메뉴 건너뛰기




Volumn 88, Issue , 2014, Pages 99-106

The pharmacogenomics of statins

Author keywords

Drug metabolism; Drug transport; LDL cholesterol; Pharmacogenomics; Statins

Indexed keywords

APOLIPOPROTEIN C1; APOLIPOPROTEIN C2; APOLIPOPROTEIN E; BREAST CANCER RESISTANCE PROTEIN; CHOLESTEROL 7ALPHA MONOOXYGENASE; CYTOCHROME P450 2C9; CYTOCHROME P450 3A4; CYTOCHROME P450 3A5; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE INHIBITOR; LIPOPROTEIN A; LOW DENSITY LIPOPROTEIN RECEPTOR; MULTIDRUG RESISTANCE PROTEIN 1; SOLUTE CARRIER ORGANIC ANION TRANSPORTER 1B1; ORGANIC ANION TRANSPORTER; PHARMACOLOGICAL BIOMARKER; SLCO1B1 PROTEIN, HUMAN;

EID: 84906791063     PISSN: 10436618     EISSN: 10961186     Source Type: Journal    
DOI: 10.1016/j.phrs.2013.12.002     Document Type: Review
Times cited : (37)

References (96)
  • 1
    • 84883337835 scopus 로고    scopus 로고
    • Statins for primary prevention of cardiovascular disease: The benefits outweigh the risks
    • C.M. Minder, R.S. Blumenthal, and M.J. Blaha Statins for primary prevention of cardiovascular disease: the benefits outweigh the risks Curr Opin Cardiol 28 5 2013 554 560
    • (2013) Curr Opin Cardiol , vol.28 , Issue.5 , pp. 554-560
    • Minder, C.M.1    Blumenthal, R.S.2    Blaha, M.J.3
  • 2
    • 73349112590 scopus 로고    scopus 로고
    • Adverse effects of statins - Mechanisms and consequences
    • J. Beltowski, G. Wojcicka, and A. Jamroz-Wisniewska Adverse effects of statins - mechanisms and consequences Curr Drug Saf 4 3 2009 209 228
    • (2009) Curr Drug Saf , vol.4 , Issue.3 , pp. 209-228
    • Beltowski, J.1    Wojcicka, G.2    Jamroz-Wisniewska, A.3
  • 3
    • 76949094840 scopus 로고    scopus 로고
    • Risk factors and drug interactions predisposing to statin-induced myopathy: Implications for risk assessment, prevention and treatment
    • Y.S. Chatzizisis, K.C. Koskinas, G. Misirli, C. Vaklavas, A. Hatzitolios, and G.D. Giannoglou Risk factors and drug interactions predisposing to statin-induced myopathy: implications for risk assessment, prevention and treatment Drug Saf 33 3 2010 171 187
    • (2010) Drug Saf , vol.33 , Issue.3 , pp. 171-187
    • Chatzizisis, Y.S.1    Koskinas, K.C.2    Misirli, G.3    Vaklavas, C.4    Hatzitolios, A.5    Giannoglou, G.D.6
  • 4
  • 5
    • 84884507686 scopus 로고    scopus 로고
    • Clinical and pharmacogenetic predictors of circulating atorvastatin and rosuvastatin concentrations in routine clinical care
    • M.K. Degorter, R.G. Tirona, U.I. Schwarz, Y.H. Choi, G.K. Dresser, and N. Suskin et al. Clinical and pharmacogenetic predictors of circulating atorvastatin and rosuvastatin concentrations in routine clinical care Circ Cardiovasc Genet 6 4 2013 400 408
    • (2013) Circ Cardiovasc Genet , vol.6 , Issue.4 , pp. 400-408
    • Degorter, M.K.1    Tirona, R.G.2    Schwarz, U.I.3    Choi, Y.H.4    Dresser, G.K.5    Suskin, N.6
  • 6
    • 84856164890 scopus 로고    scopus 로고
    • A systematic review on pharmacogenetics in cardiovascular disease: Is it ready for clinical application?
    • J.J. Verschuren, S. Trompet, J.A. Wessels, H.J. Guchelaar, M.P. de Maat, and M.L. Simoons et al. A systematic review on pharmacogenetics in cardiovascular disease: is it ready for clinical application? Eur Heart J 33 2 2012 165 175
    • (2012) Eur Heart J , vol.33 , Issue.2 , pp. 165-175
    • Verschuren, J.J.1    Trompet, S.2    Wessels, J.A.3    Guchelaar, H.J.4    De Maat, M.P.5    Simoons, M.L.6
  • 7
    • 13444251203 scopus 로고    scopus 로고
    • Chemical, pharmacokinetic and pharmacodynamic properties of statins: An update
    • DOI 10.1111/j.1472-8206.2004.00299.x
    • M. Schachter Chemical, pharmacokinetic and pharmacodynamic properties of statins: an update Fundam Clin Pharmacol 19 1 2005 117 125 (Pubitemid 40204354)
    • (2005) Fundamental and Clinical Pharmacology , vol.19 , Issue.1 , pp. 117-125
    • Schachter, M.1
  • 8
    • 33748042671 scopus 로고    scopus 로고
    • Pharmacokinetic and pharmacodynamic alterations of 3-hydroxy-3- methylglutaryl coenzyme A (HMG-CoA) reductase inhibitors: Drug-drug interactions and interindividual differences in transporter and metabolic enzyme functions
    • DOI 10.1016/j.pharmthera.2006.03.003, PII S0163725806000404
    • Y. Shitara, and Y. Sugiyama Pharmacokinetic and pharmacodynamic alterations of 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitors: drug-drug interactions and interindividual differences in transporter and metabolic enzyme functions Pharmacol Ther 112 1 2006 71 105 (Pubitemid 44301483)
    • (2006) Pharmacology and Therapeutics , vol.112 , Issue.1 , pp. 71-105
    • Shitara, Y.1    Sugiyama, Y.2
  • 9
    • 84857761731 scopus 로고    scopus 로고
    • Population differences in major functional polymorphisms of pharmacokinetics/pharmacodynamics-related genes in Eastern Asians and Europeans: Implications in the clinical trials for novel drug development
    • K. Kurose, E. Sugiyama, and Y. Saito Population differences in major functional polymorphisms of pharmacokinetics/pharmacodynamics-related genes in Eastern Asians and Europeans: implications in the clinical trials for novel drug development Drug Metab Pharmacokinet 27 1 2012 9 54
    • (2012) Drug Metab Pharmacokinet , vol.27 , Issue.1 , pp. 9-54
    • Kurose, K.1    Sugiyama, E.2    Saito, Y.3
  • 10
    • 84872229531 scopus 로고    scopus 로고
    • Clinical significance of organic anion transporting polypeptides (OATPs) in drug disposition: Their roles in hepatic clearance and intestinal absorption
    • Y. Shitara, K. Maeda, K. Ikejiri, K. Yoshida, T. Horie, and Y. Sugiyama Clinical significance of organic anion transporting polypeptides (OATPs) in drug disposition: their roles in hepatic clearance and intestinal absorption Biopharm Drug Dispos 34 1 2013 45 78
    • (2013) Biopharm Drug Dispos , vol.34 , Issue.1 , pp. 45-78
    • Shitara, Y.1    Maeda, K.2    Ikejiri, K.3    Yoshida, K.4    Horie, T.5    Sugiyama, Y.6
  • 11
    • 40949126593 scopus 로고    scopus 로고
    • Global analysis of genetic variation in SLCO1B1
    • DOI 10.2217/14622416.9.1.19
    • M.K. Pasanen, P.J. Neuvonen, and M. Niemi Global analysis of genetic variation in SLCO1B1 Pharmacogenomics 9 1 2008 19 33 (Pubitemid 351560529)
    • (2008) Pharmacogenomics , vol.9 , Issue.1 , pp. 19-33
    • Pasanen, M.K.1    Neuvonen, P.J.2    Niemi, M.3
  • 12
    • 22544454498 scopus 로고    scopus 로고
    • Functional characterization of SLCO1B1 (OATP-C) variants, SLCO1B15, SLCO1B115 and SLCO1B115 + C1007G, by using transient expression systems of HeLa and HEK293 cells
    • Y. Kameyama, K. Yamashita, K. Kobayashi, M. Hosokawa, and K. Chiba Functional characterization of SLCO1B1 (OATP-C) variants, SLCO1B1*5, SLCO1B1*15 and SLCO1B1*15+C1007G, by using transient expression systems of HeLa and HEK293 cells Pharmacogenet Genomics 15 7 2005 513 522 (Pubitemid 41017600)
    • (2005) Pharmacogenetics and Genomics , vol.15 , Issue.7 , pp. 513-522
    • Kameyama, Y.1    Yamashita, K.2    Kobayashi, K.3    Hosokawa, M.4    Chiba, K.5
  • 13
    • 33751096467 scopus 로고    scopus 로고
    • SLCO1B1 polymorphism markedly affects the pharmacokinetics of simvastatin acid
    • DOI 10.1097/01.fpc.0000230416.82349.90, PII 0121301120061200000004
    • M.K. Pasanen, M. Neuvonen, P.J. Neuvonen, and M. Niemi SLCO1B1 polymorphism markedly affects the pharmacokinetics of simvastatin acid Pharmacogenet Genomics 16 12 2006 873 879 (Pubitemid 44772805)
    • (2006) Pharmacogenetics and Genomics , vol.16 , Issue.12 , pp. 873-879
    • Pasanen, M.K.1    Neuvonen, M.2    Neuvonen, P.J.3    Niemi, M.4
  • 14
    • 36148953896 scopus 로고    scopus 로고
    • Different effects of SLCO1B1 polymorphism on the pharmacokinetics of atorvastatin and rosuvastatin
    • DOI 10.1038/sj.clpt.6100220, PII 6100220
    • M.K. Pasanen, H. Fredrikson, P.J. Neuvonen, and M. Niemi Different effects of SLCO1B1 polymorphism on the pharmacokinetics of atorvastatin and rosuvastatin Clin Pharmacol Ther 82 6 2007 726 733 (Pubitemid 350114817)
    • (2007) Clinical Pharmacology and Therapeutics , vol.82 , Issue.6 , pp. 726-733
    • Pasanen, M.K.1    Fredrikson, H.2    Neuvonen, P.J.3    Niemi, M.4
  • 15
    • 84859341661 scopus 로고    scopus 로고
    • Effects of the SLCO1B1*15 allele on the pharmacokinetics of pitavastatin
    • C.I. Choi, Y.J. Lee, H.I. Lee, B.H. Kim, M.J. Kim, and C.G. Jang et al. Effects of the SLCO1B1*15 allele on the pharmacokinetics of pitavastatin Xenobiotica 42 5 2012 496 501
    • (2012) Xenobiotica , vol.42 , Issue.5 , pp. 496-501
    • Choi, C.I.1    Lee, Y.J.2    Lee, H.I.3    Kim, B.H.4    Kim, M.J.5    Jang, C.G.6
  • 16
    • 38549159477 scopus 로고    scopus 로고
    • Influence of OATP1B1 genotype on the pharmacokinetics of rosuvastatin in Koreans
    • DOI 10.1038/sj.clpt.6100267, PII 6100267
    • J.H. Choi, M.G. Lee, J.Y. Cho, J.E. Lee, K.H. Kim, and K. Park Influence of OATP1B1 genotype on the pharmacokinetics of rosuvastatin in Koreans Clin Pharmacol Ther 83 2 2008 251 257 (Pubitemid 351147710)
    • (2008) Clinical Pharmacology and Therapeutics , vol.83 , Issue.2 , pp. 251-257
    • Choi, J.H.1    Lee, M.G.2    Cho, J.-Y.3    Lee, J.-E.4    Kim, K.H.5    Park, K.6
  • 17
    • 49949104757 scopus 로고    scopus 로고
    • SLCO1B1 variants and statin-induced myopathy - A genomewide study
    • E. Link, S. Parish, J. Armitage, L. Bowman, S. Heath, and F. Matsuda et al. SLCO1B1 variants and statin-induced myopathy - a genomewide study N Engl J Med 359 8 2008 789 799
    • (2008) N Engl J Med , vol.359 , Issue.8 , pp. 789-799
    • Link, E.1    Parish, S.2    Armitage, J.3    Bowman, L.4    Heath, S.5    Matsuda, F.6
  • 18
    • 70349739250 scopus 로고    scopus 로고
    • The SLCO1B1*5 genetic variant is associated with statin-induced side effects
    • D. Voora, S.H. Shah, I. Spasojevic, S. Ali, C.R. Reed, and B.A. Salisbury et al. The SLCO1B1*5 genetic variant is associated with statin-induced side effects J Am Coll Cardiol 54 17 2009 1609 1616
    • (2009) J Am Coll Cardiol , vol.54 , Issue.17 , pp. 1609-1616
    • Voora, D.1    Shah, S.H.2    Spasojevic, I.3    Ali, S.4    Reed, C.R.5    Salisbury, B.A.6
  • 19
    • 84862600938 scopus 로고    scopus 로고
    • The clinical pharmacogenomics implementation consortium: CPIC guideline for SLCO1B1 and simvastatin-induced myopathy
    • R.A. Wilke, L.B. Ramsey, S.G. Johnson, W.D. Maxwell, H.L. McLeod, and D. Voora et al. The clinical pharmacogenomics implementation consortium: CPIC guideline for SLCO1B1 and simvastatin-induced myopathy Clin Pharmacol Ther 92 1 2012 112 117
    • (2012) Clin Pharmacol Ther , vol.92 , Issue.1 , pp. 112-117
    • Wilke, R.A.1    Ramsey, L.B.2    Johnson, S.G.3    Maxwell, W.D.4    McLeod, H.L.5    Voora, D.6
  • 20
    • 78951469667 scopus 로고    scopus 로고
    • Common nonsynonymous substitutions in SLCO1B1 predispose to statin intolerance in routinely treated individuals with type 2 diabetes: A go-DARTS study
    • L.A. Donnelly, A.S. Doney, R. Tavendale, C.C. Lang, E.R. Pearson, and H.M. Colhoun et al. Common nonsynonymous substitutions in SLCO1B1 predispose to statin intolerance in routinely treated individuals with type 2 diabetes: a go-DARTS study Clin Pharmacol Ther 89 2 2011 210 216
    • (2011) Clin Pharmacol Ther , vol.89 , Issue.2 , pp. 210-216
    • Donnelly, L.A.1    Doney, A.S.2    Tavendale, R.3    Lang, C.C.4    Pearson, E.R.5    Colhoun, H.M.6
  • 22
    • 33646205286 scopus 로고    scopus 로고
    • Effects of organic anion transporting polypeptide 1B1 haplotype on pharmacokinetics of pravastatin, valsartan, and temocapril
    • K. Maeda, I. Ieiri, K. Yasuda, A. Fujino, H. Fujiwara, and K. Otsubo et al. Effects of organic anion transporting polypeptide 1B1 haplotype on pharmacokinetics of pravastatin, valsartan, and temocapril Clin Pharmacol Ther 79 5 2006 427 439
    • (2006) Clin Pharmacol Ther , vol.79 , Issue.5 , pp. 427-439
    • Maeda, K.1    Ieiri, I.2    Yasuda, K.3    Fujino, A.4    Fujiwara, H.5    Otsubo, K.6
  • 23
    • 74349126111 scopus 로고    scopus 로고
    • OATP1B1 388A>G polymorphism and pharmacokinetics of pitavastatin in Chinese healthy volunteers
    • J. Wen, and Y. Xiong OATP1B1 388A>G polymorphism and pharmacokinetics of pitavastatin in Chinese healthy volunteers J Clin Pharm Ther 35 1 2010 99 104
    • (2010) J Clin Pharm Ther , vol.35 , Issue.1 , pp. 99-104
    • Wen, J.1    Xiong, Y.2
  • 24
    • 84876765967 scopus 로고    scopus 로고
    • Effects of grapefruit juice and SLCO1B1 388A>G polymorphism on the pharmacokinetics of pitavastatin
    • M. Hu, V.W. Mak, O.Q. Yin, T.T. Chu, and B. Tomlinson Effects of grapefruit juice and SLCO1B1 388A>G polymorphism on the pharmacokinetics of pitavastatin Drug Metab Pharmacokinet 28 2 2013 104 108
    • (2013) Drug Metab Pharmacokinet , vol.28 , Issue.2 , pp. 104-108
    • Hu, M.1    Mak, V.W.2    Yin, O.Q.3    Chu, T.T.4    Tomlinson, B.5
  • 25
    • 80053436675 scopus 로고    scopus 로고
    • The ABCG family of membrane-associated transporters: You don't have to be big to be mighty
    • I.D. Kerr, A.J. Haider, and I.C. Gelissen The ABCG family of membrane-associated transporters: you don't have to be big to be mighty Br J Pharmacol 164 7 2011 1767 1779
    • (2011) Br J Pharmacol , vol.164 , Issue.7 , pp. 1767-1779
    • Kerr, I.D.1    Haider, A.J.2    Gelissen, I.C.3
  • 28
    • 84867873811 scopus 로고    scopus 로고
    • Understanding the critical disposition pathways of statins to assess drug-drug interaction risk during drug development: It's not just about OATP1B1
    • R. Elsby, C. Hilgendorf, and K. Fenner Understanding the critical disposition pathways of statins to assess drug-drug interaction risk during drug development: it's not just about OATP1B1 Clin Pharmacol Ther 92 5 2012 584 598
    • (2012) Clin Pharmacol Ther , vol.92 , Issue.5 , pp. 584-598
    • Elsby, R.1    Hilgendorf, C.2    Fenner, K.3
  • 29
    • 77951499767 scopus 로고    scopus 로고
    • ABCG2 polymorphism is associated with the low-density lipoprotein cholesterol response to rosuvastatin
    • B. Tomlinson, M. Hu, V.W. Lee, S.S. Lui, T.T. Chu, and E.W. Poon et al. ABCG2 polymorphism is associated with the low-density lipoprotein cholesterol response to rosuvastatin Clin Pharmacol Ther 87 5 2010 558 562
    • (2010) Clin Pharmacol Ther , vol.87 , Issue.5 , pp. 558-562
    • Tomlinson, B.1    Hu, M.2    Lee, V.W.3    Lui, S.S.4    Chu, T.T.5    Poon, E.W.6
  • 30
    • 84883893601 scopus 로고    scopus 로고
    • CYP2C9 and ABCG2 polymorphisms as risk factors for developing adverse drug reactions in renal transplant patients taking fluvastatin: A case-control study
    • N. Mirosevic Skvrce, N. Bozina, L. Zibar, I. Barisic, L. Pejnovic, and V. Macolic Sarinic CYP2C9 and ABCG2 polymorphisms as risk factors for developing adverse drug reactions in renal transplant patients taking fluvastatin: a case-control study Pharmacogenomics 14 12 2013 1419 1431
    • (2013) Pharmacogenomics , vol.14 , Issue.12 , pp. 1419-1431
    • Mirosevic Skvrce, N.1    Bozina, N.2    Zibar, L.3    Barisic, I.4    Pejnovic, L.5    Macolic Sarinic, V.6
  • 32
    • 56449116103 scopus 로고    scopus 로고
    • ABCB1 haplotypes differentially affect the pharmacokinetics of the acid and lactone forms of simvastatin and atorvastatin
    • J.E. Keskitalo, K.J. Kurkinen, P.J. Neuvoneni, and M. Niemi ABCB1 haplotypes differentially affect the pharmacokinetics of the acid and lactone forms of simvastatin and atorvastatin Clin Pharmacol Ther 84 4 2008 457 461
    • (2008) Clin Pharmacol Ther , vol.84 , Issue.4 , pp. 457-461
    • Keskitalo, J.E.1    Kurkinen, K.J.2    Neuvoneni, P.J.3    Niemi, M.4
  • 33
    • 68449085764 scopus 로고    scopus 로고
    • No significant effect of ABCB1 haplotypes on the pharmacokinetics of fluvastatin, pravastatin, lovastatin, and rosuvastatin
    • J.E. Keskitalo, K.J. Kurkinen, M. Neuvonen, J.T. Backman, P.J. Neuvonen, and M. Niemi No significant effect of ABCB1 haplotypes on the pharmacokinetics of fluvastatin, pravastatin, lovastatin, and rosuvastatin Br J Clin Pharmacol 68 2 2009 207 213
    • (2009) Br J Clin Pharmacol , vol.68 , Issue.2 , pp. 207-213
    • Keskitalo, J.E.1    Kurkinen, K.J.2    Neuvonen, M.3    Backman, J.T.4    Neuvonen, P.J.5    Niemi, M.6
  • 36
    • 25144433260 scopus 로고    scopus 로고
    • Multidrug resistance polypeptide 1 (MDR1, ABCB1) variant 3435C>T affects mRNA stability
    • D. Wang, A.D. Johnson, A.C. Papp, D.L. Kroetz, and W. Sadee Multidrug resistance polypeptide 1 (MDR1, ABCB1) variant 3435C>T affects mRNA stability Pharmacogenet Genomics 15 10 2005 693 704 (Pubitemid 41345321)
    • (2005) Pharmacogenetics and Genomics , vol.15 , Issue.10 , pp. 693-704
    • Wang, D.1    Johnson, A.D.2    Papp, A.C.3    Kroetz, D.L.4    Sadee, W.5
  • 39
    • 33644666953 scopus 로고    scopus 로고
    • An association study of 43 SNPs in 16 candidate genes with atorvastatin response
    • J.F. Thompson, M. Man, K.J. Johnson, L.S. Wood, M.E. Lira, and D.B. Lloyd et al. An association study of 43 SNPs in 16 candidate genes with atorvastatin response Pharmacogenomics J 5 6 2005 352 358
    • (2005) Pharmacogenomics J , vol.5 , Issue.6 , pp. 352-358
    • Thompson, J.F.1    Man, M.2    Johnson, K.J.3    Wood, L.S.4    Lira, M.E.5    Lloyd, D.B.6
  • 40
    • 62649085032 scopus 로고    scopus 로고
    • Variability in response to medicines in older people: Phenotypic and genotypic factors
    • A.J. McLachlan, S.N. Hilmer, and D.G. Le Couteur Variability in response to medicines in older people: phenotypic and genotypic factors Clin Pharmacol Ther 85 4 2009 431 433
    • (2009) Clin Pharmacol Ther , vol.85 , Issue.4 , pp. 431-433
    • McLachlan, A.J.1    Hilmer, S.N.2    Le Couteur, D.G.3
  • 41
    • 78651511585 scopus 로고    scopus 로고
    • Clinical implications of pharmacogenetic variation on the effects of statins
    • S.D. Maggo, M.A. Kennedy, and D.W. Clark Clinical implications of pharmacogenetic variation on the effects of statins Drug Saf 34 1 2011 1 19
    • (2011) Drug Saf , vol.34 , Issue.1 , pp. 1-19
    • Maggo, S.D.1    Kennedy, M.A.2    Clark, D.W.3
  • 42
    • 0035023185 scopus 로고    scopus 로고
    • Clinical pharmacokinetics of fluvastatin
    • C.D. Scripture, and J.A. Pieper Clinical pharmacokinetics of fluvastatin Clin Pharmacokinet 40 4 2001 263 281 (Pubitemid 32458153)
    • (2001) Clinical Pharmacokinetics , vol.40 , Issue.4 , pp. 263-281
    • Scripture, C.D.1    Pieper, J.A.2
  • 43
    • 0042627731 scopus 로고    scopus 로고
    • Influence of CYP2C9 polymorphisms on the pharmacokinetics and cholesterol-lowering activity of (-)-3S, 5R-fluvastatin and (+)-3R, 5S-fluvastatin in healthy volunteers
    • DOI 10.1016/S0009-9236(03)00121-8
    • J. Kirchheiner, D. Kudlicz, C. Meisel, S. Bauer, I. Meineke, and I. Roots et al. Influence of CYP2C9 polymorphisms on the pharmacokinetics and cholesterol-lowering activity of (-)-3S,5R-fluvastatin and (+)-3R,5S-fluvastatin in healthy volunteers Clin Pharmacol Ther 74 2 2003 186 194 (Pubitemid 36951816)
    • (2003) Clinical Pharmacology and Therapeutics , vol.74 , Issue.2 , pp. 186-194
    • Kirchheiner, J.1    Kudlicz, D.2    Meisel, C.3    Bauer, S.4    Meineke, I.5    Roots, I.6    Brockmoller, J.7
  • 44
    • 84866131000 scopus 로고    scopus 로고
    • Lipid-lowering effect of fluvastatin in relation to cytochrome P450 2C9 variant alleles frequently distributed in the Czech population
    • H. Buzkova, K. Pechandova, V. Danzig, T. Vareka, F. Perlik, and A. Zak et al. Lipid-lowering effect of fluvastatin in relation to cytochrome P450 2C9 variant alleles frequently distributed in the Czech population Med Sci Monit 18 8 2012 CR512 CR517
    • (2012) Med Sci Monit , vol.18 , Issue.8
    • Buzkova, H.1    Pechandova, K.2    Danzig, V.3    Vareka, T.4    Perlik, F.5    Zak, A.6
  • 45
    • 3242695305 scopus 로고    scopus 로고
    • Effect of gemfibrozil on the metabolism of pitavastatin - Determining the best animal model for human CYP and UGT activities
    • H. Fujino, T. Saito, Y. Tsunenari, and J. Kojima Effect of gemfibrozil on the metabolism of pitavastatin - determining the best animal model for human CYP and UGT activities Drug Metabol Drug Interact 20 1-2 2004 25 42 (Pubitemid 38943446)
    • (2004) Drug Metabolism and Drug Interactions , vol.20 , Issue.1-2 , pp. 25-42
    • Fujino, H.1    Saito, T.2    Tsunenari, Y.3    Kojima, J.4
  • 46
    • 84882247785 scopus 로고    scopus 로고
    • Effects of polymorphisms in ABCG2, SLCO1B1, SLC10A1 and CYP2C9/19 on plasma concentrations of rosuvastatin and lipid response in Chinese patients
    • H.K. Lee, M. Hu, S. Lui, C.S. Ho, C.K. Wong, and B. Tomlinson Effects of polymorphisms in ABCG2, SLCO1B1, SLC10A1 and CYP2C9/19 on plasma concentrations of rosuvastatin and lipid response in Chinese patients Pharmacogenomics 14 11 2013 1283 1294
    • (2013) Pharmacogenomics , vol.14 , Issue.11 , pp. 1283-1294
    • Lee, H.K.1    Hu, M.2    Lui, S.3    Ho, C.S.4    Wong, C.K.5    Tomlinson, B.6
  • 47
    • 84871450636 scopus 로고    scopus 로고
    • CYP3A4*22: Promising newly identified CYP3A4 variant allele for personalizing pharmacotherapy
    • L. Elens, T. van Gelder, D.A. Hesselink, V. Haufroid, and R.H. van Schaik CYP3A4*22: promising newly identified CYP3A4 variant allele for personalizing pharmacotherapy Pharmacogenomics 14 1 2013 47 62
    • (2013) Pharmacogenomics , vol.14 , Issue.1 , pp. 47-62
    • Elens, L.1    Van Gelder, T.2    Hesselink, D.A.3    Haufroid, V.4    Van Schaik, R.H.5
  • 49
    • 80053339932 scopus 로고    scopus 로고
    • Effect of cytochrome P450 3A5 genotype on atorvastatin pharmacokinetics and its interaction with clarithromycin
    • J. Shin, D.F. Pauly, M.A. Pacanowski, T. Langaee, R.F. Frye, and J.A. Johnson Effect of cytochrome P450 3A5 genotype on atorvastatin pharmacokinetics and its interaction with clarithromycin Pharmacotherapy 31 10 2011 942 950
    • (2011) Pharmacotherapy , vol.31 , Issue.10 , pp. 942-950
    • Shin, J.1    Pauly, D.F.2    Pacanowski, M.A.3    Langaee, T.4    Frye, R.F.5    Johnson, J.A.6
  • 51
    • 70649100416 scopus 로고    scopus 로고
    • Cytochrome P450 2C8 pharmacogenetics: A review of clinical studies
    • E.B. Daily, and C.L. Aquilante Cytochrome P450 2C8 pharmacogenetics: a review of clinical studies Pharmacogenomics 10 9 2009 1489 1510
    • (2009) Pharmacogenomics , vol.10 , Issue.9 , pp. 1489-1510
    • Daily, E.B.1    Aquilante, C.L.2
  • 52
    • 0035657076 scopus 로고    scopus 로고
    • Association of polymorphism in the cytochrome CYP2D6 and the efficacy and tolerability of simvastatin
    • DOI 10.1067/mcp.2001.120251
    • A.B. Mulder, H.J. van Lijf, M.A. Bon, F.A. van den Bergh, D.J. Touw, and C. Neef et al. Association of polymorphism in the cytochrome CYP2D6 and the efficacy and tolerability of simvastatin Clin Pharmacol Ther 70 6 2001 546 551 (Pubitemid 34008412)
    • (2001) Clinical Pharmacology and Therapeutics , vol.70 , Issue.6 , pp. 546-551
    • Mulder, A.B.1    Van Lijf, H.J.2    Bon, M.A.M.3
  • 53
    • 34047136751 scopus 로고    scopus 로고
    • Tolerability of statins is not linked to CYP450 polymorphisms, but reduced CYP2D6 metabolism improves cholesteraemic response to simvastatin and fluvastatin
    • DOI 10.1016/j.phrs.2006.12.009, PII S1043661807000138
    • P. Zuccaro, G. Mombelli, L. Calabresi, D. Baldassarre, I. Palmi, and C.R. Sirtori Tolerability of statins is not linked to CYP450 polymorphisms, but reduced CYP2D6 metabolism improves cholesteraemic response to simvastatin and fluvastatin Pharmacol Res 55 4 2007 310 317 (Pubitemid 46518161)
    • (2007) Pharmacological Research , vol.55 , Issue.4 , pp. 310-317
    • Zuccaro, P.1    Mombelli, G.2    Calabresi, L.3    Baldassarre, D.4    Palmi, I.5    Sirtori, C.R.6
  • 55
    • 84864279111 scopus 로고    scopus 로고
    • Impact of CYP2D6 polymorphisms on the pharmacokinetics of lovastatin in Chinese subjects
    • O.Q. Yin, V.W. Mak, M. Hu, B.S. Fok, M.S. Chow, and B. Tomlinson Impact of CYP2D6 polymorphisms on the pharmacokinetics of lovastatin in Chinese subjects Eur J Clin Pharmacol 68 6 2012 943 949
    • (2012) Eur J Clin Pharmacol , vol.68 , Issue.6 , pp. 943-949
    • Yin, O.Q.1    Mak, V.W.2    Hu, M.3    Fok, B.S.4    Chow, M.S.5    Tomlinson, B.6
  • 56
    • 84872203308 scopus 로고    scopus 로고
    • Atorvastatin-related rhabdomyolysis and acute renal failure in a genetically predisposed patient with potential drug-drug interaction
    • S. Marusic, A. Lisicic, I. Horvatic, V. Bacic-Vrca, and N. Bozina Atorvastatin-related rhabdomyolysis and acute renal failure in a genetically predisposed patient with potential drug-drug interaction Int J Clin Pharm 34 6 2012 825 827
    • (2012) Int J Clin Pharm , vol.34 , Issue.6 , pp. 825-827
    • Marusic, S.1    Lisicic, A.2    Horvatic, I.3    Bacic-Vrca, V.4    Bozina, N.5
  • 57
    • 84881614204 scopus 로고    scopus 로고
    • Gene-gene-environment interactions between drugs, transporters, receptors, and metabolizing enzymes: Statins, SLCO1B1, and CYP3A4 as an example
    • W. Sadee Gene-gene-environment interactions between drugs, transporters, receptors, and metabolizing enzymes: statins, SLCO1B1, and CYP3A4 as an example J Pharm Sci 102 9 2013 2924 2929
    • (2013) J Pharm Sci , vol.102 , Issue.9 , pp. 2924-2929
    • Sadee, W.1
  • 58
    • 0026448725 scopus 로고
    • The discovery and development of HMG-CoA reductase inhibitors
    • A. Endo The discovery and development of HMG-CoA reductase inhibitors J Lipid Res 33 11 1992 1569 1582
    • (1992) J Lipid Res , vol.33 , Issue.11 , pp. 1569-1582
    • Endo, A.1
  • 60
    • 0035843962 scopus 로고    scopus 로고
    • Structural mechanism for statin inhibition of HMG-CoA reductase
    • DOI 10.1126/science.1059344
    • E.S. Istvan, and J. Deisenhofer Structural mechanism for statin inhibition of HMG-CoA reductase Science 292 5519 2001 1160 1164 (Pubitemid 32440937)
    • (2001) Science , vol.292 , Issue.5519 , pp. 1160-1164
    • Istvan, E.S.1    Deisenhofer, J.2
  • 62
    • 57149124098 scopus 로고    scopus 로고
    • A paucimorphic variant in the HMG-CoA reductase gene is associated with lipid-lowering response to statin treatment in diabetes: A GoDARTS study
    • L.A. Donnelly, A.S. Doney, J. Dannfald, A.L. Whitley, C.C. Lang, and A.D. Morris et al. A paucimorphic variant in the HMG-CoA reductase gene is associated with lipid-lowering response to statin treatment in diabetes: a GoDARTS study Pharmacogenet Genomics 18 12 2008 1021 1026
    • (2008) Pharmacogenet Genomics , vol.18 , Issue.12 , pp. 1021-1026
    • Donnelly, L.A.1    Doney, A.S.2    Dannfald, J.3    Whitley, A.L.4    Lang, C.C.5    Morris, A.D.6
  • 64
    • 49149095635 scopus 로고    scopus 로고
    • Alternative splicing of 3-hydroxy-3-methylglutaryl coenzyme A reductase is associated with plasma low-density lipoprotein cholesterol response to simvastatin
    • M.W. Medina, F. Gao, W. Ruan, J.I. Rotter, and R.M. Krauss Alternative splicing of 3-hydroxy-3-methylglutaryl coenzyme A reductase is associated with plasma low-density lipoprotein cholesterol response to simvastatin Circulation 118 4 2008 355 362
    • (2008) Circulation , vol.118 , Issue.4 , pp. 355-362
    • Medina, M.W.1    Gao, F.2    Ruan, W.3    Rotter, J.I.4    Krauss, R.M.5
  • 65
    • 84860174535 scopus 로고    scopus 로고
    • Effect of HMGCR variant alleles on low-density lipoprotein cholesterol-lowering response to atorvastatin in healthy Korean subjects
    • J.Y. Chung, S.K. Cho, E.S. Oh, D.H. Lee, L.A. Lim, and S.B. Jang et al. Effect of HMGCR variant alleles on low-density lipoprotein cholesterol-lowering response to atorvastatin in healthy Korean subjects J Clin Pharmacol 52 3 2012 339 346
    • (2012) J Clin Pharmacol , vol.52 , Issue.3 , pp. 339-346
    • Chung, J.Y.1    Cho, S.K.2    Oh, E.S.3    Lee, D.H.4    Lim, L.A.5    Jang, S.B.6
  • 66
    • 69549111453 scopus 로고    scopus 로고
    • Comprehensive whole-genome and candidate gene analysis for response to statin therapy in the Treating to New Targets (TNT) cohort
    • J.F. Thompson, C.L. Hyde, L.S. Wood, S.A. Paciga, D.A. Hinds, and D.R. Cox et al. Comprehensive whole-genome and candidate gene analysis for response to statin therapy in the Treating to New Targets (TNT) cohort Circ Cardiovasc Genet 2 2 2009 173 181
    • (2009) Circ Cardiovasc Genet , vol.2 , Issue.2 , pp. 173-181
    • Thompson, J.F.1    Hyde, C.L.2    Wood, L.S.3    Paciga, S.A.4    Hinds, D.A.5    Cox, D.R.6
  • 67
    • 55449105227 scopus 로고    scopus 로고
    • Common SNPs in HMGCR in micronesians and whites associated with LDL-cholesterol levels affect alternative splicing of exon13
    • R. Burkhardt, E.E. Kenny, J.K. Lowe, A. Birkeland, R. Josowitz, and M. Noel et al. Common SNPs in HMGCR in micronesians and whites associated with LDL-cholesterol levels affect alternative splicing of exon13 Arterioscler Thromb Vasc Biol 28 11 2008 2078 2084
    • (2008) Arterioscler Thromb Vasc Biol , vol.28 , Issue.11 , pp. 2078-2084
    • Burkhardt, R.1    Kenny, E.E.2    Lowe, J.K.3    Birkeland, A.4    Josowitz, R.5    Noel, M.6
  • 68
    • 84894056238 scopus 로고    scopus 로고
    • HNRNPA1 regulates HMGCR alternative splicing and modulates cellular cholesterol metabolism
    • 10.1093/hmg/ddt422 [Epub ahead of print]
    • C.Y. Yu, E. Theusch, K. Lo, L.M. Mangravite, D. Naidoo, and M. Kutilova et al. HNRNPA1 regulates HMGCR alternative splicing and modulates cellular cholesterol metabolism Hum Mol Genet 2013 10.1093/hmg/ddt422 [Epub ahead of print]
    • (2013) Hum Mol Genet
    • Yu, C.Y.1    Theusch, E.2    Lo, K.3    Mangravite, L.M.4    Naidoo, D.5    Kutilova, M.6
  • 69
    • 68349083490 scopus 로고    scopus 로고
    • The HMG-CoA reductase gene and lipid and lipoprotein levels: The multi-ethnic study of atherosclerosis
    • Y.C. Chen, Y.D. Chen, X. Li, W. Post, D. Herrington, and J.F. Polak et al. The HMG-CoA reductase gene and lipid and lipoprotein levels: the multi-ethnic study of atherosclerosis Lipids 44 8 2009 733 743
    • (2009) Lipids , vol.44 , Issue.8 , pp. 733-743
    • Chen, Y.C.1    Chen, Y.D.2    Li, X.3    Post, W.4    Herrington, D.5    Polak, J.F.6
  • 71
    • 77958497833 scopus 로고    scopus 로고
    • Exploring genetic determinants of plasma total cholesterol levels and their predictive value in a longitudinal study
    • Y. Lu, E.J. Feskens, J.M. Boer, S. Imholz, W.M. Verschuren, and C. Wijmenga et al. Exploring genetic determinants of plasma total cholesterol levels and their predictive value in a longitudinal study Atherosclerosis 213 1 2010 200 205
    • (2010) Atherosclerosis , vol.213 , Issue.1 , pp. 200-205
    • Lu, Y.1    Feskens, E.J.2    Boer, J.M.3    Imholz, S.4    Verschuren, W.M.5    Wijmenga, C.6
  • 72
    • 84860798384 scopus 로고    scopus 로고
    • Genetic determinants of statin-induced low-density lipoprotein cholesterol reduction: The Justification for the Use of statins in Prevention: An Intervention Trial Evaluating Rosuvastatin (JUPITER) Trial
    • D.I. Chasman, F. Guilianini, J. MacFadyen, B.J. Barratt, F. Nyberg, and P.M. Ridker Genetic determinants of statin-induced low-density lipoprotein cholesterol reduction: the Justification for the Use of statins in Prevention: An Intervention Trial Evaluating Rosuvastatin (JUPITER) Trial Circ Cardiovasc Genet 5 2012 257 264
    • (2012) Circ Cardiovasc Genet , vol.5 , pp. 257-264
    • Chasman, D.I.1    Guilianini, F.2    Macfadyen, J.3    Barratt, B.J.4    Nyberg, F.5    Ridker, P.M.6
  • 73
    • 34547793131 scopus 로고    scopus 로고
    • A common polymorphism decreases low-density lipoprotein receptor exon 12 splicing efficiency and associates with increased cholesterol
    • DOI 10.1093/hmg/ddm124
    • H. Zhu, H.M. Tucker, K.E. Grear, J.F. Simpson, A.K. Manning, and L.A. Cupples et al. A common polymorphism decreases low-density lipoprotein receptor exon 12 splicing efficiency and associates with increased cholesterol Hum Mol Genet 16 14 2007 1765 1772 (Pubitemid 47241835)
    • (2007) Human Molecular Genetics , vol.16 , Issue.14 , pp. 1765-1772
    • Zhu, H.1    Tucker, H.M.2    Grear, K.E.3    Simpson, J.F.4    Manning, A.K.5    Cupples, L.A.6    Estus, S.7
  • 74
    • 84875259926 scopus 로고    scopus 로고
    • A common polymorphism in the LDL receptor gene has multiple effects on LDL receptor function
    • F. Gao, H.E. Ihn, M.W. Medina, and R.M. Krauss A common polymorphism in the LDL receptor gene has multiple effects on LDL receptor function Hum Mol Genet 22 7 2013 1424 1431
    • (2013) Hum Mol Genet , vol.22 , Issue.7 , pp. 1424-1431
    • Gao, F.1    Ihn, H.E.2    Medina, M.W.3    Krauss, R.M.4
  • 75
    • 79955758640 scopus 로고    scopus 로고
    • Coordinately regulated alternative splicing of genes involved in cholesterol biosynthesis and uptake
    • M.W. Medina, F. Gao, D. Naidoo, L.L. Rudel, R.E. Temel, and A.L. McDaniel et al. Coordinately regulated alternative splicing of genes involved in cholesterol biosynthesis and uptake PLoS ONE 6 4 2011 e19420
    • (2011) PLoS ONE , vol.6 , Issue.4 , pp. 19420
    • Medina, M.W.1    Gao, F.2    Naidoo, D.3    Rudel, L.L.4    Temel, R.E.5    McDaniel, A.L.6
  • 76
    • 79960698030 scopus 로고    scopus 로고
    • Genetic variability within the cholesterol lowering pathway and the effectiveness of statins in reducing the risk of MI
    • B.J. Peters, H. Pett, O.H. Klungel, B.H. Stricker, B.M. Psaty, and N.L. Glazer et al. Genetic variability within the cholesterol lowering pathway and the effectiveness of statins in reducing the risk of MI Atherosclerosis 217 2 2011 458 464
    • (2011) Atherosclerosis , vol.217 , Issue.2 , pp. 458-464
    • Peters, B.J.1    Pett, H.2    Klungel, O.H.3    Stricker, B.H.4    Psaty, B.M.5    Glazer, N.L.6
  • 77
    • 33646382116 scopus 로고    scopus 로고
    • The C.43-44insCTG variation in PCSK9 is associated with low plasma LDL-cholesterol in a Caucasian population
    • P. Yue, M. Averna, X. Lin, and G. Schonfeld The c.43-44insCTG variation in PCSK9 is associated with low plasma LDL-cholesterol in a Caucasian population Hum Mutat 27 5 2006 460 466
    • (2006) Hum Mutat , vol.27 , Issue.5 , pp. 460-466
    • Yue, P.1    Averna, M.2    Lin, X.3    Schonfeld, G.4
  • 78
    • 84866029049 scopus 로고    scopus 로고
    • Leucine 10 allelic variant in signal peptide of PCSK9 increases the LDL cholesterol-lowering effect of statins in patients with familial hypercholesterolaemia
    • L. Pisciotta, R. Sallo, C. Rabacchi, A. Wunsch, S. Calandra, and S. Bertolini Leucine 10 allelic variant in signal peptide of PCSK9 increases the LDL cholesterol-lowering effect of statins in patients with familial hypercholesterolaemia Nutr Metab Cardiovasc Dis 22 10 2012 831 835
    • (2012) Nutr Metab Cardiovasc Dis , vol.22 , Issue.10 , pp. 831-835
    • Pisciotta, L.1    Sallo, R.2    Rabacchi, C.3    Wunsch, A.4    Calandra, S.5    Bertolini, S.6
  • 79
    • 84861092119 scopus 로고    scopus 로고
    • Post-transcriptional regulation of lipoprotein receptors by the E3-ubiquitin ligase inducible degrader of the low-density lipoprotein receptor
    • V. Sorrentino, and N. Zelcer Post-transcriptional regulation of lipoprotein receptors by the E3-ubiquitin ligase inducible degrader of the low-density lipoprotein receptor Curr Opin Lipidol 23 3 2012 213 219
    • (2012) Curr Opin Lipidol , vol.23 , Issue.3 , pp. 213-219
    • Sorrentino, V.1    Zelcer, N.2
  • 81
    • 38349118892 scopus 로고    scopus 로고
    • Association of the Trp719Arg polymorphism in kinesin-like protein 6 with myocardial infarction and coronary heart disease in 2 prospective trials: The CARE and WOSCOPS trials
    • O.A. Iakoubova, C.H. Tong, C.M. Rowland, T.G. Kirchgessner, B.A. Young, and A.R. Arellano et al. Association of the Trp719Arg polymorphism in kinesin-like protein 6 with myocardial infarction and coronary heart disease in 2 prospective trials: the CARE and WOSCOPS trials J Am Coll Cardiol 51 4 2008 435 443
    • (2008) J Am Coll Cardiol , vol.51 , Issue.4 , pp. 435-443
    • Iakoubova, O.A.1    Tong, C.H.2    Rowland, C.M.3    Kirchgessner, T.G.4    Young, B.A.5    Arellano, A.R.6
  • 82
    • 38349171836 scopus 로고    scopus 로고
    • Polymorphism in KIF6 gene and benefit from statins after acute coronary syndromes: Results from the PROVE IT-TIMI 22 study
    • O.A. Iakoubova, M.S. Sabatine, C.M. Rowland, C.H. Tong, J.J. Catanese, and K. Ranade et al. Polymorphism in KIF6 gene and benefit from statins after acute coronary syndromes: results from the PROVE IT-TIMI 22 study J Am Coll Cardiol 51 4 2008 449 455
    • (2008) J Am Coll Cardiol , vol.51 , Issue.4 , pp. 449-455
    • Iakoubova, O.A.1    Sabatine, M.S.2    Rowland, C.M.3    Tong, C.H.4    Catanese, J.J.5    Ranade, K.6
  • 83
    • 82955247864 scopus 로고    scopus 로고
    • Lack of association between the Trp719Arg polymorphism in kinesin-like protein-6 and cardiovascular risk and efficacy of atorvastatin among subjects with diabetes on dialysis: The 4D study
    • M.M. Hoffmann, W. Marz, B. Genser, C. Drechsler, and C. Wanner Lack of association between the Trp719Arg polymorphism in kinesin-like protein-6 and cardiovascular risk and efficacy of atorvastatin among subjects with diabetes on dialysis: the 4D study Atherosclerosis 219 2 2011 659 662
    • (2011) Atherosclerosis , vol.219 , Issue.2 , pp. 659-662
    • Hoffmann, M.M.1    Marz, W.2    Genser, B.3    Drechsler, C.4    Wanner, C.5
  • 84
    • 84855953137 scopus 로고    scopus 로고
    • KIF6, LPA, TAS2R50, and VAMP8 genetic variation, low density lipoprotein cholesterol lowering response to pravastatin, and heart disease risk reduction in the elderly
    • H. Akao, E. Polisecki, K. Kajinami, S. Trompet, M. Robertson, and I. Ford et al. KIF6, LPA, TAS2R50, and VAMP8 genetic variation, low density lipoprotein cholesterol lowering response to pravastatin, and heart disease risk reduction in the elderly Atherosclerosis 220 2 2012 456 462
    • (2012) Atherosclerosis , vol.220 , Issue.2 , pp. 456-462
    • Akao, H.1    Polisecki, E.2    Kajinami, K.3    Trompet, S.4    Robertson, M.5    Ford, I.6
  • 85
    • 78049327781 scopus 로고    scopus 로고
    • Lack of association between the Trp719Arg polymorphism in kinesin-like protein-6 and coronary artery disease in 19 case-control studies
    • T.L. Assimes, H. Holm, S. Kathiresan, M.P. Reilly, G. Thorleifsson, and B.F. Voight et al. Lack of association between the Trp719Arg polymorphism in kinesin-like protein-6 and coronary artery disease in 19 case-control studies J Am Coll Cardiol 56 19 2010 1552 1563
    • (2010) J Am Coll Cardiol , vol.56 , Issue.19 , pp. 1552-1563
    • Assimes, T.L.1    Holm, H.2    Kathiresan, S.3    Reilly, M.P.4    Thorleifsson, G.5    Voight, B.F.6
  • 86
    • 84870924855 scopus 로고    scopus 로고
    • Meta-analyses of KIF6 Trp719Arg in coronary heart disease and statin therapeutic effect
    • P. Peng, J. Lian, R.S. Huang, L. Xu, Y. Huang, and Y. Ba et al. Meta-analyses of KIF6 Trp719Arg in coronary heart disease and statin therapeutic effect PLoS ONE 7 12 2012 e50126
    • (2012) PLoS ONE , vol.7 , Issue.12 , pp. 50126
    • Peng, P.1    Lian, J.2    Huang, R.S.3    Xu, L.4    Huang, Y.5    Ba, Y.6
  • 87
    • 84902781240 scopus 로고    scopus 로고
    • Providing patients with pharmacogenetic test results affects adherence to statin therapy: Results of the Additional KIF6 Risk Offers Better Adherence to Statins (AKROBATS) trial
    • S.L. Charland, B.C. Agatep, V. Herrera, B. Schrader, F.W. Frueh, and M. Ryvkin et al. Providing patients with pharmacogenetic test results affects adherence to statin therapy: results of the Additional KIF6 Risk Offers Better Adherence to Statins (AKROBATS) trial Pharmacogenomics J 2013
    • (2013) Pharmacogenomics J
    • Charland, S.L.1    Agatep, B.C.2    Herrera, V.3    Schrader, B.4    Frueh, F.W.5    Ryvkin, M.6
  • 88
    • 80053498680 scopus 로고    scopus 로고
    • Replication of LDL GWAs hits in PROSPER/PHASE as validation for future (pharmaco)genetic analyses
    • S. Trompet, A.J. de Craen, I. Postmus, I. Ford, N. Sattar, and M. Caslake et al. Replication of LDL GWAs hits in PROSPER/PHASE as validation for future (pharmaco)genetic analyses BMC Med Genet 12 2011 131
    • (2011) BMC Med Genet , vol.12 , pp. 131
    • Trompet, S.1    De Craen, A.J.2    Postmus, I.3    Ford, I.4    Sattar, N.5    Caslake, M.6
  • 89
    • 77951533290 scopus 로고    scopus 로고
    • Genome-wide association of lipid-lowering response to statins in combined study populations
    • M.J. Barber, L.M. Mangravite, C.L. Hyde, D.I. Chasman, J.D. Smith, and C.A. McCarty et al. Genome-wide association of lipid-lowering response to statins in combined study populations PLoS ONE 5 3 2010 e9763
    • (2010) PLoS ONE , vol.5 , Issue.3 , pp. 9763
    • Barber, M.J.1    Mangravite, L.M.2    Hyde, C.L.3    Chasman, D.I.4    Smith, J.D.5    McCarty, C.A.6
  • 90
    • 84860271201 scopus 로고    scopus 로고
    • Genome-wide association study of genetic determinants of LDL-c response to atorvastatin therapy: Importance of Lp(a)
    • H.A. Deshmukh, H.M. Colhoun, T. Johnson, P.M. McKeigue, D.J. Betteridge, and P.N. Durrington et al. Genome-wide association study of genetic determinants of LDL-c response to atorvastatin therapy: importance of Lp(a) J Lipid Res 53 5 2012 1000 1011
    • (2012) J Lipid Res , vol.53 , Issue.5 , pp. 1000-1011
    • Deshmukh, H.A.1    Colhoun, H.M.2    Johnson, T.3    McKeigue, P.M.4    Betteridge, D.J.5    Durrington, P.N.6
  • 91
    • 84885031446 scopus 로고    scopus 로고
    • Robust association of the LPA locus with low-density lipoprotein cholesterol lowering response to statin treatment in a meta-analysis of 30 467 individuals from both randomized control trials and observational studies and association with coronary artery disease outcome during statin treatment
    • L.A. Donnelly, N.R. van Zuydam, K. Zhou, R. Tavendale, F. Carr, and A.H. Maitland-van der Zee et al. Robust association of the LPA locus with low-density lipoprotein cholesterol lowering response to statin treatment in a meta-analysis of 30 467 individuals from both randomized control trials and observational studies and association with coronary artery disease outcome during statin treatment Pharmacogenet Genomics 23 10 2013 518 525
    • (2013) Pharmacogenet Genomics , vol.23 , Issue.10 , pp. 518-525
    • Donnelly, L.A.1    Van Zuydam, N.R.2    Zhou, K.3    Tavendale, R.4    Carr, F.5
  • 92
    • 84875983072 scopus 로고    scopus 로고
    • Impact of common genetic variation on response to simvastatin therapy among 18 705 participants in the Heart Protection Study
    • J.C. Hopewell, S. Parish, A. Offer, E. Link, R. Clarke, and M. Lathrop et al. Impact of common genetic variation on response to simvastatin therapy among 18 705 participants in the Heart Protection Study Eur Heart J 34 13 2013 982 992
    • (2013) Eur Heart J , vol.34 , Issue.13 , pp. 982-992
    • Hopewell, J.C.1    Parish, S.2    Offer, A.3    Link, E.4    Clarke, R.5    Lathrop, M.6
  • 93
    • 82955173728 scopus 로고    scopus 로고
    • Genetic variants in the apolipoprotein(a) gene and coronary heart disease
    • Y. Li, M.M. Luke, D. Shiffman, and J.J. Devlin Genetic variants in the apolipoprotein(a) gene and coronary heart disease Circ Cardiovasc Genet 4 5 2011 565 573
    • (2011) Circ Cardiovasc Genet , vol.4 , Issue.5 , pp. 565-573
    • Li, Y.1    Luke, M.M.2    Shiffman, D.3    Devlin, J.J.4
  • 94
    • 84868370256 scopus 로고    scopus 로고
    • CYP7A1 polymorphism influences the LDL cholesterol-lowering response to atorvastatin
    • X.Y. Jiang, Q. Zhang, P. Chen, S.Y. Li, N.N. Zhang, and X.D. Chen et al. CYP7A1 polymorphism influences the LDL cholesterol-lowering response to atorvastatin J Clin Pharm Ther 37 6 2012 719 723
    • (2012) J Clin Pharm Ther , vol.37 , Issue.6 , pp. 719-723
    • Jiang, X.Y.1    Zhang, Q.2    Chen, P.3    Li, S.Y.4    Zhang, N.N.5    Chen, X.D.6
  • 95
    • 84877997203 scopus 로고    scopus 로고
    • Review of the cost effectiveness of pharmacogenetic-guided treatment of hypercholesterolaemia
    • M.J. Sorich, M.D. Wiese, R.L. O'Shea, and B. Pekarsky Review of the cost effectiveness of pharmacogenetic-guided treatment of hypercholesterolaemia Pharmacoeconomics 31 5 2013 377 391
    • (2013) Pharmacoeconomics , vol.31 , Issue.5 , pp. 377-391
    • Sorich, M.J.1    Wiese, M.D.2    O'Shea, R.L.3    Pekarsky, B.4
  • 96
    • 45549091043 scopus 로고    scopus 로고
    • Pharmacokinetic comparison of the potential over-The-Counter statins simvastatin, lovastatin, fluvastatin and pravastatin
    • DOI 10.2165/00003088-200847070-00003
    • P.J. Neuvonen, J.T. Backman, and M. Niemi Pharmacokinetic comparison of the potential over-the-counter statins lovastatin, fluvastatin and pravastatin Clin Pharmacokinet 47 7 2008 463 474 (Pubitemid 351861958)
    • (2008) Clinical Pharmacokinetics , vol.47 , Issue.7 , pp. 463-474
    • Neuvonen, P.J.1    Backman, J.T.2    Niemi, M.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.