Design and development of a novel pH triggered nanoemulsified in-situ ophthalmic gel of fluconazole: Ex-vivo transcorneal permeation, corneal toxicity and irritation testing

Drug Development and Industrial Pharmacy

Volumn 39, Issue 5, 2013, Pages 780-790

  Pathak, Mukesh K ^a   Chhabra, Gulshan ^a   Pathak, Kamla ^a  

^a Rajiv Academy for Pharmacy ^*  (India)

Author keywords

Corneal toxicity; Fluconazole; HET CAM test; in situ gel; Ocular nanoemulsion; Transcorneal permeation

Indexed keywords

CARBOPOL 934; DIETHYLENE GLYCOL MONOETHYL ETHER; EYE DROPS; FLUCONAZOLE; OCTANOIN; POLYSORBATE 80;

ANIMAL TISSUE; ANTIFUNGAL ACTIVITY; ARTICLE; CANDIDA ALBICANS; CHORIOALLANTOIS; CONTROLLED STUDY; CORNEA; CORNEA DISEASE; CORNEA PERMEABILITY; DRUG DESIGN; DRUG EFFICACY; DRUG FORMULATION; DRUG PENETRATION; DRUG SAFETY; DRUG SOLUBILITY; DRUG STABILITY; EGG; EX VIVO STUDY; EYE IRRITATION; EYE PROTECTION; EYE TOXICITY; EYEBALL; FLOW KINETICS; GEL; GELATION; GOAT; HEN; IN VITRO STUDY; MEAN RESIDENCE TIME; NANOEMULSION; NONHUMAN; PH; SUSTAINED DRUG RELEASE; TRANSMISSION ELECTRON MICROSCOPY;

ACRYLATES; ADMINISTRATION, OPHTHALMIC; ANIMALS; ANTIFUNGAL AGENTS; CORNEA; CORNEAL DISEASES; DELAYED-ACTION PREPARATIONS; DRUG DESIGN; FLUCONAZOLE; GELS; GOATS; HUMANS; HYDROGEN-ION CONCENTRATION; NANOPARTICLES; OPHTHALMIC SOLUTIONS;

EID: 84875875253     PISSN: 03639045     EISSN: 15205762     Source Type: Journal    
DOI: 10.3109/03639045.2012.707203     Document Type: Article

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