Expression of the neural stem cell markers NG2 and L1 in human angiomyolipoma: Are angiomyolipomas neoplasms of stem cells?

Molecular Medicine

Volumn 13, Issue 3-4, 2007, Pages 160-165

  So, Dug Lim ^a   Stallcup, William ^b   Lefkove, Benjamin ^a   Govindarajan, Baskaran ^a   Kit, Sing Au ^c,d   Northrup, Hope ^c,d   Lang, Deborah ^c,d   Fisher, David E ^e   Patel, Avani ^a   Amin, Mahul B ^a   Arbiser, Jack L ^a  

^a EMORY UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b BURNHAM INSTITUTE   (United States)

^c UNIVERSITY OF TEXAS MEDICAL SCHOOL   (United States)

^d UNIVERSITY OF PENNSYLVANIA   (United States)

^e DANA FARBER CANCER INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CELL SURFACE MARKER; PROTEIN L1; PROTEIN NG2; UNCLASSIFIED DRUG;

ANGIOMYOLIPOMA; ARTICLE; CONTROLLED STUDY; HISTOGENESIS; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; KIDNEY CARCINOMA; KIDNEY TUMOR; NEURAL STEM CELL; PRIORITY JOURNAL; PROTEIN EXPRESSION;

ANGIOMYOLIPOMA; ANTIGENS; CELL LINE, TRANSFORMED; CELL TRANSFORMATION, VIRAL; HUMANS; IMMUNOHISTOCHEMISTRY; KIDNEY NEOPLASMS; LEUKOCYTE L1 ANTIGEN COMPLEX; PROTEOGLYCANS; SIMIAN VIRUS 40; STEM CELLS; TUMOR MARKERS, BIOLOGICAL;

EID: 34250657345     PISSN: 10761551     EISSN: None     Source Type: Journal    
DOI: 10.2119/2006-00070.Lim     Document Type: Article

References (36)

1. Oesterling JE, Fishman EK, Goldman SM, Marshall FF. (1986) The management of renal angiomyolipoma. J. Urol. 135:1121-4.
2. Shepherd CW, Gomez MR, Lie JT, Crowson CS. (1991) Causes of death in patients with tuberous sclerosis. Mayo Clin. Proc. 66:792-6.
3. The European Chromosome 16 Tuberous Sclerosis Consortium. (1993) Identification and characterization of the tuberous sclerosis gene on chromosome 16. Cell. 75:1305-15.
4. Sampson JR, Harris PC. (1994) The molecular genetics of tuberous sclerosis. Hum. Mol. Genet. 3 Spec No:1477-80.
5. Plank TL, Yeung RS, Henske EP. (1998) Hamartin, the product of the tuberous sclerosis 1 (TSC1) gene, interacts with tuberin and appears to be localized to cytoplasmic vesicles. Cancer Res. 58:4766-70.
6. Henske EP et al. (1997) Loss of tuberin in both subependymal giant cell astrocytomas and angiomyolipomas supports a two-hit model for the pathogenesis of tuberous sclerosis tumors. Am. J. Pathol. 151:1639-47.
7. Kyin R et al. (2001) Differential cellular expression of neurotrophins in cortical tubers of the tuberous sclerosis complex. Am. J. Pathol. 159:1541-54.
8. Maldonado M et al. (2003) Expression of ICAM-1, TNF-alpha, NF kappa B, and MAP kinase in tubers of the tuberous sclerosis complex. Neurobiol. Dis. 14:279-90.
9. Eble JN. (1998) Angiomyolipoma of kidney. Semin. Diagn. Pathol. 15:21-40.
10. Kattar MM et al. (1999) Chromosomal analysis of renal angiomyolipoma by comparative genomic hybridization: evidence for clonal origin. Hum. Pathol. 30:295-9.
11. Smolarek TA et al. (1998) Evidence that lymphangiomyomatosis is caused by TSC2 mutations: chromosome 16p13 loss of heterozygosity in angiomyolipomas and lymph nodes from women with lymphangiomyomatosis. Am. J. Hum. Genet. 62:810-5.
12. Henske EP et al. (1996) Allelic loss is frequent in tuberous sclerosis kidney lesions but rare in brain lesions. Am. J. Hum. Genet. 59:400-6.
13. Stallcup WB. (1981) The Ng2 antigen, a putative lineage marker: immunofluorescent localization in primary cultures of rat-brain. Dev. Biol. 83:154-65.
14. Nishiyama A, Lin XH, Giese N, Heldin CH, Stallcup WB. (1996) Co-localization of NG2 proteoglycan and PDGF alpha-receptor on O2A progenitor cells in the developing rat brain. J. Neurosci. Res. 43:299-314.
15. Ozerdem U, Grako KA, Dahlin-Huppe K, Monosov E, Stallcup WB. (2001) NG2 proteoglycan is expressed exclusively by mural cells during vascular morphogenesis. Dev. Dyn. 222:218-27.
16. Grako KA, Ochiya T, Barritt D, Nishiyama A, Stallcup WB. (1999) PDGF alpha-receptor is unresponsive to PDGF-AA in aortic smooth muscle cells from the NG2 knockout mouse. J. Cell Sci. 112:905-15.
17. Chekenya M, Hjelstuen M, Enger PO, Thorsen F, Jacob AL, Probst B, Haraldseth O, Pilkington G, Butt A, Levine JM, Bjerkvig R. (2002) The NG2 proteoglycan promotes angiogenesis-dependent tumor growth in CNS by sequestering angiostatin. FASEB J. 2002, 6:586-588.
18. Arbiser JL et al. (2001) The generation and characterization of a cell line derived from a sporadic renal angiomyolipoma: use of telomerase to obtain stable populations of cells from benign neoplasms. Am. J. Pathol. 159:483-91.
19. Arbiser JL et al. (2002) Functional tyrosine kinase inhibitor profiling: a generally applicable method points to a novel role of platelet-derived growth factor receptor-beta in tuberous sclerosis. Am. J. Pathol 161:781-6.
20. Houghton AN, Eisinger M, Albino AP, Cairncross JG, Old LJ. (1982) Surface antigens of melanocytes and melanomas. Markers of melanocyte differentiation and melanoma subsets. J Exp Med. 156(6):1755-1766.
21. Prince JT, Nishiyama A, Healy PA, Beasley L, Stallcup WB. (1992) Expression of the F84.1 glycoprotein in the spinal cord and cranial nerves of the developing rat. Brain. Res. Dev. Brain Res. 68:193-201.
22. Nayeem N et al. (1999) A potential role for the plasmin(ogen) system in the posttranslational cleavage of the neural cell adhesion molecule L1. J. Cell Sci. 112:4739-49.
23. Burns FR, Vonkannen S, Guy L, Raper JA, Kamholz J, Chang S. (1991) DM-GRASP, a novel immunoglobulin superfamily axonal surface protein that supports neurite extension. Neuron. 7:209-20.
24. Lang D, Chen F, Milewski R, Li J, Lu MM, Epstein JA. (2000) Pax3 is required for enteric ganglia formation and functions with Sox10 to modulate expression of c-ret. J. Clin. Invest. 106:963-71.
25. Li J, Jin F, Lu MM, Epstein JA. (1999) Transgenic Rescue of Congenital Heart Disease and Spina Bifida in Splotch Mice. Development, 1999, 126:2495-503.
26. Leveen P, Pekny M, Gebre-Medhin S, Swolin B, Larsson E, Betsholtz C. (1994) Mice deficient for PDGF B show renal, cardiovascular, and hematological abnormalities. Genes Dev. 8:1875-87.
27. Soriano P. (1994) Abnormal kidney development and hematological disorders in PDGF beta- receptor mutant mice. Genes Dev. 8:1888-96.
28. Sariola H et al. (1991) Dependence of Kidney Morphogenesis on the Expression of Nerve Growth-Factor Receptor. Science. 254:571-3.
29. Karavanov A, Sainio K, Palgi J, Saarma M, Saxen L, Sariola H. (1995) Neurotrophin-3 rescues neuronal precursors from apoptosis and promotes neuronal differentiation in the embryonic metanephric kidney. Proc. Natl Acad Sci U. S. A. 92:11279-83.
30. Goretzki L, Lombardo CR, Stallcup WB. (2000) Binding of the NG2 proteoglycan to kringle domains modulates the functional properties of angiostatin and plasmin(ogen). J. Biol. Chem. 275:28625-33.
31. Burg MA, Pasqualini R, Arap W, Ruoslahti E, Stallcup WB. (1999) NG2 proteoglycan-binding peptides target tumor neovasculature. Cancer Res. 59:2869-74.
32. Garraway LA et al. (2005) Integrative genomic analyses identify MITF as a lineage survival oncogene amplified in malignant melanoma. Nature. 436:117-22.
33. Nijman SM, Hijmans EM, El MS, van Dongen MM, Sardet C, Bernards R. (2006) A functional genetic screen identifies TFE3 as a gene that confers resistance to the anti-proliferative effects of the retinoblastoma protein and transforming growth factor-beta. J. Biol. Chem. 281:21582-7.
34. Ladanyi M et al. (2001) The der(17)t(X;17) (p11;q25) of human alveolar soft part sarcoma fuses the TFE3 transcription factor gene to ASPL, a novel gene at 17q25. Oncogene. 20:48-57.
35. Weterman MA, Wilbrink M, Geurts van KA. (1996) Fusion of the transcription factor TFE3 gene to a novel gene, PRCC, in t(X;1)(p11;q21)- positive papillary renal cell carcinomas. Proc. Natl. Acad. Sci. U. S. A. 93:15294-8.
36. Burg MA, Pasqualini R, Arap W, Ruoslahti E, Stallcup WB. (1999( NG2 proteoglycan-binding peptides target tumor neovasculature. Cancer Res. 59:2869-74.