Neuroimmune mechanisms of alcohol and drug addiction

International Review of Neurobiology

Volumn 118, Issue , 2014, Pages 1-12

  Cui, Changhai ^a   Shurtleff, David ^b   Harris, R Adron ^c  

^a NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM   (United States)

^b National Institutes of Health   (United States)

^c UNIVERSITY OF TEXAS AT AUSTIN   (United States)

Author keywords

Addiction; Alcohol; Chemokine; Cytokine; Drugs of abuse; Microglia; Neuroimmune; Neuroinflammation

Indexed keywords

CANNABIS; CHEMOKINE; CHEMOKINE RECEPTOR CXCR4; COCAINE; INTERLEUKIN 1BETA; INTERLEUKIN 6; METHAMPHETAMINE; OPIATE; STROMAL CELL DERIVED FACTOR 1; TUMOR NECROSIS FACTOR ALPHA; ALCOHOL DERIVATIVE; STREET DRUG; IBUDILAST; INTERLEUKIN 10; TOLL LIKE RECEPTOR;

ALCOHOLISM; ARTICLE; BEHAVIOR CHANGE; BRAIN FUNCTION; CYTOKINE PRODUCTION; DISEASE ASSOCIATION; DRUG DEPENDENCE; DRUG EXPOSURE; HUMAN; HYPOTHALAMUS HYPOPHYSIS ADRENAL SYSTEM; IMMUNOMODULATION; NERVE CELL DIFFERENTIATION; NERVOUS SYSTEM INFLAMMATION; NEUROENDOCRINE SYSTEM; NEUROIMMUNOLOGY; NEUROMODULATION; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION; SYNAPTIC TRANSMISSION; ANIMAL; CENTRAL NERVOUS SYSTEM; DRUG EFFECTS; GENE EXPRESSION REGULATION; IMMUNOLOGY; CANNABIS ADDICTION; COCAINE DEPENDENCE; INNATE IMMUNITY; METHAMPHETAMINE DEPENDENCE; MICROGLIA; NERVOUS SYSTEM DEVELOPMENT; NEUROTRANSMITTER RELEASE; OPIATE ADDICTION; WITHDRAWAL SYNDROME;

ALCOHOLS; ANIMALS; CENTRAL NERVOUS SYSTEM; GENE EXPRESSION REGULATION; HUMANS; NEUROIMMUNOMODULATION; SIGNAL TRANSDUCTION; STREET DRUGS;

EID: 84906776836     PISSN: 00747742     EISSN: None     Source Type: Book Series    
DOI: 10.1016/B978-0-12-801284-0.00001-4     Document Type: Chapter

References (78)

1. Alfonso-Loeches S., Pascual-Lucas M., Blanco A.M., Sanchez-Vera I., Guerri C. Pivotal role of TLR4 receptors in alcohol-induced neuroinflammation and brain damage. The Journal of Neuroscience 2010, 30:8285-8295.
2. Avital A., Goshen I., Kamsler A., Segal M., Iverfeldt K., Richter-Levin G., et al. Impaired interleukin-1 signaling is associated with deficits in hippocampal memory processes and neural plasticity. Hippocampus 2003, 13:826-834.
3. Bajo M., Madamba S.G., Roberto M., Blednov Y.A., Sagi V.N., Roberts E., et al. Innate immune factors modulate ethanol interaction with GABAergic transmission in mouse central amygdala. Brain, Behavior, and Immunity 2014, 40:191-202.
4. Beardsley P.M., Shelton K.L., Hendrick E., Johnson K.W. The glial cell modulator and phosphodiesterase inhibitor, AV411 (ibudilast), attenuates prime- and stress-induced methamphetamine relapse. European Journal of Pharmacology 2010, 637:102-108.
5. Bell R.L., Lopez M.F., Cui C., Egli M., Johnson K.W., Franklin K.M., et al. Ibudilast reduces alcohol drinking in multiple animal models of alcohol dependence. Addiction Biology 2013, [Epub ahead of print]. 10.1111/adb.12106.
6. Bilbo S.D., Schwarz J.M. The immune system and developmental programming of brain and behavior. Frontiers in Neuroendocrinology 2012, 33:267-286.
7. Bland S.T., Hutchinson M.R., Maier S.F., Watkins L.R., Johnson K.W. The glial activation inhibitor AV411 reduces morphine-induced nucleus accumbens dopamine release. Brain, Behavior, and Immunity 2009, 23:492-497.
8. Blednov Y.A., Bergeson S.E., Walker D., Ferreira V.M., Kuziel W.A., Harris R.A. Perturbation of chemokine networks by gene deletion alters the reinforcing actions of ethanol. Behavioural Brain Research 2005, 165:110-125.
9. Blednov Y.A., Ponomarev I., Geil C., Bergeson S., Koob G.F., Harris R.A. Neuroimmune regulation of alcohol consumption: Behavioral validation of genes obtained from genomic studies. Addiction Biology 2012, 17:108-120.
10. Boulanger L.M. Immune proteins in brain development and synaptic plasticity. Neuron 2009, 64:93-109.
11. Cali C., Marchaland J., Regazzi R., Bezzi P. SDF 1-alpha (CXCL12) triggers glutamate exocytosis from astrocytes on a millisecond time scale: Imaging analysis at the single-vesicle level with TIRF microscopy. Journal of Neuroimmunology 2008, 198:82-91.
12. Callewaere C., Banisadr G., Desarmenien M.G., Mechighel P., Kitabgi P., Rostene W.H., et al. The chemokine SDF-1/CXCL12 modulates the firing pattern of vasopressin neurons and counteracts induced vasopressin release through CXCR4. Proceedings of the National Academy of Sciences of the United States of America 2006, 103:8221-8226.
13. Callewaere C., Banisadr G., Rostene W., Parsadaniantz S.M. Chemokines and chemokine receptors in the brain: Implication in neuroendocrine regulation. Journal of Molecular Endocrinology 2007, 38:355-363.
14. Camarillo C., Kumar L.S., Bake S., Sohrabji F., Miranda R.C. Ethanol regulates angiogenic cytokines during neural development: Evidence from an in vitro model of mitogen-withdrawal-induced cerebral cortical neuroepithelial differentiation. Alcoholism, Clinical and Experimental Research 2007, 31:324-335.
15. Canetta S.E., Brown A.S. Prenatal infection, maternal immune activation, and risk for schizophrenia. Translational Neuroscience 2012, 3:320-327.
16. Chiamulera C., Epping-Jordan M.P., Zocchi A., Marcon C., Cottiny C., Tacconi S., et al. Reinforcing and locomotor stimulant effects of cocaine are absent in mGluR5 null mutant mice. Nature Neuroscience 2001, 4:873-874.
17. Coller J.K., Hutchinson M.R. Implications of central immune signaling caused by drugs of abuse: Mechanisms, mediators and new therapeutic approaches for prediction and treatment of drug dependence. Pharmacology and Therapeutics 2012, 134:219-245.
18. Crews F.T., Nixon K. Mechanisms of neurodegeneration and regeneration in alcoholism. Alcohol and Alcoholism 2009, 44:115-127.
19. Crews F.T., Qin L., Sheedy D., Vetreno R.P., Zou J. High mobility group box 1/Toll-like receptor danger signaling increases brain neuroimmune activation in alcohol dependence. Biological Psychiatry 2013, 73:602-612.
20. Crews F.T., Vetreno R.P. Addiction, adolescence, and innate immune gene induction. Frontiers in Psychiatry 2011, 2:19.
21. Dantzer R., O'Connor J.C., Freund G.G., Johnson R.W., Kelley K.W. From inflammation to sickness and depression: When the immune system subjugates the brain. Nature Reviews. Neuroscience 2008, 9:46-56.
22. Deverman B.E., Patterson P.H. Cytokines and CNS development. Neuron 2009, 64:61-78.
23. Ehrlich L.C., Hu S., Sheng W.S., Sutton R.L., Rockswold G.L., Peterson P.K., et al. Cytokine regulation of human microglial cell IL-8 production. Journal of Immunology 1998, 160:1944-1948.
24. Flatscher-Bader T., van der Brug M., Hwang J.W., Gochee P.A., Matsumoto I., Niwa S., et al. Alcohol-responsive genes in the frontal cortex and nucleus accumbens of human alcoholics. Journal of Neurochemistry 2005, 93:359-370.
25. Frank M.G., Watkins L.R., Maier S.F. Stress- and glucocorticoid-induced priming of neuroinflammatory responses: Potential mechanisms of stress-induced vulnerability to drugs of abuse. Brain, Behavior, and Immunity 2011, 25(Suppl. 1):S21-S28.
26. Gadient R.A., Otten U.H. Interleukin-6 (IL-6)-A molecule with both beneficial and destructive potentials. Progress in Neurobiology 1997, 52:379-390.
27. Garay P.A., McAllister A.K. Novel roles for immune molecules in neural development: Implications for neurodevelopmental disorders. Frontiers in Synaptic Neuroscience 2010, 2:136.
28. Guyon A., Nahon J.L. Multiple actions of the chemokine stromal cell-derived factor-1alpha on neuronal activity. Journal of Molecular Endocrinology 2007, 38:365-376.
29. Haroon E., Raison C.L., Miller A.H. Psychoneuroimmunology meets neuropsychopharmacology: Translational implications of the impact of inflammation on behavior. Neuropsychopharmacology 2012, 37:137-162.
30. Heinisch S., Kirby L.G. SDF-1alpha/CXCL12 enhances GABA and glutamate synaptic activity at serotonin neurons in the rat dorsal raphe nucleus. Neuropharmacology 2010, 58:501-514.
31. Hueston C.M., Deak T. The inflamed axis: The interaction between stress, hormones, and the expression of inflammatory-related genes within key structures comprising the hypothalamic-pituitary-adrenal axis. Physiology and Behavior 2014, 124:77-91.
32. Irwin M.R., Miller A.H. Depressive disorders and immunity: 20 years of progress and discovery. Brain, Behavior, and Immunity 2007, 21:374-383.
33. Kane C.J., Phelan K.D., Douglas J.C., Wagoner G., Johnson J.W., Xu J., et al. Effects of ethanol on immune response in the brain: Region-specific changes in adolescent versus adult mice. Alcoholism, Clinical and Experimental Research 2014, 38:384-391.
34. Kaul M., Ma Q., Medders K.E., Desai M.K., Lipton S.A. HIV-1 coreceptors CCR5 and CXCR4 both mediate neuronal cell death but CCR5 paradoxically can also contribute to protection. Cell Death and Differentiation 2007, 14:296-305.
35. Kettenmann H., Kirchhoff F., Verkhratsky A. Microglia: New roles for the synaptic stripper. Neuron 2013, 77:10-18.
36. Knapp D.J., Whitman B.A., Wills T.A., Angel R.A., Overstreet D.H., Criswell H.E., et al. Cytokine involvement in stress may depend on corticotrophin releasing factor to sensitize ethanol withdrawal anxiety. Brain, Behavior, and Immunity 2011, 25(Suppl. 1):S146-S154.
37. Koob G.F., Volkow N.D. Neurocircuitry of addiction. Neuropsychopharmacology 2010, 35:217-238.
38. Leclercq S., Cani P.D., Neyrinck A.M., Starkel P., Jamar F., Mikolajczak M., et al. Role of intestinal permeability and inflammation in the biological and behavioral control of alcohol-dependent subjects. Brain, Behavior, and Immunity 2012, 26:911-918.
39. Leclercq, S., De Saeger, C., Delzenne, N., de Timary, P., & Starkel, P. (2014). Role of inflammatory pathways, blood mononuclear cells, and Gut-derived bacterial products in alcohol dependence. Biological Psychiatry, pii: S0006-3223(14) 00097-3. [Epub ahead of print]. http://dx.doi.org/10.1016/j.biopsych.2014.02.003.
40. Liu L., Hutchinson M.R., White J.M., Somogyi A.A., Coller J.K. Association of IL-1B genetic polymorphisms with an increased risk of opioid and alcohol dependence. Pharmacogenetics and Genomics 2009, 19:869-876.
41. Liu J., Lewohl J.M., Harris R.A., Iyer V.R., Dodd P.R., Randall P.K., et al. Patterns of gene expression in the frontal cortex discriminate alcoholic from nonalcoholic individuals. Neuropsychopharmacology 2006, 31:1574-1582.
42. Liu J., Yang A.R., Kelly T., Puche A., Esoga C., June H.L., et al. Binge alcohol drinking is associated with GABAA alpha2-regulated Toll-like receptor 4 (TLR4) expression in the central amygdala. Proceedings of the National Academy of Sciences of the United States of America 2011, 108:4465-4470.
43. Lu M., Grove E.A., Miller R.J. Abnormal development of the hippocampal dentate gyrus in mice lacking the CXCR4 chemokine receptor. Proceedings of the National Academy of Sciences of the United States of America 2002, 99:7090-7095.
44. Lu L., Wang X., Wu P., Xu C., Zhao M., Morales M., et al. Role of ventral tegmental area glial cell line-derived neurotrophic factor in incubation of cocaine craving. Biological Psychiatry 2009, 66:137-145.
45. Marcos M., Pastor I., Gonzalez-Sarmiento R., Laso F.J. Interleukin-10 gene polymorphism is associated with alcoholism but not with alcoholic liver disease. Alcohol and Alcoholism 2008, 43:523-528.
46. Mayfield J., Ferguson L., Harris R.A. Neuroimmune signaling: A key component of alcohol abuse. Current Opinion in Neurobiology 2013, 23:513-520.
47. McGuire S.O., Ling Z.D., Lipton J.W., Sortwell C.E., Collier T.J., Carvey P.M. Tumor necrosis factor alpha is toxic to embryonic mesencephalic dopamine neurons. Experimental Neurology 2001, 169:219-230.
48. Miyamoto A., Wake H., Moorhouse A.J., Nabekura J. Microglia and synapse interactions: Fine tuning neural circuits and candidate molecules. Frontiers in Cellular Neuroscience 2013, 7:70.
49. Monje M.L., Toda H., Palmer T.D. Inflammatory blockade restores adult hippocampal neurogenesis. Science 2003, 302:1760-1765.
50. Mori F., Nistico R., Mandolesi G., Piccinin S., Mango D., Kusayanagi H., et al. Interleukin-1beta promotes long-term potentiation in patients with multiple sclerosis. Neuromolecular Medicine 2014, 16:38-51.
51. Mulligan M.K., Ponomarev I., Hitzemann R.J., Belknap J.K., Tabakoff B., Harris R.A., et al. Toward understanding the genetics of alcohol drinking through transcriptome meta-analysis. Proceedings of the National Academy of Sciences of the United States of America 2006, 103:6368-6373.
52. Munhoz C.D., Lepsch L.B., Kawamoto E.M., Malta M.B., Lima Lde S., Avellar M.C., et al. Chronic unpredictable stress exacerbates lipopolysaccharide-induced activation of nuclear factor-kappaB in the frontal cortex and hippocampus via glucocorticoid secretion. The Journal of Neuroscience 2006, 26:3813-3820.
53. Pannell M., Szulzewsky F., Matyash V., Wolf S.A., Kettenmann H. The subpopulation of microglia sensitive to neurotransmitters/neurohormones is modulated by stimulation with LPS, interferon-gamma, and IL-4. Glia 2014, 62:667-679.
54. Paolicelli R.C., Bolasco G., Pagani F., Maggi L., Scianni M., Panzanelli P., et al. Synaptic pruning by microglia is necessary for normal brain development. Science 2011, 333:1456-1458.
55. Parkhurst C.N., Yang G., Ninan I., Savas J.N., Yates J.R., Lafaille J.J., et al. Microglia promote learning-dependent synapse formation through brain-derived neurotrophic factor. Cell 2013, 155:1596-1609.
56. Pastor I.J., Laso F.J., Romero A., Gonzalez-Sarmiento R. Interleukin-1 gene cluster polymorphisms and alcoholism in Spanish men. Alcohol and Alcoholism 2005, 40:181-186.
57. Pribiag H., Stellwagen D. TNF-alpha downregulates inhibitory neurotransmission through protein phosphatase 1-dependent trafficking of GABA(A) receptors. The Journal of Neuroscience 2013, 33:15879-15893.
58. Pribiag H., Stellwagen D. Neuroimmune regulation of homeostatic synaptic plasticity. Neuropharmacology 2014, 78:13-22.
59. Qin L., He J., Hanes R.N., Pluzarev O., Hong J.S., Crews F.T. Increased systemic and brain cytokine production and neuroinflammation by endotoxin following ethanol treatment. Journal of Neuroinflammation 2008, 5:10.
60. Raghavendra V., Tanga F.Y., DeLeo J.A. Attenuation of morphine tolerance, withdrawal-induced hyperalgesia, and associated spinal inflammatory immune responses by propentofylline in rats. Neuropsychopharmacology 2004, 29:327-334.
61. Rivest S. Regulation of innate immune responses in the brain. Nature Reviews. Immunology 2009, 9:429-439.
62. Rogers J., Mastroeni D., Leonard B., Joyce J., Grover A. Neuroinflammation in Alzheimer's disease and Parkinson's disease: Are microglia pathogenic in either disorder?. International Review of Neurobiology 2007, 82:235-246.
63. Rostene W., Kitabgi P., Parsadaniantz S.M. Chemokines: A new class of neuromodulator?. Nature Reviews. Neuroscience 2007, 8:895-903.
64. Schafer D.P., Lehrman E.K., Kautzman A.G., Koyama R., Mardinly A.R., Yamasaki R., et al. Microglia sculpt postnatal neural circuits in an activity and complement-dependent manner. Neuron 2012, 74:691-705.
65. Schafer D.P., Lehrman E.K., Stevens B. The "quad-partite" synapse: Microglia-synapse interactions in the developing and mature CNS. Glia 2013, 61:24-36.
66. Sekine Y., Ouchi Y., Sugihara G., Takei N., Yoshikawa E., Nakamura K., et al. Methamphetamine causes microglial activation in the brains of human abusers. The Journal of Neuroscience 2008, 28:5756-5761.
67. Shatz C.J. MHC class I: An unexpected role in neuronal plasticity. Neuron 2009, 64:40-45.
68. Sorrells S.F., Caso J.R., Munhoz C.D., Sapolsky R.M. The stressed CNS: When glucocorticoids aggravate inflammation. Neuron 2009, 64:33-39.
69. Stellwagen D., Malenka R.C. Synaptic scaling mediated by glial TNF-alpha. Nature 2006, 440:1054-1059.
70. Stertz L., Magalhaes P.V., Kapczinski F. Is bipolar disorder an inflammatory condition? The relevance of microglial activation. Current Opinion in Psychiatry 2013, 26:19-26.
71. Terashvili M., Wu H.E., Schwasinger E.T., Hung K.C., Hong J.S., Tseng L.F. (+)-Morphine attenuates the (-)-morphine-produced conditioned place preference and the mu-opioid receptor-mediated dopamine increase in the posterior nucleus accumbens of the rat. European Journal of Pharmacology 2008, 587:147-154.
72. Thomas D.M., Kuhn D.M. Attenuated microglial activation mediates tolerance to the neurotoxic effects of methamphetamine. Journal of Neurochemistry 2005, 92:790-797.
73. Tiveron M.C., Rossel M., Moepps B., Zhang Y.L., Seidenfaden R., Favor J., et al. Molecular interaction between projection neuron precursors and invading interneurons via stromal-derived factor 1 (CXCL12)/CXCR4 signaling in the cortical subventricular zone/intermediate zone. The Journal of Neuroscience 2006, 26:13273-13278.
74. Trecki J., Unterwald E.M. Modulation of cocaine-induced activity by intracerebral administration of CXCL12. Neuroscience 2009, 161:13-22.
75. Tremblay M.E., Stevens B., Sierra A., Wake H., Bessis A., Nimmerjahn A. The role of microglia in the healthy brain. The Journal of Neuroscience 2011, 31:16064-16069.
76. Wake H., Moorhouse A.J., Miyamoto A., Nabekura J. Microglia: Actively surveying and shaping neuronal circuit structure and function. Trends in Neurosciences 2013, 36:209-217.
77. Whitman B.A., Knapp D.J., Werner D.F., Crews F.T., Breese G.R. The cytokine mRNA increase induced by withdrawal from chronic ethanol in the sterile environment of brain is mediated by CRF and HMGB1 release. Alcoholism, Clinical and Experimental Research 2013, 37:2086-2097.
78. Xanthos D.N., Sandkuhler J. Neurogenic neuroinflammation: Inflammatory CNS reactions in response to neuronal activity. Nature Reviews. Neuroscience 2014, 15:43-53.