Modelling drug elution from stents: Effects of reversible binding in the vascular wall and degradable polymeric matrix

Computer Methods in Biomechanics and Biomedical Engineering

Volumn 11, Issue 4, 2008, Pages 367-377

  Borghi, A ^a   Foa, E ^a   Balossino, R ^a   Migliavacca, F ^a   Dubini, G ^a  

^a Lab of Biol Structure Mechanics   (Italy)

Author keywords

Drug eluting stent; Finite element method; Numerical model; Reversible binding

Indexed keywords

ANTICOAGULANT AGENT; HEPARIN;

ARTICLE; BIOLOGICAL MODEL; BLOOD VESSEL PROSTHESIS; CHEMISTRY; COMPUTER SIMULATION; DRUG IMPLANT; EQUIPMENT; HUMAN; PATHOPHYSIOLOGY; RESTENOSIS; STENT;

ANTICOAGULANTS; BLOOD VESSEL PROSTHESIS; COMPUTER SIMULATION; CORONARY RESTENOSIS; DRUG IMPLANTS; EQUIPMENT FAILURE ANALYSIS; HEPARIN; HUMANS; MODELS, CARDIOVASCULAR; STENTS;

EID: 51649124468     PISSN: 10255842     EISSN: 14768259     Source Type: Journal    
DOI: 10.1080/10255840801887555     Document Type: Article

References (21)

1. Balakrishnan, B., Tzafriri, AR, Seifert, P., Groothuis, A., Rogers, C. and Edelman, ER (2005) Strut position, blood flow and drug deposition: implications for single and overlapping drug-eluting stents. Circulation 111, pp. 2958-2965.
2. Creel, CJ, Lovich, MA and Edelman, ER (2000) Arterial paclitaxel distribution and deposition. Circ Res 86, pp. 879-884.
3. Fattori, R. and Piva, T. (2003) Drug-eluting stents in vascular intervention. Lancet 361, pp. 247-249.
4. Faxon, P. (2002) Systemic drug therapy for restenosis: 'Deja vu all over again'. Circulation 106, pp. 2296-2298.
5. Hose, DR, Narracott, AJ, Griffiths, B., Mahmood, S., Gunn, J., Sweeney, D. and Lawford, PV (2004) A thermal analogy for modelling drug elution from cardiovascular stents. Comput Methods Biomech Biomed Eng 7, pp. 257-264.
6. Hwang, CW and Edelman, ER (2002) Arterial ultrastructure influences transport of locally delivered drugs. Circ Res 90, pp. 826-832.
7. Hwang, CW, Wu, D. and Edelman, ER (2001) Physiological transport forces govern drug distribution for stent-based delivery. Circulation 104, pp. 600-605.
8. Levin, AD, Vukmirovic, N., Hwang, CW and Edelman, ER (2004) Specific binding to intracellular proteins determines arterial transport properties for rapamycin and paclitaxel. Proc Natl Acad Sci USA 101, pp. 9463-9467.
9. Lovich, MA and Edelman, ER (1996) Computational simulations of local vascular heparin deposition and distribution. Am J Physiol 271, pp. H2014-H2024.
10. Lovich, MA, Philbrook, M., Sawyer, S., Weselcouch, E. and Edelman, ER (1998) Arterial heparin deposition: role of diffusion, convection and extravascular space. Am J Physiol 275, pp. H2236-H2242.
11. Lovich, MA, Creel, C., Hong, K., Hwang, CW and Edelman, ER (2001) Carrier proteins determine local pharmacokinetics and arterial distribution of paclitaxel. J Pharm Sci 90, pp. 1324-1335.
12. Mason, DW and Williams, AF (1980) The kinetics of antibody binding to membrane antigens in solution and at the cell surface. Biochem J 187, pp. 1-20.
13. Migliavacca, F., Gervaso, F., Prosi, M., Zunino, P., Minisini, S., Formaggia, L. and Dubini, G. (2007) Expansion and drug elution model of a coronary stent. Comput Methods Biomech Biomed Eng 10, pp. 63-73.
14. Moses, JW, Stone, GW, Nikolsky, E., Mintz, GS, Dangas, G., Grube, E., Ellis, SG, Lansky, AJ, Weisz, G. Fahy, M. et al. (2006) Drug-eluting stents in the treatment of intermediate lesions: pooled analysis from four randomized trials. J Am Coll Cardiol 47, pp. 2164-2171.
15. Sakharov, DV, Kalachev, LV and Rijken, DC (2002) Numerical simulation of local pharmacokinetics of a drug after intravascular delivery with an eluting stent. J Drug Target 10, pp. 507-514.
16. Salame, MY, Verheye, S., Crocker, IR, Chronos, NA, Robinson, KA and King IIIrd, SB (2001) Intracoronary radiation therapy. Eur Heart J 22, pp. 629-647.
17. Scheller, B., Grandt, A., Wnendt, S., Lorenz, G., Bohm, M. and Nickenig, G. (2005) Comparative study of tacrolimus and paclitaxel stent coating in the porcine coronary model. Z Kardiol 94, pp. 445-452.
18. Serruys, PW, Sianos, G., Abizaid, A., Aoki, J., den Heijer, P, Bonnier, H., Smits, P., McClean, D., Verheye, S. Belardi, J. et al. (2005) The effect of variable dose and release kinetics on neointimal hyperplasia using a novel paclitaxel-eluting stent platform: the paclitaxel in-stent controlled elution study (PISCES). J Am Coll Cardiol 46, pp. 253-260.
19. van der Hoeven, BL, Pires, NM, Warda, HM, Oemrawsingh, PV, van Vlijmen, BJ, Quax, PH, Schalij, MJ, van der Wall, EE and Jukema, JW (2005) Drug-eluting stents: results, promises and problems. Int J Cardiol 99, pp. 9-17.
20. Zhang, F., Fath, M., Marks, R. and Linhardt, RJ (2002) A highly stable covalent conjugated heparin biochip for heparin-protein interaction studies. Anal Biochem 304, pp. 271-273.
21. Zunino, P. (2004) Multidimensional pharmacokinetic models applied to the design of drug-eluting stents. Int J Cardiovasc Eng 4, pp. 181-191.