Direct evidence for susceptibility genes for type 2 diabetes on mouse chromosomes 11 and 14

Diabetologia

Volumn 53, Issue 7, 2010, Pages 1362-1371

  Babaya, N ^a   Fujisawa, T ^b   Nojima, K ^b   Itoi Babaya, M ^b   Yamaji, K ^b   Yamada, K ^b   Kobayashi, M ^c   Ueda, H ^b   Hiromine, Y ^a   Noso, S ^a   Ikegami, H ^a  

^a KINKI UNIVERSITY   (Japan)

^b OSAKA UNIVERSITY   (Japan)

^c NAGOYA UNIVERSITY   (Japan)

Author keywords

Complex trait; Interaction; Mouse chromosome 11; Mouse chromosome 14; Nidd1n; Nidd2n; Nidd4n; NSY mouse

Indexed keywords

GLUCOKINASE; INSULIN;

AGE; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BODY FAT; CHROMOSOME 11; CHROMOSOME 14; CONTROLLED STUDY; DISEASE PREDISPOSITION; DISEASE SEVERITY; GENE FUNCTION; GENE IDENTIFICATION; GENE INTERACTION; GENE SEQUENCE; GENETIC SUSCEPTIBILITY; GENETIC VARIABILITY; HOMOZYGOSITY; HYPERGLYCEMIA; INSULIN RELEASE; INSULIN RESISTANCE; MALE; MONITORING; MOUSE; MOUSE STRAIN; NON INSULIN DEPENDENT DIABETES MELLITUS; NONHUMAN; NUCLEOTIDE SEQUENCE; OBESITY; PHENOTYPE; PRIORITY JOURNAL; ANIMAL; CHROMOSOME; GENETIC PREDISPOSITION; GENETICS;

ANIMALS; CHROMOSOMES, MAMMALIAN; DIABETES MELLITUS, TYPE 2; GENETIC PREDISPOSITION TO DISEASE; HYPERGLYCEMIA; MICE; PHENOTYPE;

EID: 77955654470     PISSN: 0012186X     EISSN: 14320428     Source Type: Journal    
DOI: 10.1007/s00125-010-1737-5     Document Type: Article

References (48)

1. Shibata M, Yasuda B (1980) New experimental congenital diabetic mice (NSY mice). Tohoku J Exp Med 130:139-142.
2. Hamada Y, Ikegami H, Ueda H et al (2001) Insulin secretion to glucose as well as nonglucose stimuli is impaired in spontaneously diabetic Nagoya-Shibata-Yasuda mice. Metabolism 50:1282-1285.
3. Ikegami H, Fujisawa T, Ogihara T (2004) Mouse models of type 1 and type 2 diabetes derived from the same closed colony: genetic susceptibility shared between two types of diabetes. ILAR J 45: 268-277.
4. Itoi-Babaya M, Ikegami H, Fujisawa T et al (2007) Fatty liver and obesity: phenotypically correlated but genetically distinct traits in a mouse model of type 2 diabetes. Diabetologia 50:1641-1648.
5. Ueda H, Ikegami H, Kawaguchi Y et al (2000) Paternal-maternal effects on phenotypic characteristics in spontaneously diabetic Nagoya-Shibata-Yasuda mice. Metabolism 49:651-656.
6. Ueda H, Ikegami H, Kawaguchi Y et al (2000) Age-dependent changes in phenotypes and candidate gene analysis in a polygenic animal model of Type II diabetes mellitus; NSY mouse. Diabetologia 43:932-938.
7. Ueda H, Ikegami H, Kawaguchi Yet al (1999) Genetic analysis of late-onset type 2 diabetes in a mouse model of human complex trait. Diabetes 48:1168-1174.
8. Ueda H, Ikegami H, Yamato E et al (1995) The NSY mouse: a new animal model of spontaneous NIDDM with moderate obesity. Diabetologia 38:503-508.
9. Ghosh S, Palmer SM, Rodrigues NR et al (1993) Polygenic control of autoimmune diabetes in nonobese diabetic mice. Nat Genet 4:404-409.
10. Todd JA, Aitman TJ, Cornall RJ et al (1991) Genetic analysis of autoimmune type 1 diabetes mellitus in mice. Nature 351:542-547.
11. Wicker LS, Todd JA, Prins JB, Podolin PL, Renjilian RJ, Peterson LB (1994) Resistance alleles at two non-major histocompatibility complex-linked insulin-dependent diabetes loci on chromosome 3, Idd3 and Idd10, protect nonobese diabetic mice from diabetes. J Exp Med 180:1705-1713.
12. Singer JB, Hill AE, Burrage LC et al (2004) Genetic dissection of complex traits with chromosome substitution strains of mice. Science 304:445-448.
13. Markel P, Shu P, Ebeling C et al (1997) Theoretical and empirical issues for marker-assisted breeding of congenic mouse strains. Nat Genet 17:280-284.
14. Magnuson MA, Shelton KD (1989) An alternate promoter in the glucokinase gene is active in the pancreatic beta cell. J Biol Chem 264:15936-15942.
15. Heinemeyer T, Wingender E, Reuter I et al (1998) Databases on transcriptional regulation: TRANSFAC, TRRD and COMPEL. Nucleic Acids Res 26:362-367.
16. Watanabe M, Houten SM, Mataki C et al (2006) Bile acids induce energy expenditure by promoting intracellular thyroid hormone activation. Nature 439:484-489.
17. Kahn BB (1998) Type 2 diabetes: when insulin secretion fails to compensate for insulin resistance. Cell 92:593-596.
18. Cai G, Cole SA, Freeland-Graves JH, MacCluer JW, Blangero J, Comuzzie AG (2004) Genome-wide scans reveal quantitative trait Loci on 8p and 13q related to insulin action and glucose metabolism: the San Antonio Family Heart Study. Diabetes 53: 1369-1374.
19. Demenais F, Kanninen T, Lindgren CM et al (2003) A metaanalysis of four European genome screens (GIFT Consortium) shows evidence for a novel region on chromosome 17p11.2-q22 linked to type 2 diabetes. Hum Mol Genet 12:1865-1873.
20. Duggirala R, Blangero J, Almasy L et al (1999) Linkage of type 2 diabetes mellitus and of age at onset to a genetic location on chromosome 10q in Mexican Americans. Am J Hum Genet 64: 1127-1140.
21. Mitchell BD, Cole SA, Hsueh WC et al (2000) Linkage of serum insulin concentrations to chromosome 3p in Mexican Americans. Diabetes 49:513-516.
22. Parker A, Meyer J, Lewitzky S et al (2001) A gene conferring susceptibility to type 2 diabetes in conjunction with obesity is located on chromosome 18p11. Diabetes 50:675-680.
23. Pezzolesi MG, Nam M, Nagase T et al (2004) Examination of candidate chromosomal regions for type 2 diabetes reveals a susceptibility locus on human chromosome 8p23.1. Diabetes 53: 486-491.
24. Reynisdottir I, Thorleifsson G, Benediktsson R et al (2003) Localization of a susceptibility gene for type 2 diabetes to chromosome 5q34-q35.2. Am J Hum Genet 73:323-335.
25. Bouatia-Naji N, Bonnefond A, Cavalcanti-Proenca C et al (2009) A variant near MTNR1B is associated with increased fasting plasma glucose levels and type 2 diabetes risk. Nat Genet 41:89-94.
26. Lyssenko V, Nagorny CL, Erdos MR et al (2009) Common variant in MTNR1B associated with increased risk of type 2 diabetes and impaired early insulin secretion. Nat Genet 41:82-88.
27. Prokopenko I, Langenberg C, Florez JC et al (2009) Variants in MTNR1B influence fasting glucose levels. Nat Genet 41:77-81.
28. Prokopenko I, McCarthy MI, Lindgren CM (2008) Type 2 diabetes: new genes, new understanding. Trends Genet 24:613-621.
29. Reiling E, van't Riet E, Groenewoud MJ et al (2009) Combined effects of single-nucleotide polymorphisms in GCK, GCKR, G6PC2 and MTNR1B on fasting plasma glucose and type 2 diabetes risk. Diabetologia 52:1866-1870.
30. Hirayama I, Yi Z, Izumi S et al (1999) Genetic analysis of obese diabetes in the TSOD mouse. Diabetes 48:1183-1191.
31. Leiter EH, Reifsnyder PC, Flurkey K, Partke HJ, Junger E, Herberg L (1998) NIDDM genes in mice: deleterious synergism by both parental genomes contributes to diabetogenic thresholds. Diabetes 47:1287-1295.
32. Takeshita S, Moritani M, Kunika K, Inoue H, Itakura M (2006) Diabetic modifier QTLs identified in F2 intercrosses between Akita and A/J mice. Mamm Genome 17:927-940.
33. Toye AA, Lippiat JD, Proks P et al (2005) A genetic and physiological study of impaired glucose homeostasis control in C57BL/6J mice. Diabetologia 48:675-686.
34. Almind K, Kahn CR (2004) Genetic determinants of energy expenditure and insulin resistance in diet-induced obesity in mice. Diabetes 53:3274-3285.
35. Almind K, Kulkarni RN, Lannon SM, Kahn CR (2003) Identification of interactive loci linked to insulin and leptin in mice with genetic insulin resistance. Diabetes 52:1535-1543.
36. Reifsnyder PC, Churchill G, Leiter EH (2000) Maternal environment and genotype interact to establish diabesity in mice. Genome Res 10:1568-1578.
37. Suto J, Matsuura S, Imamura K, Yamanaka H, Sekikawa K (1998) Genetic analysis of non-insulin-dependent diabetes mellitus in KK and KK-Ay mice. Eur J Endocrinol 139:654-661.
38. Babaya N, Ikegami H, Fujisawa T et al (2005) Susceptibility to streptozotocin-induced diabetes is mapped to mouse chromosome 11. Biochem Biophys Res Commun 328:158-164.
39. Ueda H, Ikegami H, Kawaguchi Y et al (2001) Mapping and promoter sequencing of HNF-1beta gene in diabetes-prone and -resistant mice. Diabetes Res Clin Pract 53:67-71.
40. Yamada K, Ikegami H, Kawaguchi Y et al (2001) Sequence analysis of candidate genes for common susceptibility to type 1 and type 2 diabetes in mice. Endocr J 48:241-247.
41. Froguel P, Vaxillaire M, Sun F et al (1992) Close linkage of glucokinase locus on chromosome 7p to early-onset non-insulindependent diabetes mellitus. Nature 356:162-164.
42. Gloyn AL (2003) Glucokinase (GCK) mutations in hyper- and hypoglycemia: maturity-onset diabetes of the young, permanent neonatal diabetes, and hyperinsulinemia of infancy. Hum Mutat 22:353-362.
43. Rose CS, Ek J, Urhammer SA et al (2005) A -30G > A polymorphism of the beta-cell-specific glucokinase promoter associates with hyperglycemia in the general population of whites. Diabetes 54:3026-3031.
44. Terauchi Y, Sakura H, Yasuda K et al (1995) Pancreatic beta-cellspecific targeted disruption of glucokinase gene. Diabetes mellitus due to defective insulin secretion to glucose. J Biol Chem 270:30253-30256.
45. Aigner B, Rathkolb B, Herbach N, Hrabe de Angelis M, Wanke R, Wolf E (2008) Diabetes models by screen for hyperglycemia in phenotype-driven ENU mouse mutagenesis projects. Am J Physiol Endocrinol Metabol 294:E232-E240.
46. Inoue M, Sakuraba Y, Motegi H et al (2004) A series of maturity onset diabetes of the young, type 2 (MODY2) mouse models generated by a large-scale ENU mutagenesis program. Hum Mol Genet 13:1147-1157.
47. Toye AA, Moir L, Hugill A et al (2004) A new mouse model of type 2 diabetes, produced by N-ethyl-nitrosourea mutagenesis, is the result of a missense mutation in the glucokinase gene. Diabetes 53:1577-1583.
48. Kaku K, Fiedorek FT Jr, Province M, Permutt MA (1988) Genetic analysis of glucose tolerance in inbred mouse strains. Evidence for polygenic control. Diabetes 37:707-713.