A novel way to tricyclic heteroaromatics; Thiazolo[5,4- b ]thieno[3,2- e ]pyridine derivatives

Synthesis (Germany)

Volumn 46, Issue 17, 2014, Pages 2317-2326

  Huang, Liye ^a   Yu, Ruina ^a   Leng, Ling ^b   Gong, Feng ^b   Zhu, Xinhai ^a   Wan, Yiqian ^a  

^a SUN YAT SEN UNIVERSITY   (China)

^b Beijing Institute of Blood Transfusion   (China)

Author keywords

catalysis; cyclization; heterocycles; Lewis acid; rearrangement

Indexed keywords

CATALYSIS; PYRIDINE; SCANDIUM COMPOUNDS; SYNTHESIS (CHEMICAL);

HETEROAROMATICS; HETEROCYCLES; LEWIS ACID; ONE-POT REACTION; PYRIDINE DERIVATIVES; REARRANGEMENT; REARRANGEMENT REACTIONS; TRIFLATES;

CYCLIZATION;

1 [4 [8 (2 CHLOROPHENYL) 6 ISOPROPYLTHIAZOLO[5,4 B]THIENO[3,2 E]PYRIDIN 2 YL]PHENYL]ETHANONE; 2 (4 CHLOROPHENYL) 6 ISOPROPYL 8 PHENYLTHIAZOLO[5,4 B]THIENO[3,2 E]PYRIDINE; 2,8 BIS(2 CHLOROPHENYL) 6 ISOPROPYLTHIAZOLO[5,4 B]THIENO[3,2 E]PYRIDINE; 4 [8 (2 CHLOROPHENYL) 6 ISOPROPYLTHIAZOLO[5,4 B]THIENO[3,2 E]PYRIDIN 2 YL]BENZONITRILE; 4 [8 (2 CHLOROPHENYL) 6 ISOPROPYLTHIAZOLO[5,4 B]THIENO[3,2 E]PYRIDIN 2 YL]PHENOL; 8 (2 CHLOROPHENYL) 2 (4 CHLOROPHENYL) 6 ISOPROPYLTHIAZOLO[5,4 B]THIENO[3,2 E]PYRIDINE; 8 (2 CHLOROPHENYL) 2 (FURAN 2 YL) 6 ISOPROPYLTHIAZOLO[5,4 B]THIENO[3,2 E]PYRIDINE; 8 (2 CHLOROPHENYL) 2 ISOBUTYL 6 ISOPROPYLTHIAZOLO[5,4 B]THIENO[3,2 E]PYRIDINE; 8 (2 CHLOROPHENYL) 6 ISOPROPYL 2 (4 ISOPROPYLPHENYL)THIAZOLO[5,4 B]THIENO[3,2 E]PYRIDINE; 8 (2 CHLOROPHENYL) 6 ISOPROPYL 2 (4 METHOXYPHENYL)THIAZOLO[5,4 B]THIENO[3,2 E]PYRIDINE; 8 (2 CHLOROPHENYL) 6 ISOPROPYL 2 (4 TOLYL)THIAZOLO[5,4 B]THIENO[3,2 E]PYRIDINE; 8 (2 CHLOROPHENYL) 6 ISOPROPYL 2 (THIOPHEN 2 YL)THIAZOLO[5,4 B]THIENO[3,2 E]PYRIDINE; 8 (2 CHLOROPHENYL) 6 ISOPROPYL 2 PHENYLTHIAZOLO[5,4 B]THIENO[3,2 E]PYRIDINE; 8 (2 CHLOROPHENYL) 6 ISOPROPYL 2 [4 (TRIFLUOROMETHYL)PHENY]THIAZOLO[5,4 B]THIENO[3,2 E]PYRIDINE; 8 (2 CHLOROPHENYL) 6 ISOPROPYLTHIAZOLO[5,4 B]THIENO[3,2 E]PYRIDINE; 8 (2 HLOROPHENYL) 2 (4 CHLOROPHENYL) 6 PHENYLTHIAZOLO[5,4 B]THIENO[3,2 E]PYRIDINE; ALDEHYDE; N METHYLPYRROLIDIN 2 ONE; PYRIDINE DERIVATIVE; SOLVENT; THIAZOLO[5,4 B]THIENO[3,2 E]PYRIDINE DERIVATIVE; TRICYCLIC AROMATIC COMPOUND; UNCLASSIFIED DRUG;

ARTICLE; CARBON NUCLEAR MAGNETIC RESONANCE; CONTROLLED STUDY; CRYSTAL STRUCTURE; CYTOTOXICITY TEST; HEK293 CELL LINE; MASS SPECTROMETRY; MTT ASSAY; ONE POT SYNTHESIS; PROCESS OPTIMIZATION; PROTON NUCLEAR MAGNETIC RESONANCE; SOLVENT EFFECT; STRUCTURE ACTIVITY RELATION; STRUCTURE ANALYSIS; THIN LAYER CHROMATOGRAPHY; X RAY DIFFRACTION; X RAY SINGLE CRYSTAL DIFFRACTION;

EID: 84906780113     PISSN: 00397881     EISSN: 1437210X     Source Type: Journal    
DOI: 10.1055/s-0033-1339138     Document Type: Article

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