Kinase domain inhibition of leucine rich repeat kinase 2 (LRRK2) using a [1,2,4]triazolo[4,3-b]pyridazine scaffold

Bioorganic and Medicinal Chemistry Letters

Volumn 24, Issue 17, 2014, Pages 4132-4140

  Galatsis, Paul ^a   Henderson, Jaclyn L ^a   Kormos, Bethany L ^a   Han, Seungil ^a   Kurumbail, Ravi G ^a   Wager, Travis T ^a   Verhoest, Patrick R ^a   Noell, G Stephen ^a   Chen, Yi ^a   Needle, Elie ^a   Berger, Zdenek ^a   Steyn, Stefanus J ^a   Houle, Christopher ^a   Hirst, Warren D ^a  

^a PFIZER INC   (United States)

Author keywords

Kinase inhibitors; Leucine rich repeat kinase 2; LRRK2; Triazolopyridazine

Indexed keywords

G 2019S; LEUCINE RICH REPEAT KINASE 2; PROTEIN SERINE THREONINE KINASE INHIBITOR; PYRIDAZINE DERIVATIVE; TRIAZOLOPYRIDAZINE DERIVATIVE; UNCLASSIFIED DRUG; [1,2,4]TRIAZOLO[4,3 BETA]PYRIDAZINE; FUSED HETEROCYCLIC RINGS; LRRK2 PROTEIN, HUMAN; PROTEIN KINASE INHIBITOR; PROTEIN SERINE THREONINE KINASE; TRIAZOLE DERIVATIVE;

ARTICLE; DRUG PROTEIN BINDING; DRUG STRUCTURE; ENZYME INHIBITION; MALE; MOUSE; NONHUMAN; PARKINSON DISEASE; STRUCTURE ACTIVITY RELATION; ANTAGONISTS AND INHIBITORS; CHEMICAL STRUCTURE; CHEMISTRY; DOSE RESPONSE; DRUG EFFECTS; HUMAN; METABOLISM; PROTEIN TERTIARY STRUCTURE; SYNTHESIS; X RAY CRYSTALLOGRAPHY;

CRYSTALLOGRAPHY, X-RAY; DOSE-RESPONSE RELATIONSHIP, DRUG; HETEROCYCLIC COMPOUNDS, 2-RING; HUMANS; MODELS, MOLECULAR; MOLECULAR STRUCTURE; PROTEIN KINASE INHIBITORS; PROTEIN STRUCTURE, TERTIARY; PROTEIN-SERINE-THREONINE KINASES; PYRIDAZINES; STRUCTURE-ACTIVITY RELATIONSHIP; TRIAZOLES;

EID: 84906934296     PISSN: 0960894X     EISSN: 14643405     Source Type: Journal    
DOI: 10.1016/j.bmcl.2014.07.052     Document Type: Article

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