Development of acetazolamide-loaded, pH-triggered polymeric nanoparticulate in situ gel for sustained ocular delivery: In vitro. ex vivo evaluation and pharmacodynamic study

Drug Development and Industrial Pharmacy

Volumn 40, Issue 9, 2014, Pages 1223-1232

  Singh, Jyotsana ^a   Chhabra, Gulshan ^a   Pathak, Kamla ^a  

^a NH 2   (India)

Author keywords

Acetazolamide; Draize's test; in situ gel; Intraocular pressure; Nanoparticles; Nanoprecipitation; Transcorneal permeation

Indexed keywords

ACETAZOLAMIDE; CARBOMER; DRUG CARRIER; EUDRAGIT; NANOPARTICLE; DELAYED RELEASE FORMULATION; EYE DROPS; GEL; POLYMER; SUSPENSION;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; COMPARATIVE STUDY; CONTROLLED STUDY; CORNEA PERMEABILITY; DRAIZE TEST; DRUG ABSORPTION; DRUG BIOAVAILABILITY; DRUG EFFICACY; DRUG FORMULATION; DRUG PENETRATION; DRUG SAFETY; DRUG SCREENING; EX VIVO STUDY; EXPERIMENTAL RABBIT; EYE EXAMINATION; EYE TOXICITY; GELATION; GLASS TRANSITION TEMPERATURE; IN VITRO STUDY; INTRAOCULAR DRUG ADMINISTRATION; INTRAOCULAR PRESSURE; NANOENCAPSULATION; NONHUMAN; OPEN ANGLE GLAUCOMA; PARTICLE SIZE; PATIENT COMPLIANCE; PH; PH MEASUREMENT; SURFACE CHARGE; SUSTAINED DRUG RELEASE; TONOMETER; TRANSMISSION ELECTRON MICROSCOPY; ZETA POTENTIAL; ADMINISTRATION AND DOSAGE; ANIMAL; CHEMISTRY; CLASSIFICATION; CORNEA; DELAYED RELEASE FORMULATION; DRUG DELIVERY SYSTEM; DRUG EFFECTS; GEL; GLAUCOMA; MEDICINAL CHEMISTRY; PERMEABILITY; PROCEDURES; RABBIT; SUSPENSION;

ACETAZOLAMIDE; ANIMALS; CHEMISTRY, PHARMACEUTICAL; CORNEA; DELAYED-ACTION PREPARATIONS; DRUG DELIVERY SYSTEMS; GELS; GLAUCOMA; HYDROGEN-ION CONCENTRATION; INTRAOCULAR PRESSURE; NANOPARTICLES; OPHTHALMIC SOLUTIONS; PARTICLE SIZE; PERMEABILITY; POLYMERS; RABBITS; SUSPENSIONS;

EID: 84906254529     PISSN: 03639045     EISSN: 15205762     Source Type: Journal    
DOI: 10.3109/03639045.2013.814061     Document Type: Article

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