Sirt2 suppresses glioma cell growth through targeting NF-κB-miR-21 axis

Biochemical and Biophysical Research Communications

Volumn 441, Issue 3, 2013, Pages 661-667

  Li, Ya'nan ^a   Dai, Dongwei ^a   Lu, Qiong ^a   Fei, Mingyu ^a   Li, Mengmeng ^b   Wu, Xi ^a  

^a SECOND MILITARY MEDICAL UNIVERSITY   (China)

^b SECOND MILITARY MEDICAL UNIVERSITY   (China)

Author keywords

Apoptosis; Deacetylation; Glioma; MiR 21; NF B; Sirt2

Indexed keywords

CASPASE 3; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; MICRORNA 21; PROTEIN BAX; PROTEIN BCL 2; SIRTUIN 2; SYNAPTOTAGMIN I;

APOPTOSIS; ARTICLE; CELL GROWTH; CELL PROLIFERATION; COLONY FORMATION; CONTROLLED STUDY; DEACETYLATION; DOWN REGULATION; GENE OVEREXPRESSION; GLIOMA CELL; HUMAN; HUMAN CELL; HUMAN TISSUE; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN BINDING; UPREGULATION;

APOPTOSIS; DEACETYLATION; GLIOMA; MIR-21; NF-ΚB; SIRT2;

APOPTOSIS; BCL-2-ASSOCIATED X PROTEIN; BRAIN NEOPLASMS; CASPASE 3; CELL LINE, TUMOR; CELL PROLIFERATION; DOWN-REGULATION; GENE KNOCKDOWN TECHNIQUES; GLIOMA; HUMANS; MICRORNAS; NF-KAPPA B; PROMOTER REGIONS, GENETIC; SIRTUIN 2; TRANSCRIPTION FACTOR RELA; TRANSCRIPTION, GENETIC;

EID: 84888294166     PISSN: 0006291X     EISSN: 10902104     Source Type: Journal    
DOI: 10.1016/j.bbrc.2013.10.077     Document Type: Article

References (26)

1. Houtkooper R.H., Pirinen E., Auwerx J. Sirtuins as regulators of metabolism and healthspan. Nat. Rev. Mol. Cell Biol. 2012, 13:225-238.
2. Burnett C., Valentini S., Cabreiro F., Goss M., Somogyvari M., Piper M.D., Hoddinott M., Sutphin G.L., Leko V., McElwee J.J., Vazquez-Manrique R.P., Orfila A.M., Ackerman D., Au C., Vinti G., Riesen M., Howard K., Neri C., Bedalov A., Kaeberlein M., Soti C., Partridge L., Gems D. Absence of effects of Sir2 overexpression on lifespan in C. elegans and Drosophila. Nature 2011, 477:482-485.
3. Finkel T., Deng C.X., Mostoslavsky R. Recent progress in the biology and physiology of sirtuins. Nature 2009, 460:587-591.
4. Haigis M.C., Guarente L.P. Mammalian sirtuins - emerging roles in physiology, aging, and calorie restriction. Genes Dev. 2006, 20:2913-2921.
5. Vaquero A., Scher M.B., Lee D.H., Sutton A., Cheng H.L., Alt F.W., Serrano L., Sternglanz R., Reinberg D. SirT2 is a histone deacetylase with preference for histone H4 Lys 16 during mitosis. Genes Dev. 2006, 20:1256-1261.
6. +-dependent tubulin deacetylase. Mol. Cell. 2003, 11:437-444.
7. Jing E., Gesta S., Kahn C.R. SIRT2 regulates adipocyte differentiation through FoxO1 acetylation/deacetylation. Cell Metab. 2007, 6:105-114.
8. Wang F., Nguyen M., Qin F.X.-F., Tong Q. SIRT2 deacetylates FOXO3a in response to oxidative stress and caloric restriction. Aging Cell 2007, 6:505-514.
9. Luthi-Carter R., Taylor D.M., Pallos J., Lambert E., Amore A., Parker A., Moffitt H., Smith D.L., Runne H., Gokce O., Kuhn A., Xiang Z., Maxwell M.M., Reeves S.A., Bates G.P., Neri C., Thompson L.M., Marsh J.L., Kazantsev A.G. SIRT2 inhibition achieves neuroprotection by decreasing sterol biosynthesis. Proc. Natl. Acad. Sci. U.S.A. 2010, 107:7927-7932.
10. Rothgiesser K.M., Erener S., Waibel S., Lüscher B., Hottiger M.O. SIRT2 regulates NF-κB-dependent gene expression through deacetylation of p65 Lys310. J. Cell Sci. 2010, 123:4251-4258.
11. Harting K., Knoll B. SIRT2-mediated protein deacetylation: an emerging key regulator in brain physiology and pathology. Eur. J. Cell Biol. 2010, 89:262-269.
12. Hiratsuka M., Inoue T., Toda T., Kimura N., Shirayoshi Y., Kamitani H., Watanabe T., Ohama E., Tahimic C.G., Kurimasa A., Oshimura M. Proteomics-based identification of differentially expressed genes in human gliomas: down-regulation of SIRT2 gene. Biochem. Biophys. Res. Commun. 2003, 309:558-566.
13. He X., Nie H., Hong Y., Sheng C., Xia W., Ying W. SIRT2 activity is required for the survival of C6 glioma cells. Biochem. Biophys. Res. Commun. 2012, 417:468-472.
14. Li N., He Y., Wang L., Mo C., Zhang J., Zhang W., Li J., Liao Z., Tang X., Xiao H. d-galactose induces necroptotic cell death in neuroblastoma cell lines. J. Cell. Biochem. 2011, 112:3834-3844.
15. Chan J.A., Krichevsky A.M., Kosik K.S. MicroRNA-21 is an antiapoptotic factor in human glioblastoma cells. Cancer Res. 2005, 65:6029-6033.
16. Corsten M.F., Miranda R., Kasmieh R., Krichevsky A.M., Weissleder R., Shah K. MicroRNA-21 knockdown disrupts glioma growth in vivo and displays synergistic cytotoxicity with neural precursor cell-delivered S-TRAIL in human gliomas. Cancer Res. 2007, 67:8994-9000.
17. Shi L., Chen J., Yang J., Pan T., Zhang S., Wang Z. MiR-21 protected human glioblastoma U87MG cells from chemotherapeutic drug temozolomide induced apoptosis by decreasing Bax/Bcl-2 ratio and caspase-3 activity. Brain Res. 2010, 1352:255-264.
18. Pais T.F., Szego E.M., Marques O., Miller-Fleming L., Antas P., Guerreiro P., de Oliveira R.M., Kasapoglu B., Outeiro T.F. The NAD-dependent deacetylase sirtuin 2 is a suppressor of microglial activation and brain inflammation. EMBO J. 2013, 32:2603-2616.
19. Liu L., Arun A., Ellis L., Peritore C., Donmez G. Sirtuin 2 (SIRT2) enhances 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced nigrostriatal damage via deacetylating forkhead box O3a (FoxO3a) and activating bim protein. J. Biol. Chem. 2012, 287:32307-32311.
20. Lynn E.G., McLeod C.J., Gordon J.P., Bao J., Sack M.N. SIRT2 is a negative regulator of anoxia-reoxygenation tolerance via regulation of 14-3-3 ζ and BAD in H9c2 cells. FEBS Lett. 2008, 582:2857-2862.
21. Li Y., Matsumori H., Nakayama Y., Osaki M., Kojima H., Kurimasa A., Ito H., Mori S., Katoh M., Oshimura M., Inoue T. SIRT2 down-regulation in HeLa can induce p53 accumulation via p38 MAPK activation-dependent p300 decrease, eventually leading to apoptosis. Genes Cells 2011, 16:34-45.
22. Matsushita N., Takami Y., Kimura M., Tachiiri S., Ishiai M., Nakayama T., Takata M. Role of NAD-dependent deacetylases SIRT1 and SIRT2 in radiation and cisplatin-induced cell death in vertebrate cells. Genes Cells 2005, 10:321-332.
23. Narayan N., Lee I.H., Borenstein R., Sun J., Wong R., Tong G., Fergusson M.M., Liu J., Rovira II., Cheng H.L., Wang G., Gucek M., Lombard D., Alt F.W., Sack M.N., Murphy E., Cao L., Finkel T. The NAD-dependent deacetylase SIRT2 is required for programmed necrosis. Nature 2012, 492:199-204.
24. Zhou X., Zhang J., Jia Q., Ren Y., Wang Y., Shi L., Liu N., Wang G., Pu P., You Y., Kang C. Reduction of miR-21 induces glioma cell apoptosis via activating caspase 9 and 3. Oncol. Rep. 2010, 24:195-201.
25. Maegdefessel L., Azuma J., Toh R., Deng A., Merk D.R., Raiesdana A., Leeper N.J., Raaz U., Schoelmerich A.M., McConnell M.V., Dalman R.L., Spin J.M., Tsao P.S. MicroRNA-21 blocks abdominal aortic aneurysm development and nicotine-augmented expansion. Sci. Transl. Med. 2012, 4:122ra122.
26. Zhou R., Hu G., Gong A.Y., Chen X.M. Binding of NF-kappaB p65 subunit to the promoter elements is involved in LPS-induced transactivation of miRNA genes in human biliary epithelial cells. Nucleic Acids Res. 2010, 38:3222-3232.