Numerical simulation of local pharmacokinetics of a drug after intravascular delivery with an eluting stent

Journal of Drug Targeting

Volumn 10, Issue 6, 2002, Pages 507-513

  Sakharov, Dmitri V ^a   Kalachev, Leonid V ^b   Rijken, Dingeman C ^c  

^a UNIVERSITY OF MONTANA   (United States)

^b TNO   (Netherlands)

^c NONE

Author keywords

Binding; Computer modelling; Diffusion; Eluting stents; Local pharmacokinetics

Indexed keywords

BASIC FIBROBLAST GROWTH FACTOR; DEXAMETHASONE; HEPARIN; PACLITAXEL; POLYMER; TISSUE FACTOR PATHWAY INHIBITOR;

AREA UNDER THE CURVE; ARTICLE; BINDING AFFINITY; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; CORONARY STENT; DRUG BINDING; DRUG DELIVERY SYSTEM; DRUG DESIGN; DRUG DIFFUSION; DRUG DISPOSITION; DRUG RELEASE; DRUG RETENTION; DRUG TOXICITY; ELUTION; MATHEMATICAL COMPUTING; MATHEMATICAL MODEL; MEAN RESIDENCE TIME; PHARMACOKINETICS; PRIORITY JOURNAL; SIMULATION; VASCULAR TISSUE;

DRUG DELIVERY SYSTEMS; INFUSIONS, INTRAVENOUS; MODELS, BIOLOGICAL; MODELS, CHEMICAL; PHARMACEUTICAL PREPARATIONS; PHARMACOKINETICS; STENTS;

EID: 0036709520     PISSN: 1061186X     EISSN: None     Source Type: Journal    
DOI: 10.1080/1061186021000038382     Document Type: Article

References (22)

1. An, Y. and Hubbell, J.A. (2000) "Intraarterial protein delivery via intimally-adherent bilayer hydrogels", J. Controlled Release 64, 205-215.
2. Baron, J.H., Gershlick, A.H., Hogrefe, K., Armstrong, J., Holt, C.M., Aggarval, R.K., Azrin, M., Ezekowitz, M. and de Bono, D.P. (2000) "In vitro evaluation of c7E3-Fab (ReoPro™) eluting polymer-coated coronary stent", Cardiovasc. Res. 46, 585-594.
3. Creel, C.J., Lovich, M.A. and Edelman, E.R. (2000) "Arterial paclitaxel distribution and deposition", Circ. Res. 86, 879-884.
4. Fry, D.L. (1985) "Mathematical models of arterial transmural transport", Am. J. Physiol. 248, H240-H263.
5. Hofma, S.H., van Beusekom, H.M., Serruys, P.W. and van der Giessen, W.J. (2001) "Recent developments in coated stents", Curr. Interv. Cardiol. Rep. 3, 28-36.
6. Huang, Z.J. and Tarbell, J.M. (1997) "Numerical simulation of mass transfer in porous media of blood vessel walls", Am. J. Physiol. 273, H464-H477.
7. Hwang, Ch-W., Wu, D. and Edelman, E.R. (2001) "Physiological transport forces govern drug distribution for stent-based delivery", Circulation 104, 600-605.
8. Lincoff, M.A., Furst, J.G., Ellis, S.G., Tuch, R.G. and Topol, E.G. (1997) "Sustained local delivery of dexamethazone by a novel intravascular eluting stent to prevent restenosis in the porcine coronary injury model", J. Am. Coll. Cardiol. 29, 808-816.
9. Lovich, M.A. and Edelman, E.R. (1996a) "Tissue average binding and equilibrium distribution: an example with heparin in arterial tissues", Biophys. J. 70, 1553-1559.
10. Lovich, M.A. and Edelman, E.R. (1996b) "Computational simulations of local vascular heparin deposition and distribution", Am. J. Physiol. 271, H214-H224.
11. Mason, D.W. and Williams, A.F. (1980) "The kinetics of antibody binding to membrane antigens in solution and at the cell surface", Biochem. J. 187, 1-20.
12. McKenna, C.J., Holmes, D.R. and Schwartz, R.S. (1997) "Novel stents for prevention of restenosis", Trends Cardiovasc. Med. 7, 245-249.
13. McKenna, C.J., Camrud, A.R., Sangiori, G., Kwon, H.M., Edwards, W.D., Holmes, D.R. and Schwartz, R.S. (1998) "Fibrin-film stenting in a porcine coronary artery model: efficacy and safety compared with uncoated stents", J. Am. Coll. Cardiol. 6, 1434-1438.
14. Raman, V.K. and Edelman, E.R. (1998) "Coated stents: local pharmacology", Semin. Intervent. Cardiol. 3, 133-137.
15. Sakharov, D.V., Jie, A.F.H., Bekkers, M.E.A., Emeis, J.J. and Rijken, D.C. (2001a) "Polylysine as a vehicle for extracellular matrix-targeted local drug delivery, providing high accumulation and long-term retention within the vessel wall", Arterioscler. Thromb. Vasc. Biol. 21, 943-948.
16. Sakharov, D., Kalachev, L.V. and Rijken, D.C. (2001b) "Numerical simulation of local pharmacokinetics of a drug delivered with an eluting stent", Eur. Heart J. 22(Suppl.), 171, Abstract.
17. Slepjan, M.J. (1996) "Polymeric endoluminal gel paving: therapeutic hydrogel barriers and sustained drug delivery depots for local arterial wall biomanipulation", Semin. Intervent. Cardiol. 1, 103-116.
18. Stenberg, M. and Nygren, H. (1988) "Kinetics of antigen-antibody reactions at solid-liquid interfaces", J. Immunol. Methods 113, 3-15.
19. Wan, W.K., Lovich, M.A., Hwang, C.W. and Edelman, E.R. (1999) "Measurement of drug distribution in vascular tissue using quantitative fluorescence microscopy", J. Pharm. Sci. 88, 822-829.
20. Whelan, D.M., van Beusekom, H.M.M. and van der Giessen, W.J. (1998) "Mechanisms of drug loading and release kinetics", Semin. Intervent. Cardiol. 3, 127-131.
21. Wilensky, R.L., Mehdi, K., Sowinski, K.M., Baek, S.H. and March, K.L. (1999) "Increased intramural retention after local delivery of molecules with increased binding properties: implications for regional delivery of pharmacologic agents", J. Cardiovasc. Pharmacol. Therapeut. 4, 103-112.
22. Yang, L.-Y., St Pierre, J., Scherer, D.E., Lasala, J.M., Walsh, R.G. and Abendschein, D.R. (1999) "Comparison of methods of local delivery of tissue factor pathway inhibitor to balloon-injured arteries in rabbits", Coron. Artery. Dis. 10, 327-333.