Prion-like proteins sequester and suppress the toxicity of huntingtin exon 1

Proceedings of the National Academy of Sciences of the United States of America

Volumn 111, Issue 33, 2014, Pages 12085-12090

  Kayatekin, Can ^a   Matlack, Kent E S ^a   Hesse, William R ^a,b   Guan, Yinghua ^c,d   Chakrabortee, Sohini ^a   Russ, Jenny ^e,g   Wanker, Erich E ^e   Shah, Jagesh V ^c,d   Lindquist, Susan ^a,f  

^a WHITEHEAD INSTITUTE FOR BIOMEDICAL RESEARCH   (United States)

^b Massachusetts Institute of Technology Cambridge   (United States)

^c HARVARD MEDICAL SCHOOL   (United States)

^d BRIGHAM AND WOMEN S HOSPITAL   (United States)

^e MAX DELBRÜCK CENTER FOR MOLECULAR MEDICINE   (Germany)

^f MASSACHUSETTS INSTITUTE OF TECHNOLOGY   (United States)

^g UNIVERSITY OF PENNSYLVANIA   (United States)

Author keywords

Prions; Protein misfolding

Indexed keywords

ASPARAGINE; GLUTAMINE; HUNTINGTIN; OLIGOMER; POLYGLUTAMINE; PRION LIKE PROTEIN; PRION PROTEIN; UNCLASSIFIED DRUG;

ARTICLE; ARTIFACT; CELL DEATH; CONTROLLED STUDY; EXON; FUNGAL GENOME; GENE OVEREXPRESSION; HUMAN; HUMAN CELL; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; YEAST;

PRIONS; PROTEIN MISFOLDING;

EXONS; GPI-LINKED PROTEINS; HUMANS; MICROSCOPY, CONFOCAL; NERVE TISSUE PROTEINS; PRIONS;

EID: 84906309148     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1412504111     Document Type: Article

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