Trafficking-deficient G572R-hERG and E637K-hERG activate stress and clearance pathways in endoplasmic reticulum

PLoS ONE

Volumn 7, Issue 1, 2012, Pages

  Wang, Ying ^a   Huang, Xiaoyan ^a   Zhou, Jianqing ^a   Yang, Xi ^a   Li, Di ^a   Mao, Haiyan ^a   Sun, Huan Huan ^b   Liu, Ningsheng ^c   Lian, Jiangfang ^a  

^a NINGBO UNIVERSITY   (China)

^b UNIVERSITY OF ROCHESTER MEDICAL CENTER   (United States)

^c NANJING MEDICAL UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

CALNEXIN; CALRETICULIN; COMPLEMENTARY DNA; POTASSIUM CHANNEL HERG; PROTEASOME; PROTEASOME INHIBITOR; UBIQUITIN; ACTIVATING TRANSCRIPTION FACTOR 6; ERG1 POTASSIUM CHANNEL; MUTANT PROTEIN;

ARTICLE; CELL LINE; CELL STRAIN HEK293; CELL STRAIN U2OS; CELLULAR DISTRIBUTION; CLEARANCE; CONFOCAL MICROSCOPY; CONTROLLED STUDY; ENDOPLASMIC RETICULUM STRESS; IMMUNOFLUORESCENCE; IMMUNOPRECIPITATION; MOLECULAR CLONING; PLASMID; PROTEIN DEGRADATION; PROTEIN EXPRESSION; PROTEIN INTERACTION; WESTERN BLOTTING; AMINO ACID SUBSTITUTION; DRUG ANTAGONISM; ENDOPLASMIC RETICULUM; GENETICS; GLYCOSYLATION; HUMAN; METABOLISM; PROTEIN BINDING; PROTEIN TRANSPORT; SIGNAL TRANSDUCTION; TUMOR CELL LINE;

MAMMALIA;

ACTIVATING TRANSCRIPTION FACTOR 6; AMINO ACID SUBSTITUTION; CALNEXIN; CALRETICULIN; CELL LINE, TUMOR; ENDOPLASMIC RETICULUM; ENDOPLASMIC RETICULUM STRESS; ETHER-A-GO-GO POTASSIUM CHANNELS; GLYCOSYLATION; HEK293 CELLS; HUMANS; MICROSCOPY, CONFOCAL; MUTANT PROTEINS; PROTEASOME ENDOPEPTIDASE COMPLEX; PROTEIN BINDING; PROTEIN TRANSPORT; PROTEOLYSIS; SIGNAL TRANSDUCTION; UBIQUITIN;

EID: 84855380889     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0029885     Document Type: Article

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