메뉴 건너뛰기




Volumn 11, Issue 1, 2014, Pages 6-18

Derivation of insulin-producing beta-cells from human pluripotent stem cells

Author keywords

Diabetes; Differentiation; Embryonic stem cells; Insulin producing cells; Pancreas; Pluripotent cells; Progenitor; Transplantation

Indexed keywords

BONE MORPHOGENETIC PROTEIN 4; FIBROBLAST GROWTH FACTOR 10; GLUCAGON; NEUROGENIN 3; OCTAMER TRANSCRIPTION FACTOR 4; SOMATOSTATIN; TRANSCRIPTION FACTOR NANOG; TRANSCRIPTION FACTOR NKX6.1; TRANSCRIPTION FACTOR PDX 1; TRANSCRIPTION FACTOR SOX2; TRANSFORMING GROWTH FACTOR BETA; WNT3A PROTEIN;

EID: 84906345800     PISSN: 16136071     EISSN: 16140575     Source Type: Journal    
DOI: 10.1900/RDS.2014.11.6     Document Type: Review
Times cited : (7)

References (98)
  • 1
    • 0019826665 scopus 로고
    • Establishment in culture of pluripotential cells from mouse embryos
    • Evans MJ, Kaufman MH. Establishment in culture of pluripotential cells from mouse embryos. Nature 1981. 292:154-156.
    • (1981) Nature , vol.292 , pp. 154-156
    • Evans, M.J.1    Kaufman, M.H.2
  • 2
    • 0001007610 scopus 로고
    • Isolation of a pluripotent cell line from early mouse embryos cultured in medium conditioned by teratocarcinoma stem cells
    • Martin GR. Isolation of a pluripotent cell line from early mouse embryos cultured in medium conditioned by teratocarcinoma stem cells. Proc Natl Acad Sci U S A 1981. 78:7634-7638.
    • (1981) Proc Natl Acad Sci U S A , vol.78 , pp. 7634-7638
    • Martin, G.R.1
  • 4
    • 0034101804 scopus 로고    scopus 로고
    • Embryonic stem cell lines from human blastocysts: Somatic differentiation in vitro
    • Reubinoff BE, Pera MF, Fong CY, Trounson A, Bongso A. Embryonic stem cell lines from human blastocysts: somatic differentiation in vitro. Nat Biotechnol 2000. 18:399-404.
    • (2000) Nat Biotechnol , vol.18 , pp. 399-404
    • Reubinoff, B.E.1    Pera, M.F.2    Fong, C.Y.3    Trounson, A.4    Bongso, A.5
  • 6
    • 0025054992 scopus 로고
    • Expression pattern of the mouse T gene and its role in mesoderm formation
    • Wilkinson DG, Bhatt S, Herrmann BG. Expression pattern of the mouse T gene and its role in mesoderm formation. Nature 1990. 343:657-659.
    • (1990) Nature , vol.343 , pp. 657-659
    • Wilkinson, D.G.1    Bhatt, S.2    Herrmann, B.G.3
  • 7
    • 0032821417 scopus 로고    scopus 로고
    • Mml, a mouse Mix-like gene expressed in the primitive streak
    • Pearce JJ, Evans MJ. Mml, a mouse Mix-like gene expressed in the primitive streak. Mech Dev 1999. 87:189-192.
    • (1999) Mech Dev , vol.87 , pp. 189-192
    • Pearce, J.J.1    Evans, M.J.2
  • 10
    • 0027425136 scopus 로고
    • The formation and maintenance of the definitive endoderm lineage in the mouse: Involvement of HNF3/forkhead proteins
    • Ang SL, Wierda A, Wong D, Stevens KA, Cascio S, Rossant J, Zaret KS. The formation and maintenance of the definitive endoderm lineage in the mouse: involvement of HNF3/forkhead proteins. Development 1993. 119:1301-1315.
    • (1993) Development , vol.119 , pp. 1301-1315
    • Ang, S.L.1    Wierda, A.2    Wong, D.3    Stevens, K.A.4    Cascio, S.5    Rossant, J.6    Zaret, K.S.7
  • 11
    • 0027318791 scopus 로고
    • Differential expression of multiple fork head related genes during gastrulation and axial pattern formation in the mouse embryo
    • Sasaki H, Hogan BL. Differential expression of multiple fork head related genes during gastrulation and axial pattern formation in the mouse embryo. Development 1993. 118:47-59.
    • (1993) Development , vol.118 , pp. 47-59
    • Sasaki, H.1    Hogan, B.L.2
  • 12
  • 15
    • 34247226529 scopus 로고    scopus 로고
    • Gene function in mouse embryogenesis: Get set for gastrulation
    • Tam PP, Loebel DA. Gene function in mouse embryogenesis: get set for gastrulation. Nature reviews Genetics 2007. 8:368-381.
    • (2007) Nature reviews Genetics , vol.8 , pp. 368-381
    • Tam, P.P.1    Loebel, D.A.2
  • 16
    • 1342263517 scopus 로고    scopus 로고
    • Hex homeobox gene-dependent tissue positioning is required for organogenesis of the ventral pancreas
    • Bort R, Martinez-Barbera JP, Beddington RS, Zaret KS. Hex homeobox gene-dependent tissue positioning is required for organogenesis of the ventral pancreas. Development 2004. 131:797-806.
    • (2004) Development , vol.131 , pp. 797-806
    • Bort, R.1    Martinez-Barbera, J.P.2    Beddington, R.S.3    Zaret, K.S.4
  • 19
    • 64149118087 scopus 로고    scopus 로고
    • Highly efficient differentiation of human ES cells and iPS cells into mature pancreatic insulin-producing cells
    • Zhang D, Jiang W, Liu M, Sui X, Yin X, Chen S, Shi Y, Deng H. Highly efficient differentiation of human ES cells and iPS cells into mature pancreatic insulin-producing cells. Cell Res 2009. 19:429-438.
    • (2009) Cell Res , vol.19 , pp. 429-438
    • Zhang, D.1    Jiang, W.2    Liu, M.3    Sui, X.4    Yin, X.5    Chen, S.6    Shi, Y.7    Deng, H.8
  • 21
    • 84864390303 scopus 로고    scopus 로고
    • Maturation of Human Embryonic Stem Cell-Derived Pancreatic Progenitors Into Functional Islets Capable of Treating Pre-existing Diabetes in Mice
    • Rezania A, Bruin JE, Riedel MJ, Mojibian M, Asadi A, Xu J, Gauvin R, Narayan K, Karanu F, O'Neil JJ, et al. Maturation of Human Embryonic Stem Cell-Derived Pancreatic Progenitors Into Functional Islets Capable of Treating Pre-existing Diabetes in Mice. Diabetes 2012. 61:2016-2029.
    • (2012) Diabetes , vol.61 , pp. 2016-2029
    • Rezania, A.1    Bruin, J.E.2    Riedel, M.J.3    Mojibian, M.4    Asadi, A.5    Xu, J.6    Gauvin, R.7    Narayan, K.8    Karanu, F.9    O'Neil, J.J.10
  • 23
    • 33750936779 scopus 로고    scopus 로고
    • Wnt and TGF-beta signaling are required for the induction of an in vitro model of primitive streak formation using embryonic stem cells
    • Gadue P, Huber TL, Paddison PJ, Keller GM. Wnt and TGF-beta signaling are required for the induction of an in vitro model of primitive streak formation using embryonic stem cells. Proc Natl Acad Sci U S A 2006. 103:16806-16811.
    • (2006) Proc Natl Acad Sci U S A , vol.103 , pp. 16806-16811
    • Gadue, P.1    Huber, T.L.2    Paddison, P.J.3    Keller, G.M.4
  • 24
    • 77956271471 scopus 로고    scopus 로고
    • Differentiating embryonic stem cells pass through 'temporal windows' that mark responsiveness to exogenous and paracrine mesendoderm inducing signals
    • Jackson SA, Schiesser J, Stanley EG, Elefanty AG. Differentiating embryonic stem cells pass through 'temporal windows' that mark responsiveness to exogenous and paracrine mesendoderm inducing signals. Plos one 2010. 5:e10706.
    • (2010) Plos one , vol.5
    • Jackson, S.A.1    Schiesser, J.2    Stanley, E.G.3    Elefanty, A.G.4
  • 25
    • 79958090845 scopus 로고    scopus 로고
    • A novel chemically directed route for the generation of definitive endoderm from human embryonic stem cells based on inhibition of GSK-3
    • Bone HK, Nelson AS, Goldring CE, Tosh D, Welham MJ. A novel chemically directed route for the generation of definitive endoderm from human embryonic stem cells based on inhibition of GSK-3. J Cell Sci 2011. 124:1992-2000.
    • (2011) J Cell Sci , vol.124 , pp. 1992-2000
    • Bone, H.K.1    Nelson, A.S.2    Goldring, C.E.3    Tosh, D.4    Welham, M.J.5
  • 26
    • 0029149656 scopus 로고
    • Bone morphogenetic protein-4 is required for mesoderm formation and patterning in the mouse
    • Winnier G, Blessing M, Labosky PA, Hogan BL. Bone morphogenetic protein-4 is required for mesoderm formation and patterning in the mouse. Genes Dev 1995. 9:2105-2116.
    • (1995) Genes Dev , vol.9 , pp. 2105-2116
    • Winnier, G.1    Blessing, M.2    Labosky, P.A.3    Hogan, B.L.4
  • 27
    • 79551580013 scopus 로고    scopus 로고
    • Stage-specific signaling through TGFbeta family members and WNT regulates patterning and pancreatic specification of human pluripotent stem cells
    • Nostro MC, Sarangi F, Ogawa S, Holtzinger A, Corneo B, Li X, Micallef SJ, Park IH, Basford C, Wheeler MB, et al. Stage-specific signaling through TGFbeta family members and WNT regulates patterning and pancreatic specification of human pluripotent stem cells. Development 2011. 138:861-871.
    • (2011) Development , vol.138 , pp. 861-871
    • Nostro, M.C.1    Sarangi, F.2    Ogawa, S.3    Holtzinger, A.4    Corneo, B.5    Li, X.6    Micallef, S.J.7    Park, I.H.8    Basford, C.9    Wheeler, M.B.10
  • 30
    • 0028084965 scopus 로고
    • Effect of nutrients, hormones and serum on survival of rat islet beta cells in culture
    • Ling Z, Hannaert JC, Pipeleers D. Effect of nutrients, hormones and serum on survival of rat islet beta cells in culture. Diabetologia 1994. 37:15-21.
    • (1994) Diabetologia , vol.37 , pp. 15-21
    • Ling, Z.1    Hannaert, J.C.2    Pipeleers, D.3
  • 31
    • 33748428184 scopus 로고    scopus 로고
    • The mechanisms of uremic serum-induced expression of bone matrix proteins in bovine vascular smooth muscle cells
    • Chen NX, Duan D, O'Neill KD, Wolisi GO, Koczman JJ, Laclair R, Moe SM. The mechanisms of uremic serum-induced expression of bone matrix proteins in bovine vascular smooth muscle cells. Kidney Int 2006. 70:1046-1053.
    • (2006) Kidney Int , vol.70 , pp. 1046-1053
    • Chen, N.X.1    Duan, D.2    O'Neill, K.D.3    Wolisi, G.O.4    Koczman, J.J.5    Laclair, R.6    Moe, S.M.7
  • 32
    • 0026448451 scopus 로고
    • The measurement of activin/EDF in mouse serum: Evidence for extragonadal production
    • Sakai R, Shiozaki M, Tabuchi M, Eto Y. The measurement of activin/EDF in mouse serum: evidence for extragonadal production. Biochem Biophys Res Commun 1992. 188:921-926.
    • (1992) Biochem Biophys Res Commun , vol.188 , pp. 921-926
    • Sakai, R.1    Shiozaki, M.2    Tabuchi, M.3    Eto, Y.4
  • 33
    • 84856745520 scopus 로고    scopus 로고
    • Retinoic acid signalling during development
    • Rhinn M, Dolle P. Retinoic acid signalling during development. Development 2012. 139:843-858.
    • (2012) Development , vol.139 , pp. 843-858
    • Rhinn, M.1    Dolle, P.2
  • 36
    • 0037162287 scopus 로고    scopus 로고
    • Retinoic acid signaling is required for a critical early step in zebrafish pancreatic development
    • Stafford D, Prince VE. Retinoic acid signaling is required for a critical early step in zebrafish pancreatic development. Curr Biol 2002. 12:1215-1220.
    • (2002) Curr Biol , vol.12 , pp. 1215-1220
    • Stafford, D.1    Prince, V.E.2
  • 37
    • 16244406880 scopus 로고    scopus 로고
    • Retinoic acid generated by Raldh2 in mesoderm is required for mouse dorsal endodermal pancreas development
    • Molotkov A, Molotkova N, Duester G. Retinoic acid generated by Raldh2 in mesoderm is required for mouse dorsal endodermal pancreas development. Dev Dyn 2005. 232:950-957.
    • (2005) Dev Dyn , vol.232 , pp. 950-957
    • Molotkov, A.1    Molotkova, N.2    Duester, G.3
  • 38
    • 2942542776 scopus 로고    scopus 로고
    • Retinoic acid signaling isessential for pancreas development and promotes endocrine at the expense of exocrine cell differentiation in Xenopus
    • Chen Y, Pan FC, Brandes N, Afelik S, Solter M, Pieler T. Retinoic acid signaling isessential for pancreas development and promotes endocrine at the expense of exocrine cell differentiation in Xenopus. Dev Biol 2004. 271:144-160.
    • (2004) Dev Biol , vol.271 , pp. 144-160
    • Chen, Y.1    Pan, F.C.2    Brandes, N.3    Afelik, S.4    Solter, M.5    Pieler, T.6
  • 39
    • 34547326050 scopus 로고    scopus 로고
    • Retinoic acidmediated patterning of the pre-pancreatic endoderm in Xenopus operates via direct and indirect mechanisms
    • Pan FC, Chen Y, Bayha E, Pieler T. Retinoic acidmediated patterning of the pre-pancreatic endoderm in Xenopus operates via direct and indirect mechanisms. Mech Dev 2007. 124:518-531.
    • (2007) Mech Dev , vol.124 , pp. 518-531
    • Pan, F.C.1    Chen, Y.2    Bayha, E.3    Pieler, T.4
  • 41
    • 18444407829 scopus 로고    scopus 로고
    • Inducing embryonic stem cells to differentiate into pancreatic beta cells by a novel three-step approach with activin A and all-trans retinoic acid
    • Shi Y, Hou L, Tang F, Jiang W, Wang P, Ding M, Deng H. Inducing embryonic stem cells to differentiate into pancreatic beta cells by a novel three-step approach with activin A and all-trans retinoic acid. Stem Cells 2005. 23:656-662.
    • (2005) Stem Cells , vol.23 , pp. 656-662
    • Shi, Y.1    Hou, L.2    Tang, F.3    Jiang, W.4    Wang, P.5    Ding, M.6    Deng, H.7
  • 43
    • 0035863135 scopus 로고    scopus 로고
    • Intercellular signals regulating pancreas development and function
    • Kim SK, Hebrok M. Intercellular signals regulating pancreas development and function. Genes Dev 2001. 15:111-127.
    • (2001) Genes Dev , vol.15 , pp. 111-127
    • Kim, S.K.1    Hebrok, M.2
  • 44
    • 0029027780 scopus 로고
    • Developmental biology of the pancreas
    • Slack JM. Developmental biology of the pancreas. Development 1995. 121:1569-1580.
    • (1995) Development , vol.121 , pp. 1569-1580
    • Slack, J.M.1
  • 45
    • 1042291971 scopus 로고    scopus 로고
    • Fission of pancreatic islets during postnatal growth of the mouse
    • Seymour PA, Bennett WR, Slack JM. Fission of pancreatic islets during postnatal growth of the mouse. J Anat 2004. 204:103-116.
    • (2004) J Anat , vol.204 , pp. 103-116
    • Seymour, P.A.1    Bennett, W.R.2    Slack, J.M.3
  • 48
    • 0034652287 scopus 로고    scopus 로고
    • Neurogenin3 is required for the development of the four endocrine cell lineages of the pancreas
    • Gradwohl G, Dierich A, LeMeur M, Guillemot F. neurogenin3 is required for the development of the four endocrine cell lineages of the pancreas. Proc Natl Acad Sci U S A 2000. 97:1607-1611.
    • (2000) Proc Natl Acad Sci U S A , vol.97 , pp. 1607-1611
    • Gradwohl, G.1    Dierich, A.2    LeMeur, M.3    Guillemot, F.4
  • 51
    • 0029930494 scopus 로고    scopus 로고
    • Neurogenic genes and vertebrate neurogenesis
    • Lewis J. Neurogenic genes and vertebrate neurogenesis. Curr Opin Neurobiol 1996. 6:3-10.
    • (1996) Curr Opin Neurobiol , vol.6 , pp. 3-10
    • Lewis, J.1
  • 52
  • 53
    • 84876539588 scopus 로고    scopus 로고
    • Factors Expressed by Murine Embryonic Pancreatic mesenchyme enhance generation of insulin-producing cells from hESCs
    • Guo T, Landsman L, Li N, Hebrok M. Factors Expressed by Murine Embryonic Pancreatic mesenchyme enhance generation of insulin-producing cells from hESCs. Diabetes 2013. 62(5):1581-1592.
    • (2013) Diabetes , vol.62 , Issue.5 , pp. 1581-1592
    • Guo, T.1    Landsman, L.2    Li, N.3    Hebrok, M.4
  • 54
    • 0036340074 scopus 로고    scopus 로고
    • Direct evidence for the pancreatic lineage: NGN3+ cells are islet progenitors and are distinct from duct progenitors
    • Gu G, Dubauskaite J, Melton DA. Direct evidence for the pancreatic lineage: NGN3+ cells are islet progenitors and are distinct from duct progenitors. Development 2002. 129:2447-2457.
    • (2002) Development , vol.129 , pp. 2447-2457
    • Gu, G.1    Dubauskaite, J.2    Melton, D.A.3
  • 55
    • 55549147549 scopus 로고    scopus 로고
    • Biphasic Ngn3 expression in the developing pancreas
    • Villasenor A, Chong DC, Cleaver O. Biphasic Ngn3 expression in the developing pancreas. Dev Dyn 2008. 237:3270-3279.
    • (2008) Dev Dyn , vol.237 , pp. 3270-3279
    • Villasenor, A.1    Chong, D.C.2    Cleaver, O.3
  • 56
    • 79951590737 scopus 로고    scopus 로고
    • Neurogenin3 initiates stepwise delamination of differentiating endocrine cells during pancreas development
    • Gouzi M, Kim YH, Katsumoto K, Johansson K, Grapin-Botton A. Neurogenin3 initiates stepwise delamination of differentiating endocrine cells during pancreas development. Dev Dyn 2011. 240:589-604.
    • (2011) Dev Dyn , vol.240 , pp. 589-604
    • Gouzi, M.1    Kim, Y.H.2    Katsumoto, K.3    Johansson, K.4    Grapin-Botton, A.5
  • 59
    • 0035694459 scopus 로고    scopus 로고
    • Fgf10 is essential for maintaining the proliferative capacityof epithelial progenitor cells during early pancreatic organogenesis
    • Bhushan A, Itoh N, Kato S, Thiery JP, Czernichow P, Bellusci S, Scharfmann R. Fgf10 is essential for maintaining the proliferative capacityof epithelial progenitor cells during early pancreatic organogenesis. Development 2001. 128:5109-5117.
    • (2001) Development , vol.128 , pp. 5109-5117
    • Bhushan, A.1    Itoh, N.2    Kato, S.3    Thiery, J.P.4    Czernichow, P.5    Bellusci, S.6    Scharfmann, R.7
  • 60
    • 0141593480 scopus 로고    scopus 로고
    • Fgf10 maintains notch activation, stimulates proliferation, and blocks differentiation of pancreatic epithelial cells
    • Hart A, Papadopoulou S, Edlund H. Fgf10 maintains notch activation, stimulates proliferation, and blocks differentiation of pancreatic epithelial cells. Dev Dyn 2003. 228:185-193.
    • (2003) Dev Dyn , vol.228 , pp. 185-193
    • Hart, A.1    Papadopoulou, S.2    Edlund, H.3
  • 61
    • 0344063697 scopus 로고    scopus 로고
    • FGF10 signaling maintains the pancreatic progenitor cell state revealing a novel role of Notch in organ development
    • Norgaard GA, Jensen JN, Jensen J. FGF10 signaling maintains the pancreatic progenitor cell state revealing a novel role of Notch in organ development. Dev Biol 2003. 264:323-338.
    • (2003) Dev Biol , vol.264 , pp. 323-338
    • Norgaard, G.A.1    Jensen, J.N.2    Jensen, J.3
  • 62
    • 0032908168 scopus 로고    scopus 로고
    • Characterization of beta cells developed in vitro from rat embryonic pancreatic epithelium
    • Miralles F, Serup P, Cluzeaud F, Vandewalle A, Czernichow P, Scharfmann R. Characterization of beta cells developed in vitro from rat embryonic pancreatic epithelium. Dev Dyn 1999. 214:116-126.
    • (1999) Dev Dyn , vol.214 , pp. 116-126
    • Miralles, F.1    Serup, P.2    Cluzeaud, F.3    Vandewalle, A.4    Czernichow, P.5    Scharfmann, R.6
  • 63
    • 31344468846 scopus 로고    scopus 로고
    • Interplay between FGF10 and Notch signalling is required for the selfrenewal of pancreatic progenitors
    • Miralles F, Lamotte L, Couton D, Joshi RL. Interplay between FGF10 and Notch signalling is required for the selfrenewal of pancreatic progenitors. Int J Dev Biol 2006. 50:17-26.
    • (2006) Int J Dev Biol , vol.50 , pp. 17-26
    • Miralles, F.1    Lamotte, L.2    Couton, D.3    Joshi, R.L.4
  • 64
    • 84870294610 scopus 로고    scopus 로고
    • Self-renewal of embryonic-stem-cell-derived progenitors by organ-matched mesenchyme
    • Sneddon JB, Borowiak M, Melton DA. Self-renewal of embryonic-stem-cell-derived progenitors by organ-matched mesenchyme. Nature 2012. 491:765-768.
    • (2012) Nature , vol.491 , pp. 765-768
    • Sneddon, J.B.1    Borowiak, M.2    Melton, D.A.3
  • 66
    • 77950947139 scopus 로고    scopus 로고
    • Conditional control of the differentiation competence of pancreatic endocrine and ductal cells by Fgf10
    • Kobberup S, Schmerr M, Dang ML, Nyeng P, Jensen JN, MacDonald RJ, Jensen J. Conditional control of the differentiation competence of pancreatic endocrine and ductal cells by Fgf10. Mech Dev 2010. 127:220-234.
    • (2010) Mech Dev , vol.127 , pp. 220-234
    • Kobberup, S.1    Schmerr, M.2    Dang, M.L.3    Nyeng, P.4    Jensen, J.N.5    McDonald, R.J.6    Jensen, J.7
  • 67
    • 0015446766 scopus 로고
    • An ultrastructural analysis of the developing embryonic pancreas
    • Pictet RL, Clark WR, Williams RH, Rutter WJ. An ultrastructural analysis of the developing embryonic pancreas. Dev Biol 1972. 29:436-467.
    • (1972) Dev Biol , vol.29 , pp. 436-467
    • Pictet, R.L.1    Clark, W.R.2    Williams, R.H.3    Rutter, W.J.4
  • 68
    • 0034121735 scopus 로고    scopus 로고
    • Adult insulin-and glucagon-producing cells differentiate from two independent cell lineages
    • Herrera PL. Adult insulin-and glucagon-producing cells differentiate from two independent cell lineages. Development 2000. 127:2317-2322.
    • (2000) Development , vol.127 , pp. 2317-2322
    • Herrera, P.L.1
  • 70
    • 0027265403 scopus 로고
    • Nicotinamide is a potent inducer of endocrine differentiation in cultured human fetal pancreatic cells
    • Otonkoski T, Beattie GM, Mally MI, Ricordi C, Hayek A. Nicotinamide is a potent inducer of endocrine differentiation in cultured human fetal pancreatic cells. J Clin Invest 1993. 92:1459-1466.
    • (1993) J Clin Invest , vol.92 , pp. 1459-1466
    • Otonkoski, T.1    Beattie, G.M.2    Mally, M.I.3    Ricordi, C.4    Hayek, A.5
  • 71
    • 33644755744 scopus 로고    scopus 로고
    • MafA expression and insulin promoter activity are induced by nicotinamide and related compounds in INS-1 pancreatic beta-cells
    • Ye DZ, Tai MH, Linning KD, Szabo C, Olson LK. MafA expression and insulin promoter activity are induced by nicotinamide and related compounds in INS-1 pancreatic beta-cells. Diabetes 2006. 55:742-750.
    • (2006) Diabetes , vol.55 , pp. 742-750
    • Ye, D.Z.1    Tai, M.H.2    Linning, K.D.3    Szabo, C.4    Olson, L.K.5
  • 79
    • 80054997189 scopus 로고    scopus 로고
    • Transgenic overexpression of the transcription factor Nkx6.1 in beta-cells of mice does not increase beta-cell proliferation, beta-cell mass, or improve glucose clearance
    • Schaffer AE, Yang AJ, Thorel F, Herrera PL, Sander M. Transgenic overexpression of the transcription factor Nkx6.1 in beta-cells of mice does not increase beta-cell proliferation, beta-cell mass, or improve glucose clearance. Mol Endocrinol 2011. 25:1904-1914.
    • (2011) Mol Endocrinol , vol.25 , pp. 1904-1914
    • Schaffer, A.E.1    Yang, A.J.2    Thorel, F.3    Herrera, P.L.4    Sander, M.5
  • 80
    • 84856715292 scopus 로고    scopus 로고
    • Immunohistochemical characterisation of cells co-producing insulin and glucagon in the developing human pancreas
    • Riedel MJ, Asadi A, Wang R, Ao Z, Warnock GL, Kieffer TJ. Immunohistochemical characterisation of cells co-producing insulin and glucagon in the developing human pancreas. Diabetologia 2012. 55:372-381.
    • (2012) Diabetologia , vol.55 , pp. 372-381
    • Riedel, M.J.1    Asadi, A.2    Wang, R.3    Ao, Z.4    Warnock, G.L.5    Kieffer, T.J.6
  • 81
    • 34547857040 scopus 로고    scopus 로고
    • Generation of insulin-producing islet-like clusters from human embryonic stem cells
    • Jiang J, Au M, Lu K, Eshpeter A, Korbutt G, Fisk G, Majumdar AS. Generation of insulin-producing islet-like clusters from human embryonic stem cells. Stem Cells 2007. 25:1940-1953.
    • (2007) Stem Cells , vol.25 , pp. 1940-1953
    • Jiang, J.1    Au, M.2    Lu, K.3    Eshpeter, A.4    Korbutt, G.5    Fisk, G.6    Majumdar, A.S.7
  • 83
    • 79955047283 scopus 로고    scopus 로고
    • Differentiation of human embryonic stem cells into pancreatic endoderm in patterned size-controlled clusters
    • Van Hoof D, Mendelsohn AD, Seerke R, Desai TA, German MS. Differentiation of human embryonic stem cells into pancreatic endoderm in patterned size-controlled clusters. Stem cell Res 2011. 6:276-285.
    • (2011) Stem cell Res , vol.6 , pp. 276-285
    • Van Hoof, D.1    Mendelsohn, A.D.2    Seerke, R.3    Desai, T.A.4    German, M.S.5
  • 84
    • 80755187146 scopus 로고    scopus 로고
    • Activin, BMP and FGF pathways cooperate to promote endoderm and pancreatic lineage cell differentiation from human embryonic stem cells
    • Xu X, Browning VL, Odorico JS. Activin, BMP and FGF pathways cooperate to promote endoderm and pancreatic lineage cell differentiation from human embryonic stem cells. Mech Dev 2011. 128:412-427.
    • (2011) Mech Dev , vol.128 , pp. 412-427
    • Xu, X.1    Browning, V.L.2    Odorico, J.S.3
  • 88
    • 1542297749 scopus 로고    scopus 로고
    • The MafA transcription factor appears to be responsible for tissue-specific expression of insulin
    • Matsuoka TA, Artner I, Henderson E, Means A, Sander M, Stein R. The MafA transcription factor appears to be responsible for tissue-specific expression of insulin. Proc Nat Acad Sci USA2004. 101:2930-2933.
    • (2004) Proc Nat Acad Sci USA , vol.101 , pp. 2930-2933
    • Matsuoka, T.A.1    Artner, I.2    Henderson, E.3    Means, A.4    Sander, M.5    Stein, R.6
  • 89
    • 0041970072 scopus 로고    scopus 로고
    • Members of the large Maf transcription family regulate insulin gene transcription in islet beta cells
    • Matsuoka TA, Zhao L, Artner I, Jarrett HW, Friedman D, Means A, Stein R. Members of the large Maf transcription family regulate insulin gene transcription in islet beta cells. Mol Cell Biol 2003. 23:6049-6062.
    • (2003) Mol Cell Biol , vol.23 , pp. 6049-6062
    • Matsuoka, T.A.1    Zhao, L.2    Artner, I.3    Jarrett, H.W.4    Friedman, D.5    Means, A.6    Stein, R.7
  • 90
    • 34447124165 scopus 로고    scopus 로고
    • MAFA controls genes implicated in insulin biosynthesis and secretion
    • Wang H, Brun T, Kataoka K, Sharma AJ, Wollheim CB. MAFA controls genes implicated in insulin biosynthesis and secretion. Diabetologia 2007. 50:348-358.
    • (2007) Diabetologia , vol.50 , pp. 348-358
    • Wang, H.1    Brun, T.2    Kataoka, K.3    Sharma, A.J.4    Wollheim, C.B.5
  • 94
    • 34247898958 scopus 로고    scopus 로고
    • Directed differentiation of human embryonic stem cells towards a pancreatic cell fate
    • Shim JH, Kim SE, Woo DH, Kim SK, Oh CH, McKay R, Kim JH. Directed differentiation of human embryonic stem cells towards a pancreatic cell fate. Diabetologia 2007. 50:1228-1238.
    • (2007) Diabetologia , vol.50 , pp. 1228-1238
    • Shim, J.H.1    Kim, S.E.2    Woo, D.H.3    Kim, S.K.4    Oh, C.H.5    McKay, R.6    Kim, J.H.7
  • 98
    • 58849146524 scopus 로고    scopus 로고
    • The reversal of hyperglycaemiain diabetic mice using PLGA scaffolds seeded with islet-like cells derived from human embryonic stem cells
    • Mao GH, Chen GA, Bai HY, Song TR, Wang YX. The reversal of hyperglycaemiain diabetic mice using PLGA scaffolds seeded with islet-like cells derived from human embryonic stem cells. Biomaterials 2009. 30:1706-1714.
    • (2009) Biomaterials , vol.30 , pp. 1706-1714
    • Mao, G.H.1    Chen, G.A.2    Bai, H.Y.3    Song, T.R.4    Wang, Y.X.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.