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Volumn 16, Issue 4, 2004, Pages 229-235

Molecular and cellular mechanisms for the polarized sorting of serotonin receptors: Relevance for genesis and treatment of psychosis

Author keywords

5 HT receptors; Neuronal sorting; Neuronal trafficking; PDZ domains; Serotonin

Indexed keywords

ARIPIPRAZOLE; ATYPICAL ANTIPSYCHOTIC AGENT; BROLAMFETAMINE; CLOZAPINE; LYSERGIDE; MESCALINE; OLANZAPINE; PHENCYCLIDINE; PSILOCYBINE; PSYCHEDELIC AGENT; PSYCHOTROPIC AGENT; SEROTONIN 2A RECEPTOR; SEROTONIN RECEPTOR;

EID: 20344367058     PISSN: 08920915     EISSN: None     Source Type: Journal    
DOI: 10.1615/CritRevNeurobiol.v16.i4.10     Document Type: Review
Times cited : (18)

References (42)
  • 1
    • 20344363815 scopus 로고
    • The effects of hallucinogenic and tranquilizing drugs on the serotonin-evoked uterine contractions
    • Costa E. The effects of hallucinogenic and tranquilizing drugs on the serotonin-evoked uterine contractions. Psychiatr Res Rep Am Psychiatr Assoc 1956; 4:11.
    • (1956) Psychiatr Res Rep Am Psychiatr Assoc , vol.4 , pp. 11
    • Costa, E.1
  • 2
    • 12644284634 scopus 로고
    • Effects of hallucinogenic and tranquilizing drugs on serotonin evoked uterine contractions
    • Costa E. Effects of hallucinogenic and tranquilizing drugs on serotonin evoked uterine contractions. Proc Soc Exp Biol Med 1956; 91(1):39.
    • (1956) Proc Soc Exp Biol Med , vol.91 , Issue.1 , pp. 39
    • Costa, E.1
  • 3
    • 0343703301 scopus 로고
    • Studies on the 5-hydroxytryptamine (serotonin) content in human brain
    • Costa E, Aprison MH. Studies on the 5-hydroxytryptamine (serotonin) content in human brain. J Nerv Ment Dis 1958; 126(3):289.
    • (1958) J Nerv Ment Dis , vol.126 , Issue.3 , pp. 289
    • Costa, E.1    Aprison, M.H.2
  • 5
    • 20344373575 scopus 로고
    • The role of serotonin in neurobiology
    • Costa E. The role of serotonin in neurobiology. Int Rev Neurobiol 1960; 2:175.
    • (1960) Int Rev Neurobiol , vol.2 , pp. 175
    • Costa, E.1
  • 6
    • 0028061499 scopus 로고
    • Multiple serotonin receptors: Clinical and experimental aspects
    • Roth BL. Multiple serotonin receptors: clinical and experimental aspects. Ann Clin Psychiatry 1994; 6(2):67.
    • (1994) Ann Clin Psychiatry , vol.6 , Issue.2 , pp. 67
    • Roth, B.L.1
  • 7
    • 0032402417 scopus 로고    scopus 로고
    • The molecular biology of serotonin receptors: Therapeutic implications for the interface of mood and psychosis
    • Kroeze WK, Roth BL. The molecular biology of serotonin receptors: therapeutic implications for the interface of mood and psychosis. Biol Psychiatry 1998; 44(11):1128.
    • (1998) Biol Psychiatry , vol.44 , Issue.11 , pp. 1128
    • Kroeze, W.K.1    Roth, B.L.2
  • 8
    • 0036599358 scopus 로고    scopus 로고
    • Molecular biology of serotonin receptors structure and function at the molecular level
    • Kroeze WK, Kristiansen K, Roth BL. Molecular biology of serotonin receptors structure and function at the molecular level, Curr Top Med Chem 2002; 2(6):507.
    • (2002) Curr Top Med Chem , vol.2 , Issue.6 , pp. 507
    • Kroeze, W.K.1    Kristiansen, K.2    Roth, B.L.3
  • 9
    • 0346882649 scopus 로고    scopus 로고
    • G-protein-coupled receptors at a glance
    • Kroeze WK, Sheffler DJ, Roth BL. G-protein-coupled receptors at a glance. J Cell Sci 2003; 116(Pt 24):4867.
    • (2003) J Cell Sci , vol.116 , Issue.PART 24 , pp. 4867
    • Kroeze, W.K.1    Sheffler, D.J.2    Roth, B.L.3
  • 10
    • 0021646446 scopus 로고
    • Evidence for 5-HT2 involvement in the mechanism of action of hallucinogenic agents
    • Glennon RA, Titler M, McKenney JD. Evidence for 5-HT2 involvement in the mechanism of action of hallucinogenic agents. Life Sciences 1984, 35:2505.
    • (1984) Life Sciences , vol.35 , pp. 2505
    • Glennon, R.A.1    Titler, M.2    McKenney, J.D.3
  • 11
    • 0024466603 scopus 로고
    • Classification of typical and atypical antipsychotic drugs on the basis of dopamine D-1, D-2 and serotonin2 pKi values
    • Meltzer HY, Matsubara S, Lee J-C. Classification of typical and atypical antipsychotic drugs on the basis of dopamine D-1, D-2 and serotonin2 pKi values. J Pharmacol Exper Therapeut 1989; 251:238.
    • (1989) J Pharmacol Exper Therapeut , vol.251 , pp. 238
    • Meltzer, H.Y.1    Matsubara, S.2    Lee, J.-C.3
  • 13
    • 0037209132 scopus 로고    scopus 로고
    • Effects of the 5-HT2A agonist psilocybin on mismatch negativity generation and AX-continuous performance task: Implications for the neuropharmacology of cognitive deficits in schizophrenia
    • Umbricht D, Vollenweider FX, Schmid L, Grubel C, Skrabo A, Huber T, Koller R. Effects of the 5-HT2A agonist psilocybin on mismatch negativity generation and AX-continuous performance task: implications for the neuropharmacology of cognitive deficits in schizophrenia. Neuropsychopharmacology 2003; 28(1):170.
    • (2003) Neuropsychopharmacology , vol.28 , Issue.1 , pp. 170
    • Umbricht, D.1    Vollenweider, F.X.2    Schmid, L.3    Grubel, C.4    Skrabo, A.5    Huber, T.6    Koller, R.7
  • 17
    • 4644271084 scopus 로고    scopus 로고
    • Magic shotguns versus magic bullets: Selectively non-selective drugs for mood disorders and schizophrenia
    • Roth BL, Sheffler DJ, Kroeze WK. Magic shotguns versus magic bullets: selectively non-selective drugs for mood disorders and schizophrenia. Nat Rev Drug Discov 2004; 3(4):353.
    • (2004) Nat Rev Drug Discov , vol.3 , Issue.4 , pp. 353
    • Roth, B.L.1    Sheffler, D.J.2    Kroeze, W.K.3
  • 19
    • 0022401097 scopus 로고
    • Quantitative autoradiographic mapping of serotonin receptors in the rat brain. II. Serotonin-2 receptors
    • Pazos A, Cortes R, Palacios JM. Quantitative autoradiographic mapping of serotonin receptors in the rat brain. II. Serotonin-2 receptors. Brain Res 1985; 346:231.
    • (1985) Brain Res , vol.346 , pp. 231
    • Pazos, A.1    Cortes, R.2    Palacios, J.M.3
  • 20
    • 0023525918 scopus 로고
    • Characterization of two [3H]ketanserin recognition sites in rat striatum
    • Roth BL, McLean S, Zhu XZ, Chuang DM. Characterization of two [3H]ketanserin recognition sites in rat striatum. J Neurochem 1987; 49(6):1833.
    • (1987) J Neurochem , vol.49 , Issue.6 , pp. 1833
    • Roth, B.L.1    McLean, S.2    Zhu, X.Z.3    Chuang, D.M.4
  • 21
    • 0030612257 scopus 로고    scopus 로고
    • Serotonin 5-HT2A receptors are expressed on pyramidal cells and interneurons in the rat cortex
    • Willins D, Deutch A, Roth B. Serotonin 5-HT2A receptors are expressed on pyramidal cells and interneurons in the rat cortex. Synapse 1997; 27:79.
    • (1997) Synapse , vol.27 , pp. 79
    • Willins, D.1    Deutch, A.2    Roth, B.3
  • 22
    • 0031594813 scopus 로고    scopus 로고
    • 5-Hydroxytryptamine2A serotonin receptors in the primate cerebral cortex: Possible site of action of hallucinogenic and antipsychotic drugs in pyramidal cell apical dendrites
    • Jakab R, Goldman-Rakic P. 5-hydroxytryptamine2A serotonin receptors in the primate cerebral cortex: possible site of action of hallucinogenic and antipsychotic drugs in pyramidal cell apical dendrites. Proc Natl Acad Sci USA 1998; 95:735.
    • (1998) Proc Natl Acad Sci USA , vol.95 , pp. 735
    • Jakab, R.1    Goldman-Rakic, P.2
  • 23
    • 0033612553 scopus 로고    scopus 로고
    • Cellular and subcellular distribution of the serotonin 5-HT2A receptor in the central nervous system of adult rat
    • Cornea-Hebert V, Riad M, Wu C, Singh SK, Descarries L. Cellular and subcellular distribution of the serotonin 5-HT2A receptor in the central nervous system of adult rat. J Comp Neurol 1999; 409(2): 187.
    • (1999) J Comp Neurol , vol.409 , Issue.2 , pp. 187
    • Cornea-Hebert, V.1    Riad, M.2    Wu, C.3    Singh, S.K.4    Descarries, L.5
  • 24
    • 0037156476 scopus 로고    scopus 로고
    • Localization of 5-HT(2A) receptors on dopamine cells in subnuclei of the midbrain A10 cell group
    • Nocjar C, Roth BL, Pehek EA. Localization of 5-HT(2A) receptors on dopamine cells in subnuclei of the midbrain A10 cell group. Neuroscience 2002; 111(1):163.
    • (2002) Neuroscience , vol.111 , Issue.1 , pp. 163
    • Nocjar, C.1    Roth, B.L.2    Pehek, E.A.3
  • 25
    • 0037439245 scopus 로고    scopus 로고
    • Ultrastructural localization of serotonin2A receptors in the middle layers of the rat prelimbic prefrontal cortex
    • Miner LA, Backstrom JR, Sanders-Bush E, Sesack SR. Ultrastructural localization of serotonin2A receptors in the middle layers of the rat prelimbic prefrontal cortex. Neuroscience 2003; 116(1):107.
    • (2003) Neuroscience , vol.116 , Issue.1 , pp. 107
    • Miner, L.A.1    Backstrom, J.R.2    Sanders-Bush, E.3    Sesack, S.R.4
  • 26
    • 0344441294 scopus 로고    scopus 로고
    • The PDZ-binding domain is essential for the dendritic targeting of 5-HT(2A) serotonin receptors in cortical pyramidal neurons in vitro
    • Xia Z, Hufeisen SJ, Gray JA, Roth BL. The PDZ-binding domain is essential for the dendritic targeting of 5-HT(2A) serotonin receptors in cortical pyramidal neurons in vitro. Neuroscience 2003; 122(4): 907.
    • (2003) Neuroscience , vol.122 , Issue.4 , pp. 907
    • Xia, Z.1    Hufeisen, S.J.2    Gray, J.A.3    Roth, B.L.4
  • 27
    • 0032971464 scopus 로고    scopus 로고
    • Structure and function of the third intracellular loop of the 5-hydroxytryptamine2A receptor: The third intracellular loop is alpha-helical and binds purified arrestins
    • Gelber EI, Kroeze WK, Willins DL, Gray JA, Sinar CA, Hyde EG, Gurevich V, Benovic J, Roth BL. Structure and function of the third intracellular loop of the 5- hydroxytryptamine2A receptor: the third intracellular loop is alpha-helical and binds purified arrestins. J Neurochem 1999; 72(5):2206.
    • (1999) J Neurochem , vol.72 , Issue.5 , pp. 2206
    • Gelber, E.I.1    Kroeze, W.K.2    Willins, D.L.3    Gray, J.A.4    Sinar, C.A.5    Hyde, E.G.6    Gurevich, V.7    Benovic, J.8    Roth, B.L.9
  • 28
    • 0037008452 scopus 로고    scopus 로고
    • Similar ultrastructural distribution of the 5-HT(2A) serotonin receptor and microtubule-associated protein MAP1A in cortical dendrites of adult rat
    • Cornea-Hebert V, Watkins KC, Roth BL, Kroeze WK, Gaudreau P, Leclerc N, Descarries L. Similar ultrastructural distribution of the 5-HT(2A) serotonin receptor and microtubule-associated protein MAP1A in cortical dendrites of adult rat. Neuroscience 2002; 113(1):23.
    • (2002) Neuroscience , vol.113 , Issue.1 , pp. 23
    • Cornea-Hebert, V.1    Watkins, K.C.2    Roth, B.L.3    Kroeze, W.K.4    Gaudreau, P.5    Leclerc, N.6    Descarries, L.7
  • 29
    • 0037484186 scopus 로고    scopus 로고
    • A direct interaction of PSD-95 with 5-HT2A serotonin receptors regulates receptor trafficking and signal transduction
    • Xia Z, Gray JA, Compton-Toth BA, Roth BL. A direct interaction of PSD-95 with 5-HT2A serotonin receptors regulates receptor trafficking and signal transduction. J Biol Chem 2003; 278(24): 21901.
    • (2003) J Biol Chem , vol.278 , Issue.24 , pp. 21901
    • Xia, Z.1    Gray, J.A.2    Compton-Toth, B.A.3    Roth, B.L.4
  • 32
    • 0034753012 scopus 로고    scopus 로고
    • Cell-type specific effects of endocytosis inhibitors on 5-hydroxytryptamine(2A) receptor desensitization and resensitization reveal an arrestin-, GRK2-, and GRK5-independent mode of regulation in human embryonic kidney 293 cells
    • Gray JA, Sheffler DJ, Bhatnagar A, Woods JA, Hufeisen SJ, Benovic JL, Roth BL. Cell-type specific effects of endocytosis inhibitors on 5-hydroxytryptamine(2A) receptor desensitization and resensitization reveal an arrestin-, GRK2-, and GRK5-independent mode of regulation in human embryonic kidney 293 cells. Mol Pharmacol 2001; 60(5): 1020.
    • (2001) Mol Pharmacol , vol.60 , Issue.5 , pp. 1020
    • Gray, J.A.1    Sheffler, D.J.2    Bhatnagar, A.3    Woods, J.A.4    Hufeisen, S.J.5    Benovic, J.L.6    Roth, B.L.7
  • 33
    • 0037847585 scopus 로고    scopus 로고
    • The interaction of a constitutively active arrestin with the arrestin-insensitive 5-HT(2A) receptor induces agonist-independent internalization
    • Gray JA, Bhatnagar A, Gurevich W, Roth BL. The interaction of a constitutively active arrestin with the arrestin-insensitive 5-HT(2A) receptor induces agonist-independent internalization. Mol Pharmacol 2003; 63(5):961.
    • (2003) Mol Pharmacol , vol.63 , Issue.5 , pp. 961
    • Gray, J.A.1    Bhatnagar, A.2    Gurevich, W.3    Roth, B.L.4
  • 34
    • 0037178412 scopus 로고    scopus 로고
    • Cell biology. A last GASP for GPCRs?
    • Gray JA, Roth BL. Cell biology. A last GASP for GPCRs? Science 2002; 297(5581):529.
    • (2002) Science , vol.297 , Issue.5581 , pp. 529
    • Gray, J.A.1    Roth, B.L.2
  • 35
    • 20344375633 scopus 로고    scopus 로고
    • Evidence for a model of agonist-induced activation of 5-HT2A serotonin receptors which involves the disruption of a strong ionic interaction between helices 3 and 6
    • Shapiro DA, Kristiansen K, Weiner DM, Kroeze WK, Roth BL. Evidence for a model of agonist-induced activation of 5-HT2A serotonin receptors which involves the disruption of a strong ionic interaction between helices 3 and 6. J Biol Chem 2002; 18:18.
    • (2002) J Biol Chem , vol.18 , pp. 18
    • Shapiro, D.A.1    Kristiansen, K.2    Weiner, D.M.3    Kroeze, W.K.4    Roth, B.L.5
  • 36
    • 0032907534 scopus 로고    scopus 로고
    • Clozapine and other 5-hydroxytryptamine2A receptor antagonists alter the subcellular distribution of 5-hydroxytryptamine2A receptors in vitro and in vivo
    • Willins D, Berry S, Alsayegh L, Backstrom J, Sanders-Bush E, Roth B. Clozapine and other 5-hydroxytryptamine2A receptor antagonists alter the subcellular distribution of 5-hydroxytryptamine2A receptors in vitro and in vivo. Neurosci 1999; 91: 599.
    • (1999) Neurosci , vol.91 , pp. 599
    • Willins, D.1    Berry, S.2    Alsayegh, L.3    Backstrom, J.4    Sanders-Bush, E.5    Roth, B.6
  • 37
    • 0035896585 scopus 로고    scopus 로고
    • The dynamin-dependent, arrestin-independent internalization of 5- hydroxytryptamine 2A (5-HT2A) serotonin receptors reveals differential sorting of arrestins and 5-HT2A receptors during endocytosis
    • Bhatnagar A, Willins DL, Gray JA, Woods J, Benovic JL, Roth BL. The dynamin-dependent, arrestin-independent internalization of 5- hydroxytryptamine 2A (5-HT2A) serotonin receptors reveals differential sorting of arrestins and 5-HT2A receptors during endocytosis. J Biol Chem 2001; 276(11): 8269.
    • (2001) J Biol Chem , vol.276 , Issue.11 , pp. 8269
    • Bhatnagar, A.1    Willins, D.L.2    Gray, J.A.3    Woods, J.4    Benovic, J.L.5    Roth, B.L.6
  • 38
    • 2942538034 scopus 로고    scopus 로고
    • A placebo-controlled evaluation of four novel compounds for the treatment of schizophrenia and schizoaffective disorder
    • Meltzer H, Arvantis L, Bauer D, Rein W, Group MS. A placebo-controlled evaluation of four novel compounds for the treatment of schizophrenia and schizoaffective disorder. Am J Psychiatry 2004; 161(6):975.
    • (2004) Am J Psychiatry , vol.161 , Issue.6 , pp. 975
    • Meltzer, H.1    Arvantis, L.2    Bauer, D.3    Rein, W.4    Group, M.S.5
  • 39
    • 0021683773 scopus 로고
    • Aortic recognition sites for serotonin (5HT) are coupled to phospholipase C and modulate phosphatidylinositol turnover
    • Roth BL, Nakaki T, Chuang DM, Costa E. Aortic recognition sites for serotonin (5HT) are coupled to phospholipase C and modulate phosphatidylinositol turnover. Neuropharmacology 1984; 23(10): 1223.
    • (1984) Neuropharmacology , vol.23 , Issue.10 , pp. 1223
    • Roth, B.L.1    Nakaki, T.2    Chuang, D.M.3    Costa, E.4
  • 40
    • 0022318366 scopus 로고
    • Evidence for an endocoid for the 5HT2 recognition site
    • Lal H, LaBella F, Lane J, editors. New York: Alan R. Liss
    • Roth BL, Nakaki T, Chuang D-M, Costa E. Evidence for an endocoid for the 5HT2 recognition site. In: Endocoids, Vol. 192. Lal H, LaBella F, Lane J, editors. New York: Alan R. Liss, 1985, 473.
    • (1985) Endocoids , vol.192 , pp. 473
    • Roth, B.L.1    Nakaki, T.2    Chuang, D.-M.3    Costa, E.4
  • 42
    • 4544383544 scopus 로고    scopus 로고
    • Caveolin-1 interacts with 5-HT2A serotonin receptors and profoundly modulates the signaling of selected Galphaq-coupled protein receptors
    • epub 2004 Jun 9
    • Bhatnagar A, Sheffler DJ, Kroeze WK, Compton-Toth B, Roth BL. Caveolin-1 interacts with 5-HT2A serotonin receptors and profoundly modulates the signaling of selected Galphaq-coupled protein receptors. J Biol Chem. 2004; 279(33):34614 (epub 2004 Jun 9).
    • (2004) J Biol Chem , vol.279 , Issue.33 , pp. 34614
    • Bhatnagar, A.1    Sheffler, D.J.2    Kroeze, W.K.3    Compton-Toth, B.4    Roth, B.L.5


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