Evidence for pericyte origin of TSC-associated renal angiomyolipomas and implications for angiotensin receptor inhibition therapy

American Journal of Physiology - Renal Physiology

Volumn 307, Issue 5, 2014, Pages

  Siroky, Brian J ^a   Yin, Hong ^a   Dixon, Bradley P ^a   Reichert, Ryan J ^a   Hellmann, Anna R ^a,e   Ramkumar, Thiruvamoor ^b   Tsuchihashi, Zenta ^c   Bunni, Marlene ^d   Dillon, Joshua ^d   Bell, P Darwin ^d   Sampson, Julian R ^e   Bissler, John J ^f  

^a CINCINNATI CHILDREN'S HOSPITAL MEDICAL CENTER   (United States)

^b NOVARTIS INSTITUTES FOR BIOMEDICAL RESEARCH   (United States)

^c DAIICHI SANKYO INC   (United States)

^d MEDICAL UNIVERSITY OF SOUTH CAROLINA   (United States)

^e CARDIFF UNIVERSITY SCHOOL OF MEDICINE   (United Kingdom)

^f UNIVERSITY OF TENNESSEE COLLEGE OF MEDICINE   (United States)

Author keywords

Angiomyolipoma; Angiotensin II type 1 receptor; Mammalian target of rapamycin; Pericyte; Perivascular epithelioid cell tumor; Tuberous sclerosis complex

Indexed keywords

ALPHA SMOOTH MUSCLE ACTIN; ANGIOTENSIN 1 RECEPTOR; ANGIOTENSIN RECEPTOR; ANGIOTENSIN RECEPTOR ANTAGONIST; CD31 ANTIGEN; COLLAGEN TYPE 4; DESMIN; ENZYME INHIBITOR; PLATELET DERIVED GROWTH FACTOR BETA RECEPTOR; PROTEIN S 100; VALSARTAN; VASCULOTROPIN A; VASCULOTROPIN D; VASCULOTROPIN RECEPTOR 2; ANGIOTENSIN II; CALCIUM; DIPEPTIDYL CARBOXYPEPTIDASE INHIBITOR; TETRAZOLE DERIVATIVE; VALINE;

ANGIOMYOLIPOMA; ARTICLE; CONTROLLED STUDY; HUMAN; HUMAN CELL; HUMAN TISSUE; HYPERTENSION; KIDNEY POLYCYSTIC DISEASE; MAJOR CLINICAL STUDY; PATHOGENESIS; PERICYTE; PRIORITY JOURNAL; RENIN ANGIOTENSIN ALDOSTERONE SYSTEM; TUBEROUS SCLEROSIS; ANALOGS AND DERIVATIVES; CELL PROLIFERATION; COMPLICATION; DRUG EFFECTS; IN VITRO STUDY; KIDNEY; KIDNEY NEOPLASMS; METABOLISM; PATHOLOGY; PATHOPHYSIOLOGY; PHYSIOLOGY; SIGNAL TRANSDUCTION; TUMOR CELL LINE;

ANGIOMYOLIPOMA; ANGIOTENSIN II; ANGIOTENSIN RECEPTOR ANTAGONISTS; ANGIOTENSIN-CONVERTING ENZYME INHIBITORS; CALCIUM; CELL LINE, TUMOR; CELL PROLIFERATION; HUMANS; IN VITRO TECHNIQUES; KIDNEY; KIDNEY NEOPLASMS; PERICYTES; RECEPTOR, ANGIOTENSIN, TYPE 1; RENIN-ANGIOTENSIN SYSTEM; SIGNAL TRANSDUCTION; TETRAZOLES; TUBEROUS SCLEROSIS; VALINE;

EID: 84906901872     PISSN: 1931857X     EISSN: 15221466     Source Type: Journal    
DOI: 10.1152/ajprenal.00569.2013     Document Type: Article

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