Role of SAP97 in the regulation of 5-HT2AR endocytosis and signaling

Molecular Pharmacology

Volumn 86, Issue 3, 2014, Pages 275-283

  Dunn, Henry A ^a   Walther, Cornelia ^a   Yuan, George Y ^a   Caetano, Fabiana A ^a   Godin, Christina M ^a   Ferguson, Stephen S G ^a  

^a ROBARTS RESEARCH INSTITUTE   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

ATYPICAL ANTIPSYCHOTIC AGENT; CORTICOTROPIN RELEASING FACTOR RECEPTOR 1; INOSITOL PHOSPHATE; MEMBRANE PROTEIN; MITOGEN ACTIVATED PROTEIN KINASE 1; PDZ PROTEIN; PROTEIN SAP 97; SEROTONIN 2A RECEPTOR; UNCLASSIFIED DRUG;

ANIMAL TISSUE; ARTICLE; BIOLUMINESCENCE RESONANCE ENERGY TRANSFER; CELL MEMBRANE; CONTROLLED STUDY; CYTOSOL; ENDOCYTOSIS; ENZYME PHOSPHORYLATION; HEK293 CELL LINE; HUMAN; HUMAN CELL; IMMUNOPRECIPITATION; INTERNALIZATION; INTRACELLULAR SIGNALING; MENTAL DISEASE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN MOTIF; PROTEIN TARGETING; RECEPTOR BINDING; RECEPTOR DOWN REGULATION; SIGNAL TRANSDUCTION;

ADAPTOR PROTEINS, SIGNAL TRANSDUCING; CELL MEMBRANE; ENDOCYTOSIS; ENZYME ACTIVATION; HUMANS; INOSITOL PHOSPHATES; MEMBRANE PROTEINS; MITOGEN-ACTIVATED PROTEIN KINASE 1; MITOGEN-ACTIVATED PROTEIN KINASE 3; PHOSPHORYLATION; PROTEIN BINDING; PROTEIN STRUCTURE, TERTIARY; PROTEIN TRANSPORT; RECEPTOR, SEROTONIN, 5-HT2A; RECEPTORS, CORTICOTROPIN-RELEASING HORMONE; SIGNAL TRANSDUCTION;

EID: 84906316549     PISSN: 0026895X     EISSN: 15210111     Source Type: Journal    
DOI: 10.1124/mol.114.093476     Document Type: Article

References (34)

1. Abbas AI, Yadav PN, Yao WD, Arbuckle MI, Grant SG, Caron MG, and Roth BL (2009) PSD-95 is essential for hallucinogen and atypical antipsychotic drug actions at serotonin receptors. J Neurosci 29:7124-7136.
2. Backstrom JR, Price RD, Reasoner DT, and Sanders-Bush E (2000) Deletion of the serotonin 5-HT2C receptor PDZ recognition motif prevents receptor phosphorylation and delays resensitization of receptor responses. J Biol Chem 275:23620-23626. (Pubitemid 30627453)
3. Barnes NM (2011) 5-HT: the promiscuous and happy hormone! Curr Opin Pharmacol 11:1-2.
4. Bassand P, Bernard A, Rafiki A, Gayet D, and Khrestchatisky M (1999) Differential interaction of the tSXV motifs of the NR1 and NR2A NMDA receptor subunits with PSD-95 and SAP97. Eur J Neurosci 11:2031-2043. (Pubitemid 29240568)
5. Bécamel C, Alonso G, Galéotti N, Demey E, Jouin P, Ullmer C, Dumuis A, Bockaert J, and Marin P (2002) Synaptic multiprotein complexes associated with 5-HT(2C) receptors: a proteomic approach. EMBO J 21:2332-2342. (Pubitemid 34546706)
6. Bécamel C, Gavarini S, Chanrion B, Alonso G, Galeotti N, Dumuis A, Bockaert J, and Marin P. (2004) The serotonin 5-HT2A and 5-HT2C receptors interact with specific sets of PDZ proteins. J Biol Chem 279:20257-20266. (Pubitemid 38623471)
7. Bobillier P, Seguin S, Petitjean F, Salvert D, Touret M, and Jouvet M (1976) The raphe nuclei of the cat brain stem: a topographical atlas of their efferent projections as revealed by autoradiography. Brain Res 113:449-486.
8. Cai C, Li H, Kangasniemi A, Pihlajamaa T, Von Ossowski L, Kerkelä K, Schulz S, Rivera C, and Keinänen K (2008) Somatostatin receptor subtype 1 is a PDZ ligand for synapse-associated protein 97 and a potential regulator of growth cone dynamics. Neuroscience 157:833-843.
9. Catapano LA and Manji HK (2007) G protein-coupled receptors in major psychiatric disorders. Biochim Biophys Acta 1768:976-993. (Pubitemid 46463941)
10. Dunn HA, Walther C, Godin CM, Hall RA, and Ferguson SSG (2013) Role of SAP97 protein in the regulation of corticotropin-releasing factor receptor 1 endocytosis and extracellular signal-regulated kinase 1/2 signaling. J Biol Chem 288:15023-15034.
11. Ferguson SSG and Caron MG (2004) Green fluorescent protein-tagged β-arrestin translocation as a measure of G protein-coupled receptor activation. Methods Mol Biol 237:121-126.
12. Fribourg M, Moreno JL, Holloway T, Provasi D, Baki L, Mahajan R, Park G, Adney SK, Hatcher C, and Eltit JM et al. (2011) Decoding the signaling of a GPCR heteromeric complex reveals a unifying mechanism of action of antipsychotic drugs. Cell 147:1011-1023.
13. Gardner LA, Naren AP, and Bahouth SW (2007) Assembly of an SAP97-AKAP79-cAMP-dependent protein kinase scaffold at the type 1 PSD-95/DLG/ZO1 motif of the human beta(1)-adrenergic receptor generates a receptosome involved in receptor recycling and networking. J Biol Chem 282:5085-5099. (Pubitemid 47100997)
14. Gardoni F, Mauceri D, Fiorentini C, Bellone C, Missale C, Cattabeni F, and Di Luca M (2003) CaMKII-dependent phosphorylation regulates SAP97/NR2A interaction. J Biol Chem 278:44745-44752. (Pubitemid 37377232)
15. Gavarini S, Bécamel C, Altier C, Lory P, Poncet J, Wijnholds J, Bockaert J, and Marin P (2006) Opposite effects of PSD-95 and MPP3 PDZ proteins on serotonin 5-hydroxytryptamine2C receptor desensitization and membrane stability. Mol Biol Cell 17:4619-4631. (Pubitemid 44665733)
16. Gray JA and Roth BL (2001) Paradoxical trafficking and regulation of 5-HT(2A) receptors by agonists and antagonists. Brain Res Bull 56:441-451. (Pubitemid 34031779)
17. Hale MW, Shekhar A, and Lowry CA (2012) Stress-related serotonergic systems: implications for symptomatology of anxiety and affective disorders. Cell Mol Neurobiol 32 :695-708.
18. He J, Bellini M, Inuzuka H, Xu J, Xiong Y, Yang X, Castleberry AM, and Hall RA (2006) Proteomic analysis of beta1-adrenergic receptor interactions with PDZ scaffold proteins. J Biol Chem 281:2820-2827. (Pubitemid 43845746)
19. Jones KA, Srivastava DP, Allen JA, Strachan RT, Roth BL, and Penzes P (2009) Rapid modulation of spine morphology by the 5-HT2A serotonin receptor through kalirin-7 signaling. Proc Natl Acad Sci USA 106:19575-19580.
20. Leonard AS, Davare MA, Horne MC, Garner CC, and Hell JW (1998) SAP97 is associated with the alpha-amino-3-hydroxy-5-methylisoxazole-4-propionic acid receptor GluR1 subunit. J Biol Chem 273:19518-19524. (Pubitemid 28367003)
21. Magalhaes AC, Holmes KD, Dale LB, Comps-Agrar L, Lee D, Yadav PN, Drysdale L, Poulter MO, Roth BL, and Pin JP et al. (2010) CRF receptor 1 regulates anxiety behavior via sensitization of 5-HT2 receptor signaling. Nat Neurosci 13:622-629.
22. Magalhaes AC, Dunn H, and Ferguson SSG (2012) Regulation of G protein-coupled receptor activity, trafficking and localization by GPCR-interacting proteins. Br J Pharmacol 65:1717-1736.
23. Mehta S, Wu H, Garner CC, and Marshall J (2001) Molecular mechanisms regulating the differential association of kainate receptor subunits with SAP90/PSD-95 and SAP97. J Biol Chem 276:16092-16099.
24. Pichon X, Wattiez AS, Becamel C, Ehrlich I, Bockaert J, Eschalier A, Marin P, and Courteix C (2010) Disrupting 5-HT(2A) receptor/PDZ protein interactions reduces hyperalgesia and enhances SSRI efficacy in neuropathic pain. Mol Ther 18:1462-1470.
25. Raymond JR, Mukhin YV, Gelasco A, Turner J, Collinsworth G, Gettys TW, Grewal JS, and Garnovskaya MN (2001) Multiplicity of mechanisms of serotonin receptor signal transduction. Pharmacol Ther 92:179-212. (Pubitemid 34251133)
26. Rochdi MD, Watier V, La Madeleine C, Nakata H, Kozasa T, and Parent JL (2002) Regulation of GTP-binding protein a q (Galpha q) signaling by the ezrin-radixin-moesin- binding phosphoprotein-50 (EBP50). J Biol Chem 277:40751-40759. (Pubitemid 35215659)
27. Roth BL and Xia Z (2004) Molecular and cellular mechanisms for the polarized sorting of serotonin receptors: relevance for genesis and treatment of psychosis. Crit Rev Neurobiol 16:229-236.
28. Rumbaugh G, Sia GM, Garner CC, and Huganir RL (2003) Synapse-associated protein-97 isoform-specific regulation of surface AMPA receptors and synaptic function in cultured neurons. J Neurosci 23:4567-4576. (Pubitemid 36706187)
29. Sabio G, Arthur JS, Kuma Y, Peggie M, Carr J, Murray-Tait V, Centeno F, Goedert M, Morrice NA, and Cuenda A (2005) p38gamma regulates the localisation of SAP97 in the cytoskeleton by modulating its interaction with GKAP. EMBO J 24:1134-1145. (Pubitemid 40516597)
30. Sans N, Racca C, Petralia RS, Wang YX, McCallum J, and Wenthold RJ (2001) Synapse-associated protein 97 selectively associates with a subset of AMPA receptors early in their biosynthetic pathway. J Neurosci 21:7506-7516. (Pubitemid 32904949)
31. Wattiez AS, Pichon X, Dupuis A, Hernández A, Privat AM, Aissouni Y, Chalus M, Pelissier T, Eschalier A, and Marin P et al. (2013) Disruption of 5-HT2A receptor-PDZ protein interactions alleviates mechanical hypersensitivity in carrageenan-induced inflammation in rats. PLoS ONE 8:e74661.
32. Weisstaub NV, Zhou M, Lira A, Lambe E, González-Maeso J, Hornung JP, Sibille E, Underwood M, Itohara S, and Dauer WT et al. (2006) Cortical 5-HT2A receptor signaling modulates anxiety-like behaviors in mice. Science 313:536-540. (Pubitemid 44148461)
33. Xia Z, Hufeisen SJ, Gray JA, and Roth BL (2003a) The PDZ-binding domain is essential for the dendritic targeting of 5-HT2A serotonin receptors in cortical pyramidal neurons in vitro . Neuroscience 122 :907 - 920.
34. Xia Z, Gray JA, Compton-Toth BA, and Roth BL (2003b) A direct interaction of PSD-95 with 5-HT2A serotonin receptors regulates receptor trafficking and signal transduction. J Biol Chem 278:21901-21908. (Pubitemid 36792597)