Silica and double-stranded RNA synergistically induce bronchial epithelial apoptosis and airway inflammation

American Journal of Respiratory Cell and Molecular Biology

Volumn 51, Issue 3, 2014, Pages 344-353

  Unno, Hirotoshi ^a,b   Futamura, Kyoko ^b   Morita, Hideaki ^b,c   Kojima, Reiji ^b,d   Arae, Ken ^b,e   Nakae, Susumu ^b,f,g   Ida, Hiroyuki ^a   Saito, Hirohisa ^b   Matsumoto, Kenji ^b   Matsuda, Akio ^b  

^a JIKEI UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^b NATIONAL RESEARCH INSTITUTE FOR CHILD HEALTH AND DEVELOPMENT   (Japan)

^c KEIO UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^d NATIONAL DEFENSE MEDICAL COLLEGE   (Japan)

^e KYORIN UNIVERSITY   (Japan)

^f UNIVERSITY OF TOKYO   (Japan)

^g JAPAN SCIENCE AND TECHNOLOGY AGENCY   (Japan)

Author keywords

Apoptosis; Bronchial epithelial cells; Caspase; Double stranded RNA; Silica crystals

Indexed keywords

APOPTOSIS; BRONCHIAL EPITHELIAL CELLS; CASPASE; DOUBLE-STRANDED RNA; SILICA CRYSTALS;

ADMINISTRATION, INTRANASAL; AIR POLLUTANTS; ANIMALS; APOPTOSIS; BRONCHI; BRONCHOALVEOLAR LAVAGE FLUID; CASPASE 9; CELL SURVIVAL; DUST; EPITHELIAL CELLS; FEMALE; HUMANS; INFLAMMATION; INTERLEUKIN-1BETA; LUNG; MICE; MICE, INBRED C57BL; POLY I-C; RESPIRATORY MUCOSA; RNA, DOUBLE-STRANDED; SILICON DIOXIDE;

EID: 84906883070     PISSN: 10441549     EISSN: 15354989     Source Type: Journal    
DOI: 10.1165/rcmb.2013-0281OC     Document Type: Article

References (51)

1. Schleimer RP, Kato A, Kern R, Kuperman D, Avila PC. Epithelium: at the interface of innate and adaptive immune responses. J Allergy Clin Immunol 2007;120:1279-1284. (Pubitemid 350216601)
2. Cook AG, Weinstein P, Centeno JA. Health effects of natural dust: role of trace elements and compounds. Biol Trace Elem Res 2005;103:1-15. (Pubitemid 40255936)
3. Mossman BT, Churg A. Mechanisms in the pathogenesis of asbestosis and silicosis. Am J Respir Crit Care Med 1998;157:1666-1680.
4. Leung CC, Yu IT, Chen W. Silicosis. Lancet 2012;379:2008-2018.
5. Gudmundsson G. Respiratory health effects of volcanic ash with special reference to Iceland: a review. Clin Respir J 2011;5:2-9.
6. Longo BM, Yang W. Acute bronchitis and volcanic air pollution: a community-based cohort study at Kilauea Volcano, Hawai'i, USA. J Toxicol Environ Health A 2008;71:1565-1571.
7. Naumova EN, Yepes H, Griffiths JK, Sempértegui F, Khurana G, Jagai JS, Játiva E, Estrella B. Emergency room visits for respiratory conditions in children increased after Guagua Pichincha volcanic eruptions in April 2000 in Quito, Ecuador observational study: time series analysis. Environ Health 2007;6:21.
8. Higuchi K, Koriyama C, Akiba S. Increased mortality of respiratory diseases, including lung cancer, in the area with large amount of ashfall from mount sakurajima volcano. J Environ Public Health 2012;2012:257831.
9. Griffin DW. Atmospheric movement of microorganisms in clouds of desert dust and implications for human health. Clin Microbiol Rev 2007;20:459-477. (Pubitemid 47175014)
10. Al Frayh AR, Shakoor Z, Gad El Rab MO, Hasnain SM. Increased prevalence of asthma in Saudi Arabia. Ann Allergy Asthma Immunol 2001;86:292-296. (Pubitemid 32240213)
11. Bener A, Abdulrazzaq YM, Al-Mutawwa J, Debuse P. Genetic and environmental factors associated with asthma. Hum Biol 1996;68:405-414. (Pubitemid 126448366)
12. Kanatani KT, Ito I, Al-Delaimy WK, Adachi Y, Mathews WC, Ramsdell JW; Toyama Asian Desert Dust and Asthma Study Team. Desert dust exposure is associated with increased risk of asthma hospitalization in children. Am J Respir Crit Care Med 2010;182:1475-1481.
13. Martinon F, Pétrilli V, Mayor A, Tardivel A, Tschopp J. Gout-associated uric acid crystals activate the NALP3 inflammasome. Nature 2006;440:237-241. (Pubitemid 43372104)
14. Dostert C, Pétrilli V, Van Bruggen R, Steele C, Mossman BT, Tschopp J. Innate immune activation through Nalp3 inflammasome sensing of asbestos and silica. Science 2008;320:674-677. (Pubitemid 351928351)
15. Hornung V, Bauernfeind F, Halle A, Samstad EO, Kono H, Rock KL, Fitzgerald KA, Latz E. Silica crystals and aluminum salts activate the NALP3 inflammasome through phagosomal destabilization. Nat Immunol 2008;9:847-856.
16. Cassel SL, Eisenbarth SC, Iyer SS, Sadler JJ, Colegio OR, Tephly LA, Carter AB, Rothman PB, Flavell RA, Sutterwala FS. The Nalp3 inflammasome is essential for the development of silicosis. Proc Natl Acad Sci USA 2008;105:9035-9040.
17. Broz P, Monack DM. Molecular mechanisms of inflammasome activation during microbial infections. Immunol Rev 2011;243:174-190.
18. Yagami A, Orihara K, Morita H, Futamura K, Hashimoto N, Matsumoto K, Saito H, Matsuda A. IL-33 mediates inflammatory responses in human lung tissue cells. J Immunol 2010;185:5743-5750.
19. Matsuda A, Morita H, Unno H, Saito H, Matsumoto K, Hirao Y, Munechika K, Abe J. Anti-inflammatory effects of high-dose IgG on TNF-α-activated human coronary artery endothelial cells. Eur J Immunol 2012;42:2121-2131.
20. Christofferson DE, Yuan J. Necroptosis as an alternative form of programmed cell death. Curr Opin Cell Biol 2010;22:263-268.
21. Timmer JC, Salvesen GS. Caspase substrates. Cell Death Differ 2007;14:66-72. (Pubitemid 44911895)
22. Elmore S. Apoptosis: a review of programmed cell death. Toxicol Pathol 2007;35:495-516. (Pubitemid 46911891)
23. Halle A, Hornung V, Petzold GC, Stewart CR, Monks BG, Reinheckel T, Fitzgerald KA, Latz E, Moore KJ, Golenbock DT. The NALP3 inflammasome is involved in the innate immune response to amyloidbeta. Nat Immunol 2008;9:857-865.
24. Brown JM, Swindle EJ, Kushnir-Sukhov NM, Holian A, Metcalfe DD. Silica-directed mast cell activation is enhanced by scavenger receptors. Am J Respir Cell Mol Biol 2007;36:43-52. (Pubitemid 46067706)
25. Thibodeau MS, Giardina C, Knecht DA, Helble J, Hubbard AK. Silica-induced apoptosis in mouse alveolar macrophages is initiated by lysosomal enzyme activity. Toxicol Sci 2004;80:34-48. (Pubitemid 38967394)
26. Iyer R, Hamilton RF, Li L, Holian A. Silica-induced apoptosis mediated via scavenger receptor in human alveolar macrophages. Toxicol Appl Pharmacol 1996;141:84-92. (Pubitemid 26414353)
27. Ichinose T, Nishikawa M, Takano H, Sera N, Sadakane K, Mori I, Yanagisawa R, Oda T, Tamura H, Hiyoshi K, et al. Pulmonary toxicity induced by intratracheal instillation of Asian yellow dust (Kosa) in mice. Environ Toxicol Pharmacol 2005;20:48-56. (Pubitemid 40615356)
28. Ichinose T, Yoshida S, Hiyoshi K, Sadakane K, Takano H, Nishikawa M, Mori I, Yanagisawa R, Kawazato H, Yasuda A, et al. The effects of microbial materials adhered to Asian sand dust on allergic lung inflammation. Arch Environ Contam Toxicol 2008;55:348-357.
29. Ichinose T, Yoshida S, Sadakane K, Takano H, Yanagisawa R, Inoue K, Nishikawa M, Mori I, Kawazato H, Yasuda A, et al. Effects of Asian sand dust, Arizona sand dust, amorphous silica and aluminum oxide on allergic inflammation in the murine lung. Inhal Toxicol 2008;20:685-694. (Pubitemid 351882929)
30. Schmidt JA, Oliver CN, Lepe-Zuniga JL, Green I, Gery I. Silica-stimulated monocytes release fibroblast proliferation factors identical to interleukin 1: a potential role for interleukin 1 in the pathogenesis of silicosis. J Clin Invest 1984;73:1462-1472. (Pubitemid 14139542)
31. Yamamoto Y, Gaynor RB. Therapeutic potential of inhibition of the NF-kappaB pathway in the treatment of inflammation and cancer. J Clin Invest 2001;107:135-142. (Pubitemid 32096826)
32. Holgate ST. The sentinel role of the airway epithelium in asthma pathogenesis. Immunol Rev 2011;242:205-219.
33. Szabó E, Kovács I, Grune T, Haczku A, Virág L. PARP-1: a new player in the asthma field? Allergy 2011;66:811-814.
34. Suzuki Y, Masini E, Mazzocca C, Cuzzocrea S, Ciampa A, Suzuki H, Bani D. Inhibition of poly(ADP-ribose) polymerase prevents allergen-induced asthma-like reaction in sensitized Guinea pigs. J Pharmacol Exp Ther 2004;311:1241-1248. (Pubitemid 39612733)
35. Boulares AH, Zoltoski AJ, Sherif ZA, Jolly P, Massaro D, Smulson ME. Gene knockout or pharmacological inhibition of poly(ADP-ribose) polymerase-1 prevents lung inflammation in a murine model of asthma. Am J Respir Cell Mol Biol 2003;28:322-329. (Pubitemid 36238009)
36. Goodwin GH, Sanders C, Johns EW. A new group of chromatin-associated proteins with a high content of acidic and basic amino acids. Eur J Biochem 1973;38:14-19.
37. Wen L, Huang JK, Johnson BH, Reeck GR. A human placental cDNA clone that encodes nonhistone chromosomal protein HMG-1. Nucleic Acids Res 1989;17:1197-1214. (Pubitemid 19062897)
38. Scaffidi P, Misteli T, Bianchi ME. Release of chromatin protein HMGB1 by necrotic cells triggers inflammation. Nature 2002;418:191-195. (Pubitemid 34773774)
39. Rovere-Querini P, Capobianco A, Scaffidi P, Valentinis B, Catalanotti F, Giazzon M, Dumitriu IE, Müller S, Iannacone M, Traversari C, et al. HMGB1 is an endogenous immune adjuvant released by necrotic cells. EMBO Rep 2004;5:825-830. (Pubitemid 39199174)
40. Qin S, Wang H, Yuan R, Li H, Ochani M, Ochani K, Rosas-Ballina M, Czura CJ, Huston JM, Miller E, et al. Role of HMGB1 in apoptosis-mediated sepsis lethality. J Exp Med 2006;203:1637-1642. (Pubitemid 44036267)
41. Bell CW, Jiang W, Reich CF III, Pisetsky DS. The extracellular release of HMGB1 during apoptotic cell death. Am J Physiol Cell Physiol 2006;291:C1318-C1325. (Pubitemid 44878603)
42. Kazama H, Ricci JE, Herndon JM, Hoppe G, Green DR, Ferguson TA. Induction of immunological tolerance by apoptotic cells requires caspase-dependent oxidation of high-mobility group box-1 protein. Immunity 2008;29:21-32. (Pubitemid 351952462)
43. Yamada Y, Fujii T, Ishijima R, Tachibana H, Yokoue N, Takasawa R, Tanuma S. The release of high mobility group box 1 in apoptosis is triggered by nucleosomal DNA fragmentation. Arch Biochem Biophys 2011;506:188-193.
44. Oboki K, Ohno T, Kajiwara N, Saito H, Nakae S. IL-33 and IL-33 receptors in host defense and diseases. Allergol Int 2010;59:143-160.
45. Gudbjartsson DF, Bjornsdottir US, Halapi E, Helgadottir A, Sulem P, Jonsdottir GM, Thorleifsson G, Helgadottir H, Steinthorsdottir V, Stefansson H, et al. Sequence variants affecting eosinophil numbers associate with asthma and myocardial infarction. Nat Genet 2009;41:342-347.
46. Moffatt MF, Gut IG, Demenais F, Strachan DP, Bouzigon E, Heath S, von Mutius E, Farrall M, Lathrop M, Cookson WO; GABRIEL Consortium. A large-scale, consortium-based genomewide association study of asthma. N Engl J Med 2010;363:1211-1221.
47. Cayrol C, Girard JP. The IL-1-like cytokine IL-33 is inactivated after maturation by caspase-1. Proc Natl Acad Sci USA 2009;106:9021-9026.
48. Lüthi AU, Cullen SP, McNeela EA, Duriez PJ, Afonina IS, Sheridan C, Brumatti G, Taylor RC, Kersse K, Vandenabeele P, et al. Suppression of interleukin-33 bioactivity through proteolysis by apoptotic caspases. Immunity 2009;31:84-98.
49. Watanabe T, Asai K, Fujimoto H, Tanaka H, Kanazawa H, Hirata K. Increased levels of HMGB-1 and endogenous secretory RAGE in induced sputum from asthmatic patients. Respir Med 2011;105:519-525.
50. He M, Ichinose T, Yoshida S, Nishikawa M, Mori I, Yanagisawa R, Takano H, Inoue K, Sun G, Shibamoto T. Airborne Asian sand dust enhances murine lung eosinophilia. Inhal Toxicol 2010;22:1012-1025.
51. Beamer CA, Migliaccio CT, Jessop F, Trapkus M, Yuan D, Holian A. Innate immune processes are sufficient for driving silicosis in mice. J Leukoc Biol 2010;88:547-557.