Glomerular-specific protein kinase C-Β-induced insulin receptor substrate-1 dysfunction and insulin resistance in rat models of diabetes and obesity

Kidney International

Volumn 79, Issue 8, 2011, Pages 883-896

  Mima, Akira ^a   Ohshiro, Yuzuru ^a   Kitada, Munehiro ^a   Matsumoto, Motonobu ^a   Geraldes, Pedro ^a   Li, Chenzhong ^a   Li, Qian ^a   White, Gregory S ^a   Cahill, Christopher ^a   Rask Madsen, Christian ^a   King, George L ^a,b  

^a HARVARD MEDICAL SCHOOL   (United States)

^b JOSLIN DIABETES CENTER   (United States)

Author keywords

diabetic nephropathy; insulin receptor substrate 1; insulin resistance; obesity; protein kinase C

Indexed keywords

ENDOTHELIAL NITRIC OXIDE SYNTHASE; GLYCOGEN SYNTHASE KINASE 3ALPHA; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INSULIN; INSULIN RECEPTOR SUBSTRATE 1; INSULIN RECEPTOR SUBSTRATE 2; MESSENGER RNA; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; PROTEIN KINASE B; PROTEIN KINASE C BETA; RUBOXISTAURIN; UBIQUITIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DIABETES MELLITUS; DIABETIC NEPHROPATHY; DISEASE MODEL; ENDOTHELIUM CELL; ENZYME INHIBITION; GLOMERULOPATHY; GLOMERULUS; INSULIN RESISTANCE; KIDNEY TUBULE; MALE; MOLECULAR MECHANICS; NONHUMAN; OBESITY; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; RAT; RECEPTOR UPREGULATION; SIGNAL TRANSDUCTION; STREPTOZOCIN DIABETES; UBIQUITINATION; ZUCKER DIABETIC FATTY RAT;

EID: 79953241079     PISSN: 00852538     EISSN: 15231755     Source Type: Journal    
DOI: 10.1038/ki.2010.526     Document Type: Article

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