Antineoplastic activity of the thiazolo[5,4-b]quinoline derivative D3CLP in K-562 cells is mediated through effector caspases activation

European Journal of Medicinal Chemistry

Volumn 46, Issue 6, 2011, Pages 2102-2108

  González Sánchez, Ignacio ^a   Solano, José D ^a   Loza Mejía, Marco A ^a   Olvera Vázquez, Susana ^a   Rodríguez Sotres, Rogelio ^a   Morán, Julio ^b   Lira Rocha, Alfonso ^a   Cerbón, Marco A ^a  

^a UNIVERSIDAD NACIONAL AUTÓNOMA DE MÉXICO   (Mexico)

^b INSTITUTO DE FISIOLOGÍA CELULAR   (Mexico)

Author keywords

9 (3 chloro)phenylamine 2 3 (diethylamine)propylamine thiazolo 5,4 b quinoline (D3CLP); Anti tumor activity; Cell death; Effector caspases; K 562 cells

Indexed keywords

9 [(3 CHLORO)PHENYLAMINE] 2 [3 (DIETHYLAMINE)PROPYLAMINE]THIAZOLO[5,4 B]QUINOLINE; ANTINEOPLASTIC AGENT; DNA; EFFECTOR CASPASE; PACLITAXEL; QUINOLINE DERIVATIVE; UNCLASSIFIED DRUG;

ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CANCER CELL CULTURE; CELL CYCLE ARREST; CELL STRAIN K 562; CHROMATIN CONDENSATION; CONTROLLED STUDY; CYTOTOXICITY; DNA FRAGMENTATION; DRUG POTENCY; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME ACTIVATION; FLOW CYTOMETRY; HISTOGRAM; HUMAN; HUMAN CELL; HUMAN CELL CULTURE; NICK END LABELING; PERIPHERAL BLOOD MONONUCLEAR CELL;

AMINOQUINOLINES; ANTINEOPLASTIC AGENTS; CASPASES; CELL CYCLE; CELL DEATH; CELL PROLIFERATION; CYSTEINE PROTEINASE INHIBITORS; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG SCREENING ASSAYS, ANTITUMOR; ENZYME ACTIVATION; HUMANS; K562 CELLS; MOLECULAR STRUCTURE; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP; THIAZOLES; TUMOR CELLS, CULTURED;

EID: 79955608057     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2011.02.063     Document Type: Article

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