A high-content biosensor-based screen identifies cell-permeable activators and inhibitors of EGFR function: Implications in drug discovery

Journal of Biomolecular Screening

Volumn 17, Issue 7, 2012, Pages 885-899

  Antczak, Christophe ^a   Mahida, Jeni P ^a   Bhinder, Bhavneet ^a   Calder, Paul A ^a   Djaballah, Hakim ^a  

^a MEMORIAL SLOAN KETTERING CANCER CENTER   (United States)

Author keywords

domain based biosensor; EGFR; high content analysis; live cell imaging

Indexed keywords

4 (3 BROMOANILINO) 6,7 DIMETHOXYQUINAZOLINE; ALVESPIMYCIN; BECLOMETASONE; BIBU 1361; CAMPTOTHECIN; EBASTINE; EPIDERMAL GROWTH FACTOR RECEPTOR; EPIDERMAL GROWTH FACTOR RECEPTOR KINASE INHIBITOR; ERBSTATIN; ERLOTINIB; FLUDROXYCORTIDE; GEFITINIB; GW 2974; GW 583340; LAPATINIB; MIDOSTAURIN; UNCLASSIFIED DRUG; VASCULOTROPIN RECEPTOR; ZM 306416;

ANTIPROLIFERATIVE ACTIVITY; ARTICLE; BIOSENSOR; CELL ASSAY; CELL MEMBRANE PERMEABILITY; CELL VIABILITY; CYTOTOXICITY; DOSE RESPONSE; DRUG SCREENING; FOLLOW UP; HIGH THROUGHPUT SCREENING; HUMAN; HUMAN CELL; IC 50; PRIORITY JOURNAL; SIGNAL NOISE RATIO;

ANTI-INFLAMMATORY AGENTS; BECLOMETHASONE; BIOSENSING TECHNIQUES; BUTYROPHENONES; CELL LINE; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG DISCOVERY; FLURANDRENOLONE; HIGH-THROUGHPUT SCREENING ASSAYS; HISTAMINE H1 ANTAGONISTS; HUMANS; PERMEABILITY; PIPERIDINES; QUINAZOLINES; RECEPTOR, EPIDERMAL GROWTH FACTOR; RECEPTORS, VASCULAR ENDOTHELIAL GROWTH FACTOR; REPRODUCIBILITY OF RESULTS; SIGNAL-TO-NOISE RATIO;

EID: 84863839475     PISSN: 10870571     EISSN: 1552454X     Source Type: Journal    
DOI: 10.1177/1087057112446174     Document Type: Article

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