptors on the and other respiratory tract reflexes in cats. Physiol. Bohemoslov. 34: 127-136, 1985.
17. Haxhiu, M. A., N. S. Cherniack, and E. Van Lunteren. Central action of tachykinins on activity of expiratory pumping muscles. J. Appl. Physiol. 69: 1981-1986, 1990.
18. Haxhiu, M. A., B. Erokwu, E. Van Lunteren, N. S. Cherniack, and K. P. Strohl. Central and spinal effects of sodium cyanide on respiratory activity. J. Appl. Physiol. 74: 574-579, 1993.
19. Hey, J. A., G. Mingo, D. C. Bolser, W. Kreutner, D. Krobatsch, and R. W. Chapman. Respiratory effects of baclofen and 3-aminopropylphosphinic acid in guinea pigs. Br. J. Pharmacol. 114: 735-738, 1995.
20. Jordan, D. Central nervous mechanisms in cough. Pulm. Pharmacol. 9: 398-392, 1997.
21. Karlsson, J. A., A. S. Lanner, and C. G. A. Persson. Airway opioid receptors mediate inhibition of cough and reflex broncho-constriction in guinea pigs. J. Pharmacol. Exp. Ther. 252: 863-868, 1989.
22. Kase, Y. Antitussive agents and their site of action. Trends Pharmacol. Sci. 1: 237-239, 1980.
23. Korpas, J., and Z. Tomori. Cough and Other Respiratory Reflexes. New York: Karger, 1979.
24. Lalley, P. M. Biphasic effect of baclofen on phrenic motoneurons: possible involvement of two types of γ-aminobutyric (GABA) receptors. J. Pharmacol. Exp. Ther. 226: 616-624, 1983.
25. May, A. J., and J. G. Widdicombe. Depression of the cough reflex by pentobarbitone and some opium derivatives. Br. J. Pharmacol. 9: 335-340, 1954.
26. Sant'Ambrogio, G., F. B. Sant'Ambrogio, and A. Davies. Airway receptors in cough. Bull. Eur. Physiopath. Respir. 20: 43-47, 1984.
27. Shannon, R. Central nervous mechanisms in cough: brainstem respiratory networks and cough. Pulm. Pharmacol. 9: 343-347, 1997.
28. Shannon, R., Baekey, D. M., Morris, K. F., and B. G. Lindsey. Ventrolateral medullary respiratory network and a model of cough motor pattern generation. J. Appl. Physiol. 84: 2020-2035, 1998.
29. Shannon, R., D. C. Bolser, and B. G. Lindsey. Neural control of coughing and sneezing. In: Neural Control of Breathing, edited by A. D. Miller, A. L. Bianchi, and B. P. Bishop. Boca Raton, FL: CRC, 1996, p. 215-224.
30. Tomori, Z., and J. G. Widdicombe. Muscular, bronchomotor, and cardiovascular reflexes elicited by mechanical stimulation of the respiratory tract. J. Physiol. (Lond.) 200: 25-49, 1969.
31. Van Lunteren, E., R. Daniels, E. C. Deal, and M. A. Haxhiu. Role of costal and crural diaphragm and parasternal intercostals during coughing in cats. J. Appl. Physiol. 66: 135-141, 1989.
32. Van Lunteren, E., M. A. Haxhiu, N. S. Cherniack, and J. S. Arnold. Role of the triangularis sterni during coughing and sneezing in dogs. J. Appl. Physiol. 65: 2440-2445, 1988.
33. Van Lunteren, E., N. R. Prabhakar, N. S. Cherniack, M. A. Haxhiu, and T. E. Dick. Inhibition of expiratory muscle EMG and motor unit activity during augmented breaths in cats. Respir. Physiol. 72: 303-314, 1988.
34. Warner, D. O., M. J. Joyner, and E. L. Ritman. Anesthesia and chest wall function in dogs. J. Appl. Physiol. 76: 2802-2813, 1994.