Bone marrow derived mesenchymal stem cells facilitate engineering of long-lasting functional vasculature

Blood

Volumn 111, Issue 9, 2008, Pages 4551-4558

  Au, Patrick ^a,b   Tam, Joshua ^a,b   Fukumura, Dai ^a   Jain, Rakesh K ^a  

^a MASSACHUSETTS GENERAL HOSPITAL   (United States)

^b MASSACHUSETTS INSTITUTE OF TECHNOLOGY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CELL MARKER; ENDOTHELIN 1; MYOCARDIN; PLATELET DERIVED GROWTH FACTOR;

ARTICLE; BLOOD FLOW; BLOOD VESSEL; CELL CONTACT; CELL DIFFERENTIATION; CELL MIGRATION; CONTROLLED STUDY; ENDOTHELIUM CELL; GENETIC TRANSCRIPTION; HEMATOPOIETIC STEM CELL; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; MESENCHYMAL STEM CELL; PRIORITY JOURNAL; PROTEIN EXPRESSION; SMOOTH MUSCLE FIBER; TISSUE ENGINEERING; UMBILICAL VEIN; UPREGULATION; VASCULARIZATION; BONE MARROW CELL; CYTOLOGY; DRUG EFFECT; GROWTH, DEVELOPMENT AND AGING; METHODOLOGY; MUSCLE CONTRACTION; PHYSIOLOGY; REGENERATIVE MEDICINE; STEM CELL; VASCULAR SMOOTH MUSCLE;

BLOOD VESSELS; BONE MARROW CELLS; ENDOTHELIN-1; HUMANS; MESENCHYMAL STEM CELLS; MUSCLE CONTRACTION; MUSCLE, SMOOTH, VASCULAR; REGENERATIVE MEDICINE; STEM CELLS; TISSUE ENGINEERING;

EID: 47149102903     PISSN: 00064971     EISSN: 15280020     Source Type: Journal    
DOI: 10.1182/blood-2007-10-118273     Document Type: Article

References (30)

1. Gnecchi M, He H, Noiseux N, et al. Evidence supporting paracrine hypothesis for Akt-modified mesenchymal stem cell-mediated cardiac protection and functional improvement. FASEB J. 2006; 20:661-669.
2. Fuchs S, Battler A, Kornowski R. Catheter-based stem cell and gene therapy for refractory myocardial ischemia. Nat Clin Pract. 2007;4(suppl 1): S89-S95.
3. Davani S, Marandin A, Mersin N, et al. Mesenchymal progenitor cells differentiate into an endothelial phenotype, enhance vascular density, and improve heart function in a rat cellular cardiomyoplasty model [see comment]. Circulation. 2003; 108(suppl 1):11253-11258.
4. Nagaya N, Fujii T, Iwase T, et al. Intravenous administration of mesenchymal stem cells improves cardiac function in rats with acute myocardial infarction through angiogenesis and myogenesis. Am J Physiol Heart Circ Physiol. 2004;287: H2670-H2676.
5. Koike N, Fukumura D, Gralla O, Au P, Schechner JS, Jain RK. Tissue engineering: creation of longlasting blood vessels. Nature. 2004;428:138-139.
6. Wang ZZ, Au P, Chen T, et al. Endothelial cells derived from human embryonic stem cells form durable blood vessels in vivo. Nat Biotechnol. 2007;25:317-318.
7. Au P, Daheron LM, Duda DG, et al. Differential in vivo potential of endothelial progenitor cells from human umbilical cord blood and adult peripheral blood to form functional long-lasting vessels. Blood. 2008;111:1302-1305.
8. Kashiwagi S, Izumi Y, Gohongi T, et al. NO mediates mural cell recruitment and vessel morphogenesis in murine melanomas and tissueengineered blood vessels. J Clin Invest. 2005; 115:1816-1827.
9. Brown EB, Campbell RB, Tsuzuki Y et al. In vivo measurement of gene expression, angiogenesis and physiological function in tumors using multiphoton laser scanning microscopy. Nat Med. 2001;7:864-868.
10. Wang D. Chang PS, Wang Z, et al. Activation of cardiac gene expression by myocardin, a transcriptional cofactorfor serum response factor. Cell. 2001;105:851-862.
11. Hirschi KK, Rohovsky SA, D'Amore PA. PDGF TGF-beta, and heterotypic cell-cell interactions mediate endothelial cell-induced recruitment of 10T1/2 cells and their differentiation to a smooth muscle fate. J Cell Biol. 1998;141:805-814.
12. Jain RK. Molecular regulation of vessel maturation. Nat Med. 2003;9:685-693.
13. Lindahl P, Johansson BR, Leveen P, Betsholtz C. Pericyte loss and microaneurysm formation in PDGF-B-deficient mice. Science. 1997;277:242-245.
14. Schechner JS, Nath AK, Zheng L, et al. In vivo formation of complex microvessels lined by human endothelial cells in an immunodeficient mouse. Proc Natl Acad Sci U S A. 2000;97:9191-9196.
15. Peppiatt CM, Howarth C, Mobbs P, Attwell D. Bidirectional control of CNS capillary diameter by pericytes. Nature. 2006;443:700-704.
16. Giordano A, Galderisi U, Marino IR. From the laboratory bench to the patient's bedside: an update on clinical trials with mesenchymal stem cells. J Cell Physiol. 2007;211:27-35.
17. Prockop DJ. Marrow stromal cells as stem cells for nonhematopoietic tissues. Science. 1997;276:71-74.
18. Oswald J, Boxberger S. Jorgensen B, et al. Mesenchymal stem cells can be differentiated into endothelial cells in vitro. Stem Cells. 2004;22:377-384.
19. Carmeliet P. Developmental biology: One cell, two fates. Nature. 2000;408:43-45.
20. Yamashita J, Itoh H, Hirashima M, et al. Flk1positive cells derived from embryonic stem cells serve as vascular progenitors. Nature. 2000;408:92-96.
21. Moretti A, Caron L, Nakano A, et al. Multipotent embryonic is 11 + progenitor cells lead to cardiac, smooth muscle, and endothelial cell diversification. Cell. 2006;127:1151-1165.
22. Kattman SJ, Huber TL Keller GM. Multipotent flk-1 + cardiovascular progenitor cells give rise to the cardiomyocyte, endothelial, and vascular smooth muscle lineages. Dev Cell. 2006;11:723-732.
23. Wang H, Riha GM, Yan S, et al. Shear stress induces endothelial differentiation from a murine embryonic mesenchymal progenitor cell line. Arterioscler Thromb Vase Biol. 2005;25:1817-1823.
24. Antonelli-Orlidge A, Saunders KB. Smith SR. D'Amore PA. An activated form of transforming growth factor beta is produced by cocultures of endothelial cells and pericytes. Proc Natl Acad Sci U S A. 1989;86:4544-4548.
25. Ross JJ, Hong Z, Willenbring B, et al. Cytokineinduced differentiation of multipotent adult progenitor cells into functional smooth muscle cells. J Clin Invest. 2006;116:3139-3149.
26. Paik JH, Skoura A. Chae SS, et al. Sphingosine 1-phosphate receptor regulation of N-cadherin mediates vascular stabilization. Genes Dev. 2004:18:2392-2403.
27. Yoshida T, Sinha S, Dandre F, et al. Myocardin is a key regulator of CArG-dependent transcription of multiple smooth muscle marker genes. Circ Res. 2003;92:856-864.
28. Sinha S, Hoofnagle MH, Kingston PA, McCanna ME, Owens GK. Transforming growth factorbetal signaling contributes to development of smooth muscle cells from embryonic stem cells. Am J Physiol. 2004;287:C1560-C1568.
29. Kaigler D, Krebsbach PH, West ER, Horger K, Huang YC, Mooney DJ. Endothelial cell modulation of bone marrow stromal cell osteogenic potential. FASEB J. 2005;19:665-667.
30. Engler AJ, Sen S, Sweeney HL, Discher DE. Matrix elasticity directs stem cell lineage specification. Cell. 2006;126:677-689.