Controlling the activity of the Tec Kinase Itk by mutation of the phenylalanine gatekeeper residue

Biochemistry

Volumn 50, Issue 2, 2011, Pages 221-229

  Joseph, Raji E ^a   Andreotti, Amy H ^a  

^a IOWA STATE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CONFORMATIONAL EQUILIBRIUM; CONSERVED RESIDUES; KINASE DOMAINS; KINASE FAMILY; LINKER REGION; N-TERMINALS; SPINE STRUCTURE; TEC KINASE;

AMINO ACIDS;

ALANINE; BRUTON TYROSINE KINASE; GLYCINE; METHIONINE; PHENYLALANINE; PROTEIN ITK; PROTEIN SH2; PROTEIN TYROSINE KINASE; UNCLASSIFIED DRUG;

AMINO TERMINAL SEQUENCE; ARTICLE; ENZYME ACTIVATION; ENZYME ACTIVE SITE; ENZYME ACTIVITY; ENZYME INACTIVATION; MUTATION; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN ASSEMBLY; PROTEIN CONFORMATION; PROTEIN DOMAIN; PROTEIN STRUCTURE; REGULATORY MECHANISM; SITE DIRECTED MUTAGENESIS; WESTERN BLOTTING;

AMINO ACID SEQUENCE; ANIMALS; MICE; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; MUTAGENESIS, SITE-DIRECTED; PHENYLALANINE; POINT MUTATION; PROTEIN-TYROSINE KINASES; SRC HOMOLOGY DOMAINS;

PYRONIA TITHONUS;

EID: 78651361760     PISSN: 00062960     EISSN: 15204995     Source Type: Journal    
DOI: 10.1021/bi101379m     Document Type: Article

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