Novel microemulsion in situ electrolyte-triggered gelling system for ophthalmic delivery of lipophilic cyclosporine A: In vitro and in vivo results

International Journal of Pharmaceutics

Volumn 365, Issue 1-2, 2009, Pages 143-149

  Gan, Li ^a,b   Gan, Yong ^b   Zhu, Chunliu ^b   Zhang, Xinxin ^b   Zhu, Jiabi ^a  

^a CHINA PHARMACEUTICAL UNIVERSITY   (China)

^b SHANGHAI INSTITUTE OF MATERIA MEDICA   (China)

Author keywords

Cyclosporine A; In situ gelling system; Kelcogel ; Microemulsion; Ophthalmic delivery

Indexed keywords

ARTIFICIAL TEAR; CASTOR OIL; CYCLOSPORIN A; GELLAN; GLYCEROL; SOLUTOL HS 15; WATER;

ANIMAL EXPERIMENT; ANIMAL TISSUE; AREA UNDER THE CURVE; ARTICLE; CONTROLLED STUDY; CORNEA; DILUTION; DRUG DELIVERY SYSTEM; DRUG DOSAGE FORM COMPARISON; DRUG TISSUE LEVEL; ENCAPSULATION; FLOW KINETICS; GELATION; LIPOPHILICITY; MALE; MICROEMULSION; MICROEMULSION IN SITU ELECTROLYTE TRIGGERED GELLING SYSTEM; NONHUMAN; PRIORITY JOURNAL; TOXICITY TESTING; VISCOSITY;

ANIMALS; AREA UNDER CURVE; CASTOR OIL; CORNEA; CYCLOSPORINE; ELECTROLYTES; EMULSIONS; EXCIPIENTS; GELS; GLYCEROL; IMMUNOSUPPRESSIVE AGENTS; MALE; OPHTHALMIC SOLUTIONS; POLYETHYLENE GLYCOLS; RABBITS; RHEOLOGY; STEARIC ACIDS; SURFACE-ACTIVE AGENTS; VISCOSITY; WATER;

EID: 57049179056     PISSN: 03785173     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ijpharm.2008.08.004     Document Type: Article

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