메뉴 건너뛰기




Volumn 24, Issue 9, 2014, Pages 979-991

Inducible tyrosine kinase inhibitors: A review of the patent literature (2010-2013)

Author keywords

Asthma; Bruton's tyrosine kinase inhibitor; Inducible tyrosine kinase inhibitor; Rheumatoid arthritis; Tec inhibitor; Thymus cell

Indexed keywords

BRUTON TYROSINE KINASE INHIBITOR; IBRUTINIB; INDUCIBLE TYROSINE KINASE INHIBITOR; JANUS KINASE INHIBITOR; PROTEIN TYROSINE KINASE INHIBITOR; RECOMBINANT GAMMA INTERFERON; UNCLASSIFIED DRUG; PROTEIN KINASE INHIBITOR; PROTEIN TYROSINE KINASE;

EID: 84906216493     PISSN: 13543776     EISSN: 17447674     Source Type: Journal    
DOI: 10.1517/13543776.2014.936381     Document Type: Review
Times cited : (6)

References (66)
  • 1
    • 84897055483 scopus 로고    scopus 로고
    • Targeting bruton's tyrosine kinase in B cell malignancies
    • Hendriks RW, Yuvaraj S, Kil LP. Targeting bruton's tyrosine kinase in B cell malignancies. Nat Rev Cancer 2014;14(4):219-32
    • (2014) Nat Rev Cancer , vol.14 , Issue.4 , pp. 219-232
    • Hendriks, R.W.1    Yuvaraj, S.2    Kil, L.P.3
  • 2
    • 84906324615 scopus 로고    scopus 로고
    • Bruton's tyrosine kinase inhibitors for the treatment of rheumatoid arthritis
    • [Epub ahead of print]
    • Whang JA, Chang BY. Bruton's tyrosine kinase inhibitors for the treatment of rheumatoid arthritis. Drug Discov Today 2014. [Epub ahead of print]
    • (2014) Drug Discov Today
    • Whang, J.A.1    Chang, B.Y.2
  • 3
    • 0033597440 scopus 로고    scopus 로고
    • Requirement for Tec kinases Rlk and Itk in T cell receptor signaling and immunity
    • Schaeffer EM, Debnath J, Yap G. Requirement for Tec kinases Rlk and Itk in T cell receptor signaling and immunity. Science 1999;284:638-41
    • (1999) Science , vol.284 , pp. 638-641
    • Schaeffer, E.M.1    Debnath, J.2    Yap, G.3
  • 4
    • 79958163806 scopus 로고    scopus 로고
    • Tec family kinases Itk and Rlk/Txk in T lymphocytes: Cross-regulation of cytokine production and T-cell fates
    • Gomez-Rodriguez J, Kraus ZJ, Schwartzberg PL. Tec family kinases Itk and Rlk/Txk in T lymphocytes: cross-regulation of cytokine production and T-cell fates. FEBS J 2011;278(12):1980-9
    • (2011) FEBS J , vol.278 , Issue.12 , pp. 1980-1989
    • Gomez-Rodriguez, J.1    Kraus, Z.J.2    Schwartzberg, P.L.3
  • 5
    • 78650193349 scopus 로고    scopus 로고
    • Inhibition of the IL-2-inducible tyrosine kinase (Itk) activity: A new concept for the therapy of inflammatory skin diseases
    • von Bonin A, Rausch A, Mengel A, et al. Inhibition of the IL-2-inducible tyrosine kinase (Itk) activity: a new concept for the therapy of inflammatory skin diseases. Exp Dermatol 2011;20(1):41-7
    • (2011) Exp Dermatol , vol.20 , Issue.1 , pp. 41-47
    • Von Bonin, A.1    Rausch, A.2    Mengel, A.3
  • 6
    • 84880686071 scopus 로고    scopus 로고
    • Inhibitors of BTK and Itk: State of the new drugs for cancer, autoimmunity and inflammatory diseases
    • Vargas L, Hamasy A, Nore BF, Smith CI. Inhibitors of BTK and Itk: state of the new drugs for cancer, autoimmunity and inflammatory diseases. Scand J Immunol 2013;78(2):130-9
    • (2013) Scand J Immunol , vol.78 , Issue.2 , pp. 130-139
    • Vargas, L.1    Hamasy, A.2    Nore, B.F.3    Smith, C.I.4
  • 7
    • 77949878560 scopus 로고    scopus 로고
    • Itk inhibitors, a Patent Review
    • Lo HY. Itk inhibitors, a Patent Review. Exp Opin Ther Patents 2010;4):459-69
    • (2010) Exp Opin Ther Patents , vol.4 , pp. 459-469
    • Lo, H.Y.1
  • 8
    • 0038557038 scopus 로고    scopus 로고
    • Attenuation of immunological symptoms of allergic asthma in mice lacking the tyrosine kinase Itk
    • Mueller C, August A. Attenuation of immunological symptoms of allergic asthma in mice lacking the tyrosine kinase Itk. J Immunol 2003;170(10):5056-63
    • (2003) J Immunol , vol.170 , Issue.10 , pp. 5056-5063
    • Mueller, C.1    August, A.2
  • 9
    • 84860461389 scopus 로고    scopus 로고
    • Regulation of T-cell responses and disease by tec kinase Itk
    • August A, Ragin MJ. Regulation of T-cell responses and disease by tec kinase Itk. Int Rev Immunol 2012;31(2):155-65
    • (2012) Int Rev Immunol , vol.31 , Issue.2 , pp. 155-165
    • August, A.1    Ragin, M.J.2
  • 10
    • 79958137465 scopus 로고    scopus 로고
    • Tec family kinases: Itk signaling and the development of NKT alpha beta and gamma delta T cells
    • Qi Q, Kannan AK, August A. Tec family kinases: itk signaling and the development of NKT alpha beta and gamma delta T cells. FEBS J 2011;278(12):1970-9
    • (2011) FEBS J , vol.278 , Issue.12 , pp. 1970-1979
    • Qi, Q.1    Kannan, A.K.2    August, A.3
  • 11
    • 84961928152 scopus 로고    scopus 로고
    • TEC and MAPK kinase signalling pathways in t helper (th) cell development, th2 differentiation and allergic asthma
    • Kannan Y, Wilson MS. TEC and MAPK kinase signalling pathways in t helper (th) cell development, th2 differentiation and allergic asthma. J Clin Cell Immunol 2012;S12:1-15
    • (2012) J Clin Cell Immunol , vol.S12 , pp. 1-15
    • Kannan, Y.1    Wilson, M.S.2
  • 12
    • 84896848164 scopus 로고    scopus 로고
    • Itk-mediated integration of T cell receptor and cytokine signaling regulates the balance between Th17 and regulatory T cells
    • Gomez-Rodriguez J, Wohlfert EA, Handon R, et al. Itk-mediated integration of T cell receptor and cytokine signaling regulates the balance between Th17 and regulatory T cells. J Exp Med 2014;211(3):529-43
    • (2014) J Exp Med , vol.211 , Issue.3 , pp. 529-543
    • Gomez-Rodriguez, J.1    Wohlfert, E.A.2    Handon, R.3
  • 13
    • 61849142482 scopus 로고    scopus 로고
    • The Tec kinases Itk and Rlk regulate conventional versus innate T-cell development
    • Prince AL, Yin CC, Enos ME, et al. The Tec kinases Itk and Rlk regulate conventional versus innate T-cell development. Immunol Rev 2009;228(1):115-31
    • (2009) Immunol Rev , vol.228 , Issue.1 , pp. 115-131
    • Prince, A.L.1    Yin, C.C.2    Enos, M.E.3
  • 14
    • 84860435487 scopus 로고    scopus 로고
    • Tec family kinases in inflammation and disease
    • Horwood NJ, Urbaniak AM, Danks L. Tec family kinases in inflammation and disease. Int Rev Immunol 2012;31(2):87-103
    • (2012) Int Rev Immunol , vol.31 , Issue.2 , pp. 87-103
    • Horwood, N.J.1    Urbaniak, A.M.2    Danks, L.3
  • 15
    • 80054783272 scopus 로고    scopus 로고
    • Imidazo[15-a]quinoxalines as irreversible BTK inhibitors for the treatment of rheumatoid arthritis
    • Kim KH, Maderna A, Schnute ME, et al. Imidazo[1,5-a]quinoxalines as irreversible BTK inhibitors for the treatment of rheumatoid arthritis. Bioorg Med Chem Lett 2011;21(21):6258-63
    • (2011) Bioorg Med Chem Lett , vol.21 , Issue.21 , pp. 6258-6263
    • Kim, K.H.1    Maderna, A.2    Schnute, M.E.3
  • 16
    • 2442511126 scopus 로고    scopus 로고
    • Crystal structures of interleukin-2 tyrosine kinase and their implications for the design of selective inhibitors
    • Brown K, Long JM, Vial SC, et al. Crystal structures of interleukin-2 tyrosine kinase and their implications for the design of selective inhibitors. J Biol Chem 2004;279(18):18727-32
    • (2004) J Biol Chem , vol.279 , Issue.18 , pp. 18727-18732
    • Brown, K.1    Long, J.M.2    Vial, S.C.3
  • 17
    • 84906279918 scopus 로고    scopus 로고
    • Vertex Pharmaceuticals Inc. 3,5-Disubstituted Pyrid-2-Ones useful as inhibitors of tec family of non-receptor tyrosine kinases. WO2007027594
    • Vertex Pharmaceuticals, Inc. 3,5-Disubstituted Pyrid-2-Ones useful as inhibitors of tec family of non-receptor tyrosine kinases. WO2007027594; 2007
    • (2007)
  • 18
    • 84906249782 scopus 로고    scopus 로고
    • Role for hydration in rationalizing the potency and selectivity of novel Itk inhibitors
    • 10 April 2013 MEDI Available from
    • Storck P, Charrier J-D, Miller A, et al. Role for hydration in rationalizing the potency and selectivity of novel Itk inhibitors. 245th ACS Meeting; 10 April 2013, MEDI Available from http://abstracts.acs.org//chem/ 245nm/program/view.php?pub-num=54&par=MEDI
    • 245th ACS Meeting
    • Storck, P.1    Charrier, J.-D.2    Miller, A.3
  • 19
    • 79953771938 scopus 로고    scopus 로고
    • Discovery and structure-activity relationship of 3-aminopyrid-2-ones as potent and selective interleukin-2 inducible t-cell kinase (itk) inhibitors
    • Charrier J-D, Miller A, Hay DP, et al. Discovery and structure-activity relationship of 3-aminopyrid-2-ones as potent and selective interleukin-2 inducible t-cell kinase (itk) inhibitors. J Med Chem 2011;54(7):2341-50
    • (2011) J Med Chem , vol.54 , Issue.7 , pp. 2341-2350
    • Charrier, J.-D.1    Miller, A.2    Hay, D.P.3
  • 20
    • 84906260925 scopus 로고    scopus 로고
    • Japan Tobacco Inc. Indole compound and pharmaceutical use thereof. WO2011065402
    • Japan Tobacco, Inc. Indole compound and pharmaceutical use thereof. WO2011065402; 2011
    • (2011)
  • 21
    • 84906255329 scopus 로고    scopus 로고
    • Glenmark Pharmaceuticals S.A. Novel urea derivatives as tec kinase inhibitors and uses thereof. WO2013024427
    • Glenmark Pharmaceuticals S.A. Novel urea derivatives as tec kinase inhibitors and uses thereof. WO2013024427; 2013
    • (2013)
  • 22
    • 84906237773 scopus 로고    scopus 로고
    • Glenmark Pharmaceuticals S.A. Tricyclic compounds as tec kinase inhibitors. WO2013153539
    • Glenmark Pharmaceuticals S.A. Tricyclic compounds as tec kinase inhibitors. WO2013153539; 2013
    • (2013)
  • 23
    • 84906264601 scopus 로고    scopus 로고
    • Glenmark Pharmaceuticals S.A. Heterocyclic amides as itk inhibitors. WO2014024119
    • Glenmark Pharmaceuticals S.A. Heterocyclic amides as itk inhibitors. WO2014024119; 2014
    • (2014)
  • 24
    • 84906212457 scopus 로고    scopus 로고
    • Glenmark Pharmaceuticals S.A. Thienopyrrole derivatives As Itk inhibitors. WO2014041518
    • Glenmark Pharmaceuticals S.A. Thienopyrrole derivatives As Itk inhibitors. WO2014041518; 2014
    • (2014)
  • 25
    • 84906263952 scopus 로고    scopus 로고
    • F Hoffmann-La Roche AG. Indazole compounds compositions and methods of use. WO2013024011
    • F Hoffmann-La Roche AG. Indazole compounds, compositions and methods of use. WO2013024011; 2013
    • (2013)
  • 26
    • 84886945855 scopus 로고    scopus 로고
    • Structure-based design and synthesis of potent benzothiazole inhibitors of interleukin-2 inducible T cell kinase (Itk)
    • MacKinnon CH, Lau K, Burch JD, et al. Structure-based design and synthesis of potent benzothiazole inhibitors of interleukin-2 inducible T cell kinase (Itk). Bioorg Med Chem Lett 2013;23(23):6331-5
    • (2013) Bioorg Med Chem Lett , vol.23 , Issue.23 , pp. 6331-6335
    • Mackinnon, C.H.1    Lau, K.2    Burch, J.D.3
  • 27
    • 84899989274 scopus 로고    scopus 로고
    • Discovery and optimization of indazoles as potent and selective interleukin-2 inducible T cell kinase (Itk) inhibitors
    • Pastor RM, Burch JD, Magnuson S, et al. Discovery and optimization of indazoles as potent and selective interleukin-2 inducible T cell kinase (Itk) inhibitors. Bioorg Med Chem Lett 2014;24(11):2448-52
    • (2014) Bioorg Med Chem Lett , vol.24 , Issue.11 , pp. 2448-2452
    • Pastor, R.M.1    Burch, J.D.2    Magnuson, S.3
  • 28
    • 84906266451 scopus 로고    scopus 로고
    • Genentech Inc. Pyrazole carboxamide compounds compositions and methods of use. WO2014023258
    • F.Hoffmann-La Roche AG, Genentech, Inc. Pyrazole carboxamide compounds, compositions and methods of use. WO2014023258; 2014
    • (2014)
    • Hoffmann-La, F.1    Roche, A.G.2
  • 29
    • 84906257189 scopus 로고    scopus 로고
    • Glaxo Group Ltd. pyrimidine derivatives used as Itk inhibitors. WO2010106016
    • Glaxo Group Ltd. pyrimidine derivatives used as Itk inhibitors. WO2010106016; 2010
    • (2010)
  • 30
    • 84906220588 scopus 로고    scopus 로고
    • Glaxo Group Ltd. Derivatives of 2-[2-(benzo-or pyrido-) thiazolylamino] -6-aminopyridine, useful in the treatment of respiratoric, allergic or inflammatory diseases. WO 2011110575
    • Glaxo Group Ltd. Derivatives of 2-[2-(benzo-or pyrido-) thiazolylamino]-6-aminopyridine, useful in the treatment of respiratoric, allergic or inflammatory diseases. WO 2011110575; 2011
    • (2011)
  • 31
    • 84906275926 scopus 로고    scopus 로고
    • Glaxo Group Ltd. Novel compounds. WO2012035055
    • Glaxo Group Ltd. Novel compounds. WO2012035055; 2012
    • (2012)
  • 32
    • 84884794348 scopus 로고    scopus 로고
    • Discovery of novel irreversible inhibitors of interleukin (IL)-2-inducible tyrosine kinase (Itk) by targeting cysteine 442 in the ATP pocket
    • Harling JD, Deakin AM, Campos S, et al. Discovery of novel irreversible inhibitors of interleukin (IL)-2-inducible tyrosine kinase (Itk) by targeting cysteine 442 in the ATP pocket. J Biol Chem 2013;288(39):28195-206
    • (2013) J Biol Chem , vol.288 , Issue.39 , pp. 28195-28206
    • Harling, J.D.1    Deakin, A.M.2    Campos, S.3
  • 33
    • 84884764926 scopus 로고    scopus 로고
    • Identification of a novel and selective series of itk inhibitors via a template-hopping strategy
    • Alder CM, Ambler M, Campbell AJ, et al. Identification of a novel and selective series of itk inhibitors via a template-hopping strategy. ACS med. Chem Lett 2013;4(10):948-52
    • (2013) ACS Med. Chem Lett , vol.4 , Issue.10 , pp. 948-952
    • Alder, C.M.1    Ambler, M.2    Campbell, A.J.3
  • 34
    • 84906253469 scopus 로고    scopus 로고
    • Development of irreversible Itk inhibitors as a potential new treatment for severe asthma
    • Hatfield; 24 April 2013
    • Campos S. Development of irreversible Itk inhibitors as a potential new treatment for severe asthma. 25th symposium on Medicinal Chemistry in Eastern England, Hatfield; 24 April 2013
    • 25th Symposium on Medicinal Chemistry in Eastern England
    • Campos, S.1
  • 35
    • 84906234601 scopus 로고    scopus 로고
    • Locus pharmaceuticals aminopyrazine compounds. WO2012121939
    • Locus pharmaceuticals aminopyrazine compounds. WO2012121939; 2012
    • (2012)
  • 36
    • 84906214157 scopus 로고    scopus 로고
    • Amgen, inc. Bis-aryl amide derivatives useful for the treatment of cancer. WO2008086014
    • Amgen, inc. Bis-aryl amide derivatives useful for the treatment of cancer. WO2008086014; 2008
    • (2008)
  • 37
    • 84870005710 scopus 로고    scopus 로고
    • Covalent inhibitors of interleukin-2 inducible T cell kinase (Itk) with nanomolar potency in a whole-blood assay
    • Zapf CW, Gerstenberger BS, Xing L, et al. Covalent inhibitors of interleukin-2 inducible T cell kinase (Itk) with nanomolar potency in a whole-blood assay. J Med Chem 2012;55(22):10047-63
    • (2012) J Med Chem , vol.55 , Issue.22 , pp. 10047-10063
    • Zapf, C.W.1    Gerstenberger, B.S.2    Xing, L.3
  • 38
    • 84900491469 scopus 로고    scopus 로고
    • Selectively targeting an inactive conformation of IL-2-induced T cell kinase by allosteric inhibitors
    • Han S, Czerwinski RM, Caspers NL, et al. Selectively targeting an inactive conformation of IL-2-induced T cell kinase by allosteric inhibitors. Biochem J 2014;460(2):211-22
    • (2014) Biochem J , vol.460 , Issue.2 , pp. 211-222
    • Han, S.1    Czerwinski, R.M.2    Caspers, N.L.3
  • 40
    • 84880447005 scopus 로고    scopus 로고
    • Inhibition of Btk with CC-292 provides early pharmacodynamic assessment of activity in mice and humans
    • Evans EK, Tester R, Aslanian S, et al. Inhibition of Btk with CC-292 provides early pharmacodynamic assessment of activity in mice and humans. J Pharmacol Exp Ther 2013;346(2):219-28
    • (2013) J Pharmacol Exp Ther , vol.346 , Issue.2 , pp. 219-228
    • Evans, E.K.1    Tester, R.2    Aslanian, S.3
  • 41
    • 84906250533 scopus 로고    scopus 로고
    • Avila Therapeutics Inc. Heteroaryl compounds and uses thereof. WO2009158571
    • Avila Therapeutics, Inc. Heteroaryl compounds and uses thereof. WO2009158571; 2009
    • (2009)
  • 42
    • 84906271931 scopus 로고    scopus 로고
    • Avila Therapeutics Inc. Heteroaryl compounds and uses thereof. WO-2010123870
    • Avila Therapeutics, Inc. Heteroaryl compounds and uses thereof. WO-2010123870; 2010
    • (2010)
  • 43
    • 84906227184 scopus 로고    scopus 로고
    • Avila Therapeutics Inc. Heteroaryl compounds and uses thereof. WO2011090760
    • Avila Therapeutics, Inc. Heteroaryl compounds and uses thereof. WO2011090760; 2011
    • (2011)
  • 44
    • 84906276729 scopus 로고    scopus 로고
    • Biogen Idec Inc. Sunesis Pharmaceuticals Inc. Heteroaryl Btk inhibitors. WO2011029043
    • Biogen Idec, Inc., Sunesis Pharmaceuticals, Inc. Heteroaryl Btk inhibitors. WO2011029043; 2011
    • (2011)
  • 45
    • 84906243829 scopus 로고    scopus 로고
    • Biogen Idec Inc. Sunesis Pharmaceuticals Inc. Bruton's tyrosine kinase inhibitors. WO2011029046
    • Biogen Idec, Inc., Sunesis Pharmaceuticals, Inc. Bruton's tyrosine kinase inhibitors. WO2011029046; 2011
    • (2011)
  • 46
    • 84906255949 scopus 로고    scopus 로고
    • Biogen Idec Inc. Sunesis Pharmaceuticalsi Inc. Heterocyclic tyrosine kinase inhibitors. WO2012058645
    • Biogen Idec, Inc., Sunesis Pharmaceuticals, Inc. Heterocyclic tyrosine kinase inhibitors. WO2012058645; 2012
    • (2012)
  • 47
    • 84906248347 scopus 로고    scopus 로고
    • University of California. Imidazoquinoxalinones and anti-tumor treatment WO2011017219
    • University of California. Imidazoquinoxalinones and anti-tumor treatment. WO2011017219; 2011
    • (2011)
  • 48
    • 84906244879 scopus 로고    scopus 로고
    • Bristol-Myers Squibb Co. Carboline carboxamide compounds useful as kinase inhibitors. WO2011159857
    • Bristol-Myers Squibb Co. Carboline carboxamide compounds useful as kinase inhibitors. WO2011159857; 2011
    • (2011)
  • 49
    • 33746517432 scopus 로고    scopus 로고
    • Discovery and SAR of 2-amino-5-(thioaryl)thiazoles as potent and selective Itk inhibitors
    • Das J, Furch JA, Liu C, et al. Discovery and SAR of 2-amino-5-(thioaryl) thiazoles as potent and selective Itk inhibitors. Bioorg Med Chem Lett 2006;16:3706-12
    • (2006) Bioorg Med Chem Lett , vol.16 , pp. 3706-3712
    • Das, J.1    Furch, J.A.2    Liu, C.3
  • 50
    • 84883160397 scopus 로고    scopus 로고
    • Ibrutinib and novel BTK inhibitors in clinical development
    • Akinleye A, Chen Y, Mukhi N, et al. Ibrutinib and novel BTK inhibitors in clinical development. J Hematol Oncol 2013;6:59
    • (2013) J Hematol Oncol , vol.6 , pp. 59
    • Akinleye, A.1    Chen, Y.2    Mukhi, N.3
  • 51
    • 84906231324 scopus 로고    scopus 로고
    • Hanmi Holdings Co Ltd. Novel fused pyrimidine derivatives for inhibition of tyrosine kinase activity. WO2011162515
    • Hanmi Holdings Co Ltd. Novel fused pyrimidine derivatives for inhibition of tyrosine kinase activity. WO2011162515; 2011
    • (2011)
  • 52
    • 84906250308 scopus 로고    scopus 로고
    • Hanmi Pharmaceutical Co Ltd. Novel imidazopyridine derivatives as a tyrosine kinase inhibitor. WO2013100631
    • Hanmi Pharmaceutical Co Ltd. Novel imidazopyridine derivatives as a tyrosine kinase inhibitor. WO2013100631; 2013
    • (2013)
  • 53
    • 84906270719 scopus 로고    scopus 로고
    • Hanmi Pharmaceutical Co Ltd. Triazolopyridine derivatives as a tyrosine kinase inhibitor. WO2013118986
    • Hanmi Pharmaceutical Co Ltd. Triazolopyridine derivatives as a tyrosine kinase inhibitor. WO2013118986; 2013
    • (2013)
  • 54
    • 84906267862 scopus 로고    scopus 로고
    • Cellzome Ltd Pyrazolo[4,3-c]pyridine derivatives as kinase inhibitors. WO2013041605
    • Cellzome Ltd. Pyrazolo[4,3-c]pyridine derivatives as kinase inhibitors. WO2013041605; 2013
    • (2013)
  • 55
    • 84906250217 scopus 로고    scopus 로고
    • Korea Institute Of Science And Technology. 2,7-substituted thieno[3,2-d] pyrimidine compounds as protein kinase inhibitors. WO2011049332
    • Korea Institute Of Science And Technology. 2,7-substituted thieno[3,2-d] pyrimidine compounds as protein kinase inhibitors. WO2011049332; 2011
    • (2011)
  • 56
    • 84906245349 scopus 로고    scopus 로고
    • Discovery of a highly potent, selective, reversible covalent inhibitor of JAK3
    • Hill RJ, Bisconte A, Bradshaw JM, et al. Discovery of a highly potent, selective, reversible covalent inhibitor of JAK3. Arthritis Rheum 2012;64(Suppl 10):2326
    • (2012) Arthritis Rheum , vol.64 , Issue.SUPPL. 10 , pp. 2326
    • Hill, R.J.1    Bisconte, A.2    Bradshaw, J.M.3
  • 57
    • 84906216178 scopus 로고    scopus 로고
    • Principia Biopharma Inc. Kinase knockdown via electrophilically enhanced inhibitors. WO2010054107
    • Principia Biopharma, Inc. Kinase knockdown via electrophilically enhanced inhibitors. WO2010054107; 2010
    • (2010)
  • 58
    • 84906238692 scopus 로고    scopus 로고
    • Principia Biopharma Inc. EGFR kinase knockdown via electrophilically enhanced inhibitors. WO2010065898
    • Principia Biopharma, Inc. EGFR kinase knockdown via electrophilically enhanced inhibitors. WO2010065898; 2010
    • (2010)
  • 59
    • 84906226263 scopus 로고    scopus 로고
    • Principia BiopharmaInc Azaindole derivatives as tyrosine kinase inhibitors. WO2012158785
    • Principia Biopharma, Inc. Azaindole derivatives as tyrosine kinase inhibitors. WO2012158785
  • 60
    • 84906255237 scopus 로고    scopus 로고
    • Principia BiopharmaInc. Pyrazolopyrimidine derivatives as tyrosine kinase inhibitors. WO2012158795
    • Principia Biopharma, Inc. Pyrazolopyrimidine derivatives as tyrosine kinase inhibitors. WO2012158795; 2012
    • (2012)
  • 61
    • 84906242267 scopus 로고    scopus 로고
    • Principia Biopharma Inc. Tyrosine kinase inhibitors. WO2012158810
    • Principia Biopharma, Inc. Tyrosine kinase inhibitors. WO2012158810; 2012
    • (2012)
  • 62
    • 84906259639 scopus 로고    scopus 로고
    • Dana-Farber Cancer Institute. Inc-Egfr inhibitors and methods of treating disorders. WO2010129053
    • Dana-Farber Cancer Institute. Inc-Egfr inhibitors and methods of treating disorders. WO2010129053; 2011
    • (2011)
  • 63
    • 84906228649 scopus 로고    scopus 로고
    • Gatekeeper Pharmaceuticals Inc. Compounds that modulate egfr activity and methods for treating or preventing conditions therewith. WO2011140338
    • Gatekeeper Pharmaceuticals, Inc. Compounds that modulate egfr activity and methods for treating or preventing conditions therewith. WO2011140338; 2011
    • (2011)
  • 64
    • 72949092456 scopus 로고    scopus 로고
    • Novel mutant-selective EGFR kinase inhibitors against EGFR T790M
    • Zhou W, Ercan D, Chen L, et al. Novel mutant-selective EGFR kinase inhibitors against EGFR T790M. Nature 2009;462(7276):1070-4
    • (2009) Nature , vol.462 , Issue.7276 , pp. 1070-1074
    • Zhou, W.1    Ercan, D.2    Chen, L.3
  • 65
    • 78651260008 scopus 로고    scopus 로고
    • Discovery of selective irreversible inhibitors for EGFR-T790M
    • Zhou W, Ercan D, Jänne PA, Gray NS. Discovery of selective irreversible inhibitors for EGFR-T790M. Bioorg Med Chem Lett 2011;21(2):638-43
    • (2011) Bioorg Med Chem Lett , vol.21 , Issue.2 , pp. 638-643
    • Zhou, W.1    Ercan, D.2    Jänne, P.A.3    Gray, N.S.4
  • 66
    • 78651361760 scopus 로고    scopus 로고
    • Controlling the activity of the Tec kinase Itk by mutation of the. Phenylalanine gatekeeper residue
    • Joseph RJ, Andreotti AH. Controlling the activity of the Tec kinase Itk by mutation of the. phenylalanine gatekeeper residue. Biochemistry 2011;50(2):221-9
    • (2011) Biochemistry , vol.50 , Issue.2 , pp. 221-229
    • Joseph, R.J.1    Andreotti, A.H.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.