Synthesis of 3-O-methylviridicatin analogues with improved anti-TNF-α properties

Bioorganic and Medicinal Chemistry Letters

Volumn 17, Issue 20, 2007, Pages 5523-5524

  Ribeiro, Nigel ^a   Tabaka, Helena ^a   Peluso, Jean ^a   Fetzer, Ludivine ^a   Nebigil, Can ^a   Dumont, Serge ^a   Muller, Christian D ^a   Désaubry, Laurent ^a  

^a UNIVERSITÉ DE STRASBOURG   (France)

Author keywords

Inflammation; TNF

Indexed keywords

3 O METHYLVIRIDICATIN DERIVATIVE; 4 PHENYL 3 METHYLTHIOQUINOLINONE; ANTIINFLAMMATORY AGENT; QUINOLINE DERIVATIVE; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG; VIRIDICATIN 3 METHYL ETHER;

ANTIINFLAMMATORY ACTIVITY; ARTICLE; CHEMICAL MODIFICATION; CONTROLLED STUDY; CYTOKINE RELEASE; DRUG IDENTIFICATION; DRUG STRUCTURE; DRUG SYNTHESIS; HUMAN; HUMAN CELL; STRUCTURE ACTIVITY RELATION;

CELLS, CULTURED; HUMANS; HYDROXYQUINOLINES; LEUKOCYTES; MOLECULAR STRUCTURE; QUINOLONES; STRUCTURE-ACTIVITY RELATIONSHIP; TUMOR NECROSIS FACTOR-ALPHA;

EID: 34548558652     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2007.08.036     Document Type: Article

References (11)

1. Palladino M.A., Bahjat F.R., Theodorakis E.A., and Moldawer L.L. Nat. Rev. Drug Disc. 2 (2003) 736
2. Desai S.B., and Furst D.E. Best Pract. Res. Clin. Rheumatol. 20 (2006) 757
3. Paul A.T., Gohil V.M., and Bhutani K.K. Drug Discovery Today 11 (2006) 725
4. Austin D.J., and Myers M.B. J. Chem. Soc. 1 (1964) 1197
5. Heguy A., Cai P., Meyn P., Houck D., Russo S., Michitsch R., Pearce C., Katz B., Bringmann G., Feineis D., Taylor D.L., and Tyms A.S. Antiviral Chem. Chemother. 9 (1998) 149
6. 13C NMR spectra and satisfactory elemental analyses.
7. Rehwald M., Gewald K., Lankau H.-J., and Unverferth K. Heterocycles 45 (1997) 483
8. Prezent M.A., and Dorokhov V.A. Russ. Chem. Bull. 52 (2003) 2454
9. Hewawasam P., Fan W., Knipe J., Moon SL., Boissard C.G., Gribkoff V.K., and Starrett Jr. J.E. Bioorg. Med. Chem. Lett. 12 (2002) 1779
10. Pinna G.F., Fiorucci M., Reimund J.M., Taquet N., Arondel Y., and Muller C.D. Biochem. Biophys. Res. Commun. 322 (2004) 778
11. Viehe H.G., Janousek Z., Merényi R., and Stella L. Acc. Chem. Res. 18 (1985) 148