Nef-mediated down-regulation of CD4 and HLA class I in HIV-1 subtype C infection: Association with disease progression and influence of immune pressure

Virology

Volumn 468-470, Issue , 2014, Pages 214-225

  Mann, Jaclyn K ^a   Chopera, Denis ^a,b   Omarjee, Saleha ^a   Kuang, Xiaomei T ^c   Le, Anh Q ^c   Anmole, Gursev ^c   Danroth, Ryan ^c   Mwimanzi, Philip ^c   Reddy, Tarylee ^d   Carlson, Jonathan ^e   Radebe, Mopo ^a   Goulder, Philip J R ^f,g   Walker, Bruce D ^g,h,i   Abdool Karim, Salim ^j   Novitsky, Vladimir ^g,k   Williamson, Carolyn ^b   Brockman, Mark A ^c,l   Brumme, Zabrina L ^c,l   Ndung'u, Thumbi ^a,g,m  

^a UNIVERSITY OF KWAZULU NATAL   (South Africa)

^b NATIONAL HEALTH LABORATORY SERVICE   (South Africa)

^c SIMON FRASER UNIVERSITY   (Canada)

^d SOUTH AFRICAN MEDICAL RESEARCH COUNCIL   (South Africa)

^e MICROSOFT RESEARCH   (United States)

^f UNIVERSITY OF OXFORD   (United Kingdom)

^g HARVARD UNIVERSITY   (United States)

^h MASSACHUSETTS GENERAL HOSPITAL   (United States)

ⁱ Howard Hughes Institute   (United States)

^j UNIVERSITY OF KWAZULU NATAL   (South Africa)

^k BOTSWANA HARVARD AIDS INSTITUTE PARTNERSHIP   (Botswana)

^l BRITISH COLUMBIA CENTRE FOR EXCELLENCE IN HIV AIDS   (Canada)

^m MAX PLANCK INSTITUTE FOR INFECTION BIOLOGY   (Germany)

more..

Author keywords

CD4 down regulation; HIV 1 disease progression; HIV 1 Nef; HIV 1 subtype C; HLA associated polymorphisms; HLA I down regulation; Immune evasion

Indexed keywords

CD4 ANTIGEN; HLA ANTIGEN CLASS 1; NEF PROTEIN; HUMAN IMMUNODEFICIENCY VIRUS VACCINE; NEF PROTEIN, HUMAN IMMUNODEFICIENCY VIRUS 1;

ARTICLE; CONTROLLED STUDY; DISEASE COURSE; DOWN REGULATION; GENE FREQUENCY; GENE FUNCTION; GENETIC ASSOCIATION; GENETIC POLYMORPHISM; GENETIC TRANSFECTION; GENETIC VARIABILITY; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS 1 INFECTION; HUMAN IMMUNODEFICIENCY VIRUS TYPE 1 SUBTYPE C; IMMUNE RESPONSE; MAJOR CLINICAL STUDY; MOLECULAR CLONING; NONHUMAN; PLASMID; PRIORITY JOURNAL; SEQUENCE HOMOLOGY; T LYMPHOCYTE; VIRUS LOAD; VIRUS PATHOGENESIS; ALLELE; AMINO ACID SEQUENCE; CELL COUNT; ENZYME ACTIVITY; GENE AMPLIFICATION; GENETIC DIFFERENCE; HUMAN IMMUNODEFICIENCY VIRUS 1 (STRAIN C); HUMAN IMMUNODEFICIENCY VIRUS INFECTION; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN POLYMORPHISM; UNINDEXED SEQUENCE; CD4+ T LYMPHOCYTE; GENE; GENE EXPRESSION REGULATION; GENETICS; HUMAN IMMUNODEFICIENCY VIRUS 1; IMMUNOLOGY; METABOLISM; PHYSIOLOGY; VIROLOGY;

HUMAN IMMUNODEFICIENCY VIRUS 1;

CD4-POSITIVE T-LYMPHOCYTES; GENE EXPRESSION REGULATION; GENES, MHC CLASS I; HIV INFECTIONS; HIV-1; HUMANS; NEF GENE PRODUCTS, HUMAN IMMUNODEFICIENCY VIRUS;

EID: 84906886112     PISSN: 00426822     EISSN: 10960341     Source Type: Journal    
DOI: 10.1016/j.virol.2014.08.009     Document Type: Article

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