Genetic dissection of susceptibility genes for diabetes and related phenotypes on mouse chromosome 14 by means of congenic strains

BMC Genetics

Volumn 15, Issue 1, 2014, Pages

  Babaya, Naru ^a   Ueda, Hironori ^b   Noso, Shinsuke ^a   Hiromine, Yoshihisa ^a   Itoi Babaya, Michiko ^b   Kobayashi, Misato ^c   Fujisawa, Tomomi ^b   Ikegami, Hiroshi ^a  

^a KINKI UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^b OSAKA UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

^c NAGOYA UNIVERSITY   (Japan)

Author keywords

Adiposity; Animal model; Complex trait; Consomic strain; Insulin resistance

Indexed keywords

ADIPONECTIN; GLUCOSE; LEPTIN; MEMBRANE PROTEIN; NIDD PROTEIN, MOUSE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BODY WEIGHT; CHROMOSOME 14; CHROMOSOME SUBSTITUTION STRAIN; CONGENIC STRAIN; CONTROLLED STUDY; GENETIC SUSCEPTIBILITY; GLUCOSE BLOOD LEVEL; HOMOZYGOTE; HORMONE BLOOD LEVEL; INSULIN RESISTANCE; INSULIN SENSITIVITY; MOUSE; NON INSULIN DEPENDENT DIABETES MELLITUS; NONHUMAN; PHENOTYPE; PROTEIN BLOOD LEVEL; ANIMAL; C3H MOUSE; DIABETES MELLITUS; DISEASE MODEL; FEMALE; GENETIC PREDISPOSITION; GENETICS; HYPERGLYCEMIA; MALE; OBESITY;

ADIPOSITY; ANIMALS; BLOOD GLUCOSE; DIABETES MELLITUS; DISEASE MODELS, ANIMAL; FEMALE; GENETIC PREDISPOSITION TO DISEASE; HYPERGLYCEMIA; INSULIN RESISTANCE; MALE; MEMBRANE PROTEINS; MICE; MICE, CONGENIC; MICE, INBRED C3H; PHENOTYPE;

EID: 84906825825     PISSN: None     EISSN: 14712156     Source Type: Journal    
DOI: 10.1186/s12863-014-0093-8     Document Type: Article

References (37)

1. McCarthy MI. Genomics, type 2 diabetes, and obesity. N Engl J Med 2010, 363:2339-2350. 10.1056/NEJMra0906948, 21142536.
2. Ueda H, Howson JM, Esposito L, Heward J, Snook H, Chamberlain G, Rainbow DB, Hunter KM, Smith AN, Di Genova G, Herr MH, Dahlman I, Payne F, Smyth D, Lowe C, Twells RC, Howlett S, Healy B, Nutland S, Rance HE, Everett V, Smink LJ, Lam AC, Cordell HJ, Walker NM, Bordin C, Hulme J, Motzo C, Cucca F, Hess JF, et al. Association of the T-cell regulatory gene CTLA4 with susceptibility to autoimmune disease. Nature 2003, 423:506-511. 10.1038/nature01621, 12724780.
3. Ikegami H, Fujisawa T, Ogihara T. Mouse models of type 1 and type 2 diabetes derived from the same closed colony: genetic susceptibility shared between two types of diabetes. ILAR J 2004, 45:268-277. 10.1093/ilar.45.3.268, 15229374.
4. Ueda H, Ikegami H, Kawaguchi Y, Fujisawa T, Nojima K, Babaya N, Yamada K, Shibata M, Yamato E, Ogihara T. Age-dependent changes in phenotypes and candidate gene analysis in a polygenic animal model of Type II diabetes mellitus; NSY mouse. Diabetologia 2000, 43:932-938. 10.1007/s001250051472, 10952468.
5. Ueda H, Ikegami H, Yamato E, Fu J, Fukuda M, Shen G, Kawaguchi Y, Takekawa K, Fujioka Y, Fujisawa T, Nakagawa Y, Hamada Y, Shibata M, Ogihara T. The NSY mouse: a new animal model of spontaneous NIDDM with moderate obesity. Diabetologia 1995, 38:503-508. 10.1007/BF00400717, 7489831.
6. Ueda H, Ikegami H, Kawaguchi Y, Fujisawa T, Yamato E, Shibata M, Ogihara T. Genetic analysis of late-onset type 2 diabetes in a mouse model of human complex trait. Diabetes 1999, 48:1168-1174. 10.2337/diabetes.48.5.1168, 10331425.
7. Itoi-Babaya M, Ikegami H, Fujisawa T, Ueda H, Nojima K, Babaya N, Kobayashi M, Noso S, Kawaguchi Y, Yamaji K, Shibata M, Ogihara T. Fatty liver and obesity: phenotypically correlated but genetically distinct traits in a mouse model of type 2 diabetes. Diabetologia 2007, 50:1641-1648. 10.1007/s00125-007-0700-6, 17549450.
8. Babaya N, Fujisawa T, Nojima K, Itoi-Babaya M, Yamaji K, Yamada K, Kobayashi M, Ueda H, Hiromine Y, Noso S, Ikegami H. Direct evidence for susceptibility genes for type 2 diabetes on mouse chromosomes 11 and 14. Diabetologia 2010, 53:1362-1371. 10.1007/s00125-010-1737-5, 20390404.
9. Cai G, Cole SA, Freeland-Graves JH, MacCluer JW, Blangero J, Comuzzie AG. Genome-wide scans reveal quantitative trait loci on 8p and 13q related to insulin action and glucose metabolism: the San Antonio Family Heart Study. Diabetes 2004, 53:1369-1374. 10.2337/diabetes.53.5.1369, 15111508.
10. Duggirala R, Blangero J, Almasy L, Dyer TD, Williams KL, Leach RJ, O'Connell P, Stern MP. Linkage of type 2 diabetes mellitus and of age at onset to a genetic location on chromosome 10q in Mexican Americans. Am J Hum Genet 1999, 64:1127-1140. 10.1086/302316, 10090898.
11. Mitchell BD, Cole SA, Hsueh WC, Comuzzie AG, Blangero J, MacCluer JW, Hixson JE. Linkage of serum insulin concentrations to chromosome 3p in Mexican Americans. Diabetes 2000, 49:513-516. 10.2337/diabetes.49.3.513, 10868977.
12. Pezzolesi MG, Nam M, Nagase T, Klupa T, Dunn JS, Mlynarski WM, Rich SS, Warram JH, Krolewski AS. Examination of candidate chromosomal regions for type 2 diabetes reveals a susceptibility locus on human chromosome 8p23.1. Diabetes 2004, 53:486-491. 10.2337/diabetes.53.2.486, 14747302.
13. Dong C, Wang S, Li WD, Li D, Zhao H, Price RA. Interacting genetic loci on chromosomes 20 and 10 influence extreme human obesity. Am J Hum Genet 2003, 72:115-124. 10.1086/345648, 12478478.
14. Babaya N, Ikegami H, Fujisawa T, Nojima K, Itoi-Babaya M, Inoue K, Ohno T, Shibata M, Ogihara T. Susceptibility to streptozotocin-induced diabetes is mapped to mouse chromosome 11. Biochem Biophys Res Commun 2005, 328:158-164. 10.1016/j.bbrc.2004.12.149, 15670764.
15. Kershaw EE, Flier JS. Adipose tissue as an endocrine organ. J Clin Endocrinol Metab 2004, 89:2548-2556. 10.1210/jc.2004-0395, 15181022.
16. Flier JS. Obesity wars: molecular progress confronts an expanding epidemic. Cell 2004, 116:337-350. 10.1016/S0092-8674(03)01081-X, 14744442.
17. Frederich RC, Hamann A, Anderson S, Lollmann B, Lowell BB, Flier JS. Leptin levels reflect body lipid content in mice: evidence for diet-induced resistance to leptin action. Nat Med 1995, 1:1311-1314. 10.1038/nm1295-1311, 7489415.
18. Haluzik M, Parizkova J, Haluzik MM. Adiponectin and its role in the obesity-induced insulin resistance and related complications. Physiol Res 2004, 53:123-129. 15046547.
19. Maeda N, Shimomura I, Kishida K, Nishizawa H, Matsuda M, Nagaretani H, Furuyama N, Kondo H, Takahashi M, Arita Y, Komuro R, Ouchi N, Kihara S, Tochino Y, Okutomi K, Horie M, Takeda S, Aoyama T, Funahashi T, Matsuzawa Y. Diet-induced insulin resistance in mice lacking adiponectin/ACRP30. Nat Med 2002, 8:731-737. 10.1038/nm724, 12068289.
20. Kubota N, Terauchi Y, Yamauchi T, Kubota T, Moroi M, Matsui J, Eto K, Yamashita T, Kamon J, Satoh H, Yano W, Froguel P, Nagai R, Kimura S, Kadowaki T, Noda T. Disruption of adiponectin causes insulin resistance and neointimal formation. J Biol Chem 2002, 277:25863-25866. 10.1074/jbc.C200251200, 12032136.
21. Almind K, Kahn CR. Genetic determinants of energy expenditure and insulin resistance in diet-induced obesity in mice. Diabetes 2004, 53:3274-3285. 10.2337/diabetes.53.12.3274, 15561960.
22. Almind K, Kulkarni RN, Lannon SM, Kahn CR. Identification of interactive loci linked to insulin and leptin in mice with genetic insulin resistance. Diabetes 2003, 52:1535-1543. 10.2337/diabetes.52.6.1535, 12765967.
23. Collin GB, Maddatu TP, Sen S, Naggert JK. Genetic modifiers interact with Cpe(fat) to affect body weight, adiposity, and hyperglycemia. Physiol Genomics 2005, 22:182-190. 10.1152/physiolgenomics.00208.2003, 15870393.
24. Kobayashi M, Io F, Kawai T, Kumazawa M, Ikegami H, Nishimura M, Ohno T, Horio F. Major quantitative trait locus on chromosome 2 for glucose tolerance in diabetic SMXA-5 mouse established from non-diabetic SM/J and A/J strains. Diabetologia 2006, 49:486-495. 10.1007/s00125-005-0121-3, 16447060.
25. Reifsnyder PC, Churchill G, Leiter EH. Maternal environment and genotype interact to establish diabesity in mice. Genome Res 2000, 10:1568-1578. 10.1101/gr.147000, 11042154.
26. Schmidt C, Gonzaludo NP, Strunk S, Dahm S, Schuchhardt J, Kleinjung F, Wuschke S, Joost HG, Al-Hasani H. A meta-analysis of QTL for diabetes-related traits in rodents. Physiol Genomics 2008, 34:42-53. 10.1152/physiolgenomics.00267.2007, 18397992.
27. Takeshita S, Moritani M, Kunika K, Inoue H, Itakura M. Diabetic modifier QTLs identified in F2 intercrosses between Akita and A/J mice. Mamm Genome 2006, 17:927-940. 10.1007/s00335-005-0130-z, 16964447.
28. Heid IM, Jackson AU, Randall JC, Winkler TW, Qi L, Steinthorsdottir V, Thorleifsson G, Zillikens MC, Speliotes EK, Magi R, Workalemahu T, White CC, Bouatia-Naji N, Harris TB, Berndt SI, Ingelsson E, Willer CJ, Weedon MN, Luan J, Vedantam S, Esko T, Kilpelainen TO, Kutalik Z, Li S, Monda KL, Dixon AL, Holmes CC, Kaplan LM, Liang L, Min JL, et al. Meta-analysis identifies 13 new loci associated with waist-hip ratio and reveals sexual dimorphism in the genetic basis of fat distribution. Nat Genet 2010, 42:949-960. 10.1038/ng.685, 20935629.
29. Braiman L, Alt A, Kuroki T, Ohba M, Bak A, Tennenbaum T, Sampson SR. Protein kinase Cdelta mediates insulin-induced glucose transport in primary cultures of rat skeletal muscle. Mol Endocrinol 1999, 13:2002-2012. 10598577.
30. Heled Y, Shapiro Y, Shani Y, Moran DS, Langzam L, Braiman L, Sampson SR, Meyerovitch J. Physical exercise enhances protein kinase C delta activity and insulin receptor tyrosine phosphorylation in diabetes-prone Psammomys obesus. Metabolism 2003, 52:1028-1033. 10.1016/S0026-0495(03)00154-9, 12898468.
31. Talior I, Yarkoni M, Bashan N, Eldar-Finkelman H. Increased glucose uptake promotes oxidative stress and PKC-delta activation in adipocytes of obese, insulin-resistant mice. Am J Physiol Endocrinol Metab 2003, 285:E295-E302. 12857675.
32. Talior I, Tennenbaum T, Kuroki T, Eldar-Finkelman H. PKC-delta-dependent activation of oxidative stress in adipocytes of obese and insulin-resistant mice: role for NADPH oxidase. Am J Physiol Endocrinol Metab 2005, 288:E405-E411. 10.1152/ajpendo.00378.2004, 15507533.
33. Sainsbury A, Baldock PA, Schwarzer C, Ueno N, Enriquez RF, Couzens M, Inui A, Herzog H, Gardiner EM. Synergistic effects of Y2 and Y4 receptors on adiposity and bone mass revealed in double knockout mice. Mol Cell Biol 2003, 23:5225-5233. 10.1128/MCB.23.15.5225-5233.2003, 12861009.
34. Lock P, Casagranda F, Dunn AR. Independent SH2-binding sites mediate interaction of Dok-related protein with RasGTPase-activating protein and Nck. J Biol Chem 1999, 274:22775-22784. 10.1074/jbc.274.32.22775, 10428862.
35. Ermann J, Glimcher LH. After GWAS: mice to the rescue?. Curr Opin Immunol 2012, 24:564-570. 10.1016/j.coi.2012.09.005, 23031443.
36. Flint J, Valdar W, Shifman S, Mott R. Strategies for mapping and cloning quantitative trait genes in rodents. Nat Rev Genet 2005, 6:271-286. 10.1038/nrg1576, 15803197.
37. Nojima K, Sugimoto K, Ueda H, Babaya N, Ikegami H, Rakugi H. Analysis of hepatic gene expression profile in a spontaneous mouse model of type 2 diabetes under a high sucrose diet. Endocr J 2013, 60:261-274. 10.1507/endocrj.EJ12-0258, 23131898.