A novel gene, MSI2, encoding a putative RNA-binding protein is recurrently rearranged at disease progression of chronic myeloid leukemia and forms a fusion gene with HOXA9 as a result of the cryptic t(7;17)(p15;q23)

Cancer Research

Volumn 63, Issue 6, 2003, Pages 1202-1206

  Barbouti, Aikaterini ^a   Höglund, Mattias ^a   Johansson, Bertil ^a   Lassen, Carin ^a   Nilsson, Per Gunnar ^a   Hagemeijer, Anne ^b   Mitelman, Felix ^a   Fioretos, Thoas ^a  

^a LUND UNIVERSITY HOSPITAL   (Sweden)

^b UNIVERSITY OF LEUVEN   (Belgium)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA INTERFERON; CYTARABINE; DAUNORUBICIN; HOX PROTEIN; HYDROXYUREA; PROTEIN HOXA9; PROTEIN MSI2; RNA BINDING PROTEIN; UNCLASSIFIED DRUG;

ADULT; ARTICLE; BLAST CELL CRISIS; CANCER CHEMOTHERAPY; CANCER GENETICS; CASE REPORT; CHROMOSOME 17Q; CHRONIC MYELOID LEUKEMIA; CYTOGENETICS; DISEASE COURSE; FEMALE; FUSION GENE; GENE IDENTIFICATION; GENE REARRANGEMENT; HOMEOBOX; HUMAN; KARYOTYPE; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN MOTIF; SEQUENCE ALIGNMENT; SEQUENCE ANALYSIS;

ADULT; AMINO ACID SEQUENCE; BASE SEQUENCE; CHROMOSOMES, HUMAN, PAIR 15; CHROMOSOMES, HUMAN, PAIR 7; DISEASE PROGRESSION; FEMALE; GENE ORDER; HOMEODOMAIN PROTEINS; HUMANS; IN SITU HYBRIDIZATION, FLUORESCENCE; LEUKEMIA, MYELOID, CHRONIC; MIDDLE AGED; MOLECULAR SEQUENCE DATA; ONCOGENE PROTEINS, FUSION; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA-BINDING PROTEINS; TRANSLOCATION, GENETIC;

EID: 0037444165     PISSN: 00085472     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (21)

1. Sawyers, C. L. Chronic myeloid leukemia. N. Engl. J. Med., 340: 1330-1340, 1999.
2. Deininger. M. W., Goldman, J. M., and Melo, J. V. The molecular biology of chronic myeloid leukemia. Blood, 96: 3343-3356, 2000.
3. Johansson, B., Fioretos, T., and Mitelman, F. Cytogenetic and molecular genetic evolution of chronic myeloid leukemia. Acta Haematol., 107: 76-94, 2002.
4. Barbouti, A., Johansson, B., Höglund, M., Mauritzson, N., Strömbeck, B., Nilsson, P., Tanke, H., Hagemeijer, A., Mitelman, F., and Fioretos, T. Multicolor COBRA-FISH analysis of chronic myeloid leukemia reveals novel cryptic balanced translocations during disease progression. Genes Chromosomes Cancer, 35: 127-137, 2002.
5. Fioretos, T., Nilsson, P. G., Åman, P., Heim, S., Kristoffersson, U., Malm, C., Simonsson, B., Turesson, I., and Mitelman, F. Clinical impact of breakpoint position within M-bcr in chronic myeloid leukemia. Leukemia (Baltimore), 7: 1225-1231, 1993.
6. Fioretos, T., Panagopoulos, I., Lassen, C., Swedin, A., Billström, R., Isaksson, M., Strömbeck, B., Olofsson, T., Mitelman, F., and Johansson, B. Fusion of the BCR and the fibroblast growth factor receptor-1 (FGFR1) genes as a result of t(8;22)(p11;q11) in a myeloproliferative disorder: the first fusion gene involving BCR but not ABL. Genes Chromosomes Cancer, 32: 302-310, 2001.
7. Borrow. J., Shearman, A. M., Stanton, V. P., Jr., Becher, R., Collins, T., Williams, A. J., Dube, I., Katz, F., Kwong, Y. L., Morris, C., Ohyashiki, K., Toyama, K., Rowley, J., and Housman, D. E. The t(7;11)(p15;p15) translocation in acute myeloid leukaemia fuses the genes for nucleoporin NUP98 and class I homeoprotein HOXA9. Nat. Genet., 12: 159-167, 1996.
8. Nakamura, T., Largaespada, D. A., Lee, M. P., Johnson, L. A., Ohyashiki, K., Toyama, K., Chen, S. J., Willman, C. L., Chen, I. M., Feinberg, A. P., Jenkins, N. A., Copeland, N. G., and Shaughnessy, J. D., Jr. Fusion of the nucleoporin gene NUP98 to HOXA9 by the chromosome translocation t(7;11)(p15;p15) in human myeloid leukaemia. Nat. Genet., 12: 154-158, 1996.
9. Nagai, K., Oubridge, C., Ito, N., Avis, J., and Evans, P. The RNP domain: a sequence-specific RNA-binding domain involved in processing and transport of RNA. Trends Biochem. Sci., 20: 235-240, 1995.
10. Krecic, A. M., and Swanson, M. S. hnRNP complexes: composition, structure, and function. Curr. Opin. Cell Biol., 11: 363-371, 1999.
11. Sakakibara, S., Nakamura, Y., Satoh, H., and Okano, H. RNA-binding protein Musashi2: developmentally regulated expression in neural precursor cells and subpopulations of neurons in mammalian CNS. J. Neurosci., 21: 8091-8107, 2001.
12. Imai, T., Tokunaga, A., Yoshida, T., Hashimoto, M., Mikoshiba, K., Weinmaster, G., Nakafuku, M., and Okano, H. The neural RNA-binding protein Musashil translationally regulates mammalian numb gene expression by interacting with its mRNA. Mol. Cell. Biol., 21: 3888-3900, 2001.
13. van Oostveen, J., Bijl, J., Raaphorst, F., Walboomers, J., and Meijer, C. The role of homeobox genes in normal hematopoiesis and hematological malignancies. Leukemia (Baltimore), 13: 1675-1690, 1999.
14. Lawrence, H. J., Helgason, C. D., Sauvageau, G., Fong, S., Izon, D. J., Humphries, R. K., and Largman, C. Mice bearing a targeted interruption of the homeobox gene HOXA9 have defects in myeloid, erythroid, and lymphoid hematopoiesis. Blood, 89: 1922-1930, 1997.
15. Thorsteinsdottir, U., Mamo, A., Kroon, E., Jerome, L., Bijl, J., Lawrence, H. J., Humphries, K., and Sauvageau, G. Overexpression of the myeloid leukemia-associated Hoxa9 gene in bone marrow cells induces stem cell expansion. Blood, 99: 121-129, 2002.
16. Lam, D. H., and Aplan, P. D. NUP98 gene fusions in hematologic malignancies. Leukemia (Baltimore), 15: 1689-1695, 2001.
17. Kasper, L. H., Brindle, P. K., Schnabel, C. A., Pritchard, C. E., Cleary, M. L., and van Deursen, J. M. CREB binding protein interacts with nucleoporin-specific FG repeats that activate transcription and mediate NUP98-HOXA9 oncogenicity. Mol. Cell. Biol., 19: 764-776, 1999.
18. Tamagnone, L., and Comoglio, P. M. Signalling by semaphorin receptors: cell guidance and beyond. Trends Cell Biol., 10: 377-383, 2000.
19. Tamagnone, L., Artigiani, S., Chen, H., He, Z., Ming, G. I., Song, H., Chedotal, A., Winberg, M. L., Goodman, C. S., Poo, M., Tessier-Lavigne, M., and Comoglio, P. M. Plexins are a large family of receptors for transmembrane, secreted, and GPI-anchored semaphorins in vertebrates. Cell, 99: 71-80, 1999.
20. Ron, D. TLS-CHOP and the role of RNA-binding proteins in oncogenic transformation. Curr. Top. Microbiol. Immunol., 220: 131-142, 1997.
21. Mercher, T., Busson-Le Coniat, M., Monni, R., Mauchauffee, M., Nguyen Khac, F., Gressin, L., Mugneret, F., Leblanc, T., Dastugue, N., and Olivier, A. B. Involvement of a human gene related to the Drosophila spen gene in the recurrent t(1;22) translocation of acute megakaryocytic leukemia. Proc. Natl. Acad. Sci. USA, 99: 5776-5779, 2001.