Amyloid-β-induced action potential desynchronization and degradation of hippocampal gamma oscillations is prevented by interference with peptide conformation change and aggregation

Journal of Neuroscience

Volumn 34, Issue 34, 2014, Pages 11416-11425

  Kurudenkandy, Firoz Roshan ^a   Zilberter, Misha ^a   Biverstål, Henrik ^a   Presto, Jenny ^a   Honcharenko, Dmytro ^a   Strömberg, Roger ^a   Johansson, Jan ^a,b,c   Winblad, Bengt ^a   Fisahn, André ^a  

^a KAROLINSKA INSTITUTE   (Sweden)

^b SWEDISH UNIVERSITY OF AGRICULTURAL SCIENCES   (Sweden)

^c TALLINN UNIVERSITY   (Estonia)

Author keywords

Alzheimer's disease; Amyloid peptide; BRICHOS domain; Gamma oscillations; Hippocampus; Neuronal synchronization

Indexed keywords

AMYLOID BETA PROTEIN; AMYLOID BETA PROTEIN[1-42]; AMINO ACID RECEPTOR STIMULATING AGENT; AMYLOID BETA-PROTEIN (1-42); KAINIC ACID; PEPTIDE FRAGMENT; PROTEIN AGGREGATE;

ACTION POTENTIAL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; ELECTRON MICROSCOPY; ELECTROPHYSIOLOGY; EVOKED RESPONSE; EXCITATORY POSTSYNAPTIC POTENTIAL; GAMMA RHYTHM; HIPPOCAMPUS; INHIBITORY POSTSYNAPTIC POTENTIAL; MOUSE; NERVE CELL NETWORK; NERVE CELL STIMULATION; NEUROTOXICITY; NONHUMAN; PRIORITY JOURNAL; PROTEIN AGGREGATION; PROTEIN FOLDING; PROTEIN STRUCTURE; SPECTRAL SENSITIVITY; SYNAPTIC TRANSMISSION; ANIMAL; BIOLOGICAL RHYTHM; C57BL MOUSE; CHEMISTRY; CYTOLOGY; DRUG EFFECTS; FEMALE; HIPPOCAMPAL CA3 REGION; IN VITRO STUDY; MALE; METABOLISM; NERVE CELL; PATCH CLAMP TECHNIQUE; PHYSIOLOGY; PROTEIN CONFORMATION; SPECTROSCOPY; TIME; ULTRASTRUCTURE;

ACTION POTENTIALS; AMYLOID BETA-PEPTIDES; ANIMALS; BIOLOGICAL CLOCKS; CA3 REGION, HIPPOCAMPAL; EXCITATORY AMINO ACID AGONISTS; FEMALE; IN VITRO TECHNIQUES; KAINIC ACID; MALE; MICE; MICE, INBRED C57BL; NERVE NET; NEURONS; PATCH-CLAMP TECHNIQUES; PEPTIDE FRAGMENTS; PROTEIN AGGREGATES; PROTEIN CONFORMATION; SPECTRUM ANALYSIS; SYNAPTIC TRANSMISSION; TIME FACTORS;

EID: 84906244988     PISSN: 02706474     EISSN: 15292401     Source Type: Journal    
DOI: 10.1523/JNEUROSCI.1195-14.2014     Document Type: Article

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