Development and characterization of Cyclosporine A loaded nanoparticles for ocular drug delivery: Cellular toxicity, uptake, and kinetic studies

Journal of Controlled Release

Volumn 151, Issue 3, 2011, Pages 286-294

  Aksungur, Pelin ^a   Demirbilek, Murat ^a   Denkbaş, Emir B ^a   Vandervoort, Jo ^b   Ludwig, Annick ^b   Ünlü, Nurşen ^a  

^a HACETTEPE UNIVERSITY   (Turkey)

^b UNIVERSITY OF ANTWERP   (Belgium)

Author keywords

Carbopol ; Cyclosporin A; Dry eye; Eudragit RL; Nanoparticles; PLGA

Indexed keywords

BIPHASIC; CARBOPOL; CELLULAR TOXICITIES; CELLULAR UPTAKE; CYCLOSPORIN A; CYCLOSPORINE A; DRUG ENTRAPMENT; DRUG RELEASE; DRY EYE; EUDRAGIT; INCUBATION TIME; KINETIC STUDY; MEAN SIZE; OCULAR DRUG DELIVERY; PLGA; POLY-LACTIDE-CO-GLYCOLIDE; PRODUCTION YIELD; RELEASE PROFILES; SURFACE CHARACTERISTICS; TEAR FILMS; WEIBULL MODELS;

CONTROLLED DRUG DELIVERY; FILM PREPARATION; POLYMER BLENDS; ZETA POTENTIAL;

NANOPARTICLES;

CARBOMER; CYCLOSPORIN A; EUDRAGIT; NANOPARTICLE; POLYGLACTIN; RESOMER; RESTASISA; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; CELL VIABILITY; CONTROLLED STUDY; CYTOTOXICITY; DRUG BIOAVAILABILITY; DRUG DELIVERY SYSTEM; DRUG DOSAGE FORM COMPARISON; DRUG EFFICACY; DRUG FORMULATION; DRUG PENETRATION; DRUG RELEASE; DRUG RETENTION; DRUG SYNTHESIS; DRY EYE; EYE INFLAMMATION; MALE; MOUSE; NONHUMAN; PARTICLE SIZE; PRIORITY JOURNAL; RABBIT; SINGLE DRUG DOSE; TEAR FILM; ZETA POTENTIAL;

ANIMALS; BIOLOGICAL AVAILABILITY; BIOLOGICAL TRANSPORT; CELL CULTURE TECHNIQUES; CELL LINE; CELL SURVIVAL; CYCLOSPORINE; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG CARRIERS; DRUG COMPOUNDING; DRY EYE SYNDROMES; EYE; FIBROBLASTS; IMMUNOSUPPRESSIVE AGENTS; KINETICS; MALE; MICE; MICROSCOPY, ELECTRON, SCANNING; NANOPARTICLES; PARTICLE SIZE; RABBITS; SOLUBILITY; SURFACE PROPERTIES; TEARS;

EID: 79957490620     PISSN: 01683659     EISSN: 18734995     Source Type: Journal    
DOI: 10.1016/j.jconrel.2011.01.010     Document Type: Article

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