Discovery and SAR of 2-amino-5-(thioaryl)thiazoles as potent and selective Itk inhibitors

Bioorganic and Medicinal Chemistry Letters

Volumn 16, Issue 14, 2006, Pages 3706-3712

  Das, Jagabandhu ^a   Furch, Joseph A ^a   Liu, Chunjian ^a   Moquin, Robert V ^a   Lin, James ^a   Spergel, Steven H ^a   McIntyre, Kim W ^a   Shuster, David J ^a   O'Day, Kathleen D ^a   Penhallow, Becky ^a   Hung, Chen Yi ^a   Doweyko, Arthur M ^a   Kamath, Amrita ^a   Zhang, Hongjian ^a   Marathe, Punit ^a   Kanner, Steven B ^a   Lin, Tai An ^a   Dodd, John H ^a   Barrish, Joel C ^a   Wityak, John ^a  

^a BRISTOL MYERS SQUIBB   (United States)

Author keywords

Amino (thioaryl)thiazoles; Selective Itk inhibitor

Indexed keywords

INTERLEUKIN 2; INTERLEUKIN 2 INDUCIBLE T CELL KINASE INHIBITOR; OVALBUMIN; PHOSPHOTRANSFERASE INHIBITOR; T LYMPHOCYTE RECEPTOR; THIAZOLE DERIVATIVE; UNCLASSIFIED DRUG;

ALLERGIC ASTHMA; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; DRUG BLOOD LEVEL; DRUG CLEARANCE; DRUG DESIGN; DRUG EFFICACY; DRUG HALF LIFE; DRUG INHIBITION; DRUG POTENCY; DRUG SELECTIVITY; DRUG SYNTHESIS; LEUKEMIA CELL LINE; MOUSE; NONHUMAN; PNEUMONIA; STRUCTURE ACTIVITY RELATION; STRUCTURE ANALYSIS;

ANIMALS; ASTHMA; CELLS, CULTURED; ENZYME INHIBITORS; HUMANS; HYPERSENSITIVITY; JURKAT CELLS; MICE; PNEUMONIA; PROTEIN-TYROSINE KINASES; STRUCTURE-ACTIVITY RELATIONSHIP; SULFIDES; THIAZOLES;

EID: 33746517432     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2006.04.060     Document Type: Article

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