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Volumn 164, Issue 7, 2011, Pages 1767-1779

The ABCG family of membrane-associated transporters: You don't have to be big to be mighty

Author keywords

ABC transporter; ABCG1; ABCG2; ABCG5; ABCG8; cancer multidrug resistance; lipid transport

Indexed keywords

ABACAVIR; ABC TRANSPORTER; ABC TRANSPORTER G; ABC TRANSPORTER G1; ABC TRANSPORTER G4; ABC TRANSPORTER G5; ABC TRANSPORTER G8; ANACETRAPIB; ANTINEOPLASTIC AGENT; APIGENIN; BIOCHANIN A; BREAST CANCER RESISTANCE PROTEIN; CIPROFLOXACIN; CYCLOSPORIN A; DALCETRAPIB; DAUNORUBICIN; DOXORUBICIN; ELACRIDAR; ERLOTINIB; ETOPOSIDE; GEFITINIB; METHOTREXATE; MITOXANTRONE; NELFINAVIR; PRAZOSIN; TACROLIMUS; TELMISARTAN; TOPOTECAN; TORCETRAPIB; UNCLASSIFIED DRUG; UNINDEXED DRUG;

EID: 80053436675     PISSN: 00071188     EISSN: 14765381     Source Type: Journal    
DOI: 10.1111/j.1476-5381.2010.01177.x     Document Type: Review
Times cited : (99)

References (108)
  • 1
    • 19644378841 scopus 로고    scopus 로고
    • Flavonoid structure-activity studies identify 6-prenylchrysin and tectochrysin as potent and specific inhibitors of breast cancer resistance protein ABCG2
    • DOI 10.1158/0008-5472.CAN-04-1817
    • Ahmed-Belkacem A, Pozza A, Munoz-Martinez F, Bates SE, Castanys S, Gamarro F, et al,. (2005). Flavonoid structure-activity studies identify 6-prenylchrysin and tectochrysin as potent and specific inhibitors of breast cancer resistance protein ABCG2. Cancer Res 65: 4852-4860. (Pubitemid 40740824)
    • (2005) Cancer Research , vol.65 , Issue.11 , pp. 4852-4860
    • Ahmed-Belkacem, A.1    Pozza, A.2    Munoz-Martinez, F.3    Bates, S.E.4    Castanys, S.5    Gamarro, F.6    Pietro, A.D.7    Perez-Victoria, J.M.8
  • 2
    • 0000890967 scopus 로고    scopus 로고
    • Potent and specific inhibition of the breast cancer resistance protein multidrug transporter in vitro and in mouse intestine by a novel analogue of fumitremorgin C
    • Allen JD, van Loevezijn A, Lakhai JM, van der Valk M, van Tellingen O, Reid G, et al,. (2002). Potent and specific inhibition of the breast cancer resistance protein multidrug transporter in vitro and in mouse intestine by a novel analogue of fumitremorgin C. Mol Cancer Ther 1: 417-425.
    • (2002) Mol Cancer Ther , vol.1 , pp. 417-425
    • Allen, J.D.1    Van Loevezijn, A.2    Lakhai, J.M.3    Van Der Valk, M.4    Van Tellingen, O.5    Reid, G.6
  • 3
    • 73949104784 scopus 로고    scopus 로고
    • ATP-binding cassette transporter G1 negatively regulates thymocyte and peripheral lymphocyte proliferation
    • Armstrong AJ, Gebre AK, Parks JS, Hedrick CC, (2010). ATP-binding cassette transporter G1 negatively regulates thymocyte and peripheral lymphocyte proliferation. J Immunol 184: 173-183.
    • (2010) J Immunol , vol.184 , pp. 173-183
    • Armstrong, A.J.1    Gebre, A.K.2    Parks, J.S.3    Hedrick, C.C.4
  • 4
    • 58149161560 scopus 로고    scopus 로고
    • Loci influencing lipid levels and coronary heart disease risk in 16 European population cohorts
    • Aulchenko YS, Ripatti S, Lindqvist I, Boomsma D, Heid IM, Pramstaller PP, et al,. (2009). Loci influencing lipid levels and coronary heart disease risk in 16 European population cohorts. Nat Genet 41: 47-55.
    • (2009) Nat Genet , vol.41 , pp. 47-55
    • Aulchenko, Y.S.1    Ripatti, S.2    Lindqvist, I.3    Boomsma, D.4    Heid, I.M.5    Pramstaller, P.P.6
  • 5
    • 0035929437 scopus 로고    scopus 로고
    • Promoter characterization and genomic organization of the human breast cancer resistance protein (ATP-binding cassette transporter G2) gene
    • DOI 10.1016/S0167-4781(01)00270-6, PII S0167478101002706
    • Bailey-Dell KJ, Hassel B, Doyle LA, Ross DD, (2001). Promoter characterization and genomic organization of the human breast cancer resistance protein (ATP-binding cassette transporter G2) gene. Biochim Biophys Acta 1520: 234-241. (Pubitemid 32868794)
    • (2001) Biochimica et Biophysica Acta - Gene Structure and Expression , vol.1520 , Issue.3 , pp. 234-241
    • Bailey-Dell, K.J.1    Hassel, B.2    Doyle L.Austin3    Ross, D.D.4
  • 6
    • 71749117559 scopus 로고    scopus 로고
    • Lessons learned from the Investigation of Lipid Level Management to Understand its Impact in Atherosclerosis Events (ILLUMINATE) trial
    • Barter P, (2009). Lessons learned from the Investigation of Lipid Level Management to Understand its Impact in Atherosclerosis Events (ILLUMINATE) trial. Am J Cardiol 104: 10E-15E.
    • (2009) Am J Cardiol , vol.104
    • Barter, P.1
  • 9
    • 23844530574 scopus 로고    scopus 로고
    • Oligomerization of the human ABC transporter ABCG2: Evaluation of the native protein and chimeric dimers
    • DOI 10.1021/bi0503807
    • Bhatia A, Schafer HJ, Hrycyna CA, (2005). Oligomerization of the Human ABC Transporter ABCG2: evaluation of the Native Protein and Chimeric Dimers. Biochemistry 44: 10893-10904. (Pubitemid 41153650)
    • (2005) Biochemistry , vol.44 , Issue.32 , pp. 10893-10904
    • Bhatia, A.1    Schafer, H.-J.2    Hrycyna, C.A.3
  • 10
    • 0016366624 scopus 로고
    • B-sitosterolemia and xanthomatosis. A newly described lipid storage disease in two sisters
    • Bhattacharya AK, Connor JE, (1974). b-sitosterolemia and xanthomatosis. A newly described lipid storage disease in two sisters. J Clin Invest 53: 1033-1043.
    • (1974) J Clin Invest , vol.53 , pp. 1033-1043
    • Bhattacharya, A.K.1    Connor, J.E.2
  • 11
    • 53149134712 scopus 로고    scopus 로고
    • Liver X receptor-mediated activation of reverse cholesterol transport from macrophages to feces in vivo requires ABCG5/G8
    • Calpe-Berdiel L, Rotllan N, Fievet C, Roig R, Blanco-Vaca F, Escola-Gil JC, (2008). Liver X receptor-mediated activation of reverse cholesterol transport from macrophages to feces in vivo requires ABCG5/G8. J Lipid Res 49: 1904-1911.
    • (2008) J Lipid Res , vol.49 , pp. 1904-1911
    • Calpe-Berdiel, L.1    Rotllan, N.2    Fievet, C.3    Roig, R.4    Blanco-Vaca, F.5    Escola-Gil, J.C.6
  • 13
    • 33750478648 scopus 로고    scopus 로고
    • Multiple drugbinding sites on the R482G isoform of the ABCG2 transporter
    • DOI 10.1038/sj.bjp.0706904, PII 0706904
    • Clark R, Kerr ID, Callaghan R, (2006). Multiple drugbinding sites on the R482G isoform of the ABCG2 transporter. Br J Pharmacol 149: 506-515. (Pubitemid 44658511)
    • (2006) British Journal of Pharmacology , vol.149 , Issue.5 , pp. 506-515
    • Clark, R.1    Kerr, I.D.2    Callaghan, R.3
  • 15
    • 77649133500 scopus 로고    scopus 로고
    • Pathways by which reconstituted high-density lipoprotein mobilizes free cholesterol from whole body and from macrophages
    • Cuchel M, Lund-Katz S, Llera-Moya M, Millar JS, Chang D, Fuki I, et al,. (2010). Pathways by which reconstituted high-density lipoprotein mobilizes free cholesterol from whole body and from macrophages. Arterioscler Thromb Vasc Biol 30: 526-532.
    • (2010) Arterioscler Thromb Vasc Biol , vol.30 , pp. 526-532
    • Cuchel, M.1    Lund-Katz, S.2    Llera-Moya, M.3    Millar, J.S.4    Chang, D.5    Fuki, I.6
  • 16
    • 77952911036 scopus 로고    scopus 로고
    • Fludarabine-based induction therapy does not overcome the negative effect of ABCG2 (BCRP) over-expression in adult acute myeloid leukemia patients
    • Damiani D, Tiribelli M, Michelutti A, Geromin A, Cavallin M, Fabbro D, et al,. (2010). Fludarabine-based induction therapy does not overcome the negative effect of ABCG2 (BCRP) over-expression in adult acute myeloid leukemia patients. Leuk Res 34: 942-945.
    • (2010) Leuk Res , vol.34 , pp. 942-945
    • Damiani, D.1    Tiribelli, M.2    Michelutti, A.3    Geromin, A.4    Cavallin, M.5    Fabbro, D.6
  • 17
    • 57049083981 scopus 로고    scopus 로고
    • Association of three genetic loci with uric acid concentration and risk of gout: A genome-wide association study
    • Dehghan A, Kottgen A, Yang Q, Hwang SJ, Kao WL, Rivadeneira F, et al,. (2008). Association of three genetic loci with uric acid concentration and risk of gout: a genome-wide association study. Lancet 372: 1953-1961.
    • (2008) Lancet , vol.372 , pp. 1953-1961
    • Dehghan, A.1    Kottgen, A.2    Yang, Q.3    Hwang, S.J.4    Kao, W.L.5    Rivadeneira, F.6
  • 18
    • 16844386327 scopus 로고    scopus 로고
    • N-linked glycosylation of the human ABC transporter ABCG2 on asparagine 596 is not essential for expression, transport activity, or trafficking to the plasma membrane
    • DOI 10.1021/bi0479858
    • Diop NK, Hrycyna CA, (2005). N-Linked glycosylation of the human ABC transporter ABCG2 on asparagine 596 is not essential for expression, transport activity, or trafficking to the plasma membrane. Biochemistry 44: 5420-5429. (Pubitemid 40489981)
    • (2005) Biochemistry , vol.44 , Issue.14 , pp. 5420-5429
    • Diop, N.K.1    Hrycyna, C.A.2
  • 19
    • 77954892297 scopus 로고    scopus 로고
    • Comparison of ATP-binding cassette transporter interactions with the tyrosine kinase inhibitors imatinib, nilotinib, and dasatinib
    • Dohse M, Scharenberg C, Shukla S, Robey RW, Volkmann T, Deeken JF, et al,. (2010). Comparison of ATP-binding cassette transporter interactions with the tyrosine kinase inhibitors imatinib, nilotinib, and dasatinib. Drug Metab Dispos 38: 1371-1380.
    • (2010) Drug Metab Dispos , vol.38 , pp. 1371-1380
    • Dohse, M.1    Scharenberg, C.2    Shukla, S.3    Robey, R.W.4    Volkmann, T.5    Deeken, J.F.6
  • 20
    • 27144483358 scopus 로고    scopus 로고
    • Identification of BCRP as transporter of benzo[a]pyrene conjugates metabolically formed in Caco-2 cells and its induction by Ah-receptor agonists
    • DOI 10.1093/carcin/bgi139
    • Ebert B, Seidel A, Lampen A, (2005). Identification of BCRP as transporter of benzo[a]pyrene conjugates metabolically formed in Caco-2 cells and its induction by Ah-receptor agonists. Carcinogenesis 26: 1754-1763. (Pubitemid 41487991)
    • (2005) Carcinogenesis , vol.26 , Issue.10 , pp. 1754-1763
    • Ebert, B.1    Seidel, A.2    Lampen, A.3
  • 21
    • 34047127402 scopus 로고    scopus 로고
    • Expression of ATP binding cassette-transporter ABCG1 prevents cell death by transporting cytotoxic 7β-hydroxycholesterol
    • DOI 10.1016/j.febslet.2007.03.038, PII S0014579307003067
    • Engel T, Kannenberg F, Fobker M, Nofer J-R, Bode G, Lueken A, et al,. (2007). Expression of ATP binding cassette-transporter ABCG1 prevents cell death by transporting cytotoxic 7beta-hydroxycholesterol. FEBS Lett 581: 1673-1680. (Pubitemid 46528932)
    • (2007) FEBS Letters , vol.581 , Issue.8 , pp. 1673-1680
    • Engel, T.1    Kannenberg, F.2    Fobker, M.3    Nofer, J.-R.4    Bode, G.5    Lueken, A.6    Assmann, G.7    Seedorf, U.8
  • 23
    • 70350244472 scopus 로고    scopus 로고
    • Genotypic effect of ABCG1 gene promoter -257T>G polymorphism on coronary artery disease severity in Japanese men
    • Furuyama S, Uehara Y, Zhang B, Baba Y, Abe S, Iwamoto T, et al,. (2009). Genotypic effect of ABCG1 gene promoter -257T>G polymorphism on coronary artery disease severity in Japanese men. J Atheroscler Thromb 16: 194-200.
    • (2009) J Atheroscler Thromb , vol.16 , pp. 194-200
    • Furuyama, S.1    Uehara, Y.2    Zhang, B.3    Baba, Y.4    Abe, S.5    Iwamoto, T.6
  • 28
    • 0348111456 scopus 로고    scopus 로고
    • ABCG5 and ABCG8 Are Obligate Heterodimers for Protein Trafficking and Biliary Cholesterol Excretion
    • DOI 10.1074/jbc.M310223200
    • Graf GA, Yu L, Li WP, Gerard R, Tuma PL, Cohen JC, et al,. (2003). ABCG5 and ABCG8 are obligate heterodimers for protein trafficking and biliary cholesterol excretion. J Biol Chem 278: 48275-48282. (Pubitemid 37523283)
    • (2003) Journal of Biological Chemistry , vol.278 , Issue.48 , pp. 48275-48282
    • Graf, G.A.1    Yu, L.2    Li, W.-P.3    Gerard, R.4    Tuma, P.L.5    Cohen, J.C.6    Hobbs, H.H.7
  • 29
    • 2642573588 scopus 로고    scopus 로고
    • Missense mutations in ABCG5 and ABCG8 disrupt heterodimerization and trafficking
    • DOI 10.1074/jbc.M402634200
    • Graf GA, Cohen JC, Hobbs HH, (2004). Missense mutations in ABCG5 and ABCG8 disrupt heterodimerization and trafficking. J Biol Chem 279: 24881-24888. (Pubitemid 38725357)
    • (2004) Journal of Biological Chemistry , vol.279 , Issue.23 , pp. 24881-24888
    • Graf, G.A.1    Cohen, J.C.2    Hobbs, H.H.3
  • 30
  • 31
    • 23044472581 scopus 로고    scopus 로고
    • Distribution of breast cancer resistance protein (BCRP/ABCG2) mRNA expression along the human GI tract
    • DOI 10.1016/j.bcp.2005.05.031, PII S0006295205003709
    • Gutmann H, Hruz P, Zimmermann C, Beglinger C, Drewe J, (2005). Distribution of breast cancer resistance protein (BCRP/ABCG2) mRNA expression along the human GI tract. Biochem Pharmacol 70: 695-699. (Pubitemid 41058704)
    • (2005) Biochemical Pharmacology , vol.70 , Issue.5 , pp. 695-699
    • Gutmann, H.1    Hruz, P.2    Zimmermann, C.3    Beglinger, C.4    Drewe, J.5
  • 32
    • 70350132811 scopus 로고    scopus 로고
    • Interaction of nilotinib, dasatinib and bosutinib with ABCB1 and ABCG2: Implications for altered anti-cancer effects and pharmacological properties
    • Hegedus C, Ozvegy-Laczka C, Apati A, Magocsi M, Nemet K, Orfi L, et al,. (2009). Interaction of nilotinib, dasatinib and bosutinib with ABCB1 and ABCG2: implications for altered anti-cancer effects and pharmacological properties. Br J Pharmacol 158: 1153-1164.
    • (2009) Br J Pharmacol , vol.158 , pp. 1153-1164
    • Hegedus, C.1    Ozvegy-Laczka, C.2    Apati, A.3    Magocsi, M.4    Nemet, K.5    Orfi, L.6
  • 33
    • 27744459366 scopus 로고    scopus 로고
    • Identification of intra- and intermolecular disulfide bridges in the multidrug resistance transporter ABCG2
    • DOI 10.1074/jbc.M502937200
    • Henriksen U, Fog JU, Litman T, Gether U, (2005). Identification of intra- and intermolecular disulfide bridges in the multidrug resistance transporter ABCG2. J Biol Chem 280: 36926-36934. (Pubitemid 41587775)
    • (2005) Journal of Biological Chemistry , vol.280 , Issue.44 , pp. 36926-36934
    • Henriksen, U.1    Fog, J.U.2    Litman, T.3    Gether, U.4
  • 34
    • 37549068911 scopus 로고    scopus 로고
    • The breast cancer resistance protein transporter ABCG2 is expressed in the human kidney proximal tubule apical membrane
    • Huls M, Brown CD, Windass AS, Sayer R, van den Heuvel JJ, Heemskerk S, et al,. (2008). The breast cancer resistance protein transporter ABCG2 is expressed in the human kidney proximal tubule apical membrane. Kidney Int 73: 220-225.
    • (2008) Kidney Int , vol.73 , pp. 220-225
    • Huls, M.1    Brown, C.D.2    Windass, A.S.3    Sayer, R.4    Van Den Heuvel, J.J.5    Heemskerk, S.6
  • 35
    • 66149145265 scopus 로고    scopus 로고
    • ABC-transporters are localized in caveolin-1-positive and reggie-1-negative and reggie-2-negative microdomains of the canalicular membrane in rat hepatocytes
    • Ismair MG, Hausler S, Stuermer CA, Guyot C, Meier PJ, Roth J, et al,. (2009). ABC-transporters are localized in caveolin-1-positive and reggie-1-negative and reggie-2-negative microdomains of the canalicular membrane in rat hepatocytes. Hepatology 49: 1673-1682.
    • (2009) Hepatology , vol.49 , pp. 1673-1682
    • Ismair, M.G.1    Hausler, S.2    Stuermer, C.A.3    Guyot, C.4    Meier, P.J.5    Roth, J.6
  • 36
    • 0038757689 scopus 로고    scopus 로고
    • Sterol transport by the human breast cancer resistance protein (ABCG2) expressed in Lactococcus lactis
    • DOI 10.1074/jbc.M301358200
    • Janvilisri T, Venter H, Shahi S, Reuter G, Balakrishnan L, van Veen HW, (2003). Sterol transport by the human breast cancer resistance protein (ABCG2) expressed in Lactococcus lactis. J Biol Chem 278: 20645-20651. (Pubitemid 36806364)
    • (2003) Journal of Biological Chemistry , vol.278 , Issue.23 , pp. 20645-20651
    • Janvilisri, T.1    Venter, H.2    Shahi, S.3    Reuter, G.4    Balakrishnan, L.5    Van Veen, H.W.6
  • 37
    • 77951229611 scopus 로고    scopus 로고
    • Bile acids stimulate ATP hydrolysis in the purified cholesterol transporter ABCG5/G8
    • Johnson BJ, Lee JY, Pickert A, Urbatsch IL, (2010). Bile acids stimulate ATP hydrolysis in the purified cholesterol transporter ABCG5/G8. Biochemistry 49: 3403-3411.
    • (2010) Biochemistry , vol.49 , pp. 3403-3411
    • Johnson, B.J.1    Lee, J.Y.2    Pickert, A.3    Urbatsch, I.L.4
  • 39
    • 75149135645 scopus 로고    scopus 로고
    • Multidrug efflux pumps: The structures of prokaryotic ATP-binding cassette transporter efflux pumps and implications for our understanding of eukaryotic P-glycoproteins and homologues
    • Kerr ID, Jones PM, George AM, (2010). Multidrug efflux pumps: the structures of prokaryotic ATP-binding cassette transporter efflux pumps and implications for our understanding of eukaryotic P-glycoproteins and homologues. FEBS J 277: 550-563.
    • (2010) FEBS J , vol.277 , pp. 550-563
    • Kerr, I.D.1    Jones, P.M.2    George, A.M.3
  • 40
    • 70349694160 scopus 로고    scopus 로고
    • Sonic hedgehog signaling proteins and ATP-binding cassette G2 are aberrantly expressed in diffuse large B-cell lymphoma
    • Kim JE, Singh RR, Cho-Vega JH, Drakos E, Davuluri Y, Khokhar FA, et al,. (2009). Sonic hedgehog signaling proteins and ATP-binding cassette G2 are aberrantly expressed in diffuse large B-cell lymphoma. Mod Pathol 22: 1312-1320.
    • (2009) Mod Pathol , vol.22 , pp. 1312-1320
    • Kim, J.E.1    Singh, R.R.2    Cho-Vega, J.H.3    Drakos, E.4    Davuluri, Y.5    Khokhar, F.A.6
  • 41
    • 10444239181 scopus 로고    scopus 로고
    • Localization of ABCG5 and ABCG8 proteins in human liver, gall bladder and intestine
    • Klett EL, Lee MH, Adams DB, Chavin KD, Patel SB, (2004). Localization of ABCG5 and ABCG8 proteins in human liver, gall bladder and intestine. BMC Gastroenterol 4: 21.
    • (2004) BMC Gastroenterol , vol.4 , pp. 21
    • Klett, E.L.1    Lee, M.H.2    Adams, D.B.3    Chavin, K.D.4    Patel, S.B.5
  • 45
    • 48249087016 scopus 로고    scopus 로고
    • Significant association of ABCG5 604Q and ABCG8 D19H polymorphisms with gallstone disease
    • Kuo KK, Shin SJ, Chen ZC, Yang YH, Yang JF, Hsiao PJ, (2008). Significant association of ABCG5 604Q and ABCG8 D19H polymorphisms with gallstone disease. Br J Surg 95: 1005-1011.
    • (2008) Br J Surg , vol.95 , pp. 1005-1011
    • Kuo, K.K.1    Shin, S.J.2    Chen, Z.C.3    Yang, Y.H.4    Yang, J.F.5    Hsiao, P.J.6
  • 52
    • 33750446035 scopus 로고    scopus 로고
    • Purification and 3D Structural Analysis of Oligomeric Human Multidrug Transporter ABCG2
    • DOI 10.1016/j.str.2006.08.014, PII S096921260600387X
    • McDevitt CA, Collins RF, Conway M, Modok S, Storm J, Kerr ID, et al,. (2006). Purification and 3D structural analysis of oligomeric human multidrug transporter ABCG2. Structure 14: 1623-1632. (Pubitemid 46107268)
    • (2006) Structure , vol.14 , Issue.11 , pp. 1623-1632
    • McDevitt, C.A.1    Collins, R.F.2    Conway, M.3    Modok, S.4    Storm, J.5    Kerr, I.D.6    Ford, R.C.7    Callaghan, R.8
  • 53
    • 49349089223 scopus 로고    scopus 로고
    • Is ATP binding responsible for initiating drug translocation by the multidrug transporter ABCG2?
    • McDevitt CA, Crowley E, Hobbs G, Starr KJ, Kerr ID, Callaghan R, (2008). Is ATP binding responsible for initiating drug translocation by the multidrug transporter ABCG2? FEBS J 275: 4354-4362.
    • (2008) FEBS J , vol.275 , pp. 4354-4362
    • McDevitt, C.A.1    Crowley, E.2    Hobbs, G.3    Starr, K.J.4    Kerr, I.D.5    Callaghan, R.6
  • 56
    • 33646409606 scopus 로고    scopus 로고
    • HDL from CETP-deficient subjects shows enhanced ability to promote cholesterol efflux from macrophages in an apoE- and ABCG1-dependent pathway
    • Matsuura F, Wang N, Chen W, Jiang XC, Tall AR, (2006). HDL from CETP-deficient subjects shows enhanced ability to promote cholesterol efflux from macrophages in an apoE- and ABCG1-dependent pathway. J Clin Invest 116: 1435-1442.
    • (2006) J Clin Invest , vol.116 , pp. 1435-1442
    • Matsuura, F.1    Wang, N.2    Chen, W.3    Jiang, X.C.4    Tall, A.R.5
  • 57
    • 33645108568 scopus 로고    scopus 로고
    • Breast cancer resistance protein (BCRP/ABCG2) transports fluoroquinolone antibiotics and affects their oral availability, pharmacokinetics, and milk secretion
    • Merino G, Alvarez AI, Pulido MM, Molina AJ, Schinkel AH, Prieto JG, (2006). Breast cancer resistance protein (BCRP/ABCG2) transports fluoroquinolone antibiotics and affects their oral availability, pharmacokinetics, and milk secretion. Drug Metab Dispos 34: 690-695.
    • (2006) Drug Metab Dispos , vol.34 , pp. 690-695
    • Merino, G.1    Alvarez, A.I.2    Pulido, M.M.3    Molina, A.J.4    Schinkel, A.H.5    Prieto, J.G.6
  • 58
    • 71449105303 scopus 로고    scopus 로고
    • Murine 12/15 lipoxygenase regulates ATP-binding cassette transporter G1 protein degradation through p38- and JNK2-dependent pathways
    • Nagelin MH, Srinivasan S, Nadler JL, Hedrick CC, (2009). Murine 12/15 lipoxygenase regulates ATP-binding cassette transporter G1 protein degradation through p38- and JNK2-dependent pathways. J Biol Chem 284: 31303-31314.
    • (2009) J Biol Chem , vol.284 , pp. 31303-31314
    • Nagelin, M.H.1    Srinivasan, S.2    Nadler, J.L.3    Hedrick, C.C.4
  • 59
    • 33744944548 scopus 로고    scopus 로고
    • Novel 5′ untranslated region variants of BCRP mRNA are differentially expressed in drug-selected cancer cells and in normal human tissues: Implications for drug resistance, tissue-specific expression, and alternative promoter usage
    • DOI 10.1158/0008-5472.CAN-05-4572
    • Nakanishi T, Bailey-Dell KJ, Hassel BA, Shiozawa K, Sullivan DM, Turner J, et al,. (2006). Novel 5′ untranslated region variants of BCRP mRNA are differentially expressed in drug-selected cancer cells and in normal human tissues: implications for drug resistance, tissue-specific expression, and alternative promoter usage. Cancer Res 66: 5007-5011. (Pubitemid 43844920)
    • (2006) Cancer Research , vol.66 , Issue.10 , pp. 5007-5011
    • Nakanishi, T.1    Bailey-Dell, K.J.2    Hassel, B.A.3    Shiozawa, K.4    Sullivan, D.M.5    Turner, J.6    Ross, D.D.7
  • 60
    • 33847068311 scopus 로고    scopus 로고
    • Total body ABCG1 expression protects against early atherosclerotic lesion development in mice
    • Out R, Hoekstra M, Meurs I, deVos P, Kuiper J, Van Eck M, et al,. (2007). Total body ABCG1 expression protects against early atherosclerotic lesion development in mice. Arterioscler Thromb Vasc Biol 27: 594-599.
    • (2007) Arterioscler Thromb Vasc Biol , vol.27 , pp. 594-599
    • Out, R.1    Hoekstra, M.2    Meurs, I.3    Devos, P.4    Kuiper, J.5    Van Eck, M.6
  • 63
    • 66849113786 scopus 로고    scopus 로고
    • MicroRNA-328 negatively regulates the expression of breast cancer resistance protein (BCRP/ABCG2) in human cancer cells
    • Pan YZ, Morris ME, Yu AM, (2009). MicroRNA-328 negatively regulates the expression of breast cancer resistance protein (BCRP/ABCG2) in human cancer cells. Mol Pharmacol 75: 1374-1379.
    • (2009) Mol Pharmacol , vol.75 , pp. 1374-1379
    • Pan, Y.Z.1    Morris, M.E.2    Yu, A.M.3
  • 64
    • 0142103471 scopus 로고    scopus 로고
    • The Role of Liver X Receptor-α in the Fatty Acid Regulation of Hepatic Gene Expression
    • DOI 10.1074/jbc.M307973200
    • Pawar A, Botolin D, Mangelsdorf DJ, Jump DB, (2003). The role of liver X receptor-alpha in the fatty acid regulation of hepatic gene expression. J Biol Chem 278: 40736-40743. (Pubitemid 37280889)
    • (2003) Journal of Biological Chemistry , vol.278 , Issue.42 , pp. 40736-40743
    • Pawar, A.1    Botolin, D.2    Mangelsdorf, D.J.3    Jump, D.B.4
  • 66
    • 0033966957 scopus 로고    scopus 로고
    • Fumitremorgin C reverses multidrug resistance in cells transfected with the breast cancer resistance protein
    • Rabindran SK, Ross DD, Doyle LA, Yang W, Greenberger LM, (2000). Fumitremorgin C reverses multidrug resistance in cells transfected with the breast cancer resistance protein. Cancer Res 60: 47-50. (Pubitemid 30058728)
    • (2000) Cancer Research , vol.60 , Issue.1 , pp. 47-50
    • Rabindran, S.K.1    Ross, D.D.2    Doyle, L.A.3    Yang, W.4    Greenberger, L.M.5
  • 68
    • 0037166261 scopus 로고    scopus 로고
    • Regulation of ATP-binding cassette sterol transporters ABCG5 and ABCG8 by the liver X receptors α and β
    • DOI 10.1074/jbc.M109927200
    • Repa JJ, Berge KE, Pomajzl C, Richardson JA, Hobbs H, Mangelsdorf DJ, (2002). Regulation of ATP-binding cassette sterol transporters ABCG5 and ABCG8 by the liver X receptors alpha and beta. J Biol Chem 277: 18793-18800. (Pubitemid 34952438)
    • (2002) Journal of Biological Chemistry , vol.277 , Issue.21 , pp. 18793-18800
    • Repa, J.J.1    Berge, K.E.2    Pomajzl, C.3    Richardson, J.A.4    Hobbs, H.5    Mangelsdorf, D.J.6
  • 69
    • 77951651875 scopus 로고    scopus 로고
    • The human breast cancer resistance protein (BCRP/ABCG2) shows conformational changes with mitoxantrone
    • Rosenberg MF, Bikadi Z, Chan J, Liu X, Ni Z, Cai X, et al,. (2010). The human breast cancer resistance protein (BCRP/ABCG2) shows conformational changes with mitoxantrone. Structure 18: 482-493.
    • (2010) Structure , vol.18 , pp. 482-493
    • Rosenberg, M.F.1    Bikadi, Z.2    Chan, J.3    Liu, X.4    Ni, Z.5    Cai, X.6
  • 70
    • 25444529284 scopus 로고    scopus 로고
    • The human ABCG1 gene: Identification of LXR response elements that modulate expression in macrophages and liver
    • DOI 10.1194/jlr.M500080-JLR200
    • Sabol SL, Brewer HB, Santamarina-Fojo S, (2005). The human ABCG1 gene: identification of LXR response elements that modulate expression in macrophages and liver. J Lipid Res 46: 2151-2167. (Pubitemid 41377467)
    • (2005) Journal of Lipid Research , vol.46 , Issue.10 , pp. 2151-2167
    • Sabol, S.L.1    Brewer Jr., H.B.2    Santamarina-Fojo, S.3
  • 71
    • 0021856672 scopus 로고
    • Increased plasma cholestanol and 5α-saturated plant sterol derivatives in subjects with sitosterolemia and xanthomatosis
    • Salen G, Kwiterovich PO, Jr, Shefer S, Tint GS, Horak I, Shore V, et al,. (1985). Increased plasma cholestanol and 5 alpha-saturated plant sterol derivatives in subjects with sitosterolemia and xanthomatosis. J Lipid Res 26: 203-209. (Pubitemid 15078100)
    • (1985) Journal of Lipid Research , vol.26 , Issue.2 , pp. 203-209
    • Salen, G.1    Kwiterovish Jr., P.O.2    Shefer, S.3
  • 73
    • 0030239673 scopus 로고    scopus 로고
    • Molecular cloning of a mammalian ABC transporter homologous to Drosophila white gene
    • Savary S, Denizot F, Luciani M-F, Mattei M-G, Chimini G, (1996). Molecular cloning of a mammalian ABC transporter homologous to Drosophila white gene. Mamm Genome 7: 673-676. (Pubitemid 126443504)
    • (1996) Mammalian Genome , vol.7 , Issue.9 , pp. 673-676
    • Savary, S.1    Denizot, F.2    Luciani, M.-F.3    Mattei, M.-G.4    Chimini, G.5
  • 75
    • 58149153296 scopus 로고    scopus 로고
    • Infusion of reconstituted high-density lipoprotein leds to acute changes in human atherosclerotic plaque
    • Shaw JA, Bobik A, Murphy A, Kanellakis P, Blombery P, Mukhamedova N, et al,. (2008). Infusion of reconstituted high-density lipoprotein leds to acute changes in human atherosclerotic plaque. Circ Res 103: 1084-1091.
    • (2008) Circ Res , vol.103 , pp. 1084-1091
    • Shaw, J.A.1    Bobik, A.2    Murphy, A.3    Kanellakis, P.4    Blombery, P.5    Mukhamedova, N.6
  • 76
    • 33746239676 scopus 로고    scopus 로고
    • The calcium channel blockers, 1,4-dihydropyridines, are substrates of the multidrug resistance-linked ABC drug transporter, ABCG2
    • DOI 10.1021/bi060552f
    • Shukla S, Robey RW, Bates SE, Ambudkar SV, (2006). The calcium channel blockers, 1,4-dihydropyridines, are substrates of the multidrug resistance-linked ABC drug transporter, ABCG2. Biochemistry 45: 8940-8951. (Pubitemid 44100690)
    • (2006) Biochemistry , vol.45 , Issue.29 , pp. 8940-8951
    • Shukla, S.1    Robey, R.W.2    Bates, S.E.3    Ambudkar, S.V.4
  • 80
    • 33845655480 scopus 로고    scopus 로고
    • Re-evaluation and functional classification of non-synonymous single nucleotide polymorphisms of the human ATP-binding cassette transporter ABCG2
    • DOI 10.1111/j.1349-7006.2006.00371.x
    • Tamura A, Wakabayashi K, Onishi Y, Takeda M, Ikegami Y, Sawada S, et al,. (2007). Re-evaluation and functional classification of non-synonymous single nucleotide polymorphisms of the human ATP-binding cassette transporter ABCG2. Cancer Sci 98: 231-239. (Pubitemid 44941876)
    • (2007) Cancer Science , vol.98 , Issue.2 , pp. 231-239
    • Tamura, A.1    Wakabayashi, K.2    Onishi, Y.3    Takeda, M.4    Ikegami, Y.5    Sawada, S.6    Tsuji, M.7    Matsuda, Y.8    Ishikawa, T.9
  • 82
    • 77952885753 scopus 로고    scopus 로고
    • Impaired development of atherosclerosis in Abcg1-/- Apoe-/- mice: Identification of specific oxysterols that both accumulate in ABCG1-/- ApoE-/- tissues and induce apoptosis
    • Tarling EJ, Bojanic DD, Tangirala RK, Wang X, Lovgren-Sandblom A, Lusis AJ, et al,. (2010). Impaired development of atherosclerosis in Abcg1-/- Apoe-/- mice: identification of specific oxysterols that both accumulate in ABCG1-/- ApoE-/- tissues and induce apoptosis. Arterioscler Thromb Vasc Biol 30: 1174-1180.
    • (2010) Arterioscler Thromb Vasc Biol , vol.30 , pp. 1174-1180
    • Tarling, E.J.1    Bojanic, D.D.2    Tangirala, R.K.3    Wang, X.4    Lovgren-Sandblom, A.5    Lusis, A.J.6
  • 83
    • 38049098102 scopus 로고    scopus 로고
    • ABCG1 and ABCG4 are co-expressed in neurons and astrocytes of the CNS and regulate cholesterol homeostasis trough SREBP-2
    • Tarr P, Edwards PA, (2008). ABCG1 and ABCG4 are co-expressed in neurons and astrocytes of the CNS and regulate cholesterol homeostasis trough SREBP-2. J Lipid Res 49: 169-182.
    • (2008) J Lipid Res , vol.49 , pp. 169-182
    • Tarr, P.1    Edwards, P.A.2
  • 86
    • 70350230378 scopus 로고    scopus 로고
    • Escape from hsa-miR-519c enables drug-resistant cells to maintain high expression of ABCG2
    • To KK, Robey RW, Knutsen T, Zhan Z, Ried T, Bates SE, (2009). Escape from hsa-miR-519c enables drug-resistant cells to maintain high expression of ABCG2. Mol Cancer Ther 8: 2959-2968.
    • (2009) Mol Cancer Ther , vol.8 , pp. 2959-2968
    • To, K.K.1    Robey, R.W.2    Knutsen, T.3    Zhan, Z.4    Ried, T.5    Bates, S.E.6
  • 88
    • 33845580066 scopus 로고    scopus 로고
    • ABCA1 and ABCG1 or ABCG4 act sequentially to remove cellular cholesterol and generate cholesterol-rich HDL
    • DOI 10.1194/jlr.M600218-JLR200
    • Vaughan AS, Oram JF, (2006). ABCA1 and ABCG1 or ABCG4 act sequentially to remove cellular cholesterol and generate cholesterol-rich HDL. J Lipid Res 47: 2433-2443. (Pubitemid 44936105)
    • (2006) Journal of Lipid Research , vol.47 , Issue.11 , pp. 2433-2443
    • Vaughan, A.M.1    Oram, J.F.2
  • 89
    • 37349015353 scopus 로고    scopus 로고
    • A functional steroid-binding element in an ATP-binding cassette multidrug transporter
    • DOI 10.1124/mol.108.038299
    • Velamakanni S, Janvilisri T, Shahi S, van Veen HW, (2008). A functional steroid-binding element in an ATP-binding cassette multidrug transporter. Mol Pharmacol 73: 12-17. (Pubitemid 350294192)
    • (2008) Molecular Pharmacology , vol.73 , Issue.1 , pp. 12-17
    • Velamakanni, S.1    Janvilisri, T.2    Shahi, S.3    Van Veen, H.W.4
  • 90
    • 0034640288 scopus 로고    scopus 로고
    • Human white/murine ABC8 mRNA levels are highly induced in lipid-loaded macrophages. A transcriptional role for specific oxysterols
    • DOI 10.1074/jbc.275.19.14700
    • Venkateswaran A, Repa JJ, Lobaccaro JM, Bronson A, Mangelsdorf DJ, Edwards PA, (2000). Human white/murine ABC8 mRNA levels are highly induced in lipid-loaded macrophages. A transcriptional role for specific oxysterols. J Biol Chem 275: 14700-14707. (Pubitemid 30339762)
    • (2000) Journal of Biological Chemistry , vol.275 , Issue.19 , pp. 14700-14707
    • Venkateswaran, A.1    Repa, J.J.2    Lobaccaro, J.-M.A.3    Bronson, A.4    Mangelsdorf, D.J.5    Edwards, P.A.6
  • 91
    • 52549087785 scopus 로고    scopus 로고
    • Cancer stem cells in solid tumours: Accumulating evidence and unresolved questions
    • Visvader JE, Lindeman GJ, (2008). Cancer stem cells in solid tumours: accumulating evidence and unresolved questions. Nat Rev Cancer 8: 755-768.
    • (2008) Nat Rev Cancer , vol.8 , pp. 755-768
    • Visvader, J.E.1    Lindeman, G.J.2
  • 92
    • 59049084011 scopus 로고    scopus 로고
    • Physiological and pharmacological roles of ABCG2 (BCRP): Recent findings in Abcg2 knockout mice
    • Vlaming ML, Lagas JS, Schinkel AH, (2009). Physiological and pharmacological roles of ABCG2 (BCRP): recent findings in Abcg2 knockout mice. Adv Drug Deliv Rev 61: 14-25.
    • (2009) Adv Drug Deliv Rev , vol.61 , pp. 14-25
    • Vlaming, M.L.1    Lagas, J.S.2    Schinkel, A.H.3
  • 93
    • 0141815941 scopus 로고    scopus 로고
    • Wild-type breast cancer resistance protein (BCRP/ABCG2) is a methotrexate polyglutamate transporter
    • Volk EL, Schneider E, (2003). Wild-type breast cancer resistance protein (BCRP/ABCG2) is a methotrexate polyglutamate transporter. Cancer Res 63: 5538-5543. (Pubitemid 37139875)
    • (2003) Cancer Research , vol.63 , Issue.17 , pp. 5538-5543
    • Volk, E.L.1    Schneider, E.2
  • 94
    • 34548686115 scopus 로고    scopus 로고
    • The sterol transporting heterodimer ABCG5/ABCG8 requires bile salts to mediate cholesterol efflux
    • DOI 10.1016/j.febslet.2007.08.052, PII S0014579307009283
    • Vrins C, Vink E, Vandenberghe KE, Frijters R, Seppen J, Groen AK, (2007). The sterol transporting heterodimer ABCG5/ABCG8 requires bile salts to mediate cholesterol efflux. FEBS Lett 581: 4616-4620. (Pubitemid 47418786)
    • (2007) FEBS Letters , vol.581 , Issue.24 , pp. 4616-4620
    • Vrins, C.1    Vink, E.2    Vandenberghe, K.E.3    Frijters, R.4    Seppen, J.5    Groen, A.K.6
  • 96
    • 33745029827 scopus 로고    scopus 로고
    • LXR-induced redistribution of ABCG1 to plasma membrane in macrophages enhances cholesterol mass efflux to HDL
    • DOI 10.1161/01.ATV.0000218998.75963.02, PII 0004360520060600000022
    • Wang N, Ranalletta M, Matsuura F, Peng F, Tall AR, (2006b). LXR-induced redistribution of ABCG1 to plasma membrane in macrophages enhances cholesterol mass efflux to HDL. Arterioscler Thromb Vasc Biol 26: 1310-1316. (Pubitemid 44305375)
    • (2006) Arteriosclerosis, Thrombosis, and Vascular Biology , vol.26 , Issue.6 , pp. 1310-1316
    • Wang, N.1    Ranalletta, M.2    Matsuura, F.3    Peng, F.4    Tall, A.R.5
  • 97
    • 42049122331 scopus 로고    scopus 로고
    • ATP-binding cassette transporters G1 and G4 mediate cholesterol and desmosterol efflux to HDL and regulate sterol accumulation in the brain
    • DOI 10.1096/fj.07-9944com
    • Wang N, Yvan-Charvet L, Lutjohann D, Mulder M, Vanmierlo T, Kim T-W, et al,. (2008). ATP-binding cassette transporters G1 and G4 mediate cholesterol and desmosterol efflux to HDL and regulate sterol accumulation in the brain. FASEB J 22: 1073-1082. (Pubitemid 351519962)
    • (2008) FASEB Journal , vol.22 , Issue.4 , pp. 1073-1082
    • Wang, N.1    Yvan-Charvet, L.2    Lutjohann, D.3    Mulder, M.4    Vanmierlo, T.5    Kim, T.-W.6    Tall, A.R.7
  • 98
    • 77955699082 scopus 로고    scopus 로고
    • Octamer 4 (Oct4) mediates chemotherapeutic drug resistance in liver cancer cells through a potential Oct4-AKT-ATP-binding cassette G2 pathway
    • Wang XQ, Ongkeko WM, Chen L, Yang ZF, Lu P, Chen KK, et al,. (2010). Octamer 4 (Oct4) mediates chemotherapeutic drug resistance in liver cancer cells through a potential Oct4-AKT-ATP-binding cassette G2 pathway. Hepatology 52: 528-539.
    • (2010) Hepatology , vol.52 , pp. 528-539
    • Wang, X.Q.1    Ongkeko, W.M.2    Chen, L.3    Yang, Z.F.4    Lu, P.5    Chen, K.K.6
  • 100
    • 77951031222 scopus 로고    scopus 로고
    • Interaction of angiotensin receptor type 1 blockers with ATP-binding cassette transporters
    • Weiss J, Sauer A, Divac N, Herzog M, Schwedhelm E, Boger RH, et al,. (2010). Interaction of angiotensin receptor type 1 blockers with ATP-binding cassette transporters. Biopharm Drug Dispos 31: 150-161.
    • (2010) Biopharm Drug Dispos , vol.31 , pp. 150-161
    • Weiss, J.1    Sauer, A.2    Divac, N.3    Herzog, M.4    Schwedhelm, E.5    Boger, R.H.6
  • 103
    • 41249100545 scopus 로고    scopus 로고
    • The 44-kDa Pim-1 kinase phosphorylates BCRP/ABCG2 and thereby promotes its multimerization and drug-resistant activity in human prostate cancer cells
    • Xie Y, Xu K, Linn DE, Yang X, Guo Z, Shimelis H, et al,. (2008). The 44-kDa Pim-1 kinase phosphorylates BCRP/ABCG2 and thereby promotes its multimerization and drug-resistant activity in human prostate cancer cells. J Biol Chem 283: 3349-3356.
    • (2008) J Biol Chem , vol.283 , pp. 3349-3356
    • Xie, Y.1    Xu, K.2    Linn, D.E.3    Yang, X.4    Guo, Z.5    Shimelis, H.6
  • 104
    • 2442520293 scopus 로고    scopus 로고
    • Characterization of Oligomeric Human Half-ABC Transporter ATP-binding Cassette G2
    • DOI 10.1074/jbc.M310785200
    • Xu J, Liu Y, Yang Y, Bates S, Zhang JT, (2004). Characterization of oligomeric human half-ABC transporter ATP-binding cassette G2. J Biol Chem 279: 19781-19789. (Pubitemid 38623417)
    • (2004) Journal of Biological Chemistry , vol.279 , Issue.19 , pp. 19781-19789
    • Xu, J.1    Liu, Y.2    Yang, Y.3    Bates, S.4    Zhang, J.-T.5
  • 105
    • 23244436716 scopus 로고    scopus 로고
    • Ezetimibe normalizes metabolic defects in mice lacking ABCG5 and ABCG8
    • DOI 10.1194/jlr.M500124-JLR200
    • Yu L, von Bergmann K, Lutjohann D, Hobbs HH, Cohen JC, (2005). Ezetimibe normalizes metabolic defects in mice lacking ABCG5 and ABCG8. J Lipid Res 46: 1739-1744. (Pubitemid 41099341)
    • (2005) Journal of Lipid Research , vol.46 , Issue.8 , pp. 1739-1744
    • Yu, L.1    Von Bergmann, K.2    Lutjohann, D.3    Hobbs, H.H.4    Cohen, J.C.5


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