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Volumn 18, Issue 11, 2008, Pages 3382-3385

Designing better coumarin-based fluorogenic substrates for PTP1B

Author keywords

Coumarin; Fluorogenic; PTP1B; Substrate

Indexed keywords

1 ETHYL 3(3' DIMETHYLAMINOPROPYL)CARBODIIMIDE; AMMONIUM HYDROXIDE; BENZOTRIAZOLE DERIVATIVE; COUMARIN; CYANAMIDE; HYDROXYBENZOTRIAZOLE; HYMECROMONE; PROTEIN TYROSINE PHOSPHATASE 1B;

EID: 44149127967     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2008.04.021     Document Type: Article
Times cited : (23)

References (18)
  • 14
    • 44149090157 scopus 로고    scopus 로고
    • note
    • 3 to afford 0.62 g of the bis-diethylphosphate intermediate as a colorless oil. To a solution of the bis-diethylphosphate (0.62 g) in 60 mL of DCM is added TMSI (0.80 mL). The reaction mixture is quenched with MeOH after 1 h, and the solvent removed under reduced pressure. The residue is purified by preparative HPLC (C18, ACN/H2O/0.1% TFA) to afford 323 mg of 13 as a white solid.
  • 18
    • 44149111726 scopus 로고    scopus 로고
    • note
    • We routinely use MUP and OMFP interchangeably in our assays as they produce qualitatively similar results.


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.