Chronic cough as a neuropathic disorder

The Lancet Respiratory Medicine

Volumn 1, Issue 5, 2013, Pages 414-422

  Chung, Kian Fan ^a,b   McGarvey, Lorcan ^c   Mazzone, Stuart ^d  

^a NATIONAL HEART AND LUNG INSTITUTE   (United Kingdom)

^b ROYAL BROMPTON HOSPITAL   (United Kingdom)

^c QUEEN'S UNIVERSITY BELFAST   (United Kingdom)

^d UNIVERSITY OF QUEENSLAND   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

AMITRIPTYLINE; ANTITUSSIVE AGENT; BOTULINUM TOXIN A; BOTULINUM TOXIN E; CALCITONIN GENE RELATED PEPTIDE; CODEINE PHOSPHATE PLUS GUAIFENESIN; GABAPENTIN; N METHYL DEXTRO ASPARTIC ACID RECEPTOR; NERVE GROWTH FACTOR; VANILLOID RECEPTOR 1; ANALGESIC AGENT;

AIRWAY REMODELING; ANTINOCICEPTION; ARTICLE; BRONCHUS BIOPSY; CHRONIC COUGH; CHRONIC PAIN; CYANOCOBALAMIN DEFICIENCY; DISEASE ASSOCIATION; HUMAN; HYPERSENSITIVITY; LARYNGEAL NERVE INJURY; NEUROPATHIC PAIN; NEUROPATHOLOGY; NEUROPATHY; NONHUMAN; PRIORITY JOURNAL; RESPIRATORY TRACT ALLERGY; RESPIRATORY TRACT INFLAMMATION; SENSORY NERVE; VIRAL RESPIRATORY TRACT INFECTION; CHRONIC DISEASE; COUGH; INNERVATION; PATHOPHYSIOLOGY; RESPIRATORY SYSTEM;

ANALGESICS; CHRONIC DISEASE; COUGH; HUMANS; RESPIRATORY SYSTEM;

EID: 84881374379     PISSN: 22132600     EISSN: None     Source Type: Journal    
DOI: 10.1016/S2213-2600(13)70043-2     Document Type: Note

References (114)

1. Chung KF, Pavord ID. Prevalence, pathogenesis, and causes of chronic cough. Lancet 2008; 371: 1364-74.
2. Zemp E, Elsasser S, Schindler C, et al. Long-term ambient air pollution and respiratory symptoms in adults (SAPALDIA study). Am J Respir Crit Care Med 1999; 159: 1257-66.
3. Cullinan P. Persistent cough and sputum: prevalence and clinical characteristics in south east England. Respir Med 1992; 86: 143-49.
4. Barbee RA, Halonen M, Kaltenborn WT, Burrows B. A longitudinal study of respiratory symptoms in a community population sample. Correlations with smoking, allergen skin-test reactivity, and serum IgE. Chest 1991; 99: 20-26.
5. Birring SS, Matos S, Patel RB, Prudon B, Evans DH, Pavord ID. Cough frequency, cough sensitivity and health status in patients with chronic cough. Respir Med 2006; 100: 1105-09.
6. O'Connell F, Thomas VE, Pride NB, Fuller RW. Capsaicin cough sensitivity decreases with successful treatment of chronic cough. Am J Respir Crit Care Med 1994; 150: 374-80.
7. Choudry NB, Fuller RW. Sensitivity of the cough reflex in patients with chronic cough. Eur Respir J 1992; 5: 296-300.
8. Vertigan AE, Gibson PG. Chronic refractory cough as a sensory neuropathy: evidence from a reinterpretation of cough triggers. J Voice 2011; 25: 596-601.
9. Bucca CB, Bugiani M, Culla B, et al. Chronic cough and irritable larynx. J Allergy Clin Immunol 2011; 127: 412-19.
10. Kok C, Kennerson ML, Spring PJ, Ing AJ, Pollard JD, Nicholson GA. A locus for hereditary sensory neuropathy with cough and gastroesophageal reflux on chromosome 3p22-p24. Am J Hum Genet 2003; 73: 632-37.
11. Spring PJ, Kok C, Nicholson GA, et al. Autosomal dominant hereditary sensory neuropathy with chronic cough and gastro-oesophageal reflux: clinical features in two families linked to chromosome 3p22-p24. Brain 2005; 128: 2797-810.
12. Javorkova N, Varechova S, Pecova R, et al. Acidification of the oesophagus acutely increases the cough sensitivity in patients with gastro-oesophageal reflux and chronic cough. Neurogastroenterol Motil 2008; 20: 119-24.
13. Canning BJ, Mazzone SB. Reflex mechanisms in gastroesophageal reflux disease and asthma. Am J Med 2003; 115 (suppl 3A): S45-48.
14. Bucca CB, Culla B, Guida G, et al. Unexplained chronic cough and vitamin B-12 deficiency. Am J Clin Nutr 2011; 93: 542-48.
15. Alon EE, Ekbom DC. Neurosarcoidosis aff ecting the vagus nerve. Ann Otol Rhinol Laryngol 2010; 119: 641-45.
16. Guler AK, Gunaldi O, Alis H, Tugcu B, Tanriverdi O, Colluoglu B. Cervical segment nervus vagus neurofibroma with associated neurofibromatosis type 1: a case report. Minim Invasive Neurosurg 2009; 52: 246-49.
17. Behera D, Das S, Dash RJ, Jindal SK. Cough reflex threshold in diabetes mellitus with and without autonomic neuropathy. Respiration 1995; 62: 263-68.
18. Canning BJ, Mazzone SB, Meeker SN, Mori N, Reynolds SM, Undem BJ. Identification of the tracheal and laryngeal aff erent neurones mediating cough in anaesthetized guinea-pigs. J Physiol 2004; 557: 543-58.
19. Davenport PW, Vovk A, Duke RK, Bolser DC, Robertson E. The urge-to-cough and cough motor response modulation by the central effects of nicotine. Pulm Pharmacol Ther 2009; 22: 82-89.
20. Hegland KW, Bolser DC, Davenport PW. Volitional control of reflex cough. J Appl Physiol 2012; 113: 39-46.
21. Davenport PW. Clinical cough I: the urge-to-cough: a respiratory sensation. Handb Exp Pharmacol 2009; 187: 263-76.
22. Widdicombe JG, Addington WR, Fontana GA, Stephens RE. Voluntary and reflex cough and the expiration reflex; implications for aspiration after stroke. Pulm Pharmacol Ther 2011; 24: 312-17.
23. Mazzone SB, Cole LJ, Ando A, Egan GF, Farrell MJ. Investigation of the neural control of cough and cough suppression in humans using functional brain imaging. J Neurosci 2011; 31: 2948-58.
24. Mazzone SB, Mori N, Canning BJ. Synergistic interactions between airway aff erent nerve subtypes regulating the cough reflex in guinea-pigs. J Physiol 2005; 569: 559-73.
25. Farrell MJ, Cole LJ, Chiapoco D, Egan GF, Mazzone SB. Neural correlates coding stimulus level and perception of capsaicin-evoked urge-to-cough in humans. Neuroimage 2012; 61: 1324-35.
26. Simonyan K, Saad ZS, Loucks TM, Poletto CJ, Ludlow CL. Functional neuroanatomy of human voluntary cough and sniff production. Neuroimage 2007; 37: 401-09.
27. Magni C, Chellini E, Lavorini F, Fontana GA, Widdicombe J. Voluntary and reflex cough: similarities and diff erences. Pulm Pharmacol Ther 2011; 24: 308-11.
28. Canning BJ, Mazzone SB, Meeker SN, Mori N, Reynolds SM, Undem BJ. Identification of the tracheal and laryngeal aff erent neurones mediating cough in anaesthetized guinea-pigs. J Physiol 2004; 557: 543-58.
29. Canning BJ, Mori N, Mazzone SB. Vagal aff erent nerves regulating the cough reflex. Respir Physiol Neurobiol 2006; 152: 223-42.
30. Chou YL, Scarupa MD, Mori N, Canning BJ. Diff erential effects of airway aff erent nerve subtypes on cough and respiration in anesthetized guinea pigs. Am J Physiol Regul Integr Comp Physiol 2008; 295: R1572-84.
31. Mazzone SB. Sensory regulation of the cough reflex. Pulm Pharmacol Ther 2004; 17: 361-68.
32. Mazzone SB, Undem BJ. Cough sensors V: pharmacological modulation of cough sensors. Handb Exp Pharmacol 2009; 187: 99-127.
33. McGovern AE, Davis-Poynter N, Farrell MJ, Mazzone SB. Transneuronal tracing of airways-related sensory circuitry using herpes simplex virus 1, strain H129. Neuroscience 2012; 207: 148-66.
34. Canning BJ, Mori N. An essential component to brainstem cough gating identified in anesthetized guinea pigs. FASEB J 2010; 24: 3916-26.
35. Canning BJ, Mori N. Encoding of the cough reflex in anesthetized guinea pigs. Am J Physiol Regul Integr Comp Physiol 2011; 300: R369-77.
36. Mutoh T, Joad JP, Bonham AC. Chronic passive cigarette smoke exposure augments bronchopulmonary C-fibre inputs to nucleus tractus solitarii neurones and reflex output in young guinea-pigs. J Physiol 2000; 523: 223-33.
37. Otake K, Ezure K, Lipski J, Wong She RB. Projections from the commissural subnucleus of the nucleus of the solitary tract: an anterograde tracing study in the cat. J Comp Neurol 1992; 324: 365-78.
38. Ezure K, Otake K, Lipski J, She RB. efferent projections of pulmonary rapidly adapting receptor relay neurons in the cat. Brain Res 1991; 564: 268-78.
39. Alheid GF, Jiao W, McCrimmon DR. Caudal nuclei of the rat nucleus of the solitary tract diff erentially innervate respiratory compartments within the ventrolateral medulla. Neuroscience 2011; 190: 207-27.
40. McKay LC, Evans KC, Frackowiak RS, Corfield DR. Neural correlates of voluntary breathing in humans. J Appl Physiol 2003; 95: 1170-78.
41. Carr MJ, Hunter DD, Jacoby DB, Undem BJ. Expression of tachykinins in nonnociceptive vagal aff erent neurons during respiratory viral infection in guinea pigs. Am J Respir Crit Care Med 2002; 165: 1071-75.
42. Chuaychoo B, Hunter DD, Myers AC, Kollarik M, Undem BJ. Allergen-induced substance P synthesis in large-diameter sensory neurons innervating the lungs. J Allergy Clin Immunol 2005; 116: 325-31.
43. Myers AC, Kajekar R, Undem BJ. Allergic inflammation-induced neuropeptide production in rapidly adapting aff erent nerves in guinea pig airways. Am J Physiol Lung Cell Mol Physiol 2002; 282: L775-81.
44. Lieu TM, Myers AC, Meeker S, Undem BJ. TRPV1 induction in airway vagal low-threshold mechanosensory neurons by allergen challenge and neurotrophic factors. Am J Physiol Lung Cell Mol Physiol 2012; 302: L941-48.
45. Groneberg DA, Niimi A, Dinh QT, et al. Increased expression of transient receptor potential vanilloid-1 in airway nerves of chronic cough. Am J Respir Crit Care Med 2004; 170: 1276-80.
46. Chaplan SR, Guo HQ, Lee DH, et al. Neuronal hyperpolarization-activated pacemaker channels drive neuropathic pain. J Neurosci 2003; 23: 1169-78.
47. Ma C, LaMotte RH. Multiple sites for generation of ectopic spontaneous activity in neurons of the chronically compressed dorsal root ganglion. J Neurosci 2007; 27: 14059-68.
48. Paton JF. Pattern of cardiorespiratory aff erent convergence to solitary tract neurons driven by pulmonary vagal C-fiber stimulation in the mouse. J Neurophysiol 1998; 79: 2365-73.
49. Mazzone SB, Canning BJ. Synergistic interactions between airway aff erent nerve subtypes mediating reflex bronchospasm in guinea pigs. Am J Physiol Regul Integr Comp Physiol 2002; 283: R86-98.
50. Plevkova J, Kollarik M, Brozmanova M, Revallo M, Varechova S, Tatar M. Modulation of experimentally-induced cough by stimulation of nasal mucosa in cats and guinea pigs. Respir Physiol Neurobiol 2004; 142: 225-35.
51. Ma QP, Woolf CJ. Noxious stimuli induce an N-methyl-D-aspartate receptor-dependent hypersensitivity of the flexion withdrawal reflex to touch: implications for the treatment of mechanical allodynia. Pain 1995; 61: 383-90.
52. Liu XG, Sandkuhler J. Activation of spinal N-methyl-D-aspartate or neurokinin receptors induces long-term potentiation of spinal C-fibre-evoked potentials. Neuroscience 1998; 86: 1209-16.
53. Dougherty PM, Palecek J, Zorn S, Willis WD. Combined application of excitatory amino acids and substance P produces long-lasting changes in responses of primate spinothalamic tract neurons. Brain Res Brain Res Rev 1993; 18: 227-46.
54. Sekizawa S, Joad JP, Pinkerton KE, Bonham AC. Distinct tachykinin NK(1) receptor function in primate nucleus tractus solitarius neurons is dysregulated after second-hand tobacco smoke exposure. Br J Pharmacol 2011; 163: 782-91.
55. Mazzone SB, McLennan L, McGovern AE, Egan GF, Farrell MJ. Representation of capsaicin-evoked urge-to-cough in the human brain using functional magnetic resonance imaging. Am J Respir Crit Care Med 2007; 176: 327-32.
56. Cheong E, Lee S, Choi BJ, Sun M, Lee CJ, Shin HS. Tuning thalamic firing modes via simultaneous modulation of T- and L-type Ca2+ channels controls pain sensory gating in the thalamus. J Neurosci 2008; 28: 13331-40.
57. Yarnitsky D. Conditioned pain modulation (the diff use noxious inhibitory control-like effect): its relevance for acute and chronic pain states. Curr Opin Anaesthesiol 2010; 23: 611-15.
58. King CD, Wong F, Currie T, Mauderli AP, Fillingim RB, Riley JL 3rd. Deficiency in endogenous modulation of prolonged heat pain in patients with irritable bowel syndrome and temporomandibular disorder. Pain 2009; 143: 172-78.
59. Flor H. Cortical reorganisation and chronic pain: implications for rehabilitation. J Rehabil Med 2003; 41 (suppl): 66-72.
60. Gustin SM, Peck CC, Cheney LB, Macey PM, Murray GM, Henderson LA. Pain and plasticity: is chronic pain always associated with somatosensory cortex activity and reorganization? J Neurosci 2012; 32: 14874-84.
61. Schweinhardt P, Glynn C, Brooks J, et al. An fMRI study of cerebral processing of brush-evoked allodynia in neuropathic pain patients. Neuroimage 2006; 32: 256-65.
62. von Hehn CA, Baron R, Woolf CJ. Deconstructing the neuropathic pain phenotype to reveal neural mechanisms. Neuron 2012; 73: 638-52.
63. Niimi A, Chung KF. Airway inflammation and remodelling changes in patients with chronic cough: do they tell us about the cause of cough? Pulm Pharmacol Ther 2004; 17: 441-46.
64. Boulet LP, Milot J, Boutet M, St Georges F, Laviolette M. Airway inflammation in non-asthmatic subjects with chronic cough. Am J Respir Crit Care Med 1994; 149: 482-89.
65. Niimi A, Torrego A, Nicholson AG, Cosio BG, Oates TB, Chung KF. Nature of airway inflammation and remodeling in chronic cough. J Allergy Clin Immunol 2005; 116: 565-70.
66. McGarvey LP, Forsythe P, Heaney LG, MacMahon J, Ennis M. Bronchoalveolar lavage findings in patients with chronic nonproductive cough. Eur Respir J 1999; 13: 59-65.
67. Birring SS, Parker D, Brightling CE, Bradding P, Wardlaw AJ, Pavord ID. Induced sputum inflammatory mediator concentrations in chronic cough. Am J Respir Crit Care Med 2004; 169: 15-19.
68. Brightling CE, Symon FA, Birring SS, Bradding P, Wardlaw AJ, Pavord ID. Comparison of airway immunopathology of eosinophilic bronchitis and asthma. Thorax 2003; 58: 528-32.
69. Jatakanon A, Lalloo UG, Lim S, Chung KF, Barnes PJ. Increased neutrophils and cytokines, TNF-a and IL-8, in induced sputum of non-asthmatic patients with chronic dry cough. Thorax 1999; 54: 234-37.
70. Xie S, Macedo P, Hew M, Nassenstein C, Lee KY, Chung KF. Expression of transforming growth factor-ß (TGF-ß) in chronic idiopathic cough. Respir Res 2009; 10: 40.
71. Costello RW, Schofield BH, Kephart GM, Gleich GJ, Jacoby DB, Fryer AD. Localization of eosinophils to airway nerves and effect on neuronal M2 muscarinic receptor function. Am J Physiol 1997; 273: L93-103.
72. Kingham PJ, McLean WG, Sawatzky DA, Walsh MT, Costello RW. Adhesion-dependent interactions between eosinophils and cholinergic nerves. Am J Physiol Lung Cell Mol Physiol 2002; 282: L1229-38.
73. Gu Q, Wiggers ME, Gleich GJ, Lee LY. Sensitization of isolated rat vagal pulmonary sensory neurons by eosinophil-derived cationic proteins. Am J Physiol Lung Cell Mol Physiol 2008; 294: L544-52.
74. Choudry NB, Fuller RW, Pride NB. Sensitivity of the human cough reflex: effect of inflammatory mediators prostaglandin E2, bradykinin, and histamine. Am Rev Respir Dis 1989; 140: 137-41.
75. Sikand P, Premkumar LS. Potentiation of glutamatergic synaptic transmission by protein kinase C-mediated sensitization of TRPV1 at the first sensory synapse. J Physiol 2007; 581: 631-47.
76. Kwong K, Lee LY. Prostaglandin E2 potentiates a TTX-resistant sodium current in rat capsaicin-sensitive vagal pulmonary sensory neurones. J Physiol 2005; 564: 437-50.
77. Groneberg DA, Niimi A, Dinh QT, et al. Increased expression of transient receptor potential vanilloid-1 in airway nerves of chronic cough. Am J Respir Crit Care Med 2004; 170: 1276-80.
78. Niimi A, Nguyen LT, Usmani O, Mann B, Chung KF. Reduced pH and chloride levels in exhaled breath condensate of patients with chronic cough. Thorax 2004; 59: 608-12.
79. Patterson RN, Johnston BT, Ardill JE, Heaney LG, McGarvey LP. Increased tachykinin levels in induced sputum from asthmatic and cough patients with acid reflux. Thorax 2007; 62: 491-95.
80. Chang AB, Gibson PG, Ardill J, McGarvey LP. Calcitonin gene-related peptide relates to cough sensitivity in children with chronic cough. Eur Respir J 2007; 30: 66-72.
81. O'Connell F, Springall DR, Krausz T, et al. Abnormal intraepithelial airway nerves in persistent unexplained cough? Am J Resp Crit Care Med 1995; 152: 2068-75.
82. Hope-Gill BD, Hilldrup S, Davies C, Newton RP, Harrison NK. A study of the cough reflex in idiopathic pulmonary fibrosis. Am J Respir Crit Care Med 2003; 168: 995-1002.
83. Zhu W, Oxford GS. Phosphoinositide-3-kinase and mitogen activated protein kinase signaling pathways mediate acute NGF sensitization of TRPV1. Mol Cell Neurosci 2007; 34: 689-700.
84. Yang XD, Liu Z, Liu HX, Wang LH, Ma CH, Li ZZ. Regulatory effect of nerve growth factor on release of substance P in cultured dorsal root ganglion neurons of rat. Neurosci Bull 2007; 23: 215-20.
85. Millqvist E, Ternesten-Hasseus E, Stahl A, Bende M. Changes in levels of nerve growth factor in nasal secretions after capsaicin inhalation in patients with airway symptoms from scents and chemicals. Environ Health Perspect 2005; 113: 849-52.
86. Dicpinigaitis PV, Bhat R, Rhoton WA, Tibb AS, Negassa A. Effect of viral upper respiratory tract infection on the urge-to-cough sensation. Respir Med 2011; 105: 615-8.
87. O'Connell F, Thomas VE, Pride NB, Fuller RW. Capsaicin cough sensitivity decreases with successful treatment of chronic cough. Am J Respir Crit Care Med 1994; 150: 374-80.
88. Eccles R, Lee PC. Cough induced by airway vibration as a model of airway hyperreactivity in patients with acute upper respiratory tract infection. Pulm Pharmacol Ther 2004; 17: 337-42.
89. Shinya K, Shimada A, Ito T, et al. Avian influenza virus intranasally inoculated infects the central nervous system of mice through the general visceral aff erent nerve. Arch Virol 2000; 145: 187-95.
90. Tanaka H, Park CH, Ninomiya A, et al. Neurotropism of the 1997 Hong Kong H5N1 influenza virus in mice. Vet Microbiol 2003; 95: 1-13.
91. Liu Y, Haas DL, Poore S, et al. Human metapneumovirus establishes persistent infection in the lungs of mice and is reactivated by glucocorticoid treatment. J Virol 2009; 83: 6837-48.
92. Bastian RW, Vaidya AM, Delsupehe KG. Sensory neuropathic cough: a common and treatable cause of chronic cough. Otolaryngol Head Neck Surg 2006; 135: 17-21.
93. Jeyakumar A, Brickman TM, Haben M. Effectiveness of amitriptyline versus cough suppressants in the treatment of chronic cough resulting from postviral vagal neuropathy. Laryngoscope 2006; 116: 2108-12.
94. Ryan NM, Birring SS, Gibson PG. Gabapentin for refractory chronic cough: a randomised, double-blind, placebo-controlled trial. Lancet 2012; 380: 1583-89.
95. Lee B, Woo P. Chronic cough as a sign of laryngeal sensory neuropathy: diagnosis and treatment. Ann Otol Rhinol Laryngol 2005; 114: 253-57.
96. Morgan V, Pickens D, Gautam S, Kessler R, Mertz H. Amitriptyline reduces rectal pain related activation of the anterior cingulate cortex in patients with irritable bowel syndrome. Gut 2005; 54: 601-07.
97. Dirksen R, Van Diejen D, Van Luijtelaar EL, Booij LH. Site- and test-dependent antinociceptive efficacy of amitriptyline in rats. Pharmacol Biochem Behav 1994; 47: 21-26.
98. Abdi S, Lee DH, Chung JM. The anti-allodynic effects of amitriptyline, gabapentin, and lidocaine in a rat model of neuropathic pain. Anesth Analg 1998; 87: 1360-66.
99. Iannetti GD, Zambreanu L, Wise RG, et al. Pharmacological modulation of pain-related brain activity during normal and central sensitization states in humans. Proc Natl Acad Sci USA 2005; 102: 18195-200.
100. Governo RJ, Morris PG, Marsden CA, Chapman V. Gabapentin evoked changes in functional activity in nociceptive regions in the brain of the anaesthetized rat: an fMRI study. Br J Pharmacol 2008; 153: 1558-67.
101. Wiff en PJ, McQuay HJ, Edwards JE, Moore RA. Gabapentin for acute and chronic pain. Cochrane Database Syst Rev 2005; 3: CD005452.
102. Bomholt SF, Mikkelsen JD, Blackburn-Munro G. Antinociceptive effects of the antidepressants amitriptyline, duloxetine, mirtazapine and citalopram in animal models of acute, persistent and neuropathic pain. Neuropharmacology 2005; 48: 252-63.
103. Mazzone SB, Reynolds SM, Mori N, et al. Selective expression of a sodium pump isozyme by cough receptors and evidence for its essential role in regulating cough. J Neurosci 2009; 29: 13662-71.
104. Hanesch U, Pawlak M, McDougall JJ. Gabapentin reduces the mechanosensitivity of fine aff erent nerve fibres in normal and inflamed rat knee joints. Pain 2003; 104: 363-66.
105. Kilic FS, Sirmagul B, Yildirim E, Oner S, Erol K. Antinociceptive effects of gabapentin & its mechanism of action in experimental animal studies. Indian J Med Res 2012; 135: 630-35.
106. Sills GJ. The mechanisms of action of gabapentin and pregabalin. Curr Opin Pharmacol 2006; 6: 108-13.
107. Chu MW, Lieser JD, Sinacori JT. Use of botulinum toxin type A for chronic cough: a neuropathic model. Arch Otolaryngol Head Neck Surg 2010; 136: 447-52.
108. Sipp JA, Haver KE, Masek BJ, Hartnick CJ. Botulinum toxin A: a novel adjunct treatment for debilitating habit cough in children. Ear Nose Throat J 2007; 86: 570-72.
109. Aoki KR, Francis J. Updates on the antinociceptive mechanism hypothesis of botulinum toxin A. Parkinsonism Relat Disord 2011; 17 (suppl 1): S28-33.
110. Bossowska A, Majewski M. Botulinum toxin type A-induced changes in the chemical coding of dorsal root ganglion neurons supplying the porcine urinary bladder. Pol J Vet Sci 2012; 15: 345-53.
111. Dolly JO, O'Connell MA. Neurotherapeutics to inhibit exocytosis from sensory neurons for the control of chronic pain. Curr Opin Pharmacol 2012; 12: 100-08.
112. Yiangou Y, Anand U, Otto WR, et al. Increased levels of SV2A botulinum neurotoxin receptor in clinical sensory disorders and functional effects of botulinum toxins A and E in cultured human sensory neurons. J Pain Res 2011; 4: 347-55.
113. Mazzone SB, McGovern AE, Koo K, Farrell MJ. Mapping supramedullary pathways involved in cough using functional brain imaging: comparison with pain. Pulm Pharmacol Ther 2009; 22: 90-96.
114. Gracely RH, Undem BJ, Banzett RB. Cough, pain and dyspnoea: similarities and diff erences. Pulm Pharmacol Ther 2007; 20: 433-37.