Comparison of effects of anti-angiogenic agents in the zebrafish efficacy-toxicity model for translational anti-angiogenic drug discovery

Drug Design, Development and Therapy

Volumn 8, Issue , 2014, Pages 1107-1123

  Chimote, Geetanjali ^a   Sreenivasan, Jayasree ^a   Pawar, Nilambari ^a   Subramanian, Jyothi ^a   Sivaramakrishnan, Hariharan ^a   Sharma, Somesh ^a  

^a Piramal Enterprises Limited   (India)

Author keywords

Angiogenesis; Therapeutic window; VEGFR inhibitors; Zebrafish toxicity assay

Indexed keywords

ANGIOGENESIS INHIBITOR; AXITINIB; BEVACIZUMAB; CABOZANTINIB; COMBRETASTATIN; ERLOTINIB; FLAVOPIRIDOL; FUMAGILLOL CHLOROACETYLCARBAMATE; MOTESANIB; PAZOPANIB; PROTEIN KINASE INHIBITOR; REGORAFENIB; SEMAXANIB; SORAFENIB; SUNITINIB; SURAMIN; THALIDOMIDE; TIVOZANIB; VANDETANIB; VASCULOTROPIN INHIBITOR; VATALANIB; VASCULOTROPIN RECEPTOR;

ANGIOGENESIS; ANIMAL EXPERIMENT; ANIMAL TISSUE; ANTIANGIOGENIC ACTIVITY; ARTICLE; BLOOD VESSEL; CARDIOTOXICITY; CELL PROLIFERATION; CONCENTRATION (PARAMETERS); CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG EFFICACY; DRUG MECHANISM; DRUG POTENCY; DRUG RESEARCH; DRUG SAFETY; EMBRYO; EMBRYOTOXICITY; ENDOTHELIUM CELL; FEMALE; INTESTINE BLOOD VESSEL; JAW MALFORMATION; MALE; MORPHOLOGY; MORTALITY; NEUROTOXICITY; NONHUMAN; PERICARDITIS; PHENOTYPE; PREDICTION; STRUCTURE ACTIVITY RELATION; TERATOGENICITY; TOXICITY TESTING; TRANSLATIONAL RESEARCH; WOUND HEALING IMPAIRMENT; ZEBRA FISH; ANIMAL; ANIMAL MODEL; ANTAGONISTS AND INHIBITORS; COMPARATIVE STUDY; DRUG DESIGN; DRUG EFFECTS; EMBRYOLOGY; LD50; NEOPLASMS; NEOVASCULARIZATION, PATHOLOGIC; PATHOLOGY; PROCEDURES; VASCULARIZATION;

ANGIOGENESIS INHIBITORS; ANIMALS; CELL PROLIFERATION; DRUG DESIGN; LETHAL DOSE 50; MODELS, ANIMAL; NEOPLASMS; NEOVASCULARIZATION, PATHOLOGIC; RECEPTORS, VASCULAR ENDOTHELIAL GROWTH FACTOR; TOXICITY TESTS; TRANSLATIONAL MEDICAL RESEARCH; ZEBRAFISH;

EID: 84906734586     PISSN: None     EISSN: 11778881     Source Type: Journal    
DOI: 10.2147/DDDT.S55621     Document Type: Article

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