Uremic toxin p-cresol induces Akt-pathway-selective insulin resistance in bone marrow-derived mesenchymal stem cells

Stem Cells

Volumn 32, Issue 9, 2014, Pages 2443-2453

  Noh, Hyunjin ^a   Yu, Mi Ra ^a   Kim, Hyun Joo ^a   Jang, Eun Jung ^b   Hwang, Eun Sook ^b   Jeon, Jin Seok ^a   Kwon, Soon Hyo ^a   Han, Dong Cheol ^a  

^a Soonchunhyang University   (South Korea)

^b Ewha Womans University   (South Korea)

Author keywords

Chronic kidney disease; Insulin resistance; Mesenchymal stem cells; p Cresol

Indexed keywords

CRESOL; ENDOTHELIAL NITRIC OXIDE SYNTHASE; HYPOXIA INDUCIBLE FACTOR 1ALPHA; INSULIN; INSULIN RECEPTOR SUBSTRATE 1; MITOGEN ACTIVATED PROTEIN KINASE; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE B; STROMAL CELL DERIVED FACTOR 1ALPHA; VASCULOTROPIN; 4-CRESOL;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BLOOD FLOW; BONE MARROW; CAPILLARY DENSITY; CHRONIC KIDNEY DISEASE; CONTROLLED STUDY; ENZYME PHOSPHORYLATION; GLOMERULUS FILTRATION RATE; HINDLIMB; HUMAN; HUMAN CELL; INSULIN RESISTANCE; ISCHEMIA; MALE; MESENCHYMAL STEM CELL; MOUSE; NONHUMAN; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION; UREMIA; ANIMAL; BAGG ALBINO MOUSE; CELL CULTURE; CELL DIFFERENTIATION; DRUG EFFECTS; GENETIC TRANSFECTION; HEK293 CELL LINE; MESENCHYMAL STROMA CELL; METABOLISM; NUDE MOUSE; PATHOLOGY;

ANIMALS; BONE MARROW; CELL DIFFERENTIATION; CELLS, CULTURED; CRESOLS; HEK293 CELLS; HUMANS; INSULIN RESISTANCE; MALE; MESENCHYMAL STROMAL CELLS; MICE; MICE, INBRED BALB C; MICE, NUDE; PROTO-ONCOGENE PROTEINS C-AKT; SIGNAL TRANSDUCTION; TRANSFECTION; UREMIA;

EID: 84906237946     PISSN: 10665099     EISSN: 15494918     Source Type: Journal    
DOI: 10.1002/stem.1738     Document Type: Article

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