Drug testing with angiogenesis models

Expert Opinion on Drug Discovery

Volumn 3, Issue 5, 2008, Pages 533-549

  Norrby, Klas ^a  

^a UNIVERSITY OF GOTHENBURG   (Sweden)

Author keywords

Angiogenesis; Chick chorioallantoic membrane; Cornea; Immune cells; Inflammation; Mast cells; Matrigel; Mesentery; Metastasis; Models; Mouse; Nitric oxide; Quantification; Rat; Tissue injury; Tumor; Xenopus laevis; Zebrafish

Indexed keywords

ANGIOGENESIS INHIBITOR; BIOLOGICAL MARKER; MATRIGEL; MATRIX METALLOPROTEINASE; POLYMER; VASCULOTROPIN;

ANGIOGENESIS; ANTIANGIOGENIC ACTIVITY; ANTIANGIOGENIC THERAPY; ANTINEOPLASTIC ACTIVITY; ASSAY; CARCINOGENESIS; CELL ASSAY; CELL CULTURE; CELL INTERACTION; CHORIOALLANTOIC MEMBRANE ASSAY; CONTROLLED DRUG RELEASE; CORNEA; CORNEAL MICROPOCKET ASSAY; DRUG SCREENING; EMBRYO DEVELOPMENT; ENDOTHELIUM CELL; EXTRACELLULAR MATRIX; GENETIC ENGINEERING; HUMAN; IN VITRO STUDY; IN VIVO STUDY; INFLAMMATION; MATRIGEL PLUG ASSAY; MESENTERY ASSAY; NEOVASCULARIZATION (PATHOLOGY); NONHUMAN; PRIORITY JOURNAL; REVIEW; SYSTEMIC THERAPY; TADPOLE; TISSUE ENGINEERING; TUMOR MODEL; TUMOR VASCULARIZATION; VASCULAR RING; ZEBRA FISH;

EID: 44649162500     PISSN: 17460441     EISSN: None     Source Type: Journal    
DOI: 10.1517/17460441.3.5.533     Document Type: Review

References (119)

1. Folkman J. Tumor angiogenesis: therapeutic implications. N Engl J Med 1971;285:1182-6
2. National Cancer Institute (USA). Cancer Bull 2006;3(9)
3. Norrby K. Human apo-lactoferrin enhances angiogenesis mediated by vascular endothelial growth factor A in vivo. J Vasc Res 2004;41:293-304
4. Cao Y, Hong AN, Schulten H, et al. Update on therapeutic neovascularization. Cardiovasc Res 2005;65:639-48
5. Angiogenesis Modulators. A market insight report; January 2007. RI Technologies. Available from: www.researchimpact.com
6. Auerbach R. An overview of current angiogenesis assays: choice of assay, precautions in interpretation, future requirements and directions. In: Staton CA, Lewis C, Bicknell R, editors, Angiogenesis assays. Wiley: Chichester; 2006. p. 361-74
7. Nicosia RF, Ottinetti A. Growth of microvessels in serum-free matrix culture of rat aorta. Lab Invest 1990;63:115-22
8. Chau CH, Figg WD. Whole or partial vessel outgrowth assays. In: Staton CA, Lewis C, Bicknell R, editors, Angiogenesis assays. Wiley: Chichester; 2006. p. 105-21
9. Angelo LS, Kurzrock R. Vascular endothelial growth factor and its relationship to inflammatory mediators. Clin Cancer Res 2007;13:2825-30
10. Rega G, Kaun C, Demyanets S, et al. Vascular endothelial growth factor is induced by the inflammatory cytokines inerleukin-6 and oncostatin M in human adipose tissue in vitro and in murine adipose tissue in vivo. Arterioscler Thromb Vasc Biol 2007;27:1587-95
11. Soucek L, Lawlor ER, Soto D, et al. Mast cells are required for angiogenesis and macroscopic expansion of Myc-induced pancreatic islet tumors. Nat Med 2007;13:1211-8
12. Coussens LM, Werb Z. Inflammation and cancer. Nature 2002;420:860-7
13. Norrby K. Mast cells and angiogenesis. APMIS 2002;110:355-71
14. Johansson M, Tan T, De Visser KE, et al. Immune cells as anti-cancer therapeutic targets and tools. J Cell Biochem 2007;101:918-26
15. Kneilling M, Hültner L, Pichler BJ, et al. Targeted mast cell silencing protects against joint destruction and angiogenesis in experimental arthritis in mice. Arthritis Rheum 2007;56:1806-16
16. Norrby K, Wolley D. Role of mast cells in mitogenesis and angiogenesis in normal tissue and tumour tissue. Adv Biosci 1993;89:71-116
17. Norrby K. Angiogenesis: new aspects relating to its initiation and control. APMIS 1997;105:417-37
18. Lin EY, Pollard JW. Tumor-associated macrophages press the angiogenic switch in breast cancer. Cancer Res 2007;67:5064-6
19. Curiel TJ, Cheng P, Mottram P, et al. Dendritic cell subsets differentially regulate angiogenesis in human ovarian cancer. Cancer Res 2004;64:5535-8
20. Fainaru O, Adini A, Benny O, et al. Dendritic cells support angiogenesis and promote lesions growth in murine model of endometriosis. FASEB J 2008;22:522-9
21. Sozzani S, Rusnati M, Riboldi E, et al. Dendritic cell-endothelial cross-talk in angiogenesis. Trends Immunol 2007;28:385-92
22. Huwiler A, Döll F, Ren S, et al. Histamine increases sphingosine kinase-1 expression and activity in the human arterial endothelial cell line EA.hy 926 by as PKC-alpha-dependent mechanism. Biochim Biophys Acta 2006;367-76
23. Norrby K. Low-molecular-weight heparins and angiogenesis. APMIS 2006;114:79-102
24. Norrby K, Jakobsson A, Sörbo J. Mast-cell-mediated angiogenesis: a novel experimental model using the rat mesentery. Virchows Arch (Cell Pathol) 1986;52:195-206
25. Varayoud J, Ramos JG, Bosquiazzo VL, et al. Mast cells degranulation affects angiogenesis in the rat uterine cervix during pregnancy. Reproduction 2004;127:379-87
26. Weller K, Foitzik K, Paus R, et al. Mast cells are required for normal healing of skin wounds in mice. FASEB J 2006;20:E1628-35
27. Kinet J-P. The essential role of mast cells in orchestrating inflammation. Immunol Rev 2007;217:5-7
28. Kalluri R. Basement membranes: structure, assembly and role in tumour angiogenesis. Nature 2003;3:422-33
29. Hasan J, Slmyder SD, Bibby M, et al. Quantitative angiogenesis assays in vivo - a review. Angiogenesis 2004;7:1-16
30. Staton CA, Stribbling SM, Tazzyman S, et al. Current methods for assaying angiogenesis in vitro and in vivo. Int J Exp Pathol 2004;85:233-48
31. Norrby K. In vivo models of angiogenesis. J Cell Mol Med 2006;10:588-612
32. Zijlstra A, Mikolon D, Stupack DG. Angiogenesis assays in the chick. In: Staton CA, Lewis C, Bicknell R, editors, Angiogenesis assays. Wiley: Chichester; 2006. p. 183-201
33. Auerbach R, Kubai L, Knighton D, et al. A simple procedure for long-term cultivation of chicken embryos. Dev Biol 1974;41(2):391-4
34. Thompson WD, Campell R, Evans T. Fibrin degradation and angiogenesis: quantitative analysis of angiogenic response in the chick chorioallantoic membrane. J Pathol 1985;145:27-37
35. Splawinski J, Michna M, Palczak R, et al. Angiogenesis: quantitative assessment of the chick chorioallantoic membrane assay. Methods Find Exp Clin Pharmcol 1988;10:221-6
36. Brooks PC, Montgomery AM, Cheresh DA. Use of the 10-day-old chick embryo model for studying angiogenesis. Methods Mol Biol 1999;129:257-69
37. Kirchner LM, Schmidt SP, Gruber BS. Quantitation of angiogenesis in the chick choriollantoic membrane model using fractal analysis. Microvasc Res 1996:51:2-14
38. Auerbach R, Akhtar N, Lewis PL, et al. Angiogenesis assays: problems and pitfalls. Cancer Metastasis Rev 2000;19:167-72
39. Vargas A, Zeisse-labouèbe M, Lange N, et al. The chick embryo and its chorioallantoic membrane (CAM) for the in vivo evaluation of drug delivery systems. Adv Drug Del Rev 2007;59:1162-76
40. Ambati BK, Nozaki M, Singh N, et al. Corneal avascularity is due to soluble VEGF receptor-1. Nature 2006;443:993-7
41. Shan S, Dewhirst MW. Corneal angiogenesis assay. In: Staton CA, Lewis C, Bicknell R, editors, Angiogenesis assays. Wiley: Chichester, 2006. p. 203-28
42. Apple DJ, Naumann GOH, Mauthey RM. Microscopic anatomy of the eye. In: Naumann GOH, Apple DJ, editors, Pathology of the eye. Springer-Verlag: New York; 1985. p. 167-72
43. Ziche M, Alessandri G, Gullino PM. Gangliosides promote the angiogenic response. Lab Invest 1989;61:629-34
44. Gimbrone MA, Cotran RS, Leapman SB, et al. Tumor growth and neovascularization: an experimental model using the rabbit cornea. J Natl Cancer Inst 1974;52:413-27
45. Folkman J. Tumor angiogenesis: from bench to bedside. In: Marmé D, Fusenig N, editors, Tumor angiogenesis. Basic mechanisms and cancer therapy. Springer: Berlin; 2008. p. 2-28
46. Morbidelli L, Ziche M. The rat and the rabbit cornea assay. In: Maragoudakis ME, editor, Angiogenesis: models, modulators, and clinical applications. Plenum Press: New York; 1998. p. 39-45
47. Muthukkaruppan VR, Auerbach R. Angiogenesis in the mouse cornea. Science 1979;205:1416-8
48. Muthukkaruppan VR, Kubai L, Auerbach R. Tumor-induced neovascularization in the mouse eye. J Natl Cancer Inst 1982;69:699-708
49. Ziche M. Corneal assay for angiogenesis. In: Murray JC, editor, Methods in molecular medicine, Volume 46. Angiogenesis protocols. Humana Press: Totowa; 2001. p. 131-42
50. Norrby K, Jakobsson A, Sörbo J. Quantitative angiogenesis in spreads of intact rat mesenteric window. Microvasc Res 1990;39:341-8
51. Zeller PJ, Skalak TC, Ponce AM, et al. In vivo chemotactile properties and spatial expression of PDGF in developing mesenteric microvascular networks. Am J Physiol Heart Circ Physiol 2001;280:H2116-25
52. Norrby K, Enestrom S. Cellular and extracellular changes following mast-cell secretion in avascular rat mesentery. An electron-microscopic study. Cell Tissue Res 1984;235:339-45
53. Enerback L, Franzén L, Norrby K. A tissue model for the study of cell proliferation parameters in vivo. Histochemistry 1976;47:207-18
54. Norrby K, Enerback L, Franzén L. Mast cell activation and tissue cell proliferation. Cell Tissue Res 1976;170:289-303
55. Norrby K. Basic fibroblast growth factor and de novo mammalian angiogenesis. Microvasc Res 1994;48:96-113
56. 165-mediated angiogenesis in the rat. Int J Cancer 2001;91:236-40
57. Mukhopadhyay D, Nagy JA, Manseau EJ, et al. Vascular permeability factor/ vascular growth factor-mediated signaling in mouse mesentery vascular endothelium. Cancer Res 1998;58:1278-84
58. Norrby K. Vascular endothelial growth factor and de novo mamallian angiogenesis. Microvasc Res 1996;51:153-63
59. Albertsson P, Lennernas B, Norrby K. On metronomic chemotherapy: modulation of angiogenesis mediated by VEGF-A. Acta Oncol 2006;45:144-55
60. Norrby K. Microvascular density in terms of number and length of microvessel segments per unit tissue volume in mammalian angiogenesis. Microvasc Res 1998;55:43-53
61. 165-induced angiogenesis. APMIS 2000;108:29-37
62. 165-mediated mammalian angiogenesis. Int J Exp Pathol 2000;81:191-8
63. Rhodin JAG, Fujita H. Capillary growth in the mesentery of normal young rats. Intravital video and electron microscope analyses. J Submicrosc Cytol Pathol 1989;21:1-34
64. Nehls V, Denzer K, Drenckhalm D. Pericyte involvement in capillary sprouting during angiogenesis in situ. Cell Tissue Res 1992;270:469-74
65. Hansen-Smith FM, Joswiak GR, Baustert JL. Regional differences in spontaneously occurring angiogenesis in the adult rat mesentery. Microvasc Res 1994;47:369-76
66. Malinda KM. In vivo Matrigel migration and angiogenesis assays. In: Murray JC, editor, Methods in molecular medicine, Volume 46. Angiogenesis protocols. Humana Press: Totowa; 2001. p. 47-52
67. Auerbach R, Lewis R, Shinners B, et al. Angiogenesis assays: a critical overview. Clin Chem 2003;49:32-40
68. Passaniti A, Taylor RM, Pili R, et al. A simple, quantitative method for assessing angiogenesis and antiangiogenetic agents using reconstituted basement membrane, heparin, and fibroblast growth factor. Lab Invest 1992;67:519-28
69. Vukicevic S, Kleinman HK, Luyten FP, et al. Identification of multiple growth factors in basement membrane matrigel suggests caution in interpretation of cellular activity related to extracellular matrix components. Exp Cell Res 1992;202:1-8
70. Baatout S. Endothelial differentiation using Matrigel. Anticancer Res 1997;17:451-6
71. Anghelina M, Krislman P, Moldovan L, et al. Monocyte/macrophages cooperate with progenitor cells during neovascularization and tissue repair: conversion of cell columns into fibrovascular bundles. Am J Pathol 2006;168:529-41
72. Baker JHE, Huxman LA, Kyle AH, et al. Vascular-specific quantification in an in vivo Matrigel chamber angiogenesis assay. Microvasc Res 2006;71:69-75
73. Kragh M, Hjarnaa PJ, Bramm E, et al. In vivo chamber angiogenesis assay: an optimized Matrigel plug assay for fast assessment of anti-angiogenic activity. Int J Oncol 2003;22:305-11
74. Ley CD, Olsen MW, Lund EL, et al. Angiogenic synergy of bFGF and VEGF is antagonized by angiopoietin-2 in a modified in vivo Matrigel assay. Microvasc Res 2004;68:161-8
75. Andrade S, Ferreira MAND, FAN T-P. Implantation of sponges and polymers. In: Staton CA, Lewis C, Bicknell R, editors, Angiogenesis assays. Wiley: Chichester; 2006. p. 167-82
76. Serbedzija GN, Flynn E, Willett CE. Zebrafish angiogenesis: a new model for drug screening. Angiogenesis 1999;3:353-9
77. Mills Shaw KR, Weinstein BM. Techniques and advances in vascular imaging in Danio rerio. In: Staton CA, Lewis C, Bicknell R, editors, Angiogenetis assays. Wiley: Chichester; 2006. p. 311-26
78. Ny A, Koch, M, Schneider M, et al. A genetic Xenopus laevis tadpole model to study lymphangiogenesis. Nat Med 2005;11:998-1004
79. Ny A, Autiero M, Carmeliet P. Zebrafish and Xenopus tadpoles: small animal models to study angiogenesis and lymphangiogenesis. Exp Cell Res 2006;312:684-93
80. Ober EA, Olofsson B, Mäkinen T, et al. Vegfc is required for vascular development and endoderm morphogenesis in zebrafish. EMBO 2004; 5:78-84
81. Chen E, Stringer SE, Rusch MA, et al. A unique role for 6-O sulfation modification in zebrafish vascular development. Dev Biol 2005;284:364-76
82. Kajimura S, Aida K, Duan C. Understanding hypoxia-induced gene expression in early development: in vitro and in vivo analysis of hypoxia-inducible factor 1-regulated zebrafish insulin-like growth factor binding protein 1 gene expression. Mol Cell Biol 2006;26:1142-55
83. Ekker SC. Morphants: a new systematic vertebrate function genomics approach. Yeast 2000;17:302-6
84. Lee P, Goishi K, Davidson AJ, et al. Neuropillin-1 is required for vascular development and is a mediator of VEGF-dependent angiogenesis in zebrafish. Proc Natl Acad Sci USA 2002;99:10470-5
85. Weis SM. Evaluating integrin function in models of angiogenesis and vascular permeability. Integrin Methods Enzymol 2007;426:505-28
86. Hillen F, Melotte V, Van Beijnum JR, et al. Endothelial cell biology. In: Staton CA, Lewis C, Bicknell R, editors, Angiogenesis assays. Wiley: Chichester; 2006. p. 1-38
87. StCroix B, Rago C, Velculescu V, et al. Genes expressed in human tumor endothelium. Science 2000;289:1197-202
88. Baker CH, Fidler IJ. Tumor microenvironment and angiogenesis. In: Davis DW, Herbst RS, Abbruzzese JL, editors, Angiogenic cancer therapy. CRC Press: London; 2008. p. 131-47
89. Sikder H, Huso DL, Zhang H, et al. Disruption of Id1 reveals major differences in angiogenesis between transplanted and autochthonous tumors. Cancer Cell 2003;4:291-9
90. Lang SA, Stoeltzing O. Tumour models: analysis of angiogenesis in vivo. In: Staton CA, Lewis C, Bicknell R, editors, Angiogenesis assays. Wiley: Chichester; 2006. p. 265-91
91. Hendrix MJC, Seftor EA, Seftor RE, et al. Reprogramming metastatic tumour cells with embryonic microenvironments. Nat Rev 2007;7:246-55
92. Hanahan D, Christofori C, Naik P, et al. Transgenic mouse models of tumour angiogenesis: the angiogenic switch, its molecular controls, and prospects for preclinical therapeutic models. Eur J Cancer 1996;32A:2386-93
93. Kuperwasser C, Chavarria T, Wu M, et al. Reconstruction of functionally normal and malignant human breast tissues in mice. Proc Natl Acad Sci USA 2004;101:4966-71
94. Hlatky L, Hahnfeldt P, Folkman J. Clinical application of antiangiogenic therapy: microvessel density, what it does and doesn't tell us. J Natl Cancer Inst 2002;94:883-93
95. Fishman SJ, Feins NR, D'amato RJ, et al. Long-term remission of Crohn's disease treated with thalidomide: a seminal case report. Angiogenesis 1999;3:201-4
96. Chidlow JH, Shukla D, Grisham MB, et al. Pathogenic angiogenesis in IBD and experimental colitis: new ideas and therapeutic avenues. Am J Physiol Gastrointest Liver Physiol 2007;293:G5-18
97. Folkman J. Angiogenesis: an organizing principle for drug discovery? Nat Rev Drug Discov 2007;6:273-86
98. Italiano JE, Richardson JL, Patel-Hett S, et al. Angiogenesis is regulated by a novel mechanism: pro- and antiangiogenic proteins are organized into separate platelet (alpha) granules and differentially released. Blood 2008;111:1227-33
99. Shaked Y, Bertolini F, Man S, et al. Genetic heterogeneity of the vasculogenic phenotype parallels angiogenesis: implications of cellular surrogate 97 marker analysis of antiangiogenesis. Cancer Cell 2005;7:101-11
100. Zurita AJ, Wu H-K, Heymach JV. Blood-based biomarkers for VEGF inhibitors. In: Davis DW, Herbst RS, Abbruzzese JL, editors, Angiogenic cancer therapy. CRC Press: London; 2008. p. 517-31
101. Cervi D, Yip TT, Bhattacharya N, et al. Platelet-associated PF-4 as a biomarker of early tumor growth. Blood 2008;111:1201-7
102. 2A receptor agonists and endotoxin involves transcriptional regulation via the hypoxia response element in the VEGF promoter. Mol Biol Cell 2007;18:14-23
103. Mattsby-Baltzer I, Jakobsson A, Sorbo J, Norrby K. Endotoxin is angiogenic. Int J Exp Path 1994;75:191-6
104. Ausprunk DH, Knighton DR, Folkman J. Differentiation of vascular endothelium in the chick chorioallantois: a structural and autoradiographic study. Dev Biol 1974;38:237-48
105. Nicoli S, Ribatti D, Cotelli, Presta M. Mammalian tumor xenografts induce neovascularization in zebrafish embryos. Cancer Res 2007;67:2927-31
106. Pipili-Synetos E, Sakkoula E, Maragoudakis ME. Nitric oxide is involved in the regulation of angiogenesis. Br J Pharmacol 1993;108:855-7
107. Ziche M, Marbidelli L, Masini E, et al. Nitric oxide mediates angiogenesis in vivo and endothelial cell growth and migration in vitro promoted by substance P. J Clin Invest 1994;94:2036-44
108. 1 in rabbit cornea. Adv Prostagl Thromb Leukotr Res 1995;23:495-7
109. Ziche M, Morbidelli L, Choudhuri R, et al. Nitric oxide synthase lies downstream from vascular endothelial growth factor-induced but not basic fibroblast growth factor-induced angiogenesis. J Clin Invest 1997;99:2625-34
110. Gallo O, Masini E, Morbidelli L, et al. Role of nitric oxide in angiogenesis and tumor progression in head and neck cancer. J Natl Cancer Inst 1998;90:587-96
111. 165-mediated angiogenesis in natively vascularized mammalian tissue. APMIS 1998;106:1142-8
112. Sennlaub F, Courtois Y, Goureau O. Nitric oxide synthase-II is expresses in severe corneal alkali burns and inhibits neavascularization. Invest Ophthalmol Vis Sci 1999;40:2773-9
113. Norrby K. Oral administration of a nitric oxide synthase inhibitor enhances de novo mammalian angiogenesis mediated by TNF-alpha, saline and mast-cell secretion. APMIS 2000;108:496-502
114. Norrby K. Constitutively synthesized nitric oxide is a physiological negative regulator of mammalian angiogenesis mediated by basic fibroblast growth factor. Int J Exp Path 2000;81:423-7
115. Pipili-Synetos E, Kritikou S, Papadimitriou E, et al. Nitric oxide synthase expression, enzyme activity and NO production during angiogenesis in the chick chorioallantoic membrane. Br J Pharmacol 2000;129:207-13
116. (G)-nitro-L-arginine methyl ester retards vascular sprouting in angiogenesis. Microvasc Res 2003;65:2-8
117. Morbidelli L, Donnini S, Ziche M. Role of nitric oxide in tumor angiogenesis. Cancer Treat Res 2004;117:155-67
118. Powell Jr JA, Mousa SA. Neutrophil-activating protein-2- and interleukin-8-mediated angiogenesis. J Cell Biochem 2007;102:412-20
119. Rohan RM, Fernandez A, Udagawa T, et al. Genetic heterogeneity of angiogenesis in mice. FASEB J 2000;14:871-6